The fissure: interlobar collateral ventilation and implications for endoscopic therapy in emphysema

Abstract

In patients with severe emphysema, bronchoscopic lung volume reduction using one-way valves is a promising therapeutic option to improve lung function and quality of life. The goal of this treatment is to achieve a complete lobar atelectasis. In a significant proportion of patients, this atelectasis cannot be achieved due to interlobar collateral ventilation. This collateral ventilation is generated through incomplete lobar fissures. Therefore, only patients with complete fissures and no collateral ventilation can be selected for endobronchial therapy with one-way valves.

Incomplete fissures are very common and exhibit a great variation in anatomy. The reported prevalence is 17%–85% for the right major fissure, 19%–74% for the left major fissure, and 20%–90% for the minor fissure. There are several methods of measuring or predicting the presence of collateral ventilation, with computed tomography (CT)-fissure analysis and the Chartis measurement being the most important. CT-fissure analysis is an indirect method to measure the completeness of fissures as a surrogate for collateral ventilation. The Chartis system is an endobronchial method to directly measure the presence of collateral ventilation. Both methods have unique value, and the combination of both can accurately predict the treatment response to the bronchoscopic placement of endobronchial valves. This review provides an in-depth view of lung fissure and collateral ventilation to help understand its importance in selecting the appropriate patients for new emphysema treatments and thus avoid useless treatment in unsuitable patients.

Keywords:

• BLVR
• ELVR
• HRCT
• one-way valve
• bronchoscopy
• collateral respiration
• COPD

Introduction

In patients with severe emphysema, lung volume reduction surgery (LVRS) can improve the quality of life, exercise capacity and lung function.¹ However, LVRS is a highly invasive therapy and is associated with significant morbidity.¹ Therefore, other and less invasive techniques for reduction of lung volume have been studied. An emerging therapy for patients with severe emphysema is bronchoscopic lung volume reduction (BLVR). Several BLVR techniques have been investigated, including one-way endobronchial valves (EBVs) and lung volume reduction coils.² In patients with severe emphysema, treatment with one-way valves shows promising results.³ The purpose of this technique is to induce atelectasis in the most diseased lobe. Like LVRS, this might relieve symptoms in emphysema patients through a reduction in hyperinflation, with an improved function of diaphragm and chest wall mechanics. Furthermore, increase in elastic recoil pressure leads to increased expiratory airflow and the inhomogeneity of ventilation and perfusion is decreased, leading to an improvement in gas exchange.^1,4

However, to achieve maximal clinical improvement with one-way valve treatment, it is important to achieve complete lobar atelectasis.^4–6 The most important factor that may prevent the development of this desired atelectasis after endobronchial one-way valve treatment is interlobar collateral ventilation (CV) through means of an incomplete interlobar fissure.^4,6 This led to the development of several methods to measure the CV and investigate the interlobar fissure integrity.

A combination of these measurements, together with endobronchial treatment using one-way valves, leads to new and successful treatment of chronic obstructive pulmonary disease (COPD).³ The use of the proper selection criteria enables customized care specifically applied to the individual patient, thereby showing real personalized medicine.

This review will focus on the prevalence, assessment, and important role of CV and interlobar fissures with respect to BLVR.

Collateral ventilation

CV is defined as “the ventilation of alveolar structures through passages or channels that bypass the normal airways”.⁷ Intralobar CV (CV within a lobe, segment, or subsegment) was originally described as collateral respiration by Van Allen et al⁸ in 1931. They observed that after obstruction of the bronchus of an airway, this was not always followed by alveolar collapse.

There are three main candidate pathways for CV to take place (Figure 1). The first described pathway consists of interalveolar communication of air through the pores of Kohn. These are situated in alveolar walls and should permit the passage of fluid and possibly air. However, these pores are small (<5 μm) and very high pressures (estimated 19.2 kPa or 196 cmH₂O) would be necessary for air transport.^9–13 A second possible pathway is through accessory communication channels (30 μm in diameter) between distal bronchioles and alveoli, as described by Lambert.¹⁴ The third pathway is described by Martin¹³ and contains accessory respiratory bronchioles between the bronchioles of adjacent lung segments. This pathway is probably the most important pathway, due to the larger size (80–150 μm) of bronchioles and thus having a lower resistance when compared to the other pathways.^12,13,15

Figure 1 Three different pathways for collateral ventilation.

