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Research Article

Testicular Germ Cell Tumors in Childhood: Treatment Results of 52 Patients

, , , , , & show all
Pages 49-56 | Published online: 09 Jul 2009
 

Abstract

We analysed the treatment results of 52 children with testicular germ cell tumors. Histopathological diagnoses were endodermal sinus tumor (63.4%), embryonal carcinoma (28.8%), teratocarcinoma (5.7%), and mixed tumors (2.1%). Radical inguinal orchiectomy was performed in 42 patients and retroperitoneal lymph node dissection in 10 (3/10 positive). Overall survival rates were: whole group: 71.2%; stage I: 89.7%; II: 68.5%; III: 31.2%; IV: 30% (p= .001). Five-year overall survival rates were 85.8% and 100% for stage I patients who received chemotherapy or not (p= .27); BEP regimen: 85.7%; classical VAC: 67.9%; vinblastine + bleomycin: 63.6%. Chemotherapy is not required in stage I. BEP regimen is effective in testicular germ cell tumors.

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