Drug Design, Development and Therapy, Volume 11, Issue (2017)

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Drug Design, Development and Therapy, Volume 11, Issue (2017)

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Original Research

Article
Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy
Mahboubeh Razavi, Hamed Karimian, Chai Hong Yeong, Mehran Fadaeinasab, Si Lay Khaing, Lip Yong Chung, Didi Erwandi B Mohamad Haron & Mohamed Ibrahim Noordin
Pages: 1-15
Published online: 03 Oct 2022
AbstractforGastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy | Full Text | References | PDF (3.1 MB)
  • 100 Views
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Open Access
Article
Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting
Jin-Seok Choi & Jeong-Sook Park
Pages: 17-26
Published online: 16 Dec 2016
AbstractforDevelopment of docetaxel nanocrystals surface modified with transferrin for tumor targeting | Full Text | References | PDF (1.9 MB)
  • 130 Views
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Open Access
Article
Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
Levente Knapp, Bence Szita, Kitti Kocsis, László Vécsei & József Toldi
Pages: 27-34
Published online: 20 Dec 2016
AbstractforNitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues | Full Text | References | PDF (2.2 MB)
  • 61 Views
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Open Access

Review

Review Article
Spotlight on the 9-valent HPV vaccine
Pier Luigi Lopalco
Pages: 35-44
Published online: 20 Dec 2016
AbstractforSpotlight on the 9-valent HPV vaccine | Full Text | References | PDF (635.6 KB)
  • 169 Views
  • 20 CrossRef citations
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Open Access

Original Research

Article
Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery
Min Soo Kim, Dong Woo Yeom, Sung Rae Kim, Ho Yub Yoon, Chang Hyun Kim, Ho Yong Son, Jin Han Kim, Sangkil Lee & Young Wook Choi
Pages: 45-57
Published online: 21 Dec 2016
AbstractforDevelopment of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery | Full Text | References | PDF (950.9 KB)
  • 111 Views
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Open Access

Expert Opinion

Article
Riluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis
Ann Margaret Dyer & Alan Smith
Pages: 59-64
Published online: 22 Dec 2016
AbstractforRiluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosis | Full Text | References | PDF (240.8 KB)
  • 282 Views
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Open Access

Review

Review Article
Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections
Olivia Ferrández, Olatz Urbina & Santiago Grau
Pages: 65-82
Published online: 22 Dec 2016
AbstractforCritical role of tedizolid in the treatment of acute bacterial skin and skin structure infections | Full Text | References | PDF (504.2 KB)
  • 76 Views
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Open Access

Original Research

Article
Analysis of pramipexole dose–response relationships in Parkinson’s disease
Ying Wang, Sheng-Gang Sun, Sui-Qiang Zhu, Chun-Feng Liu, Yi-Ming Liu, Qing Di, Hui-Fang Shang, Yan Ren, Wei Xiang & Sheng-Di Chen
Pages: 83-89
Published online: 23 Dec 2016
AbstractforAnalysis of pramipexole dose–response relationships in Parkinson’s disease | Full Text | References | PDF (503.2 KB)
  • 128 Views
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Open Access
Article
Vitamin D deficiency and the risk of tuberculosis: a meta-analysis
Shao-Jun Huang, Xian-Hua Wang, Zhi-Dong Liu, Wen-Li Cao, Yi Han, Ai-Guo Ma & Shao-Fa Xu
Pages: 91-102
Published online: 28 Dec 2016
AbstractforVitamin D deficiency and the risk of tuberculosis: a meta-analysis | Full Text | References | PDF (1,017.2 KB)
  • 366 Views
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Open Access
Article
Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii
Venoos Iman, Syam Mohan, Siddig Ibrahim Abdelwahab, Hamed Karimian, Noraziah Nordin, Mehran Fadaeinasab, Mohamad Ibrahim Noordin & Suzita Mohd Noor
Pages: 103-121
Published online: 28 Dec 2016
AbstractforAnticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii | Full Text | References | PDF (6.4 MB)
  • 288 Views
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Open Access
Article
Effects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans
Stipo Jurcevic, Pierre-Eric Juif, Colleen Hamid, Roseanna Greenlaw, Daniele D’Ambrosio & Jasper Dingemanse
Pages: 123-131
Published online: 28 Dec 2016
AbstractforEffects of multiple-dose ponesimod, a selective S1P1 receptor modulator, on lymphocyte subsets in healthy humans | Full Text | References | PDF (1.3 MB)
  • 72 Views
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Open Access

Corrigendum

Correction
A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]
Page: 133
Published online: 28 Dec 2016
CitationforA triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum] | Full Text | PDF (181.7 KB)
  • 58 Views
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Open Access

Original Research

Article
Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen
Dongseong Shin, Sook Joung Lee, Yu-Mi Ha, Young-Sim Choi, Jae-Won Kim, Se-Rin Park & Min Kyu Park
Pages: 135-141
Published online: 04 Jan 2017
AbstractforPharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen | Full Text | References | PDF (491.2 KB)
  • 1285 Views
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Open Access

Review

Review Article
Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy
Ádám Annus & László Vécsei
Pages: 143-151
Published online: 09 Jan 2017
AbstractforSpotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy | Full Text | References | PDF (405.7 KB)
  • 112 Views
  • 21 CrossRef citations
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Open Access

