OncoImmunology, Volume 5, Issue 4 (2016)

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OncoImmunology, Volume 5, Issue 4 (2016)

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Author's View

Opinion
RIPK3—a predictive marker for personalized immunotherapy?
Sigrun Smola
Article: e1075695
Published online: 08 Apr 2016
AbstractforRIPK3—a predictive marker for personalized immunotherapy? | Full Text | References | PDF (357.4 KB)
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Opinion
Ameliorating the tumor microenvironment for antitumor responses through TLR5 ligand-secreting T cells
Sabina Kaczanowska & Eduardo Davila
Article: e1076609
Published online: 08 Apr 2016
AbstractforAmeliorating the tumor microenvironment for antitumor responses through TLR5 ligand-secreting T cells | Full Text | References | PDF (307.8 KB)
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Opinion
The controversial role of TNF in melanoma
Marco Donia, Julie Westerlin Kjeldsen & Inge Marie Svane
Article: e1107699
Published online: 08 Apr 2016
AbstractforThe controversial role of TNF in melanoma | Full Text | References | PDF (303.1 KB)
  • 896 Views
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Opinion
Procarcinogenic regulatory T cells in microbial-induced colon cancer
Abby L. Geis & Franck Housseau
Article: e1118601
Published online: 08 Apr 2016
AbstractforProcarcinogenic regulatory T cells in microbial-induced colon cancer | Full Text | References | PDF (337.9 KB)
  • 701 Views
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Opinion
Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity
Wan-Chen Cheng & Ping-Chih Ho
Article: e1119355
Published online: 08 Apr 2016
AbstractforMetabolic tug-of-war in tumors results in diminished T cell antitumor immunity | Full Text | References | PDF (427 KB)
  • 881 Views
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Opinion
FAK goes nuclear to control antitumor immunity—a new target in cancer immuno-therapy
Alan Serrels & Margaret C. Frame
Article: e1119356
Published online: 08 Apr 2016
AbstractforFAK goes nuclear to control antitumor immunity—a new target in cancer immuno-therapy | Full Text | References | PDF (382 KB)
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Opinion
Prospective strategies to combine conventional, targeted and immunotherapies in non-small cell lung cancer
Danila Valmori & Maha Ayyoub
Article: e947175
Published online: 29 Oct 2014
AbstractforProspective strategies to combine conventional, targeted and immunotherapies in non-small cell lung cancer | Full Text | References | PDF (163.2 KB)
  • 504 Views
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Opinion
Secreted microRNAs from tumor cells can suppress immune function
Xi Chen, Hongwei Liang, Ke Zen & Chen-Yu Zhang
Article: e982407
Published online: 08 Apr 2016
AbstractforSecreted microRNAs from tumor cells can suppress immune function | Full Text | References | PDF (213.7 KB)
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Brief Report

Brief Report
Attenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer
Kiah L. Sanders, Barbara A. Fox & David J. Bzik
Article: e1104447
Published online: 08 Apr 2016
AbstractforAttenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer | Full Text | References | PDF (385 KB)
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Original Research

