Expert Opinion on Therapeutic Targets, Volume 2, Issue 1 (1998)

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Emerging Therapeutic Targets, Volume 2, Issue 1 (1998)

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Stimulation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by flavonoids
Beate Illek, Terry E Machen, Jonathen Widdicombe & Horst Fischer
Pages: 1-4
Published online: 25 Feb 2005
First Page PreviewforStimulation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by flavonoids | References | PDF (24.6 KB)
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Proposed target Introduction of a chloride selective channel to the apical membrane of epithelial cells in lung airways and the gut
John M Tomich, Takeo Iwamoto & Lawrence P Sullivan
Pages: 5-9
Published online: 25 Feb 2005
First Page PreviewforProposed target Introduction of a chloride selective channel to the apical membrane of epithelial cells in lung airways and the gut | References | PDF (24.2 KB)
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Prevention and resolution of airway obstruction
John Morley
Pages: 9-11
Published online: 25 Feb 2005
First Page PreviewforPrevention and resolution of airway obstruction | References | PDF (21.3 KB)
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Suppression of atopy
John Morley
Pages: 13-14
Published online: 25 Feb 2005
CitationforSuppression of atopy | References | PDF (13.6 KB)
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Antimicrobial defence capabilities of the lung
Marc Peters-Golden & Theodore Standiford
Pages: 15-18
Published online: 25 Feb 2005
First Page PreviewforAntimicrobial defence capabilities of the lung | References | PDF (23.5 KB)
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Inhibition of matrix metalloproteinases (MMPs)
olli Teronen, Timo Sorsa & Tuula Salo
Pages: 19-21
Published online: 25 Feb 2005
First Page PreviewforInhibition of matrix metalloproteinases (MMPs) | References | PDF (19.8 KB)
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Inhibition of tumour necrosis factor-alpha (TNF-α)
George Tu, Qing-na Cau, Feng Zhou & Yedy Isreal
Pages: 23-25
Published online: 25 Feb 2005
First Page PreviewforInhibition of tumour necrosis factor-alpha (TNF-α) | References | PDF (21.8 KB)
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Polyisoprenyl phosphates: a novel class of intracellular stop signals in neutrophils
Bruce D Levy & Charles N Serhan
Pages: 27-29
Published online: 25 Feb 2005
First Page PreviewforPolyisoprenyl phosphates: a novel class of intracellular stop signals in neutrophils | References | PDF (17.2 KB)
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Design and synthesis of potent cyclic analogues and mimetics of myelin basic protein epitope MBP87-99 for suppression of experimental allergic encephalomyelitis (EAE)
John Matsoukas
Pages: 31-32
Published online: 25 Feb 2005
CitationforDesign and synthesis of potent cyclic analogues and mimetics of myelin basic protein epitope MBP87-99 for suppression of experimental allergic encephalomyelitis (EAE) | References | PDF (17 KB)
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Inhibition of lymphocyte apoptosis
Claudio De Simone & Giuseppe Famularo
Pages: 33-37
Published online: 25 Feb 2005
First Page PreviewforInhibition of lymphocyte apoptosis | References | PDF (29.6 KB)
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Specific inhibition of eubacterial DNA ligase
L Tilley & Giovanni Ciarrocchi
Pages: 39-41
Published online: 25 Feb 2005
First Page PreviewforSpecific inhibition of eubacterial DNA ligase | References | PDF (20.1 KB)
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Neuronal nicotinic receptors (nNAChRs)
Francesco Clementi, Diego Fornasari & Cecilia Gotti
Pages: 43-44
Published online: 25 Feb 2005
CitationforNeuronal nicotinic receptors (nNAChRs) | References | PDF (18.7 KB)
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Ultraselective antagonists of the d-opioid receptor
Lawrence H Lazarus, Severo Salvadori, Piero A Temussi, Gianfranco Balboni, Remo Guerrini, Sharon D Bryant & Peter S Cooper
Pages: 45-47
Published online: 25 Feb 2005
First Page PreviewforUltraselective antagonists of the d-opioid receptor | References | PDF (24.1 KB)
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Development of an orphanin FQ (OFQ) receptor antagonist for the treatment of chronic pain
A Montkowski & R Reinscheid
Pages: 49-51
Published online: 25 Feb 2005
First Page PreviewforDevelopment of an orphanin FQ (OFQ) receptor antagonist for the treatment of chronic pain | References | PDF (17.2 KB)
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gamma-Aminobutyric acid (GABA) and glutamate neurotransmission during epileptiform activity in in vitro neural models
Cristina Sunol & Carmen Vale
Pages: 53-56
Published online: 25 Feb 2005
First Page Previewforgamma-Aminobutyric acid (GABA) and glutamate neurotransmission during epileptiform activity in in vitro neural models | References | PDF (28.7 KB)
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Evaluation of the anxiolytic profile of atrial natriuretic peptides (ANP) via ANP-A, ANP-B or ANP-C receptors
K Weidemann, A Montkowski, M Kellner & K Jahn
Pages: 57-59
Published online: 25 Feb 2005
First Page PreviewforEvaluation of the anxiolytic profile of atrial natriuretic peptides (ANP) via ANP-A, ANP-B or ANP-C receptors | References | PDF (19.3 KB)
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Prevention and reversal of thrombotic and inflammatory processes
Adrien R Beaudoin, Jean Sevigny, Fernand-Pierre Gendron, Maryse St George & Marie-Claude Leclerc
Pages: 61-64
Published online: 25 Feb 2005
First Page PreviewforPrevention and reversal of thrombotic and inflammatory processes | References | PDF (22.9 KB)
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Measurement of the binding parameters of therapeutically active peptides (e.g., insulin, insulin-like growth factor-1 [IGF-1], endothelin-1 [ET1], angiotensin-II [ATII]) and their antagonists on the endothelium of the coronary vasculature and myocytes, in perfused heart models.