Original Research

Article
Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
G Logan Draughn, C Leigh Allen, Patricia A Routh, Maria R Stone, Kelly R Kirker, Laura Boegli, Ryan M Schuchman, Keith E Linder, Ronald E Baynes, Garth James, Christian Melander, Angela Pollard & John Cavanagh
Pages: 153-162
Published online: 11 Jan 2017
AbstractforEvaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections | Full Text | References | PDF (1.4 MB)
  • 76 Views
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Open Access
Article
Resveratrol inhibits transforming growth factor-β2-induced epithelial-to-mesenchymal transition in human retinal pigment epithelial cells by suppressing the Smad pathway
Ching-Long Chen, Yi-Hao Chen, Ming-Cheng Tai, Chang-Min Liang, Da-Wen Lu & Jiann-Torng Chen
Pages: 163-173
Published online: 11 Jan 2017
AbstractforResveratrol inhibits transforming growth factor-β2-induced epithelial-to-mesenchymal transition in human retinal pigment epithelial cells by suppressing the Smad pathway | Full Text | References | PDF (2.2 MB)
  • 121 Views
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Open Access

Corrigendum

Correction
Golimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials [Corrigendum]
Page: 175
Published online: 11 Jan 2017
CitationforGolimumab in radiographic and nonradiographic axial spondyloarthritis: a review of clinical trials [Corrigendum] | Full Text | PDF (146.3 KB)
  • 48 Views
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Open Access

Review

Review Article
Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies
Alex Françoso & Patricia Ucelli Simioni
Pages: 177-184
Published online: 11 Jan 2017
AbstractforImmunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trial monoclonal antibodies | Full Text | References | PDF (263 KB)
  • 76 Views
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Open Access

Original Research

Article
Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction
Minkyung Kang, Hyounggeun Park, Joon-Ho Jun, Miwon Son & Myung Joo Kang
Pages: 185-191
Published online: 11 Jan 2017
AbstractforFacilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction | Full Text | References | PDF (1.3 MB)
  • 88 Views
  • 3 CrossRef citations
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Open Access
Article
Computational intelligence models to predict porosity of tablets using minimum features
Mohammad Hassan Khalid, Pezhman Kazemi, Lucia Perez-Gandarillas, Abderrahim Michrafy, Jakub Szlęk, Renata Jachowicz & Aleksander Mendyk
Pages: 193-202
Published online: 12 Jan 2017
AbstractforComputational intelligence models to predict porosity of tablets using minimum features | Full Text | References | PDF (1.9 MB)
  • 92 Views
  • 8 CrossRef citations
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Open Access
Article
Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients
Seung Yeon Son, Hye Ryoun Jang, Jung Eun Lee, Heejin Yoo, Kyunga Kim, Jae Berm Park, Sung Joo Kim, Ha Young Oh & Wooseong Huh
Pages: 203-210
Published online: 12 Jan 2017
AbstractforComparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients | Full Text | References | PDF (538.3 KB)
  • 87 Views
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Open Access

Review

Review Article
Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
Chiara Crotti, Maria Gabriella Raimondo, Andrea Becciolini, Martina Biggioggero & Ennio Giulio Favalli
Pages: 211-223
Published online: 03 Oct 2022
AbstractforSpotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date | Full Text | References | PDF (647.1 KB)
  • 74 Views
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Open Access

Original Research

Article
N-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation
Jianhui Wu, Ming Zhao, Yuji Wang, Yaonan Wang, Haimei Zhu, Shurui Zhao, Lin Gui, Xiaoyi Zhang & Shiqi Peng
Pages: 225-239
Published online: 17 Jan 2017
AbstractforN-(3-hydroxymethyl-β-carboline-1-yl-ethyl- 2-yl)-l-Phe: development toward a nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation | Full Text | References | PDF (5.4 MB)
  • 63 Views
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Open Access
Article
Effect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis
Pezhman Kazemi, Mohammad Hassan Khalid, Ana Pérez Gago, Peter Kleinebudde, Renata Jachowicz, Jakub Szlęk & Aleksander Mendyk
Pages: 241-251
Published online: 18 Jan 2017
AbstractforEffect of roll compaction on granule size distribution of microcrystalline cellulose–mannitol mixtures: computational intelligence modeling and parametric analysis | Full Text | References | PDF (1.6 MB)
  • 192 Views
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Open Access

Review

Review Article
Plitidepsin: design, development, and potential place in therapy
Sara Alonso-Álvarez, Emilia Pardal, Diego Sánchez-Nieto, Miguel Navarro, Maria Dolores Caballero, Maria Victoria Mateos & Alejandro Martín
Pages: 253-264
Published online: 19 Jan 2017
AbstractforPlitidepsin: design, development, and potential place in therapy | Full Text | References | PDF (502.7 KB)
  • 319 Views
  • 61 CrossRef citations
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Open Access

Original Research

Article
Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach
Luca Gallelli, Daniela Falcone, Roberto Cannataro, Mariarita Perri, Raffaele Serra, Girolamo Pelaia, Rosario Maselli, Rocco Savino, Giuseppe Spaziano & Bruno D’Agostino
Pages: 265-272
Published online: 23 Jan 2017
AbstractforTheophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach | Full Text | References | PDF (720.5 KB)
  • 81 Views
  • 14 CrossRef citations
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Open Access

