The decisive role of fumarase: Responsive signaling to glucose deficiency

Qiujing YuThe Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaView further author information

Ting WangThe Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaView further author information

Yuhui JiangThe Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, ChinaCorrespondence[email protected]
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ABSTRACT

Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest. Meanwhile, O-GlcNAc transferase can compete with AMPK to O-GlcNAcylate FH. In tumor cells, FH is highly O-GlcNAcylated and is proinhibited from AMPK-ATF2 signaling.

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No potential conflicts of interest were disclosed.

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National Natural Science Foundation of China (NSFC) 81572722

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The decisive role of fumarase: Responsive signaling to glucose deficiency

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The decisive role of fumarase: Responsive signaling to glucose deficiency

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