Article
Interactions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1
Huayang Wang, Qianqian Shao, Jintang Sun, Chao Ma, Wenjuan Gao, Qingjie Wang, Lei Zhao & Xun Qu
Article: e1122157
Published online: 08 Apr 2016
AbstractforInteractions between colon cancer cells and tumor-infiltrated macrophages depending on cancer cell-derived colony stimulating factor 1 | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1918 Views
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Article
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC
Benjamin Besse, Mélinda Charrier, Valérie Lapierre, Eric Dansin, Olivier Lantz, David Planchard, Thierry Le Chevalier, Alain Livartoski, Fabrice Barlesi, Agnès Laplanche, Stéphanie Ploix, Nadège Vimond, Isabelle Peguillet, Clotilde Théry, Ludovic Lacroix, Inka Zoernig, Kavita Dhodapkar, Madhav Dhodapkar, Sophie Viaud, Jean-Charles Soria, Katrin S. Reiners, Elke Pogge von Strandmann, Frédéric Vély, Sylvie Rusakiewicz, Alexander Eggermont, Jonathan M. Pitt, Laurence Zitvogel & Nathalie Chaput
Article: e1071008
Published online: 08 Apr 2016
AbstractforDendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC | Full Text | References | PDF (1.1 MB) | Supplemental
  • 8266 Views
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Article
Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma
Giovanni Francesco Castino, Nina Cortese, Giovanni Capretti, Simone Serio, Giuseppe Di Caro, Rossana Mineri, Elena Magrini, Fabio Grizzi, Paola Cappello, Francesco Novelli, Paola Spaggiari, Massimo Roncalli, Cristina Ridolfi, Francesca Gavazzi, Alessandro Zerbi, Paola Allavena & Federica Marchesi
Article: e1085147
Published online: 08 Apr 2016
AbstractforSpatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma | Full Text | References | PDF (1.7 MB) | Supplemental
  • 2916 Views
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Article
NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors
Guranda Chitadze, Marcus Lettau, Stefanie Luecke, Ting Wang, Ottmar Janssen, Daniel Fürst, Joannis Mytilineos, Daniela Wesch, Hans-Heinrich Oberg, Janka Held-Feindt & Dieter Kabelitz
Article: e1093276
Published online: 08 Apr 2016
AbstractforNKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2071 Views
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Article
Overexpression of KIR inhibitory ligands (HLA-I) determines that immunosurveillance of myeloma depends on diverse and strong NK cell licensing
María V. Martínez-Sánchez, Adela Periago, Isabel Legaz, Lourdes Gimeno, Anna Mrowiec, Natividad R. Montes-Barqueros, José A. Campillo, José M. Bolarin, María V. Bernardo, María R. López-Álvarez, Consuelo González, María C. García-Garay, Manuel Muro, Valentin Cabañas-Perianes, Jose L. Fuster, Ana M. García-Alonso, José M. Moraleda, María R. Álvarez-Lopez & Alfredo Minguela
Article: e1093721
Published online: 08 Apr 2016
AbstractforOverexpression of KIR inhibitory ligands (HLA-I) determines that immunosurveillance of myeloma depends on diverse and strong NK cell licensing | Full Text | References | PDF (1.1 MB)
  • 1125 Views
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Article
Peripheral trafficking of bone-marrow-derived stem cells in patients with different types of gastric neoplasms
Wojciech Błogowski, Ewa Zuba-Surma, Daria Sałata, Marta Budkowska, Barbara Dołęgowska & Teresa Starzyńska
Article: e1099798
Published online: 08 Apr 2016
AbstractforPeripheral trafficking of bone-marrow-derived stem cells in patients with different types of gastric neoplasms | Full Text | References | PDF (570 KB)
  • 889 Views
  • 15 CrossRef citations
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Article
Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab
Jon Bjoern, Nikolaj Juul Nitschke, Trine Zeeberg Iversen, Henrik Schmidt, Kirsten Fode & Inge Marie Svane
Article: e1100788
Published online: 08 Apr 2016
AbstractforImmunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab | Full Text | References | PDF (854.7 KB)
  • 1425 Views
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Article
Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion
Bharat K. R. Chaganty, Yang Lu, Songbo Qiu, Srinivas S. Somanchi, Dean A. Lee & Zhen Fan
Article: e1100790
Published online: 08 Apr 2016
AbstractforTrastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion | Full Text | References | PDF (1.4 MB)
  • 2178 Views
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Article
GM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses
Serena S. Kwek, James Kahn, Samantha K. Greaney, Jera Lewis, Edward Cha, Li Zhang, Robert W. Weber, Lonnie Leonard, Svetomir N. Markovic, Lawrence Fong & Lynn E. Spitler
Article: e1101204
Published online: 08 Apr 2016
AbstractforGM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses | Full Text | References | PDF (964.6 KB) | Supplemental
  • 1278 Views
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Article
Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients
Pierpaolo Correale, Cirino Botta, Elodia Claudio Martino, Cristina Ulivieri, Giuseppe Battaglia, Tommaso Carfagno, Maria Grazia Rossetti, Antonella Fioravanti, Giacomo Maria Guidelli, Sara Cheleschi, Claudia Gandolfo, Francesco Carbone, Tatiana Cosima Baldari, Pierfrancesco Tassone, Pierosandro Tagliaferri, Luigi Pirtoli & Maria Grazia Cusi
Article: e1101205
Published online: 08 Apr 2016
AbstractforPhase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients | Full Text | References | PDF (572.5 KB)
  • 921 Views
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Article
Vemurafenib and ipilimumab: A promising combination? Results of a case series
Jessica C. Hassel, Sophia B. Lee, Frank Meiss, Friedegund Meier, Antonia Dimitrakopoulou-Strauss, Dirk Jäger & Alexander H. Enk