Anwar B Bikhazi, Zaher A Nahle, Marwan E El-Sabban & Khalil M Bitar
Pages: 65-67
Published online: 25 Feb 2005
First Page PreviewforMeasurement of the binding parameters of therapeutically active peptides (e.g., insulin, insulin-like growth factor-1 [IGF-1], endothelin-1 [ET1], angiotensin-II [ATII]) and their antagonists on the endothelium of the coronary vasculature and myocytes, in perfused heart models. | References | PDF (23.6 KB)
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Novel calcium promotor PCA50941 to treat shock states
Antonio G Garcia, Mercedes Villarroya & Manuela G Lopez
Pages: 69-72
Published online: 25 Feb 2005
First Page PreviewforNovel calcium promotor PCA50941 to treat shock states | References | PDF (24.3 KB)
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Synthesis of new derivatives of diltiazem blocking neuronal non-L-type calcium channel subtypes
Antonio Garcia, Mercedes Villarroya, Manuela G Lopez & Julio Alvarez-Builla
Pages: 73-75
Published online: 25 Feb 2005
First Page PreviewforSynthesis of new derivatives of diltiazem blocking neuronal non-L-type calcium channel subtypes | References | PDF (22.2 KB)
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Inhibition of the cardiac sarcolemma (cell membrane) Na+-Ca2+ exchanger (NCX1) by peptide based blockers
Daniel Khananshvili
Pages: 77-79
Published online: 25 Feb 2005
First Page PreviewforInhibition of the cardiac sarcolemma (cell membrane) Na+-Ca2+ exchanger (NCX1) by peptide based blockers | References | PDF (22.5 KB)
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Discovery of steroid glycosides with selective inotropic action using Na+/K+-ATPase isoforms expressed in 'receptor blasts'. Selective inhibition of a1-isoform of Na+/K+-transporting ATPase (Na+/K+-ATPase) in cardiac muscle of man.
