http://orcid.org/0000-0001-5090-3732
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ABSTRACT
Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch.
Disclosure of Potential Conflicts of Interest
The authors declare no potential conflicts of interest.
Additional information
Funding
This research was supported by Academia Sinica and Ministry of Science and Technology (MOST 107-0210-01-19-01) and by the MOST, Taiwan: (MOST 106-2321-B-001-051 and MOST104-2320-B-001-009MY3).