Article: e1101207
Published online: 08 Apr 2016
AbstractforVemurafenib and ipilimumab: A promising combination? Results of a case series | Full Text | References | PDF (491.3 KB)
  • 877 Views
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Article
Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients
Michal Hensler, Irena Vančurová, Etienne Becht, Ondřej Palata, Pavel Strnad, Petra Tesařová, Michaela Čabiňaková, David Švec, Mikael Kubista, Jiřina Bartůňková, Radek Špíšek & Luděk Sojka
Article: e1102827
Published online: 08 Apr 2016
AbstractforGene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2626 Views
  • 31 CrossRef citations
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Open Access
Article
Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma
Cristian Capasso, Mari Hirvinen, Mariangela Garofalo, Dmitrii Romaniuk, Lukasz Kuryk, Teea Sarvela, Andrea Vitale, Maxim Antopolsky, Aniket Magarkar, Tapani Viitala, Teemu Suutari, Alex Bunker, Marjo Yliperttula, Arto Urtti & Vincenzo Cerullo
Article: e1105429
Published online: 08 Apr 2016
AbstractforOncolytic adenoviruses coated with MHC-I tumor epitopes increase the antitumor immunity and efficacy against melanoma | Full Text | References | PDF (807.6 KB)
  • 3569 Views
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Article
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Stalin Chellappa, Harald Hugenschmidt, Morten Hagness, Pål D. Line, Knut J. Labori, Gro Wiedswang, Kjetil Taskén & Einar M. Aandahl
Article: e1102828
Published online: 08 Apr 2016
AbstractforRegulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2939 Views
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Article
Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells
Joyce M. van Dodewaard-de Jong, Saskia JAM Santegoets, Peter M. van de Ven, Jurjen Versluis, Henk M. W. Verheul, Tanja D. de Gruijl, Winald R. Gerritsen & Alfons J. M. van den Eertwegh
Article: e1105431
Published online: 08 Apr 2016
AbstractforImproved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells | Full Text | References | PDF (557.6 KB)
  • 793 Views
  • 11 CrossRef citations
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Article
Phenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome
Viktor H. Koelzer, Katharina Canonica, Heather Dawson, Lena Sokol, Eva Karamitopoulou-Diamantis, Alessandro Lugli & Inti Zlobec
Article: e1106677
Published online: 08 Apr 2016
AbstractforPhenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome | Full Text | References | PDF (923.9 KB) | Supplemental
  • 2829 Views
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Article
Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course
An Coosemans, Judit Decoene, Thaïs Baert, Annouschka Laenen, Ahmad Kasran, Tina Verschuere, Sven Seys & Ignace Vergote
Article: e1111505
Published online: 08 Apr 2016
AbstractforImmunosuppressive parameters in serum of ovarian cancer patients change during the disease course | Full Text | References | PDF (607.8 KB) | Supplemental
  • 1667 Views
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Article
Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells
Pavel Otáhal, Dana Průková, Vlastimil Král, Milan Fabry, Petra Vočková, Lucie Latečková, Marek Trněný & Pavel Klener
Article: e1115940
Published online: 08 Apr 2016
AbstractforLenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells | Full Text | References | PDF (899.6 KB) | Supplemental
  • 3857 Views
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Article
Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity
Yuan Hong, Indumathi Manoharan, Amol Suryawanshi, Arulkumaran Shanmugam, Daniel Swafford, Shamim Ahmad, Raghavan Chinnadurai, Balaji Manicassamy, Yukai He, Andrew L. Mellor, Muthusamy Thangaraju, David H. Munn & Santhakumar Manicassamy
Article: e1115941
Published online: 08 Apr 2016
AbstractforDeletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity | Full Text | References | PDF (888.7 KB) | Supplemental
  • 1895 Views
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Article
MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition
Justin M. David, Duane H. Hamilton & Claudia Palena
Article: e1117738
Published online: 08 Apr 2016
AbstractforMUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1947 Views
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Article
Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression
Ruihua Ma, Tiantian Ji, Degao Chen, Wenqian Dong, Huafeng Zhang, Xiaonan Yin, Jingwei Ma, Xiaoyu Liang, Yi Zhang, Guanxin Shen, Xiaofeng Qin & Bo Huang
Article: e1118599
Published online: 08 Apr 2016
AbstractforTumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression | Full Text | References | PDF (1.4 MB) | Supplemental
  • 4052 Views
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Article
Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival
Sabrina Genßler, Michael C. Burger, Congcong Zhang, Sarah Oelsner, Iris Mildenberger, Marlies Wagner, Joachim P. Steinbach & Winfried S. Wels
Article: e1119354
Published online: 08 Apr 2016
AbstractforDual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival | Full Text | References | PDF (1.3 MB) | Supplemental
  • 3869 Views
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Article
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer
Guy Berchem, Muhammad Zaeem Noman, Manon Bosseler, Jerome Paggetti, Sonia Baconnais, Eric Le cam, Arash Nanbakhsh, Etienne Moussay, Fathia Mami-Chouaib, Bassam Janji & Salem Chouaib
Article: e1062968
Published online: 08 Apr 2016
AbstractforHypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer | Full Text | References | PDF (1.9 MB)
  • 4004 Views
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Point of View