Notes: Interalveolar ventilation through the pores of Kohn. Bronchiole–alveolar ventilation through channels of Lambert. Interbronchiolar ventilation through channels of Martin.

In healthy persons, CV does not seem to play an important role, as the resistance of the collateral channels is much higher than the regular airways and large pressure gradients are needed for CV.^12,16 It is not exactly known why collateral channels exist or why they develop, but they all seem to originate after birth of both animals and humans.¹³

Despite their origin, CV may assume importance in several diseases. The prevention of atelectasis after obstruction is probably the most important function of CV. For example, obstruction of airways by mucus impaction, tumor or foreign bodies does not always lead to atelectasis due to CV.⁸ Furthermore, in patients with emphysema, with increased airway resistance, collateral resistance is lower. This was demonstrated by Hogg et al,¹⁸ who measured the resistance of CV in excised normal and emphysematous lungs. In normal lungs, the resistance of collateral channels was 260–330 cmH₂O (25–324 kPa), whereas this was 5–20 cmH₂O (0.5–2.0 kPa) in emphysematous lungs. Therefore, air flows much more easily through collateral channels in an emphysematous than a normal lung.¹⁷ Although CV was first only described as intralobar ventilation, there is also interlobar (ie, between the lobes) CV across the fissures. Probably due to the same mechanism, the flow between different lobes is higher in patients with emphysema.^15,17,18

Obviously, interlobar CV is an important factor in BLVR therapy, as this therapy is based on complete atelectasis of a lobe (Figure 2). Most probably, incomplete fissures are responsible for the interlobar collateral flow, although not found in every study regarding this subject.^6,15 There is no literature regarding the mechanism of CV in incomplete fissures between lobes. It can be assumed that the mechanism of collateral flow between lobes is the same as within a lobe.

Figure 2 Collateral ventilation.

Notes: Schematic figure illustrating the role of intra- and interlobar collateral ventilation, and the implications for bronchoscopic lung volume reduction using one-way endobronchial valves. The interlobar collateral ventilation from the left upper to the left lower lobe, impedes the desired atelectasis of the lower lobe. Because all segments of the left lower lobe have endobronchial valves, intralobar collateral ventilation does not influence the development of atelectasis.

Embryology

Incomplete fissures are present in the majority of people and arise during fetal development. Approximately 4 weeks after conception, the airways start to develop. The respiratory diverticulum branches into two lung buds, which divide in the lobar bronchi.¹⁹

During the development of the fetus, the coelomic cavity is divided into the pericardium, the pleural cavities, and the peritoneal cavity. The pleural cavity is lined by a mesothelial membrane, the pleura. As the lung buds grow into the left and right pleural cavities, they are still covered by this membrane. The membrane covering the pleural cavity becomes the parietal pleura, whereas the mesothelial covering of the lung buds becomes the visceral pleura. As early as the visceral pleura has formed (after around 7 weeks), invaginations of the pleura start to separate the lobar bronchi. This gives rise to the lobar fissure and formation of the lung lobes. However, lobes can be fused if the pleura does not cover the complete lobe, leading to “incomplete fissures”. As the pleura invaginates from lateral, it can be assumed that the fissures are incomplete near the hilus most often, as will be described later.^19,20