Review

Review Article
Drugs in development for toxoplasmosis: advances, challenges, and current status
P Holland Alday & Joseph Stone Doggett
Pages: 273-293
Published online: 25 Jan 2017
AbstractforDrugs in development for toxoplasmosis: advances, challenges, and current status | Full Text | References | PDF (2 MB)
  • 647 Views
  • 169 CrossRef citations
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Open Access
Review Article
Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy
Othman Al-Sawaf, Kirsten Fischer, Anja Engelke, Natali Pflug, Michael Hallek & Valentin Goede
Pages: 295-304
Published online: 25 Jan 2017
AbstractforObinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy | Full Text | References | PDF (597.9 KB)
  • 114 Views
  • 11 CrossRef citations
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Open Access

Original Research

Article
Impact of metoprolol treatment on mental status of chronic heart failure patients with neuropsychiatric disorders
Xuelu Liu, Xueming Lou, Xianliang Cheng & Yong Meng
Pages: 305-312
Published online: 25 Jan 2017
AbstractforImpact of metoprolol treatment on mental status of chronic heart failure patients with neuropsychiatric disorders | Full Text | References | PDF (376.7 KB)
  • 170 Views
  • 15 CrossRef citations
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Open Access
Article
Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro
Xin Shen, Nan Zhou, Le Mi, Zishuo Hu, Libin Wang, Xueying Liu & Shengyong Zhang
Pages: 313-324
Published online: 07 Feb 2017
AbstractforPhloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro | Full Text | References | PDF (4.1 MB)
  • 168 Views
  • 30 CrossRef citations
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Open Access

Review

Review Article
Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting
Carlotta Marianecci, Federica Rinaldi, Patrizia Nadia Hanieh, Luisa Di Marzio, Donatella Paolino & Maria Carafa
Pages: 325-335
Published online: 27 Jan 2017
AbstractforDrug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting | Full Text | References | PDF (1.2 MB)
  • 131 Views
  • 29 CrossRef citations
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Open Access

Original Research

Article
Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo
Hamed Karimian, Aditya Arya, Mehran Fadaeinasab, Mahboubeh Razavi, Maryam Hajrezaei, Ataul Karim Khan, Hapipah Mohd Ali, Mahmood Ameen Abdulla & Mohamad Ibrahim Noordin
Pages: 337-350
Published online: 03 Oct 2022
AbstractforKelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo | Full Text | References | PDF (6.8 MB)
  • 95 Views
  • 9 CrossRef citations
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Open Access
Article
Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10
Noraziah Mohamad Zin, Mohd Shukri Baba, Abu Hassan Zainal-Abidin, Jalifah Latip, Noor Wini Mazlan & RuAngelie Edrada-Ebel
Pages: 351-363
Published online: 08 Feb 2017
AbstractforGancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10 | Full Text | References | PDF (5.7 MB)
  • 151 Views
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Open Access

Review

Review Article
Effect of dexmedetomidine in preventing etomidate-induced myoclonus: a meta-analysis
Xueke Du, Chengmao Zhou, Linghui Pan & Changlong Li
Pages: 365-370
Published online: 08 Feb 2017
AbstractforEffect of dexmedetomidine in preventing etomidate-induced myoclonus: a meta-analysis | Full Text | References | PDF (592.3 KB)
  • 95 Views
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Open Access

Corrigendum

Correction
Evaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells [Corrigendum]
Page: 371
Published online: 08 Feb 2017
CitationforEvaluation of effects of various drugs on platelet functions using phorbol 12-myristate 13-acetate-induced megakaryocytic human erythroid leukemia cells [Corrigendum] | Full Text | PDF (400.6 KB)
  • 55 Views
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Open Access

Original Research

Article
Pharmacokinetics of conivaptan use in patients with severe hepatic impairment
Thomas Marbury, Jerry Fox, Byron Kaelin & Leo Pavliv
Pages: 373-382
Published online: 13 Feb 2017
AbstractforPharmacokinetics of conivaptan use in patients with severe hepatic impairment | Full Text | References | PDF (454.9 KB)
  • 80 Views
  • 6 CrossRef citations
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Open Access
Article
Antioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less
Nitinet Ketsuwan, Jirakrit Leelarungrayub, Suchart Kothan & Supawatchara Singhatong
Pages: 383-391
Published online: 13 Feb 2017
AbstractforAntioxidant compounds and activities of the stem, flower, and leaf extracts of the anti-smoking Thai medicinal plant: Vernonia cinerea Less | Full Text | References | PDF (2.4 MB)
  • 247 Views
  • 11 CrossRef citations
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Open Access

Review

Review Article
Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
Rajan Rajabalaya, Muhammad Nuh Musa, Nurolaini Kifli & Sheba R David
Pages: 393-406
Published online: 13 Feb 2017
AbstractforOral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals | Full Text | References | PDF (3.1 MB)
  • 707 Views
  • 78 CrossRef citations
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Open Access

