OncoImmunology, Volume 6, Issue 7 (2017)

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OncoImmunology, Volume 6, Issue 7 (2017)

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Author's View

Opinion
PD-L1 immune suppression in cancer: Tumor cells or host cells?
Jan Willem Kleinovink, Thorbald van Hall, Ferry Ossendorp & Marieke F. Fransen
Article: e1325982
Published online: 28 Jun 2017
AbstractforPD-L1 immune suppression in cancer: Tumor cells or host cells? | Full Text | References | PDF (420.5 KB)
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Brief Report

Article
PD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation
Huanbin Wang, Han Yao, Chushu Li, Lunxi Liang, Yao Zhang, Hubing Shi, Chongzhi Zhou, Yingxuan Chen, Jing-Yuan Fang & Jie Xu
Article: e1327494
Published online: 28 Jun 2017
AbstractforPD-L2 expression in colorectal cancer: Independent prognostic effect and targetability by deglycosylation | Full Text | References | PDF (1.5 MB) | Supplemental
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Article
IL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò & Vincenzo Barnaba
Article: e1328337
Published online: 28 Jun 2017
AbstractforIL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer | Full Text | References | PDF (945.2 KB) | Supplemental
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Article
K27M-mutant histone-3 as a novel target for glioma immunotherapy
Katharina Ochs, Martina Ott, Theresa Bunse, Felix Sahm, Lukas Bunse, Katrin Deumelandt, Jana K. Sonner, Melanie Keil, Andreas von Deimling, Wolfgang Wick & Michael Platten
Article: e1328340
Published online: 05 Jul 2017
AbstractforK27M-mutant histone-3 as a novel target for glioma immunotherapy | Full Text | References | PDF (1 MB) | Supplemental
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Article
Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells
Fengyang Lei, Mohammad Haque, Praneet Sandhu, Swetha Ravi, Jianyong Song, Bing Ni, Songguo Zheng, Deyu Fang, Hongyan Jia, Jin-Ming Yang & Jianxun Song
Article: e1334027
Published online: 28 Jun 2017
AbstractforDevelopment and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells | Full Text | References | PDF (1.2 MB) | Supplemental
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Editorial

Article
PD-L1 blockade for urothelial carcinoma
Josephine Kang & Lorenzo Galluzzi
Article: e1334028
Published online: 28 Jun 2017
First Page PreviewforPD-L1 blockade for urothelial carcinoma | Full Text | References | PDF (280.2 KB)
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Original Research

