Advances in leishmaniasis chemotherapy and new relevant patents

Jose E Piñero Departamento de Parasitologia, Facultad de Farmacia, Universidad de La Laguna, Avda Astrofisico F Sanchez s/n, La Laguna, 38206 Tenerife, Canary Islands, Spain

Ignacio A Jiménez Departamento de Parasitologia, Facultad de Farmacia, Universidad de La Laguna, Avda Astrofisico F Sanchez s/n, La Laguna, 38206 Tenerife, Canary Islands, Spain

Basilio Valladares Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Avda. Astrofisico F Sanchez 2, La Laguna, 38206 Tenerife, Canary Islands, Spain. Instituto Canario de Investigacion del Cancer (ICIC)

Ángel G Ravelo Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Avda. Astrofisico F Sanchez 2, La Laguna, 38206 Tenerife, Canary Islands, Spain. Instituto Canario de Investigacion del Cancer (ICIC)

Abstract

Current treatments for the parasitic disease leishmaniasis are unsatisfactory due to their route of administration, toxicity and expense. Resistance is also developing to first-line antimonial drugs. Recently, the efficacy of some low-cost generic drugs was verified, their mechanism of action elucidated and the manner in which the parasites become resistant to the drugs determined. This review presents a synopsis of the patents and lead compounds that have been investigated over the last 4 years against leishmaniasis, giving a perspective on the chemotherapeutic potential of each, and discusses some of the obstacles to antileishmanial drug development.

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