Original Research

Article
Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study
Omolbanin Shahraki, Najmeh Edraki, Mehdi Khoshneviszadeh, Farshid Zargari, Sara Ranjbar, Luciano Saso, Omidreza Firuzi & Ramin Miri
Pages: 407-418
Published online: 14 Feb 2017
AbstractforNovel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study | Full Text | References | PDF (3.6 MB)
  • 113 Views
  • 17 CrossRef citations
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Open Access
Article
Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes
Wooseong Kim, Yejin Yang, Dohoon Kim, Seongkeun Jeong, Jin-Wook Yoo, Jeong-Hyun Yoon & Yunjin Jung
Pages: 419-429
Published online: 14 Feb 2017
AbstractforConjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes | Full Text | References | PDF (929.9 KB)
  • 77 Views
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Open Access
Article
Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
Chunguang Yang, Xueyou Ma, Zhihua Wang, Xing Zeng, Zhiquan Hu, Zhangqun Ye & Guanxin Shen
Pages: 431-439
Published online: 14 Feb 2017
AbstractforCurcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation | Full Text | References | PDF (3.4 MB)
  • 160 Views
  • 60 CrossRef citations
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Open Access
Article
Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes
Juan Song, Weifang Ren, Tingting Xu, Yi Zhang, Hongyu Guo, Shanshan Zhu & Li Yang
Pages: 441-449
Published online: 03 Oct 2022
AbstractforReversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes | Full Text | References | PDF (2.1 MB)
  • 76 Views
  • 6 CrossRef citations
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Open Access
Article
Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study
Donglou Liang, Qiaowan Chen, Yujin Guo, Ting Zhang & Wentao Guo
Pages: 451-461
Published online: 17 Feb 2017
AbstractforInsight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study | Full Text | References | PDF (5 MB)
  • 87 Views
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Open Access

Review

Review Article
Profile of mirabegron in the treatment of overactive bladder: place in therapy
Ala’a Sharaf & Hashim Hashim
Pages: 463-467
Published online: 20 Feb 2017
AbstractforProfile of mirabegron in the treatment of overactive bladder: place in therapy | Full Text | References | PDF (271 KB)
  • 114 Views
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Open Access

Original Research

Article
Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes
Ali Kadivar, Behnam Kamalidehghan, Hamid Akbari Javar, Benyamin Karimi, Reihaneh Sedghi & Mohamed Ibrahim Noordin
Pages: 469-481
Published online: 03 Oct 2022
AbstractforAntiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes | Full Text | References | PDF (1.5 MB)
  • 129 Views
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Open Access
Article
Polyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA
Hadeel Elzeny, Fuwu Zhang, Esraa N Ali, Heba A Fathi, Shiyi Zhang, Richen Li, Mohamed A El-Mokhtar, Mostafa A Hamad, Karen L Wooley & Mahmoud Elsabahy
Pages: 483-496
Published online: 22 Feb 2017
AbstractforPolyphosphoester nanoparticles as biodegradable platform for delivery of multiple drugs and siRNA | Full Text | References | PDF (1.9 MB)
  • 115 Views
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Open Access

Review

Review Article
Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure
Fazia Mir, Alp S Kahveci, Jamal A Ibdah & Veysel Tahan
Pages: 497-502
Published online: 23 Feb 2017
AbstractforSofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure | Full Text | References | PDF (298.1 KB)
  • 143 Views
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Open Access

Original Research

Article
Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?
Choon Ok Kim, Eun Sil Oh, Hohyun Kim & Min Soo Park
Pages: 503-512
Published online: 03 Oct 2022
AbstractforPharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? | Full Text | References | PDF (574.6 KB)
  • 139 Views
  • 9 CrossRef citations
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Open Access
Article
Combined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning
Wenping Xiang, Hui Xue, Baojun Wang, Yuechun Li, Jun Zhang, Changchun Jiang, Furu Liang, Jiangxia Pang & Lehua Yu
Pages: 513-519
Published online: 03 Oct 2022
AbstractforCombined application of dexamethasone and hyperbaric oxygen therapy yields better efficacy for patients with delayed encephalopathy after acute carbon monoxide poisoning | Full Text | References | PDF (1.1 MB)
  • 137 Views
  • 23 CrossRef citations
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Open Access
Article
Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract
Cătălina Bogdan, Sonia Iurian, Ioan Tomuta & Mirela Moldovan
Pages: 521-531
Published online: 24 Feb 2017
AbstractforImprovement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract | Full Text | References | PDF (1.6 MB)
  • 679 Views
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Open Access

Review

Review Article
Eteplirsen in the treatment of Duchenne muscular dystrophy
Kenji Rowel Q Lim, Rika Maruyama & Toshifumi Yokota
Pages: 533-545
Published online: 03 Oct 2022
AbstractforEteplirsen in the treatment of Duchenne muscular dystrophy | Full Text | References | PDF (538.6 KB)
  • 3115 Views
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Open Access
Review Article
Defective DNA repair mechanisms in prostate cancer: impact of olaparib
Francesca De Felice, Vincenzo Tombolini, Francesco Marampon, Angela Musella & Claudia Marchetti
Pages: 547-552
Published online: 01 Mar 2017
AbstractforDefective DNA repair mechanisms in prostate cancer: impact of olaparib | Full Text | References | PDF (257.5 KB)
  • 174 Views
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Open Access

Original Research

Article
Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction
Jaqueline S da Silva, Daniele Gabriel-Costa, Roberto T Sudo, Hao Wang, Leanne Groban, Emanuele B Ferraz, José Hamilton M Nascimento, Carlos Alberto M Fraga, Eliezer J Barreiro & Gisele Zapata-Sudo
Pages: 553-562
Published online: 06 Mar 2017
AbstractforAdenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction | Full Text | References | PDF (1.6 MB)
  • 80 Views
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Open Access
Article
In silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA)
Junie B Billones, Maria Constancia O Carrillo, Voltaire G Organo, Jamie Bernadette A Sy, Nina Abigail B Clavio, Stephani Joy Y Macalino, Inno A Emnacen, Alexandra P Lee, Paul Kenny L Ko & Gisela P Concepcion
Pages: 563-574
Published online: 02 Mar 2017
AbstractforIn silico discovery and in vitro activity of inhibitors against Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase (Mtb BioA) | Full Text | References | PDF (3.3 MB)
  • 343 Views
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Open Access