Anatomy and prevalence of incomplete fissures

The anatomy of fissures and the completeness of fissures have been studied postmortem and by computed tomography (CT). Both the orientation (eg, medially, laterally) and the configuration (eg, concave, convex) exhibits a large variation. A large study performed by Aziz et al,²¹ described the anatomy of the pulmonary fissures using high-resolution computed tomography (HRCT) in 662 patients without significant pulmonary disease. For the left major fissure, they found that, in most cases, the fissure faces medial in the superior zone (66%), lateral in the suprahilar zone (64%), and medial in the infrahilar and inferior zones (54% and 68%, respectively).²¹ For the right major fissure, the fissure faces medial in the superior zone (85%) and lateral in the lower zones (63% suprahilar, 55% infrahilar, and 62% inferior). Other studies partly describe the same orientations, but individual variation is large.^22–25

There is also some variation in the reported degree of incompleteness of the fissures. Some studies were based on autopsies. For example, Raasch et al²² studied 100 lung specimens and found that incomplete fissures are very common. The incidence ranged from 70% in the right major fissure (mainly superior), 46% across the left major fissure (mainly inferior) and 94% across the minor fissure.²² Other cadaver studies reported incomplete horizontal fissures in 47%–63% of cases, 36%–47% incomplete left oblique fissures, and 37%–39% incomplete right oblique fissures.^26,27

Studies using CT also mention variable numbers, which are summarized in Table 1. The reported prevalence of incomplete fissures is 17%–85% for the right major fissure, 19%–74% for the left major fissure, and 20%–90% for the minor fissure.^{21,23,28–35} These studies consistently find that compared to the other fissures, the minor fissure is incomplete most frequently. Furthermore fissures are incomplete near the hilus most frequently.^21,30 The reported prevalence exhibits a great variation. Possible explanations are the varying patient groups with and without pulmonary disease, different kind of reviewers, various or no criteria to define an incomplete fissure, or used CT-scan technique (eg, slide thickness).³⁴

Table 1 Prevalence of incomplete fissures

Author (year)	Subjects (N)	Research	Measurement	Incomplete (%)	Patient group/remarks
Aziz et al^Citation21 (2004)	622	HRCT	Not described	RMF: 48 LMF: 43 MF: 63	No pulmonary disease
Koenigkam-Santos et al^Citation28 (2013)	247	MDCT	• Two radiologists • Consensus#	RMF: 81 LMF: 50 MF: 89	Varying population. No statistical difference between GOLD stages
Koenigkam-Santos et al^Citation29 (2012)	35	MDCT	• Two pneumologists and three radiologists • Consensus#	RMF: 85 LMF: 65–74 MF: 88–91	COPD GOLD III/IV
Gülsün et al^Citation23 (2006)	144	HRCT	• Two radiologists • Consensus#	RMF: 63 LMF: 60 MF: –	No pulmonary disease
Heřmanová et al^Citation30 (2014)	250	HRCT	• Medical student • Diagnostic criteria*	RMF: 35 LMF: 24 MF: 74	Varying population, no significant pathological changes
Cronin et al^Citation31 (2010)	150	MDCT	• Two radiologists • Consensus#	RMF: 34 LMF: 25 MF: 48	No pulmonary disease
Mahmut and Nishitani^Citation32 (2007)	1,000	MDCT	• Medical student • Diagnostic criteria*	RMF: 17 LMF: 19 MF: 20	Exclusion: lung lesions around interlobar fissures
Ozmen et al^Citation33 (2010)	307	MDCT	• Two radiologists • Consensus#	RMF: 70 LMF: 48 MF: 87	Exclusion: advanced fibrosis, kyphoscoliosis, chest deformity, massive pleural fluid, atelectasis, consolidation, or giant pleural bullae
Guan et al^Citation34 (2015)	208	MDCT	• Two radiologists • Diagnostic criteria*	RMF: 41 LMF: 46 MF: 62	No pulmonary disease
Pu et al^Citation35 (2014)	573	HRCT	• Computerized	RMF: 74 LMF: 75 MF: 86	Healthy population and COPD-patients

Notes:

* Diagnostic criteria: 1) neither a clear avascular zone nor interlobar line is observed; 2) vascular images in adjacent lobes cross over the interlobar region; 3) pulmonary blood vessels, particularly the pulmonary vein, penetrate the interlobar region; 4) the pulmonary vein is observed in the interlobar region and is related to the vascular images in adjacent lobes.

