https://orcid.org/0000-0002-0548-429X
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ABSTRACT
Curcumin (diferuloylmethane) is a natural polyphenolic compound that targets multiple signaling molecules and helps in supporting health benefits as it aids in the management of oxidative and inflammatory conditions. However, curcumin by itself has poor absorption, rapid metabolism, and fast elimination, which makes its bioavailability very low. Therefore, curcumin is more active when combined with piperine to provide major health benefits. Several studies indicated that curcumin has powerful effects on post-surgical outcomes such as in ischemia-related surgeries, it improves postoperative pain and fatigue following laparoscopic cholecystectomy. Also, it is effective against traumatic brain injury outcomes through several molecular signaling pathways that include oxidative stress, inflammation, apoptosis, and autophagy. Finally, it has topical applications that improve granulation tissue formation, deposition of collagen, wound contraction, and remodeling of the tissue. In conclusion, curcumin has been shown to have strong antioxidant and anti-inflammatory effects that could result in improved post-surgical outcomes.
GRAPHICAL ABSTRACT
Abbreviations
| UCH-L1 | = | ubiquitin carboxy-terminal hydrolase L1 |
| MI | = | myocardial infarction |
| CABG | = | coronary artery bypass grafting |
| TBI | = | traumatic brain injury |
| BDNF | = | brain-derived neurotrophic factor |
| CREB | = | cAMP response element binding protein |
| HO1 | = | heme oxygenase 1 |
| NQO1 | = | NAD(P)H,quinone oxidoreductase 1 |
| GSH | = | glutathione peroxidase |
| ROS | = | reactive oxygen species |
| RNS | = | Reactive Nitrogen Species |
| hs-CRP | = | high sensitivity C-reactive protein |
| FOXO | = | Forkhead box O |
| MDA | = | malondialdehyde |
| TLR4 | = | Toll like receptor 4 |
| Pl3k | = | Phosphoinositide 3-kinases |
| Akt | = | protein kinase B |
| NF-kB | = | nuclear factor kappa light chain enhancer of activated B cells |
| COX2 | = | Cyclooxygenase-2 |
| IL-1β | = | Interleukin-1β |
| IL-6 | = | Interleukin-6 |
| TNF-α | = | Tumor necrosis factor-α |
| SIRT 1 | = | Sirtuin 1 |
| SIRT3 | = | Sirtuin 3 |
| PGC-1α | = | Peroxisome proliferator-activated receptor gamma coactivator 1-α |
| GPx | = | Glutathione peroxidase |
| SOD | = | superoxide dismutase |
| CAT | = | Catalase |
Acknowledgment
Qatar national library for supporting APC chargesOpen Access funding provided by the Qatar National Library.
Disclosure statement
No potential conflict of interest was reported by the authors.