A novel function for the mitotic checkpoint protein Mad2p in translation

ABSTRACT

MAD2L1 (Mitotic Arrest Deficient 2 Like 1), a member of the mitotic checkpoint, maintains the genomic stability by insuring the proper segregation of the sister chromatids. Deregulation of MAD2L1 protein expression is a recurrent feature in cancer cells. In our recent publication, we uncovered a role for its yeast homolog, Mad2p, in protein synthesis during S-phase.

Keywords:

• Mad2
• translation
• cyclins
• replication
• intra-S checkpoint
• spindle assembly checkpoint
• Caf20

Disclosure of Potential Conflicts of Interest

The author has no conflicts of interest.

Additional information

Funding

S.G. was supported by a postdoctoral fellowship from the Fondazione Veronesi and by a grant from the Associazione Italiana per la Ricerca sul Cancro to Marco Foiani.