# Consensus: individual evaluation of fissure and classified as complete or incomplete, consensus with colleagues.

Abbreviations: HRCT, high-resolution computed tomography; MDCT, multidetector computed tomography; RMF, right major fissure/right oblique fissure; LMF, left major fissure/left oblique fissure; MF, minor fissure/horizontal fissure; COPD, chronic obstructive pulmonary disease; GOLD, Global initiative for chronic Obstructive Lung Disease.

Measurement of CV

There are several methods to assess the presence of CV. Invasive measurement methods include nuclear techniques and an endobronchial pulmonary assessment system. Noninvasive methods for measurement of CV include imaging techniques such as hyperpolarized gas magnetic resonance imaging (MRI) or CT-fissure analysis, which is an indirect method.

Endobronchial CV assessment

Although several endobronchial methods has been described for endobronchial assessment of CV, the study of Aljuri and Freitag³⁶ in 2009 was the first to present a method assessing collateral flow to predict the clinical response to BLVR treatment. Based on this technique the Chartis System^® (PulmonX Inc., Redwood City, CA, USA) was developed, and is described and used in several articles regarding this topic.^3,37–41

The Chartis system consists of a catheter with a balloon component at the distal tip (Figure 3A). After inflation of the balloon, the airway is blocked and air from the targeted segment or lobe can flow only through the catheter (Figure 3B). The air is directed to the Chartis console, which can assess both expiratory air flow, pressure, and resistance (Figure 3C–E). If expiratory airflow persists after occlusion of a lobe, this indicates the presence of collateral airflow. In contrast, if there is no more flow, this indicates high collateral resistance and thus no collateral airflow, indicating a suitable candidate for BLVR therapy (Figures 2 and 3).⁴²

Figure 3 Chartis measurement.

Notes: (A) The Chartis balloon at the distal tip of the catheter. (B) Bronchoscopic view of the Chartis balloon blocking the entrance to the right lower lobe to measure collateral ventilation to this lobe. (C) Example of a negative Chartis measurement with absence of collateral ventilation, measured in spontaneous breathing patient. The orange pattern shows the expired flow (mL/min). The decrease of the flow pattern indicates there is no collateral flow. The blue pattern shows the negative intrapleural pressure (cmH₂O) and indicates the quality of the occlusion by the balloon. (D) Example of a positive Chartis measurement with collateral ventilation, as there is no decline in the expired flow. (E) Example of a negative Chartis measurement with absence of collateral ventilation, measured in a sedated patient with positive pressure ventilation. Therefore, only the decreasing flow pattern is shown, indicating there is no collateral flow.
Abbreviations: F, flow; P, pressure.

Gompelmann et al⁴³ performed the first clinical trial with the Chartis system in 2010 and showed that in 90% of the patients, the measurements correctly predicted if atelectasis on chest radiograph would occur. A subsequent larger study by Herth et al⁴⁴ investigated the diagnostic value of the Chartis pulmonary assessment system to predict treatment response, defined as a target lung volume reduction (TLVR) of 350 mL or more. There was a total accuracy of 75%, with a positive predictive value of 71% and negative predictive value of 83%.

For optimal result and reliability of the Chartis measurement, there are several technical aspects to consider. For example, coughing or multiple mucus plugs might impede the measurement. Furthermore, especially in the lower lobes, the balloon might occlude a segment – for example, B6 in the left lower lobe – so that this segment may not get included in the assessment of CV. Moreover, dynamic airway collapse can occur, which might show as an abrupt or gradual ending of flow, with <100 mL of total exhaled air. To maximize the chance of a successful and reliable measurement, adequate training is required.^37,43,45,46 Furthermore, the measurement can be performed under general anesthesia with positive pressure support (Figure 3E), or high frequency jet ventilation. This creates optimal circumstances for a reliable and fast measurement, and if there is no CV, the treatment with EBVs can take place immediately, in the same treatment session (Figure 4).

