A comprehensive review of the therapeutic potential of citrus bioflavonoid hesperidin against lifestyle-related disorders

Abstract

The fruits of citrus family are rich in flavonoids with superior antioxidant properties; citrus bioactive components are potentially beneficial without adverse effects or cytotoxicity in healthy individuals. Citrus fruit peel contains ample amount of hesperidin which is flavanone glycoside and has showed effective role in biological systems as an antioxidant and anti-inflammatory bioactive compound. Different studies have investigated such roles of hesperidin. Due to superior antioxidant potential of hesperidin and its derivatives, these compounds have been intensively studied for their anti-cancer and cardio protective perspective. This review article is a collection of updated data covering different aspects of hesperidin and its derivatives, like occurrence, physical and chemical composition, pharmacokinetics and safety of these compounds. Moreover, effective role of these compounds against different lifestyle-related metabolic syndromes in mechanistic perspective has also been extensively discussed in this article.

Keywords:

• Hesperidin
• citrus peel
• therapeutic
• antioxidant
• aglycone

PUBLIC INTEREST STATEMENT

Hesperidin is often found in citrus fruits including lemons, limes, mandarins, oranges, and grapefruits. Hesperidin works best when taken alongside vitamin C, like other bioflavonoids. Comparatively speaking, hesperidin from orange juice is more readily available than hesperidin from whole oranges. Hesperidin may offer a variety of advantages. They include reducing blood pressure, treating diabetes and its consequences, depression, decreasing blood cholesterol, and improving skin health. They also include easing the symptoms of vascular disorders including chronic venous insufficiency and hemorrhoids. Other advantages of hesperidin include immune system support, possible cancer prevention, and menopausal symptom management. Depending on the problem it is being used to treat, hesperidin may also be mixed with other antioxidants, herbs, or substances. If you are using certain medications, such as anticoagulants, blood thinners, blood pressure medicines, or calcium channel blockers, you should not take this supplement.

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article