MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

Abstract

MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.

Keywords:

• MiR-30a-5p
• prostate cancer
• PCLAF
• proliferation

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Military Medical Scientific Youth Cultivation Project (No.15QNP205) and Outstanding Youth Funds of Fuzhou General Hospital (2015Q04, 2017Q05).