Figure 4 Implanted one-way endobronchial valve.

Notes: (A) Open valve, allowing trapped air and fluids to escape. (B) Closed valve, no air or fluids can enter the valve.

Nuclear techniques

Nuclear imaging can be used to demonstrate the presence of CV. For example, Morrell et al⁴⁷ measured CV using a balloon-tipped catheter, to occlude segmental bronchi. Subjects then breathed heliox (79% helium, 21% oxygen) and the rise of helium concentration in the occluded segment was used as index for CV. Another study used ¹³³Xenon ventilation scintigraphy to prove the presence of interlobar CV, by selectively intubating a lobe and measuring the ventilation of the adjacent lobes.⁴⁸

Currently, there are no studies that compared the use of nuclear technique with Chartis measurement or CT-fissure analysis, nor their predictive values for developing atelectasis after endobronchial lung volume reduction therapy.

Another, noninvasive, method to measure CV was described by Marshall et al.⁴⁹ In this study, a mix of hyperpolarized ³He and N₂ was inhaled and ³He images were acquired using MRI during a single breath-hold. They found ventilation defects with delayed filling in a large proportion of patients. Although this delayed filling may be due to several causes (eg, CV, air trapping), the specific pattern of ³He filling from the edges of the ventilation defect toward the centre was believed to be due to CV.

However, although CV may be demonstrated by this method, it demonstrates intersegmental and not the interlobar CV. Therefore, this method is probably less valuable to predict the response to BLVR. Moreover, its availability is probably less than the other measurement methods in most clinics.

CT-fissure analysis

A surrogate- or indirect method for the measurement of CV is by using CT-fissure analysis. CT can be used to assess the completeness of the fissure. If a fissure is complete, there is most probably no CV. However, if the fissures are incomplete and lobes are fused, CV is very likely. Usually, the analysis is done by experienced radiologists or pulmonologists, but it is prone for interobserver variability.

Several authors described the following diagnostic criteria for incomplete interlobar fissures: “1) neither a clear avascular zone nor interlobar line is observed; 2) vascular images in adjacent lobes cross over the interlobar region; 3) pulmonary blood vessels, particularly the pulmonary vein, penetrate the interlobar region; 4) the pulmonary vein is observed in the interlobar region and is related to the vascular images in adjacent lobes.”^30,32,34 Other authors did not use predefined diagnostic criteria, but they used consensus or experts opinion to describe the fissures as complete or incomplete.^{23,28,29,31,33}

Interobserver agreement was investigated by several authors. Koenigkam-Santos et al²⁹ described a high agreement between experienced radiologists for the major fissures, but rather moderate for the minor fissure (k=0.53). Cronin et al³¹ described a greater than 90% agreement for all fissures, Guan et al³⁴ found a fair to nearly perfect agreement between two radiologists (k=0.593–0.652) and Koenigkam-Santos et al²⁸ described a reported interobserver agreement of 0.70–0.76. This is the case with experienced radiologists or pneumologists; inexperienced readers most probably have lower agreement.

Several studies compared the results of CT to intraoperative assessment of the fissures. For example, Diso et al³⁸ evaluated a group of 21 patients undergoing surgery for lung cancer and then compared the intraoperative assessment of fissures to both the Chartis and HRCT measurement of fissures. Compared to inspection at surgery, Chartis measurement had an accuracy of 71% and HRCT of 76%; there was no significant difference between them. Kent et al⁵⁰ compared CT to intraoperative assessment and also found high predictive values for both major fissures but a positive predictive value of only 33% for the minor fissure.

More recently, automatic methods have been developed to quantify the completeness of the fissures. Several of these methods have been described and used in literature, and the results are comparable to the interpretation of radiologists.^35,37,51

Studies comparing CT-fissure analysis and Chartis

The response of valve-based lung volume reduction can be predicted by both the Chartis measurement and the CT-fissure analysis. An interesting question is which of these methods is better to predict this response, or if a combination of both is better.

