Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

ABSTRACT

As a malignant disease, lung cancer has a high morbidity and mortality rate. Baicalin is derived from Radix Scutellariae and has anti-tumor effects, however, its role in lung cancer remains unknown. Here, functional assays suggested baicalin suppressed in vitro lung cancer phenotypes. We used micro (mi)RNA array analysis to explore baicalin effects on miRNA expression. We observed baicalin increased miR-340-5p expression, whereas inhibition of this expression abolished anti-tumor effects of baicalin. Furthermore, neuroepithelial cell transforming 1 (NET1) functioned as a miR-340-5p target, and acted in a baicalin-dependent manner to regulate lung cancer progression. Thus, baicalin elicited antitumor activities by affecting the miR-340-5p/NET1 axis, suggesting a new approach to lung cancer clinical management.

KEYWORDS:

• Lung cancer
• baicalin
• miR-340-5p
• NET1

Highlights

• 1. Baicalin reduces lung cancer cells proliferation and invasion

• 2. MiR-340-5p directly targets NET1

• 3. Baicalin reduces lung cancer cells phenotypes by targeting the miR-340-5p/NET1 axis

Acknowledgements

None.

Ethics statement

Ethical approval was given by the Ethics Committee of the First Affiliated Hospital of Xinxiang Medical University.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The dataset supporting the conclusions of this article is included within the article.

Supplementary material

Supplemental data for this article can be accessed here.