KRH Repke, R Megges & H Repke
Pages: 81-83
Published online: 25 Feb 2005
First Page PreviewforDiscovery of steroid glycosides with selective inotropic action using Na+/K+-ATPase isoforms expressed in 'receptor blasts'. Selective inhibition of a1-isoform of Na+/K+-transporting ATPase (Na+/K+-ATPase) in cardiac muscle of man. | References | PDF (20.7 KB)
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An improved blood substitute
Jan Simoni, Grace Simoni, Shelley Weinstock, Charles Lox & Mario Feola
Pages: 85-91
Published online: 25 Feb 2005
First Page PreviewforAn improved blood substitute | References | PDF (43 KB)
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Inhibition of pathological apoptosis
Susan C Wright & James W Larrick
Pages: 93-95
Published online: 25 Feb 2005
First Page PreviewforInhibition of pathological apoptosis | References | PDF (22 KB)
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Inhibition of phosphatidylinositol 3-kinase
Peter Zahradka
Pages: 97-99
Published online: 25 Feb 2005
First Page PreviewforInhibition of phosphatidylinositol 3-kinase | References | PDF (18.7 KB)
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Purinoceptors (P2X-receptor isoforms)
Walter Zidek, Martin Tepel, Hartmut Schluter, Markus van der Giet & Joachim Jankowski
Pages: 101-103
Published online: 25 Feb 2005
First Page PreviewforPurinoceptors (P2X-receptor isoforms) | References | PDF (20.4 KB)
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Inhibition of the interaction between the CDC25 phosphatase cell cycle activator and the 14.3.3 proteins
Bernard Ducommun
Pages: 105-107
Published online: 25 Feb 2005
First Page PreviewforInhibition of the interaction between the CDC25 phosphatase cell cycle activator and the 14.3.3 proteins | References | PDF (18.8 KB)
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Inhibition of Ca2+-calmodulin dependent phosphodiesterase (PDE1B1)
Paul M Epstein
Pages: 109-112
Published online: 25 Feb 2005
First Page PreviewforInhibition of Ca2+-calmodulin dependent phosphodiesterase (PDE1B1) | References | PDF (21.8 KB)
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Inhibition of aldo-keto reductases (AKRs)
T Geoff Flynn & David Hyndman
Pages: 113-115
Published online: 25 Feb 2005
First Page PreviewforInhibition of aldo-keto reductases (AKRs) | References | PDF (18.7 KB)
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Thymidylate synthase (TS) inhibition
Willaiam H Gmeiner
Pages: 117-119
Published online: 25 Feb 2005
First Page PreviewforThymidylate synthase (TS) inhibition | References | PDF (19.4 KB)
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Inhibition of P-glycoprotein in tumour cells
Gerald A LeBlanc
Pages: 121-123
Published online: 25 Feb 2005
First Page PreviewforInhibition of P-glycoprotein in tumour cells | References | PDF (19.9 KB)
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N-Myristoyl transferase (NMT) as a marker for diagnosis and prognosis of colon cancer
RVS Raju, TN Moyana, RSS Dalta, R Kakkar & RK Sharma
Pages: 129-131
Published online: 25 Feb 2005
First Page PreviewforN-Myristoyl transferase (NMT) as a marker for diagnosis and prognosis of colon cancer | References | PDF (21 KB)
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DNA alkylation
Pier Giovanni Beraldi, Barbara Caciari, Romeo Romagnoli & Giampiero Spalluta
Pages: 133-136
Published online: 25 Feb 2005
First Page PreviewforDNA alkylation | References | PDF (22.3 KB)
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Feeding regulatory mechanisms
Yvette Tache, Jen Yu Wei, Vicente Martinez & Maria Dolores Barrachima
Pages: 137-139
Published online: 25 Feb 2005
First Page PreviewforFeeding regulatory mechanisms | References | PDF (18 KB)
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Transcriptional modulation of hepatocyte nuclear factor 4a (HNF-4a) and/or peroxisome proliferator-activated receptor a (PPARa)-controlled genes by low molecular weight compounds
J Bar-Tana
Pages: 141-144
Published online: 25 Feb 2005
First Page PreviewforTranscriptional modulation of hepatocyte nuclear factor 4a (HNF-4a) and/or peroxisome proliferator-activated receptor a (PPARa)-controlled genes by low molecular weight compounds | References | PDF (26.2 KB)
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Drug delivery and targeting system
Mauro Magnani
Pages: 145-146
Published online: 25 Feb 2005
CitationforDrug delivery and targeting system | References | PDF (17.5 KB)
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Inhibition of mammalian small heat shock protein 25 (HSP25) kinase (MAPKAP kinase-2)
Rainer Benndorf, Richard R Ransom, Robert R Gilmont, Katrin Hayess & Micheal J Welsh
Pages: 147-149
Published online: 25 Feb 2005
First Page PreviewforInhibition of mammalian small heat shock protein 25 (HSP25) kinase (MAPKAP kinase-2) | References | PDF (20 KB)
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A system for in situ generation of hormones, clotting factors or novel biopharmaceuticals.
John Morley
Pages: 151-153
Published online: 25 Feb 2005
First Page PreviewforA system for in situ generation of hormones, clotting factors or novel biopharmaceuticals. | PDF (18.1 KB)
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A novel screening approach to the modulation of unfavourable human serum albumin (HSA)/drug interactions
Nadhipuram V Bhagavan & Charles E Petersen
Pages: 155-157
Published online: 25 Feb 2005
First Page PreviewforA novel screening approach to the modulation of unfavourable human serum albumin (HSA)/drug interactions | References | PDF (21.4 KB)
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Human serum albumin (HSA) as a binding agent for detoxification of the blood
Nadhipara V Bhagavan & Charles E Peterson
Pages: 159-161
Published online: 25 Feb 2005
First Page PreviewforHuman serum albumin (HSA) as a binding agent for detoxification of the blood | References | PDF (23.9 KB)
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