Currently, there are few studies that compare these methods. Schuhmann et al³⁷ retrospectively compared CT to the Chartis measurement in a testing dataset of 33 patients. A positive response to treatment was defined as a target lung volume reduction of 350 mL or more. The authors concluded that CT-fissure was comparable with Chartis (P=0.55) with an accuracy of 75.8% for Chartis and 78.8% for CT. In this study, both methods disagreed in eleven of 33 subjects, and the proportion of misclassifications was equal between both methods. However, in 22 of 33 subjects, the methods agreed and the classification into responders and nonresponders was 90.9% correct. There were no false negatives in subjects classified as nonresponders by both Chartis and CT. Two patients were misclassified as responders, but that was due to valve procedural errors in these patients. These results suggest that an agreement of both methods leads to few false positives or false negatives. Comparison of the combination of predictors (Chartis and CT) and CT alone resulted in a small but nonsignificant difference in favor of the combined model.

Gompelmann et al⁴⁰ also retrospectively compared Chartis to CT-fissure analysis in 69 patients. A complete fissure was defined as >90% of the fissure present. A positive result was defined as a TLVR ≥350 mL. The Chartis method had an accuracy of 74% and the HRCT fissure analysis an accuracy of 77%, meaning both methods are similar in classifying patients to respond or not respond to EBV treatment. Both methods were concordant in two-thirds of the patients, similar to the study of Schuhmann et al.³⁷

Reymond et al⁴¹ compared CT-fissure analysis to the Chartis measurement in patients with severe emphysema, but not its clinical response. This retrospective study showed an agreement of 73% between the two methods, with a high sensitivity and few false negatives.

Although these studies were retrospective and originally not designed to compare these methods, Chartis and CT-fissure analysis appear to be equivalent to correctly predict a positive or negative response to EBV. New and preferably prospective studies are required to confirm this conclusion and see if the combination of the two methods is superior to a single method to successfully predict the response to EBV.

Clinical application

Another question is whether the measurement of CV is indeed correlated with the results of BLVR.

The first study to correlate the success of EBV placement to CV was the Endobronchial Valve for Emphysema Palliation Trial (VENT), performed by Sciurba et al.⁶ They randomly assigned patients to endobronchial therapy, independent of CV or fissure completeness. Although there was a significant improvement of pulmonary function in the treated patients, in a post hoc analysis, they found an enhanced effect of therapy in patients with complete fissures (>90% complete) on CT.

A European multicenter study by Herth et al,⁴⁴ designed as a validation study for the Chartis system, compared patients with and without CV. There were significantly more responders in the group without CV (target lung volume reduction of 350 mL or more). The TLVR was 743 versus 99 mL in favor of the group without CV. Furthermore, the FEV₁ increased (mean percentage 16 vs 1). The 6 minutes walking distance and St George’s Respiratory Questionnaire were in favor of the collateral negative group, but not significant.

An important study is the BeLieVeR-HIFi study by Davey et al;³⁹ a double-blind sham controlled trial. Patients were selected for bronchoscopic intervention based on the CT-scan alone. They found an increase of the FEV₁ of 8.77%. However, the CV was also measured to compare these two methods. Of the 25 patients with intact fissures and who received EBVs, CV was found in four patients. These patients had no benefit or less benefit from the treatment.

More recently, Klooster et al³ published the STELVIO-trial, a randomized controlled trial to compare endobronchial-valve treatment with standard medical care. Only patients with a complete or near complete fissure were included. CV was measured using the Chartis measurement system. Patients without interlobar CV were randomized to treatment with EBVs or as control. The EBV group improved significantly in FEV₁ (+22.7%), FVC (+442 mL), and 6 minutes walking distance (+106 m).³

An important question is whether the HRCT and Chartis measurement should always be used to determine if a patient is a potential responder to EBVs. Schuhmann et al³⁷ reported a high response rate of almost 65% if the fissure was >90% complete. Nevertheless, this means there is a significant proportion of patients without response. This is also shown by the studies by Klooster et al³ and Davey et al.³⁹ As shown in both studies, an HRCT with complete or near complete fissure (>90%) does not predict the presence of CV in all patients. Therefore, the Chartis measurement is probably useful in all patients who are eligible for treatment with EBVs based on fissure completeness.

