Pseudomonas aeruginosa infection increases the readmission rate of COPD patients

Abstract

Introduction

Acute exacerbation of COPD (AECOPD) leads to rapid deterioration of pulmonary function and quality of life. It is unclear whether the prognosis for AECOPD differs depending on the bacterium or virus identified. The purpose of this study is to determine whether readmission of patients with severe AECOPD varies according to the bacterium or virus identified.

Methods

We performed a retrospective review of medical records of 704 severe AECOPD events at Korea University Guro Hospital from January 2011 to May 2017. We divided events into two groups, one in which patients were readmitted within 30 days after discharge and the other in which there was no readmission.

Results

Of the 704 events, 65 were followed by readmission within 30 days. Before propensity score matching, the readmission group showed a higher rate of bacterial identification with no viral identification and a higher rate of identification with the Pseudomonas aeruginosa (P=0.003 and P=0.007, respectively). Using propensity score matching, the readmission group still showed a higher P. aeruginosa identification rate (P=0.030), but there was no significant difference in the rate of bacterial identification, with no viral identification (P=0.210). In multivariate analysis, the readmission group showed a higher P. aeruginosa identification rate than the no-readmission group (odds ratio, 4.749; 95% confidence interval, 1.296–17.041; P=0.019).

Conclusion

P. aeruginosa identification is associated with a higher readmission rate in AECOPD patients.

Keywords:

• acute exacerbation of COPD
• Pseudomonas aeruginosa
• readmission
• bacterium
• virus

Acknowledgments

This study was supported by a grant from Korea University, Seoul, Korea (K1719301).

Author contributions

All authors contributed toward data analysis, drafting, and revising this paper and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.