Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity

ABSTRACT

Glycolytic activity in T cells governs T cell responses by controlling various cellular processes, including proliferation, survival, and effector functions. We recently showed that the tumor microenvironment diminishes T cell antitumor responses by depriving glucose to infiltrating T cells. Moreover, metabolic rewiring tumor-reactive T cells sustain T cell metabolic fitness and antitumor responses.

KEYWORDS:

• Immunotherapy
• immune checkpoint
• metabolic reprogramming
• PEP
• tumor infiltrating T cell

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Funding

P.-C. H. is supported by ISREC research grant (26075483), SNSF Project Grant (31003A_163204), and Ludwig Center for Cancer Research (2607011910).