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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 47, 2019 - Issue 1
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Review

MicroRNA-based potential diagnostic, prognostic and therapeutic applications in triple-negative breast cancer

Qian Tanga Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, ChinaView further author information
,
Hu Ouyanga Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, ChinaView further author information
,
Dongxiu Hea Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China;b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, ChinaCorrespondence[email protected]
View further author information
,
Cuiyun Yua Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China;b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, ChinaView further author information
&
Guotao Tanga Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China;b Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, ChinaView further author information
Pages 2800-2809 | Received 03 Apr 2019, Accepted 24 Jun 2019, Published online: 09 Jul 2019
 
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Abstract

Triple-negative breast cancer (TNBC) is a distinct subtype of breast cancer characterized by high recurrence rates and poor prognosis compared to other breast cancers. MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of various post-transcriptional gene and silence a broad set of target genes. Many recent studies have demonstrated that miRNAs play an important role in the initiation, promotion, malignant conversion, progression, and metastasis of TNBC. Therefore, the aim of this review is to focus on recent advancements of microRNAs-based potential applications in diagnosis, treatment and prognosis of triple-negative breast cancer.

Acknowledgement

Financial assistance received from Innovation platform Open Foundation of education department of Hunan province is acknowledged with thanks.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This work was supported by Innovation platform Open Foundation of education department of Hunan province [contract grant number 16K079, 17K082] and University of South China Innovation Foundation For Postgraduate.

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