LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Alba Maiques-DiazLeukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United KingdomCorrespondence[email protected]
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James T. LynchLeukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United KingdomView further author information

Gary J. SpencerLeukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United KingdomView further author information

Tim C.P. SomervailleLeukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom

http://orcid.org/0000-0002-9188-4379 View further author information

ABSTRACT

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.

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No conflicts of interest disclosed.

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Funding

This work was supported by Cancer Research UK grant number C5759/A20971.

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex

ABSTRACT

Disclosures of potential conflicts of interest

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