Dietary Polyphenols and Human Gut Microbiota: a Review

Abstract

Dietary polyphenols are substrates for colonic microbiota. They and their metabolites contribute to the maintenance of gastrointestinal health by interacting with epithelial cells, and largely by modulating the gut microbial composition. Polyphenols may act as promoting factors of growth, proliferation, or survival for beneficial gut bacteria—mainly Lactobacillus strains—and thus, exerting prebiotic actions and inhibiting the proliferation of some pathogenic bacteria such as Salmonella and Helicobacter pylori species. To date the interactions affecting metabolic pathways and numerous metabolites of dietary polyphenols have been widely documented. However, the effects of dietary polyphenols on the modulation of the intestinal ecology and on the growth of gut microbial species are still poorly understood. This paper summarizes data on the influence of dietary polyphenols on gut microbiota and the main interactions between dietary polyphenols and beneficial and pathogenic intestinal bacteria.

Keywords:

• polyphenols
• gut microbiota
• gastrointestinal health
• Lactobacillus
• Bifidobacterium
• antimicrobial properties

Acknowledgments

This research was supported by the Spanish Ministerio de Ciencia e Innovación (project AGL2008-01633). DHH acknowledges predoctoral fellowships from the Mexican institutions CONACyT and SEP.