However, if the fissure is not (near) complete (<80%–90%), the chance of success is very small, and it is probably not necessary to perform a Chartis measurement.³⁷ The combination of a complete fissure on HRCT and no CV with Chartis measurement should result in an atelectasis of the target lobe. If nevertheless, there is no response, there is most likely a problem at the endobronchial level (forgotten subsegment, misplaced valve, wrong sizing), and a re-bronchoscopy might resolve the problem.^6,46

Airway bypass

Although this review mainly focuses on BLVR using EBVs, the concept of CV has also been used in the treatment of emphysema with so called “airway bypasses”.⁵² With this method, a direct passage between the lung parenchyma and large airways or through the thorax is created, allowing air to exit the lung, and thus bypassing the expiratory flow limitation. CV then should ensure the exit of air and clinical benefit. Two approaches using the airway bypass have been investigated. The transthoracic airway bypass approach has been described by Saad Junior et al⁵³ and Moore et al.⁵⁴ Saad Junior et al⁵³ performed this procedure in three patients with emphysema. These patients reported improvement of symptoms. However, due to the small number treated, no statistical analysis was performed.⁵³ Moore et al⁵⁴ first performed an ex vivo study and found an increase in the expiratory flow (169–235 mL; P<0.05) after insertion of an extrapulmonary airway bypass in seven explanted emphysematous lungs. After that, an in vivo study was performed in four patients. There was a reduction of total lung capacity in all patients and an increase of the FEV₁ in three patients.⁵⁴ A larger study (trial ID: ACTRN12610000190000) using the transthoracic airway bypass approach was prematurely stopped due to lack of funding.⁵⁵

The bronchoscopic approach to create airway bypasses using drug-eluting transbronchial airway stents has been extensively studied in severe emphysema patients. In the “EASE-trial” by Shah et al,⁵⁶ a multicentre, randomized, full sham bronchoscopy controlled trial, 319 patients were randomized and 212 were assigned to airway bypasses. Although after 1 day the pulmonary function significantly improved, showing a strong signal for proof of concept, there was no sustained long-term effect at 6 months or 1 year due to closure of the created bypasses.⁵⁶ There are no other larger studies regarding this subject, and currently not much more is known about the optimal patient selection criteria, number of airway bypasses, and optimal target areas.

Conclusion

Endobronchial lung volume reduction is a promising and proven effective therapy for selected patients with emphysema. The absence of interlobar CV is the most discriminating factor for therapeutic success, as this may prevent the intended lobar atelectasis after valve placement. CV is generated through incomplete lobar fissures. Therefore, only patients with complete fissures and no CV can be selected for endobronchial therapy. Both CT-fissure analysis (indirect) and Chartis measurement (direct) appear to successfully predict the presence of CV and thus the success rate of endobronchial therapy. Both methods have specific pros and cons. However, a combination of the two methods most probably provides the highest accuracy and has proven to successfully predict a positive or negative treatment response. This approach enables personalized medicine and provides an excellent treatment strategy in selected patients with the right phenotype of emphysema, whilst it avoids the possibility of unsuitable patients with the wrong phenotype undergoing useless treatment.

Disclosure

TDK reports no conflicts of interest in this work. DJS is receiving consulting fees from PneumRx/BTG, lecture fees from PneumRx/BTG, Boston Scientific, Holaira, Olympus Europe, and Pulmonx, devices for treatments from PneumRx/BTG, Holaira, and Pulmonx, travel support from PneumRx/BTG, Boston Scientific, Holaira, Olympus Europe, and Pulmonx, and grant support from PneumRx/BTG, Boston Scientific, Aeris Therapeutics, Holaira, and Pulmonx, and reports no other conflicts of interest in this work.