Deficient regulatory B cells in human chronic graft-versus-host disease

Abstract

Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10–producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.

Keywords:

• chronic graft-versus-host disease
• allogeneic stem cell transplantation
• regulatory B cells
• interleukin-10

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Funding

Adèle de Masson was supported by the Institut National du Cancer (INCa) – Institut Thématique Multi-Organismes (ITMO) Cancer. This work was funded by a grant from the Société Française de Dermatologie.