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Review

Advances in leishmaniasis chemotherapy and new relevant patents

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Pages 1113-1123 | Published online: 25 Feb 2005

Bibliography

  • DESJEUX P: Leishmaniasis: public healthaspects and control. Clin. Dermatol (1996) 14:417–423.
  • SHAW JJ: Taxonomy of the genus Leishmania: present and future trends and their implications. Mem. Inst. Oswaldo Cruz (1994) 89:471–478.
  • ASHFORD RW: The leishmaniases as model zoonoses. Ann. Trop. Med. Parasitol (1997) 91:693–701.
  • BORST P, OUELLETTE M: New mechanisms of drug resistance in parasitic protozoa. Ann. Rev. Microbial. (1995) 49:427–460.
  • GALLAGHER RB, MARX J, HINES PJ:Progress in parasitology. Science (1994) 264:1827.
  • HIRST SI, STAPLEY LA: Parasitology: thedawn of a new millennium. Parasitol . Today (2000) 16:1–3.
  • WORLD HEALTH ORGANIZATION: Annex 3: Burden of disease in DALYs by cause, sex and mortality stratum in WHO regions, estimates for 2001. In: The World Health Report. WHO, Geneva (2002):192–197.
  • SEAMAN J, MERCER AJ, SONDORP E: The epidemic of visceral leishmaniasis in western Upper Nile southern Sudan: course and impact from 1984 to 1994. Int. J. Epidemiol (1996) 25:862–871.
  • HEWITT S, REYBURN H, ASHFORD R, ROWLAND M: Anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: vertical distribution of cases in apartment blocks. Trans. Roy Soc. Trop. Med. Hyg. (1998) 92:273–274.
  • GUERIN PJ, OLLIARO P, SUNDAR S et al: Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect. Dis. (2002) 2:494–501.
  • DAVIES CR, KAYE P, CROFT SL, SUNDAR S: Leishmaniasis: new approaches to disease control. BE Med. j (2003) 326:377–382.
  • WORLD HEALTH ORGANIZATION: WHO Mode] prescribing information: drugs used IP parasitic diseases (2nd ed). WHO, Geneva (1995).
  • BERMAN JD: Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin. Infect. Dis. (1997) 24:684–703.
  • HERWALDT BL, BERMAN JD: Recommendations for treating leishmaniasis with sodium stibogluconate Wentostan0 and review of pertinent clinical studies. Am. Trop . Med. Hyg. (1992) 46:296–306.
  • MOORE E, O'FLAHERTY D, HEUVELMANS H et al: Comparison of generic and proprietary sodium stibogluconate for the treatment of visceral leishmaniasis in Kenya Bull. World Health Organ. (2001) 79:388–393.
  • ROBERTS WL, MCMURRAY WJ, RAINEY PM: Characterization of the antimonial antileishmanial agent meglumine antimonate (Glucantime). Antimicrob. Agents Chemother. (1998) 42:1076–1082.
  • PATHAK MK, YI T: Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. Immunol (2001) 167:3391–3397.
  • THAKUR CP, SINGH RK, HASSAN SM, KUMAR R, NARAIN S, KUMAR A: Amphotericin B deoxycholate treatment of visceral leishmaniasis with newer modes of administration and precautions: a study of 938 cases. Trans. R. Soc. Trop. Med. Hyg. (1999) 93:319–323.
  • CROFT SL, URBINA JA, BRUN R: Chemotherapy of human leishmaniasis and trypanosomiasis. In: Trypanasomiesis and Leishmaniasis. Hide G, Mottram JC, Commbs GB, Holmes PH (Eds), CAB International, London, UK (1997):245–257.
  • BERMAN JD: Editorial Response: US Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. Infect . Dis. (1999) 28:49–51.
  • MURRAY HW: Clinical and experimental advances in treatment of visceral leishmaniasis. Antimicrob. Agents Chemother. (2001) 45:2185–2197.
  • BERMAN JD, BADARO R, THAKUR CP et al.: Efficacy and safety of liposomal amphotericin B (AmBisome) for visceral leishmaniasis in endemic developing countries. Bull. World Health Organ. (1998) 76:25–32.
  • MEYERHOFF A: US Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. Clin. Infect. Dis. (1999) 28:49–51.
