SETD2 in MLL-rearranged leukemia – a complex case

ABSTRACT

Oncogenic MLL-fusion proteins often hijack essential molecular mechanisms during leukemogenesis. The histone methyltransferase SETD2 was implicated in the regulation of transcription, DNA damage and other cellular processes. Recent studies identified a critical role for SETD2 in MLL-rearranged leukemia. These results may help to unravel important functions of SETD2 in hematopoiesis.

Keywords:

• AML
• MLL-rearranged leukemia
• fusion proteins
• SETD2

Additional information

Funding

This work was supported by the FP7 People: Marie-Curie Actions [289611];H2020 European Research Council [636855/StG];Österreichische Forschungsförderungsgesellschaft [857935];