Article
Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma
Julie S. Nielsen, Andrew R. Chang, Darin A. Wick, Colin G. Sedgwick, Zusheng Zong, Andrew J. Mungall, Spencer D. Martin, Natalie N. Kinloch, Susann Ott-Langer, Zabrina L. Brumme, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, John R. Webb, Brian R. Berry, Ryan D. Morin, Nicol Macpherson & Brad H. Nelson
Article: e1321184
Published online: 28 Jun 2017
AbstractforMapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma | Full Text | References | PDF (898.9 KB) | Supplemental
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Article
Soluble NKG2D ligands are biomarkers associated with the clinical outcome to immune checkpoint blockade therapy of metastatic melanoma patients
Cristina Maccalli, Diana Giannarelli, Carla Chiarucci, Ornella Cutaia, Gianluca Giacobini, Wouter Hendrickx, Giovanni Amato, Diego Annesi, Davide Bedognetti, Maresa Altomonte, Riccardo Danielli, Luana Calabrò, Anna Maria Di Giacomo, Francesco M. Marincola, Giorgio Parmiani & Michele Maio
Article: e1323618
Published online: 20 Jun 2017
AbstractforSoluble NKG2D ligands are biomarkers associated with the clinical outcome to immune checkpoint blockade therapy of metastatic melanoma patients | Full Text | References | PDF (874.5 KB) | Supplemental
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Article
Rehmannia glutinosa polysaccharide induces toll-like receptor 4 dependent spleen dendritic cell maturation and anti-cancer immunity
Li Xu, Minseok Kwak, Wei Zhang, Ling Zeng, Peter Chang-Whan Lee & Jun-O Jin
Article: e1325981
Published online: 20 Jun 2017
AbstractforRehmannia glutinosa polysaccharide induces toll-like receptor 4 dependent spleen dendritic cell maturation and anti-cancer immunity | Full Text | References | PDF (1.5 MB) | Supplemental
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Article
An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors
Satyen Harish Gohil, Solange Rosa Paredes-Moscosso, Micaela Harrasser, Marzia Vezzalini, Aldo Scarpa, Emma Morris, Andrew M. Davidoff, Claudio Sorio, Amit Chunilal Nathwani & Marco Della Peruta
Article: e1326437
Published online: 11 Jul 2017
AbstractforAn ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors | Full Text | References | PDF (1.5 MB) | Supplemental
  • 6244 Views
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Open Access
Article
Characterization of the cryoablation-induced immune response in kidney cancer patients
Taigo Kato, Tomoyuki Iwasaki, Motohide Uemura, Akira Nagahara, Hiroki Higashihara, Keigo Osuga, Yuji Ikeda, Kazuma Kiyotani, Jae-Hyun Park, Norio Nonomura & Yusuke Nakamura
Article: e1326441
Published online: 28 Jun 2017
AbstractforCharacterization of the cryoablation-induced immune response in kidney cancer patients | Full Text | References | PDF (1.4 MB) | Supplemental
  • 1538 Views
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Article
Adjuvant immunotherapy with autologous dendritic cells for hepatocellular carcinoma, randomized phase II study
Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Yong-Soo Bae & Yoon Jun Kim
Article: e1328335
Published online: 28 Jun 2017
AbstractforAdjuvant immunotherapy with autologous dendritic cells for hepatocellular carcinoma, randomized phase II study | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1957 Views
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Article
IL-32α-induced inflammation constitutes a link between obesity and colon cancer
Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Victor A. Ortega, José Luis Hernández-Lizoain, Jorge Baixauli, Sara Becerril, Fernando Rotellar, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador & Gema Frühbeck
Article: e1328338
Published online: 28 Jun 2017
AbstractforIL-32α-induced inflammation constitutes a link between obesity and colon cancer | Full Text | References | PDF (915.8 KB) | Supplemental
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Article
Preclinical immunoPET/CT imaging using Zr-89-labeled anti-PD-L1 monoclonal antibody for assessing radiation-induced PD-L1 upregulation in head and neck cancer and melanoma
Masahiro Kikuchi, David A. Clump, Raghvendra M. Srivastava, Lingyi Sun, Dexing Zeng, Julio A. Diaz-Perez, Carolyn J. Anderson, W. Barry Edwards & Robert L. Ferris
Article: e1329071
Published online: 20 Jun 2017
AbstractforPreclinical immunoPET/CT imaging using Zr-89-labeled anti-PD-L1 monoclonal antibody for assessing radiation-induced PD-L1 upregulation in head and neck cancer and melanoma | Full Text | References | PDF (1.4 MB) | Supplemental
  • 3522 Views
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Article
Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments
Manuele G. Muraro, Simone Muenst, Valentina Mele, Luca Quagliata, Giandomenica Iezzi, Alexandar Tzankov, Walter P. Weber, Giulio C. Spagnoli & Savas D. Soysal
Article: e1331798
Published online: 11 Jul 2017
AbstractforEx-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2821 Views
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Article
Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment
Xiuyun Jiang, Y. David Seo, Jae Hyuck Chang, Andrew Coveler, Eslam N. Nigjeh, Sheng Pan, Florencia Jalikis, Raymond S. Yeung, Ian N. Crispe & Venu G. Pillarisetty
Article: e1333210
Published online: 11 Jul 2017
AbstractforLong-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment | Full Text | References | PDF (1.6 MB) | Supplemental
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Open Access
Article
Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer
Marcello Rubino, Paolo Kunderfranco, Gianluca Basso, Carolina Magdalen Greco, Fabio Pasqualini, Simone Serio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Roberto Papait & Cecilia Garlanda
Article: e1333215
Published online: 11 Jul 2017
AbstractforEpigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer | Full Text | References | PDF (1.9 MB) | Supplemental
  • 1728 Views
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Article
ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K. Grabowska & Angelika B. Riemer
Article: e1336594
Published online: 28 Jun 2017
AbstractforERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism | Full Text | References | PDF (1 MB) | Supplemental
  • 1753 Views
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Miata Compliant Research Paper

Article
NK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors
Alexander W. MacFarlane IV, Mowafaq Jillab, Mitchell R. Smith, R. Katherine Alpaugh, Marion E. Cole, Samuel Litwin, Michael M. Millenson, Tahseen Al-Saleem, Adam D. Cohen & Kerry S. Campbell
Article: e1330235
Published online: 20 Jun 2017
AbstractforNK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1523 Views
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Point of View

Review
Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death
Ruan F. V. Medrano, Aline Hunger, João P. P. Catani & Bryan E. Strauss
Article: e1329072
Published online: 20 Jun 2017
AbstractforUncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death | Full Text | References | PDF (477.8 KB)
  • 980 Views
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Review

Article
T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma
Daniele Maggioni, Lorenzo Pignataro & Werner Garavello
Article: e1325066
Published online: 20 Jun 2017
AbstractforT-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma | Full Text | References | PDF (487.1 KB)
  • 1049 Views
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Article
CEACAM1 as a multi-purpose target for cancer immunotherapy
Matthew Dankner, Scott D. Gray-Owen, Yu-Hwa Huang, Richard S. Blumberg & Nicole Beauchemin
Article: e1328336
Published online: 28 Jun 2017
AbstractforCEACAM1 as a multi-purpose target for cancer immunotherapy | Full Text | References | PDF (1.1 MB)
  • 4653 Views
  • 38 CrossRef citations
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Open Access
Article
Trial watch: Dendritic cell-based anticancer immunotherapy
Abhishek D. Garg, Monica Vara Perez, Marco Schaaf, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e1328341
Published online: 28 Jun 2017
AbstractforTrial watch: Dendritic cell-based anticancer immunotherapy | Full Text | References | PDF (841.8 KB)
  • 4532 Views
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Article
Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells
Zibing Wang, Brian Till & Quanli Gao
Article: e1331807
Published online: 11 Jul 2017
AbstractforChemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells | Full Text | References | PDF (483.9 KB)
  • 2347 Views
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