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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 8
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Original Articles

Synthesis of Antibiotic Stilbenes by Reductive Metalation of 3,4,5-Trimethoxybenzaldehyde Dimethyl Acetal

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Pages 1309-1317 | Received 01 Apr 2002, Published online: 15 Aug 2006

References

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  • As an alternative, reaction of benzaldehyde 3c with PhCH2MgCl in Et2O (81%), followed by catalytic hydrogenation of the C–C double bond (5% Pd/C, EtOH, 90%) and dehydration (DMSO, reflux, 28%), afforded stilbene 4b with an overall lower yield
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