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ABSTRACT
For cancer cells to survive during extracellular matrix (ECM)-detachment, they must inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death. Here, we highlight and discuss our recent study implicating receptor-interacting protein kinase-1 (RIPK1) in the induction of mitophagy, the production of reactive oxygen species (ROS) and the consequent elimination of ECM-detached cells.
Disclosure of potential conflicts of interest
No potential conflicts of interest were disclosed.
Additional information
Funding
Z.T. Schafer is supported by a Research Scholar Grant from the American Cancer Society (RSG-14-145-01), a Career Catalyst Grant from Susan G. Komen (CCR14302768), a grant from Phi Beta Psi Sorority, and funds from the Coleman Foundation. M.A. Hawk is supported by a GRFP award from the National Science Foundation.