  • YARDLEY V, CROFT SL: A comparison ofthe activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis. bit. J. Antimicrob. Agents. (2000) 13:243–248.
  • PINERO JE, MARTINEZ S, DEL CASTILLO A, PORTUS M, VALLADARES B: In vitro susceptibility of Leishmania infant strains isolated from Spanish HIV-positive patients to Abelcet and Fungizone. Antimicrob. Chemother. (2002) 50:304–306.
  • SUNDAR S, MEHTA H, SURESH AV, SINGH SP, RAI M, MURRAY HW: Amphotericin B treatment for Indian visceral leishmaniasis: conventional versus lipid formulations. Clin. Infect. Dis. (2004) 38:377–383.
  • MURRAY HW, BROOKS EB, DEVECCHIO JL, HEINZEL FP: Immuno enhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis. Antimicrob. Agents Chemother. (2003) 47:2513–2517.
  • CROFT SL, NEAL RA, PENDERGAST W, CHAN JH: The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani Biochem Pharmacol (1987) 36:2633–2636.
  • KUHLENCORD A, MANIERA T, EIBL H, UNGER C: Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice. Antimicrob. Agents Chemother. (1992) 36:1630–1634.
  • LE FICHOUX Y, ROUSSEAU D, FERRUA B et al.: Short- and long-term efficacy of hexadecylphosphocholine against established Leishmania infant infection in BALM mice. Antimicrob. Agents Chemother. (1998) 42:654–658.
  • CROFT SL, SNOWDON D, YARDLEY V: The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosome cruzi and Trypanosome brucei Antimicrob. Chemother. (1996) 38:1041–1047.
  • CROFT SL, SEIFERT K, DUCHENE M: Antiprotozoal activities of phospholipid analogues. MoL Biochem. Parasitol (2003) 126:165–172.
  • LUX H, HART DT, PARKER PJ, KLENNER T: Ether lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkyl phospholipid analogues. Adv. Exp. Med. Biol. (1996) 416:201–211.
  • LUX H, HEISE N, KLENNER T, HART D, OPPERDOES FR: Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania. Mol. Biochem. Parasitol (2000) 111:1–14.
  • PARIS C, LOISEAU PM, BORIES C, BREARD J: Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob. Agents Chemother. (2004) 48:852–859.
  • SUNDAR S, ROSENKAIMER F, MAKHARIA MK et al: Trial of oral miltefosine for visceral leishmaniasis. Lancet (1998) 352:1821–1823.
  • SUNDAR S, JHA TK, THAKUR CP et al:Oral miltefosine for Indian visceral leishmaniasis. N Engl. J. Med. (2002) 347:1739–1746.
  • PRASAD R, KUMAR R, JAISWAL BP, SINGH UK: Miltefosine: an oral drug for visceral leishmaniasis. Indianj Pediatr. (2004) 71:143–144.
  • BHATTACHARYA SK, JHA TK, SUNDAR S et al: Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India. Clin. Infect. Dis. (2004) 38:217–221.
  • SOTO J, TOLEDO J, GUTIERREZ P et al.: Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent. Clin. Infect. Dis. (2001) 33:57–61.
  • SOTO J, ARANA BA, TOLEDO J et al:Miltefosine for new world cutaneous leishmaniasis. Clin. Infect. Dis. (2004) 38:1266–1272.
  • ESCOBAR P, MATU S, MARQUES C, CROFT SL: Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET- 18- OCH3 (edelfosine) and amphotericin B. Acta Trop. (2002) 81:151–157.
  • PEREZ-VICTORIA JM, PEREZ-VICTORIA FJ, PARODI-TALICE A et al.: Alkyl-lysophospholipid resistance in multidrug resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. Antimicrob. Agents Chemother. (2001) 45:2468–2474.
  • SHERWOOD JA, GACHIHI GS, MUIGAI RK et al: Phase II efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis. Infect. Dis. (1994) 19:1034–1039.
  • DIETZE R, CARVALHO SF, VALLI LC et al: Phase II trial of WR6026, an orally administered 8-aminoquinoline, in the treatment of visceral leishmaniasis caused by Leishmania chagasi Am. I Trop. Med. Hyg. (2001) 65:685–689.
  • MBUI J, RASHID R, LODENYO H et al.:Visceral leishmaniasis with concomittant post kala-azar dermal leishmaniasis responds to oral sitamaquine: case report. East Afr. Med. J. (2003) 80:440–442.
