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Research Article

Association of TP73-AS1 gene polymorphisms with the risk and survival of gastric cancer in a Chinese Han Population

, , , , , , , , & show all
Pages 3814-3822 | Received 06 Jul 2019, Accepted 04 Sep 2019, Published online: 24 Sep 2019
 

Abstract

It was investigated that TP73-AS1(TP73 antisense RNA 1) could function as an oncogene in gastric cancer (GC). The expression and function of long noncoding RNAs (lncRNAs) could be impacted by single nucleotide polymorphisms (SNPs), which are related to cancer susceptibility and prognosis. This study was to reveal the association between lncRNAs TP73-AS1 polymorphisms (rs1181865 A > G, rs9800 G > C, rs3737589 A > G, rs2298222 G > A, rs7515164 C > A) and GC in 1000 GC cases and 1000 controls in a Chinese Han population. Rs3737589 G allele had significant associations with the increasing risk of GC (G vs. A: p = .005). Rs3737589 variant genotypes (AG + GG) were related to an increased risk of GC in the elder population (age ≥60), females, nonsmokers, nondrinkers, individuals living in urban, and individuals without family history of GC in stratified analyses. Rs3737589 variant genotypes (AG + GG) were related to the advanced depth of tumor invasion (T3 + T4). Besides, we found that GC patients with AG or GG genotype of rs3737589 had poorer overall survival (OS) than those with AA genotype (p < .05). Our findings showed that the lncRNA TP73-AS1 rs3737589 polymorphism might increase the risk of GC, and rs3737589 polymorphism could be a potential biomarker to predict the prognosis of GC patients.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Nature Science Foundation of China [81874219(BA18)], the Natural Science Foundation of Jiangsu Province [Grant no. BK20171505], the “Medical ZhongDianRenCai Project” of Jiangsu Province [Grant no. RC2011059], the six one project of Jiangsu Province [2017 (IC17)] and Jiangsu Provincial Project [Grant no. BRA2013280 (RS13)].