Clinical Trial Report

Case Report
Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus
Hanan Polansky, Edan Itzkovitz & Adrian Javaherian
Pages: 575-583
Published online: 03 Oct 2022
AbstractforHuman papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus | Full Text | References | PDF (1 MB)
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Original Research

Article
Rifapentine-linezolid-loaded PLGA microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization
Jieyun Huang, Zhi Chen, Ying Li, Li Li & Guangyu Zhang
Pages: 585-592
Published online: 03 Oct 2022
AbstractforRifapentine-linezolid-loaded PLGA microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization | Full Text | References | PDF (2.1 MB)
  • 292 Views
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Article
Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil
Andrea Prontera, Stefano Baroni, Andrea Marudi, Franco Valzania, Alberto Feletti, Francesca Benuzzi, Elisabetta Bertellini & Giacomo Pavesi
Pages: 593-598
Published online: 03 Mar 2017
AbstractforAwake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil | Full Text | References | PDF (229.9 KB)
  • 128 Views
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Review

Review Article
Metal complexes in cancer therapy – an update from drug design perspective
Umar Ndagi, Ndumiso Mhlongo & Mahmoud E Soliman
Pages: 599-616
Published online: 03 Oct 2022
AbstractforMetal complexes in cancer therapy – an update from drug design perspective | Full Text | References | PDF (1.2 MB)
  • 2494 Views
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Original Research

Article
β3-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells
Xia-qing Gao, Yan-fang Li & Zhi-li Jiang
Pages: 617-627
Published online: 03 Mar 2017
Abstractforβ3-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells | Full Text | References | PDF (3.5 MB)
  • 53 Views
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Article
MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
Peixin Huang, Mark W Lee Jr, Keivan Sadrerafi, Daniel P Heruth, Li Q Zhang, Dev Maulik & Shui Qing Ye
Pages: 629-641
Published online: 03 Mar 2017
AbstractforMC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866 | Full Text | References | PDF (2.1 MB)
  • 70 Views
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Review

Review Article
New developments in the management of partial-onset epilepsy: role of brivaracetam
Giangennaro Coppola, Giulia Iapadre, Francesca Felicia Operto & Alberto Verrotti
Pages: 643-657
Published online: 06 Mar 2017
AbstractforNew developments in the management of partial-onset epilepsy: role of brivaracetam | Full Text | References | PDF (471.1 KB)
  • 166 Views
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Original Research

Article
Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance
Yongsheng Su, Jian Hu, Zhibin Huang, Yubin Huang, Bingsheng Peng, Ni Xie & Hui Liu
Pages: 659-668
Published online: 06 Mar 2017
AbstractforPaclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance | Full Text | References | PDF (1.6 MB)
  • 116 Views
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Article
Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol
Magdalena Donejko, Edyta Rysiak, Elżbieta Galicka, Robert Terlikowski, Edyta Katarzyna Głażewska & Andrzej Przylipiak
Pages: 669-676
Published online: 06 Mar 2017
AbstractforProtective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol | Full Text | References | PDF (1.6 MB)
  • 77 Views
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Article
Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?
E Erkılıç, E Kesimci, F Alaybeyoğlu, I Kılınç, R Tural, A Yazgan, T Gümüş, A Sepici Dinçel, EG Dumlu & O Kanbak
Pages: 677-683
Published online: 08 Mar 2017
AbstractforDoes remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney? | Full Text | References | PDF (1.8 MB)
  • 72 Views
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Review

Review Article
Development of venetoclax for therapy of lymphoid malignancies
Huayuan Zhu & Alexandru Almasan
Pages: 685-694
Published online: 09 Mar 2017
AbstractforDevelopment of venetoclax for therapy of lymphoid malignancies | Full Text | References | PDF (1,017.7 KB)
  • 142 Views
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Original Research

Article
Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model
Song Guo, Xiaowei Lu, Ruihuan Gu, Di Zhang, Yijuan Sun & Yun Feng
Pages: 695-704
Published online: 03 Oct 2022
AbstractforTranscriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model | Full Text | References | PDF (2.3 MB)
  • 82 Views
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Article
Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers
Kyungho Jang, Min-Kyoung Kim, Jaeseong Oh, SeungHwan Lee, Joo-Youn Cho, Kyung-Sang Yu, Tai Kiu Choi, Sang-Hyuk Lee & Kyoung Soo Lim
Pages: 705-711
Published online: 09 Mar 2017
AbstractforEffects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers | Full Text | References | PDF (503.2 KB)
  • 80 Views
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Article
Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects
Dongseong Shin, SeungHwan Lee, Sojeong Yi, Seo Hyun Yoon, Joo-Youn Cho, Mi Young Bahng, In-Jin Jang & Kyung-Sang Yu
Pages: 713-723
Published online: 10 Mar 2017
AbstractforPharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects | Full Text | References | PDF (1.2 MB)
  • 79 Views
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Article
An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch
Chao Zhang, Haiyan Li, Xin Xiong, Suodi Zhai, Yudong Wei, Shuang Zhang, Yuanyuan Zhang, Lin Xu & Li Liu
Pages: 725-731
Published online: 10 Mar 2017
AbstractforAn open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch | Full Text | References | PDF (446.1 KB)
  • 88 Views
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Article
Risk assessment and experimental design in the development of a prolonged release drug delivery system with paliperidone
Sonia Iurian, Luana Turdean & Ioan Tomuta
Pages: 733-746
Published online: 13 Mar 2017
AbstractforRisk assessment and experimental design in the development of a prolonged release drug delivery system with paliperidone | Full Text | References | PDF (1.5 MB)
  • 188 Views
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Review