  • THAKUR CP, KANYOK TP, PANDEY AK, SINHA GP, MESSICK C, OLLIARO P: Treatment of visceral leishmaniasis with injectable paromomycin (aminosidine). An open-label randomized Phase-II clinical study. Trans. R. Soc. Trop. Med. Hyg. (2000) 94:432–433.
  • KAGER PA, REES PH, WELLDE BT, HOCKMEYER WT, LYVERLY WH: Allopurinol in the treatment of visceral leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. (1981) 75:556–559.
  • CHUNGE CN, GACHIHI G, MUIGAI R: Visceral leishmaniasis unresponsive to antimonial drugs. III. Successful treatment using a combination of sodium stibogluconate plus allopurinol. Trans. R. Soc. Trop. Med. Hyg. (1985) 79:715–718.
  • JHA TK. Evaluation of allopurinol in thetreatment of kala-azar occurring in North Bihar, India. Trans. R. Soc. Trop. Med. Hyg. (1983) 77:204–207.
  • RAGUSA R, DI CATALDO A, SAMPERI P, SCHILIRO G: Treatment of visceral leishmaniasis with meglumine and allopurinol. Am. J. Dis. Child (1993) 147:611–612.
  • DAS VN, RANJAN A, SINHA AN et al: A randomized clinical trial of low dosage combination of pentamidine and allopurinol in the treatment of antimony unresponsive cases of visceral leishmaniasis. .1. Assoc Physicians India (2001) 49:609–613.
  • RODRIGUEZ N, BAILEY BN, MARTIN MB, OLDFIEL E, URBINA JA, DOCAMPO R: Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate../. Infect. Dis. (2002) 186:138–140.
  • DOCAMPO R, MORENO SN: Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites. Curt: Drug Targets Infect. Disord. (2001) 1:51–61.
  • AKENDENGUE B, NGOU-MILAMA E, LAURENS A, HOCQUEMILLER R: Recent advances in the fight against leishmaniasis with natural products. Parasite (1999) 6:3–8.
  • CHAN-BACAB MJ, PENA -RODRIGUEZ LM: Plant natural products with leishmanicidal activity. Nat. Prod. Rep. (2001) 18:674–688.
  • FOURNET A, MUNOZ V: Natural products as trypanocidal, antileishmanial and antimalarial drugs. Curt: Top. Med. Chem. (2002) 2:1215–1237.
  • NIELSEN SF, CHRISTENSEN SB, CRUCIANI G, KHARAZMI A, LILJEFORS T: Antileishmanial chalcones: statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis. Med . Chem. (1998) 41:4819–4832.
  • KAYSER 0, KIDERLEN AF: In vitro leishmanicidal activity of naturally occurring chalcones. Phytother. Res. (2001) 15:148–152.
  • HERMOSO A, JIMENEZ IA, MAMANI ZA et al: Antileishmanial activities of dihydrochalcones from Piper elongatum and synthetic related compounds. Structural requirements for activity. Bioorg. Med. Chem. (2003) 11:3975–3980.
  • CHEN M, ZHAI L, CHRISTENSEN SB, THEANDER TG, KHARAZMI A: Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones. Antimicrob. Agents Chemother. (2001) 45:2023–2029.
  • FOURNET A, FERREIRA ME, ROJAS DE ARIAS A et al: In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis. Antimicrob. Agents Chemother. (1996) 40:2447–2451.
  • MEDDA S, MUKHOPADHYAY S, BASU MK: Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms. J. Antimicrob. Chemother. (1999) 44:791–794.
  • MAES L, VANDEN BERGHE D, GERMONPREZ N et al: In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansee against visceral leishmania species. Antimicrob. Agents Chemother. (2004) 48:130–136.
  • LUQUE-ORTEGA JR, MARTINEZ S, SAUGAR JM et al.: Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminate) target mitochondria of Leishmania donovani promastigotes. Antimicrob. Agents Chemother. (2004) 48:1534–1540.
  • MURRAY HW, GRANGER AM, MOHANTY SK: Response to chemotherapy in experimental visceral leishmaniasis: T cell-dependent but interferon-gamma and interleukin-2-independent. I Infect. Dis. (1991) 163:622–624.
  • BADARO R, FALCOFF E, BADARO FS et al.: Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. N Engl. I Med. (1990) 322:16–21.
