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Abstract
Background
The aim was to assess and compare reported sleep disturbances and objectively measured sleep in men and women with COPD compared with controls and also explore sex differences.
Methods
A total of 96 patients with COPD and 90 age- and sex-matched controls answered a sleep questionnaire, underwent ambulatory polysomnography, a post-bronchodilatory spirometry, and blood sampling.
Results
Of the patients with COPD, 51% reported sleep disturbances as compared with 31% in controls (P=0.008). Sleep disturbances were significantly more prevalent in males with COPD compared with controls, whereas there was no significant difference in females. The use of hypnotics was more common among patients with COPD compared with controls, both in men (15% vs 0%, P=0.009) and women (36% vs 16%, P=0.03). The men with COPD had significantly longer recorded sleep latency than the male control group (23 vs 9.3 minutes, P<0.001), while no corresponding difference was found in women. In men with COPD, those with reported sleep disturbances had lower forced vital capacity, higher C-reactive protein, myeloperoxidase, and higher prevalence of chronic bronchitis.
Conclusion
The COPD was associated with impaired sleep in men while the association was less clear in women. This was also confirmed by recorded longer sleep latency in male subjects with COPD compared with controls.
Acknowledgments
The study was financially supported by the Swedish Heart and Lung Foundation and the Swedish Association against Heart and Lung Diseases. Preliminary results from the study were presented as an abstract at the American Thoracic Society 2010 International Conference, May 14–19, 2010; New Orleans, LA, USA.
Author contributions
JTH contributed to data collection, data analysis, and manuscript preparation. ISÓ contributed to study design, data analysis, and manuscript preparation. BB, TG, and EL contributed to study design and review of the manuscript. CJ contributed to study design, data collection, data analysis, and manuscript preparation. JTH, ISÓ, and CJ had full access to all the data in the study and were responsible for the integrity of the data and the accuracy of the data analysis. All authors contributed toward data analysis, drafting and critically revising the paper, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
Disclosure
The authors report no conflicts of interest in this work.