Article
Non-redundant roles for Th17 and Th22 cells in multiple myeloma clinical correlates
Giulia Di Lullo, Magda Marcatti & Maria Pia Protti
Article: e1093278
Published online: 08 Apr 2016
AbstractforNon-redundant roles for Th17 and Th22 cells in multiple myeloma clinical correlates | Full Text | References | PDF (518.5 KB)
  • 743 Views
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Review

Review
Have lessons from past failures brought us closer to the success of immunotherapy in metastatic pancreatic cancer?
Laura Rosa Brunet, Thorsten Hagemann, Andrew Gaya, Satvinder Mudan & Aurelien Marabelle
Article: e1112942
Published online: 08 Apr 2016
AbstractforHave lessons from past failures brought us closer to the success of immunotherapy in metastatic pancreatic cancer? | Full Text | References | PDF (382.5 KB)
  • 1885 Views
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Review
CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses
Bhushan Dharmadhikari, Meihui Wu, Nur Sharalyn Abdullah, Sakthi Rajendran, Nur Diana Ishak, Emily Nickles, Zulkarnain Harfuddin & Herbert Schwarz
Article: e1113367
Published online: 08 Apr 2016
AbstractforCD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses | Full Text | References | PDF (721.9 KB)
  • 3284 Views
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Article
Advances in clinical NK cell studies: Donor selection, manufacturing and quality control
U. Koehl, C. Kalberer, J. Spanholtz, D. A. Lee, J. S. Miller, S. Cooley, M. Lowdell, L. Uharek, H. Klingemann, A. Curti, W. Leung & E. Alici
Article: e1115178
Published online: 08 Apr 2016
AbstractforAdvances in clinical NK cell studies: Donor selection, manufacturing and quality control | Full Text | References | PDF (581.7 KB)
  • 5583 Views
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Review
Perspectives on sipuleucel-T: Its role in the prostate cancer treatment paradigm
James L. Gulley, Peter Mulders, Peter Albers, Jacques Banchereau, Michel Bolla, Klaus Pantel & Thomas Powles
Article: e1107698
Published online: 08 Apr 2016
AbstractforPerspectives on sipuleucel-T: Its role in the prostate cancer treatment paradigm | Full Text | References | PDF (522.4 KB)
  • 1759 Views
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