Complex role of SIRT6 in NF-κB pathway regulation

ABSTRACT

The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα,  increasing its expression and leading to NF-κB pathway inactivation.

KEYWORDS:

• SIRT6
• NF-κB
• Sirtuins, NAD⁺
• IκBα
• SUV39H1
• SKP2

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Additional information

Funding

Fundació La Marató de TV3 (20133810); Spanish Ministry of Economy and Competitiveness (SAF2011-25860; SAF2014-55964R) AGAUR-Generalitat de Catalunya (SGR2009-914; SGR2014-400).