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Abstract
Soybean protein (SPI) and diacylglycerol (DAG) are functional components with benefits for lipid metabolism. Since simultaneous intake of such components is expected to exert effects additively and/or synergistically in lifestyle-related diseases, we examined the effects of simultaneous intake of SPI and DAG on lipid profiles. Five-week-old male Wistar rats were fed experimental diets with and without cholesterol for 28 d. In the rats fed cholesterol-free diets, significant interactions between dietary oil and protein were observed in the serum triacylglycerol (TG), hepatic cholesterol, and TG concentrations, whereas in the rats fed cholesterol diets, the serum and hepatic lipid concentrations were significantly lower in rats fed SPI than in those fed casein. Although our results suggest that simultaneous intake of SPI and DAG has slightly ameliorating effects on lipid profiles in rats, simultaneous intake of foods or foods components with similar functions are not necessarily effective.