Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

Ruan F. V. MedranoViral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

Aline HungerViral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

João P. P. CataniViral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, Brazil

Bryan E. StraussViral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, BrazilCorrespondence[email protected]

http://orcid.org/0000-0002-4113-9450

ABSTRACT

Simultaneous reestablishment of p53/p19^Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4⁺ and CD8⁺ T lymphocytes.

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Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Funding

We are grateful for the São Paulo Research Foundation for grants (BES) 13/25167–5 and 15/26580–9; and fellowships (RFVM) 13/09474–5, (AH) 11/10656–5.

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Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

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Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

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