PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation

ABSTRACT

We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer. Here we place these findings in context with the role of inflammasomes in colorectal carcinoma, and with a recent study indicating that PTPN2-silencing promotes anti-cancer immunotherapy.

KEYWORDS:

• Tyrosine Phosphatase
• TC-PTP
• Inflammasome
• IFN-gamma
• PTPN2
• Colitis-associated cancer
• Biology of malignant cells
• Biology of the tumor stroma
• Mechanisms of oncogenesis and tumor progression
• Tumor-stroma interactions

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.