Review Article
Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date
Aleksander Lenert, Timothy B Niewold & Petar Lenert
Pages: 747-757
Published online: 13 Mar 2017
AbstractforSpotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date | Full Text | References | PDF (560.5 KB)
  • 108 Views
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Original Research

Article
Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound
Angela Mastelić, Vedrana Čikeš Čulić, Nikolina Režić Mužinić, Milena Vuica-Ross, David Barker, Euphemia Y Leung, Jóhannes Reynisson & Anita Markotić
Pages: 759-769
Published online: 14 Mar 2017
AbstractforGlycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound | Full Text | References | PDF (2.3 MB)
  • 85 Views
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Article
Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers
Chaw Yee Beh, Chee Wun How, Jhi Biau Foo, Jia Ning Foong, Gayathri Thevi Selvarajah & Abdullah Rasedee
Pages: 771-782
Published online: 14 Mar 2017
AbstractforDevelopment of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers | Full Text | References | PDF (2 MB)
  • 152 Views
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Article
HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo
Shuang Jiang & Xiaolong Chen
Pages: 783-795
Published online: 15 Mar 2017
AbstractforHMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo | Full Text | References | PDF (5 MB)
  • 129 Views
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Review

Review Article
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer’s disease and Parkinson’s disease
Gargi Ganguly, Sasanka Chakrabarti, Uttara Chatterjee & Luciano Saso
Pages: 797-810
Published online: 03 Oct 2022
AbstractforProteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer’s disease and Parkinson’s disease | Full Text | References | PDF (481.1 KB)
  • 498 Views
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Original Research

Article
Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability
Thomas J Dennison, Julian C Smith, Raj K Badhan & Afzal R Mohammed
Pages: 811-826
Published online: 16 Mar 2017
AbstractforFixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability | Full Text | References | PDF (2.1 MB)
  • 161 Views
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Article
Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives
Do Hyun Kim, Su Jeong Kim, Sultan Ullah, Hwi Young Yun, Pusoon Chun & Hyung Ryong Moon
Pages: 827-836
Published online: 16 Mar 2017
AbstractforDesign, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives | Full Text | References | PDF (1.4 MB)
  • 74 Views
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Review

Review Article
Cardioprotection with halogenated gases: how does it occur?
Jose Luis Guerrero-Orriach, Juan Jose Escalona Belmonte, Alicia Ramirez Fernandez, Marta Ramirez Aliaga, Manuel Rubio Navarro & Jose Cruz Mañas
Pages: 837-849
Published online: 16 Mar 2017
AbstractforCardioprotection with halogenated gases: how does it occur? | Full Text | References | PDF (338.9 KB)
  • 65 Views
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Original Research

Article
Efficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis
Ruili Yu, Bo Yang, Xiaohua Chi, Lili Cai, Cui Liu, Lei Yang, Xueyan Wang, Peifeng He & Xuechun Lu
Pages: 851-864
Published online: 17 Mar 2017
AbstractforEfficacy of cytokine-induced killer cell infusion as an adjuvant immunotherapy for hepatocellular carcinoma: a systematic review and meta-analysis | Full Text | References | PDF (958.9 KB)
  • 100 Views
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Article
Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
Imaobong Christopher Etti, Abdullah Rasedee, Najihah Mohd Hashim, Ahmad Bustamam Abdul, Arifah Kadir, Swee Keong Yeap, Peter Waziri, Ibrahim Malami, Kian Lam Lim & Christopher J Etti
Pages: 865-879
Published online: 03 Oct 2022
AbstractforArtonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells | Full Text | References | PDF (3.4 MB)
  • 113 Views
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Review

Review Article
Delafloxacin: design, development and potential place in therapy
Francisco Javier Candel & Marina Peñuelas
Pages: 881-891
Published online: 20 Mar 2017
AbstractforDelafloxacin: design, development and potential place in therapy | Full Text | References | PDF (462.6 KB)
  • 429 Views
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Review Article
Clinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma
Reed Friend, Manisha Bhutani, Peter M Voorhees & Saad Z Usmani
Pages: 893-900
Published online: 20 Mar 2017
AbstractforClinical potential of SLAMF7 antibodies – focus on elotuzumab in multiple myeloma | Full Text | References | PDF (349.8 KB)
  • 94 Views
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Original Research