  • SUNDAR S, SINGH VP, SHARMA S, MAKHARIA MK, MURRAY HW: Response to interferon-gamma plus pentavalent antimony in Indian visceral leishmaniasis. Infect . Dis. (1997) 176:1117–1119.
  • HARRISON CJ, MILLER RL, BERNSTEIN DI: Post-therapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Antimicrob. Agents Chemother. (1994) 38:2059–2064.
  • TESTERMAN TL, GERSTER JF, IMBERTSON LM et al: Cytokine induction by the immunomodulators imiquimod and S-27609. I Leukoc. Biol. (1995) 58:365–372.
  • BUATES S, MATLASHEWSKI G: Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: efficacy and mode of action. J. Infect. Dis. (1999) 179:1485–1494.
  • AREVALO I, WARD B, MILLER R et al: Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator. Clin. Infect. Dis. (2001) 33:1847–1851.
  • SELZER PM, CHEN X, CHAN VJ et al: Leishmania major molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp. Paresitol (1997) 87:212–221.
  • MOTTRAM JC, BROOKS DR, COOMBS GH: Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions. Curt: Opin. Microbiol (1998) 1:455–460.
  • MCKERROW JH: Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. Intl Paresitol (1999) 29:833–837.
  • MCKERROW JH, ENGEL JC, CAFFREY CR: Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg. Med. Chem. (1999) 7:639–644.
  • SALVATI L, MATTU M, COLASANTI M et al: NO donors inhibit Leishmania infantum cysteine proteinase activity. Bloch/m. Biophys. Acta (2001) 1545:357–366.
  • ZEINA B, BANFIELD C, AL-ASSAD S: Topical glyceryl trinitrate: a possible treatment for cutaneous leishmaniasis. Clin. Exp. Dermatol (1997) 22:244–245.
  • LOPEZ-JARAMILLO P, RUANO C, RIVERA J et al.: Treatment of cutaneous leishmaniasis with nitric-oxide donor. Lancet (1998) 351:1176–1177.
  • DAVIDSON RN, YARDLEY V, CROFT SL, KONECNY P, BENJAMIN N: A topical nitric oxide-generating therapy for cutaneous leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. (2000) 94:319–322.
  • BOCEDI A, GRADONI L, MENEGATTI E, ASCENZI P: Kinetics of parasite cysteine proteinase inactivation by NO-donors. Biochem. Biophy Res. Commun. (2004) 315:710–718.
  • JUNGHAE M, RAYNES JG: Activation ofp38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages. Infect. Immun. (2002) 70:5026–5035.
  • AWASTHI A, MATHUR R, KHAN A et al.: CD40 signalling is impaired in L . major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J. Exp. Med. (2003) 197:1037–1043.
  • YEATES C: Sitamaquine GlaxoSmithKline /Walter Reed Army Institute. Curr. Opin. Investig. Drugs (2002) 3(10):1446–1452.
  • SUNDAR S, RAI M: Advances in the treatment of leishmaniasis. Current Opinion in Infectious Diseases. (2002) 15 (6):593–598.
  • MARTY P, ROSENTHAL E: Treatment ofvisceral leishmaniasis: a review of current treatment practices. Expert Opin. Pharmacother. (2002) 3(8):1101–1108.
  • KAMINSKY R: Miltefosine Zentaris. Curr. Opin. Investig. Drugs (2002) 3(4):50–54.
  • CROFT SL, YARDLEY V: Chemotherapy of leishmaniasis. Curl: Pharm. Dec. (2002) 8:319–342.
  • CROFT SL, COOMBS GH: Leishmaniasis -current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol (2003) 19:502–508.

Websites

  • http://www.whainthdr/diseases/leish/default .htm Leishmaniasis Webpage of TDR.
  • http://www.whaint/health_topics/leishmania sis/en/ Leishmaniasis Webpage of WHO.
  • http://www.neglecteddiseases.org/1–2.pdf Drugs for the Treatment of Visceral Leishmaniasis: Current Status, Needs, and a Proposed R&D Agenda.
  • http://www.ebi.ac.uldparasites/leish.html Leishmania genome Network.
  • http:\\www.ebi.ac.uklparasites/leish.html The Leishmania Proteome Classification and Analysis.
  • http://www.zentaris.com/ Zentaris developed Impavido° (Miltefosine) in co-operation with the WHO to fight the deadly visceral leishmaniasis.

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