http://orcid.org/0000-0002-8723-252X
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ABSTRACT
Epigenetic regulator plays a pivotal role in breast cancer progression. We recently demonstrated that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) mediates breast cancer progression and metastasis by activating hypoxia-inducible factor (HIF). This discovery provides new insights into the molecular mechanism underlying HIF activation and breast cancer progression.
Disclosure of potential conflicts of interest
The authors report no conflicts of interest.
Additional information
Funding
This work was supported by grants from Susan G. Komen (CCR16376227), NIH (R00CA168746), the Cancer Prevention & Research Institute of Texas (CPRIT, RR140036), Welch Foundation (I-1903-20160319), and the American Cancer Society/UTSW Simmons Cancer Center (ACS-IRG-02-196) to WL, and grants from NIH (R00NS078049, R35GM124693), CPRIT (RP170671), and Welch Foundation (I-1939-20170325) to YW. W.L. is a CPRIT Scholar in Cancer Research.