Article
Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats
Wessam M Abdel-Wahab, Farouzia I Moussa & Najwa A Saad
Pages: 901-908
Published online: 20 Mar 2017
AbstractforSynergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats | Full Text | References | PDF (506.7 KB)
  • 195 Views
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Article
Nanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis
Mariana R Sato, João A Oshiro Junior, Rachel TA Machado, Paula C de Souza, Débora L Campos, Fernando R Pavan, Patricia B da Silva & Marlus Chorilli
Pages: 909-921
Published online: 20 Mar 2017
AbstractforNanostructured lipid carriers for incorporation of copper(II) complexes to be used against Mycobacterium tuberculosis | Full Text | References | PDF (2.3 MB)
  • 153 Views
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Review

Review Article
Sodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale
Sayf A Yassin & Vanita R Aroda
Pages: 923-937
Published online: 21 Mar 2017
AbstractforSodium-glucose cotransporter 2 inhibitors combined with dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: a review of current clinical evidence and rationale | Full Text | References | PDF (427.4 KB)
  • 87 Views
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Original Research

Article
Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria
Xiaozhe Wu, Zhan Li, Xiaolu Li, Yaomei Tian, Yingzi Fan, Chaoheng Yu, Bailing Zhou, Yi Liu, Rong Xiang & Li Yang
Pages: 939-946
Published online: 22 Mar 2017
AbstractforSynergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug-resistant bacteria | Full Text | References | PDF (1 MB)
  • 479 Views
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Review

Review Article
Differential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV)
Noha Rashad & Omar Abdel-Rahman
Pages: 947-954
Published online: 24 Mar 2017
AbstractforDifferential clinical pharmacology of rolapitant in delayed chemotherapy-induced nausea and vomiting (CINV) | Full Text | References | PDF (272.2 KB)
  • 90 Views
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Original Research

Article
Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro
Yunlong Wang, Yuling Luo, Chunhong Li, Xiaoqin Zhang, Chao Pi, Lu Yu, Shurong Wang & Zhirong Zhong
Pages: 955-968
Published online: 27 Mar 2017
AbstractforOptimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro | Full Text | References | PDF (11.9 MB)
  • 100 Views
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Article
Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis
Nan Zhang, Yanyang Liu, Yuyi Wang, Maoyuan Zhao, Li Tu & Feng Luo
Pages: 969-983
Published online: 28 Mar 2017
AbstractforDecitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis | Full Text | References | PDF (5.3 MB)
  • 104 Views
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Article
An open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis
LS Martin-Martin, F Giovannangeli, E Bizzi, U Massafra, E Ballanti, M Cassol & A Migliore
Pages: 985-994
Published online: 29 Mar 2017
AbstractforAn open randomized active-controlled clinical trial with low-dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis | Full Text | References | PDF (947.9 KB)
  • 72 Views
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Article
RETRACTED ARTICLE: The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer
Nahla Saeed AL-Wajeeh, Maryam Hajrezaie, Nawal Al-Henhena, Sareh Kamran, Elham Bagheri, Maryam Zahedifard, Kamelia Saremi, Suzita Mohd Noor, Hapipah Mohd Ali & Mahmood Ameen Abdulla
Pages: 995-1009
Published online: 30 Mar 2017
AbstractforRETRACTED ARTICLE: The antiulcer effect of Cibotium barometz leaves in rats with experimentally induced acute gastric ulcer | PDF (2.8 MB)
  • 192 Views
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Article
Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats
Grandhi Venkata Ramalingayya, Sri Pragnya Cheruku, Pawan G Nayak, Anoop Kishore, Rekha Shenoy, Chamallamudi Mallikarjuna Rao & Nandakumar Krishnadas
Pages: 1011-1026
Published online: 29 Mar 2017
AbstractforRutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats | Full Text | References | PDF (3.7 MB)
  • 309 Views
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Article
Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients
Anis Barati, Ahmad Reza Jamshidi, Hossein Ahmadi, Zahra Aghazadeh & Abbas Mirshafiey
Pages: 1027-1033
Published online: 30 Mar 2017
AbstractforEffects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients | Full Text | References | PDF (496.3 KB)
  • 89 Views
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Article
Mirtazapine for symptom control in refractory gastroparesis
Mark Malamood, Aaron Roberts, Rahul Kataria, Henry P Parkman & Ron Schey
Pages: 1035-1041
Published online: 30 Mar 2017
AbstractforMirtazapine for symptom control in refractory gastroparesis | Full Text | References | PDF (365.8 KB)
  • 1280 Views
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Clinical Trial Report

Case Report
Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer
Gab-jin Park, Soo Hyeon Bae, Wan-Su Park, Seunghoon Han, Min-Ho Park, Seok-Ho Shin, Young G Shin & Dong-Seok Yim
Pages: 1043-1053
Published online: 30 Mar 2017
AbstractforDrug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer | Full Text | References | PDF (1.9 MB)
  • 143 Views
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Review

Review Article
Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy
David Buchbinder, Diane Nugent & Loan Hsieh
Pages: 1055-1063
Published online: 30 Mar 2017
AbstractforSpotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy | Full Text | References | PDF (269.3 KB)
  • 55 Views
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Original Research

