Measurement of the binding parameters of therapeutically active peptides (e.g., insulin, insulin-like growth factor-1 [IGF-1], endothelin-1 [ET1], angiotensin-II [ATII]) and their antagonists on the endothelium of the coronary vasculature and myocytes, in perfused heart models.

Anwar B Bikhazi Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Tel: +961 1 341 310 (Extn. 4811); Fax: +961 1 744 464; [email protected]

Zaher A Nahle Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Tel: +961 1 341 310 (Extn. 4811); Fax: +961 1 744 464; [email protected]

Marwan E El-Sabban Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Tel: +961 1 341 310 (Extn. 4811); Fax: +961 1 744 464; [email protected]

Khalil M Bitar Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. Tel: +961 1 341 310 (Extn. 4811); Fax: +961 1 744 464; [email protected]

Measurement of the binding parameters of therapeutically active peptides (e.g., insulin, insulin-like growth factor-1 [IGF-1], endothelin-1 [ET1], angiotensin-II [ATII]) and their antagonists on the endothelium of the coronary vasculature and myocytes, in perfused heart models.

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Measurement of the binding parameters of therapeutically active peptides (e.g., insulin, insulin-like growth factor-1 [IGF-1], endothelin-1 [ET1], angiotensin-II [ATII]) and their antagonists on the endothelium of the coronary vasculature and myocytes, in perfused heart models.

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