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Abstract
Elotuzumab is one of the first monoclonal antibodies to be approved for the treatment of multiple myeloma. It is a humanized immunoglobulin G kappa (IgGκ) antibody that targets signaling lymphocytic activation molecule family member 7 (SLAMF7), a surface marker that is highly expressed on normal and malignant plasma cells. This review summarizes the preclinical and clinical data that led to the approval of elotuzumab, along with a discussion on the ongoing and future clinical investigations.
Disclosure
SZU has consulted for Amgen, Celgene, Takeda, Novartis, Janssen and Sanofi; received speaker fees for Celgene, Millennium Takeda and Onyx and received research funding from Amgen, Array Biopharma, Celgene, Janssen Oncology, Onyx, Pharmacyclics, Sanofi and Takeda. The other authors report no conflicts of interest in this work.