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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 8
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Original Articles

Synthesis of Antibiotic Stilbenes by Reductive Metalation of 3,4,5-Trimethoxybenzaldehyde Dimethyl Acetal

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Pages 1309-1317 | Received 01 Apr 2002, Published online: 15 Aug 2006
 

Abstract

Reductive metalation of 3,4,5-trimethoxybenzaldehyde dimethyl acetal followed by reaction with suitable electrophiles is the key step of a reaction sequence leading to the synthesis of naturally occurring 4-alkyl-3,5-dihydroxy-substituted trans-stilbenes having antibiotic activity.

Acknowledgment

Financial support from the University of Sassari (ex 60% funds) is gratefully acknowledged.

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