Article
Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
Guannan Yang, Zongjiang Zhao, Xinxue Zhang, Amin Wu, Yawei Huang, Yonghui Miao & Meijuan Yang
Pages: 1065-1079
Published online: 31 Mar 2017
AbstractforEffect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice | Full Text | References | PDF (3.4 MB)
  • 114 Views
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Article
Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl
Mohamed A El Nabarawi, Mahmoud H Teaima, Rehab A Abd El-Monem, Nagla A El Nabarawy & Dalia A Gaber
Pages: 1081-1093
Published online: 03 Apr 2017
AbstractforFormulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl | Full Text | References | PDF (912.7 KB)
  • 517 Views
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Article
Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection
Cristiane França da Silva, Denise da Gama Jaén Batista, Julianna Siciliano de Araújo, Edézio Ferreira Cunha-Junior, Chad E Stephens, Moloy Banerjee, Abdelbasset A Farahat, Senol Akay, Mary K Fisher, David W Boykin & Maria de Nazaré Correia Soeiro
Pages: 1095-1105
Published online: 03 Apr 2017
AbstractforPhenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection | Full Text | References | PDF (739.4 KB)
  • 61 Views
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Clinical Trial Report

Case Report
Effects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial
Karim Nasseri, Negin Ghadami & Bijan Nouri
Pages: 1107-1113
Published online: 03 Apr 2017
AbstractforEffects of intrathecal dexmedetomidine on shivering after spinal anesthesia for cesarean section: a double-blind randomized clinical trial | Full Text | References | PDF (575.5 KB)
  • 213 Views
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Original Research

Article
Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines
Pengliang Xin, Chuntuan Li, Yan Zheng, Qunyi Peng, Huifang Xiao, Yuanling Huang & Xiongpeng Zhu
Pages: 1115-1126
Published online: 03 Apr 2017
AbstractforEfficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines | Full Text | References | PDF (4.3 MB)
  • 66 Views
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Article
Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals
Yingxiao Li, Kai Chun Cheng, Chiang-Shan Niu, Shih-Hsiang Lo, Juei-Tang Cheng & Ho-Shan Niu
Pages: 1127-1134
Published online: 05 Apr 2017
AbstractforInvestigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals | Full Text | References | PDF (1.1 MB)
  • 102 Views
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Article
Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects
Hye In Woo, Suk Ran Kim, Wooseong Huh, Jae-Wook Ko & Soo-Youn Lee
Pages: 1135-1146
Published online: 04 Apr 2017
AbstractforAssociation of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects | Full Text | References | PDF (921.4 KB)
  • 120 Views
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Article
Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib
Tong Lin & Lan Gong
Pages: 1147-1158
Published online: 05 Apr 2017
AbstractforInhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib | Full Text | References | PDF (7.4 MB)
  • 104 Views
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Corrigendum

Correction
Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum]
Page: 1159
Published online: 10 Apr 2017
CitationforRelaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway [Corrigendum] | Full Text | PDF (193.7 KB)
  • 52 Views
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Correction
Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis [Corrigendum]
Page: 1161
Published online: 10 Apr 2017
CitationforDecitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis [Corrigendum] | Full Text | PDF (143.5 KB)
  • 47 Views
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Original Research

Article
Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models
Lukas Uebbing, Lukas Klumpp, Gregory K Webster & Raimar Löbenberg
Pages: 1163-1174
Published online: 11 Apr 2017
AbstractforJustification of disintegration testing beyond current FDA criteria using in vitro and in silico models | Full Text | References | PDF (2 MB)
  • 254 Views
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Review

Review Article
Spotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy
Vyshak Alva Venur, Monika Joshi, Kenneth G Nepple & Yousef Zakharia
Pages: 1175-1182
Published online: 11 Apr 2017
AbstractforSpotlight on nivolumab in the treatment of renal cell carcinoma: design, development, and place in therapy | Full Text | References | PDF (269.4 KB)
  • 88 Views
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Original Research

Article
Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers
Milko Radicioni, Chiara Castiglioni, Andrea Giori, Irma Cupone, Valeria Frangione & Stefano Rovati
Pages: 1183-1192
Published online: 11 Apr 2017
AbstractforBioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers | Full Text | References | PDF (625.4 KB)
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Letter

Letter
Vitamin D deficiency and tuberculosis: what about body mass index?
Eduardo Hernández-Garduño
Pages: 1193-1194
Published online: 11 Apr 2017
CitationforVitamin D deficiency and tuberculosis: what about body mass index? | Full Text | References | PDF (217 KB)
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Review

Review Article
Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
Tian-Yu Lian, Xin Jiang & Zhi-Cheng Jing
Pages: 1195-1207
Published online: 13 Apr 2017
AbstractforRiociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension | Full Text | References | PDF (1.7 MB)
  • 122 Views
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Review Article
United States experience of insulin degludec alone or in combination for type 1 and type 2 diabetes
Marc Rendell
Pages: 1209-1220
Published online: 13 Apr 2017
AbstractforUnited States experience of insulin degludec alone or in combination for type 1 and type 2 diabetes | Full Text | References | PDF (381 KB)
  • 71 Views
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Review Article
Profile of romosozumab and its potential in the management of osteoporosis
Sian Yik Lim & Marcy B Bolster
Pages: 1221-1231
Published online: 13 Apr 2017
AbstractforProfile of romosozumab and its potential in the management of osteoporosis | Full Text | References | PDF (1,023.6 KB)
  • 368 Views
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Original Research

Article
A comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis
Mariya Kronlage, Ilka Printz, Britta Vogel, Erwin Blessing, Oliver J Müller, Hugo A Katus & Christian Erbel
Pages: 1233-1241
Published online: 18 Apr 2017
AbstractforA comparative study on endovascular treatment of (sub)acute critical limb ischemia: mechanical thrombectomy vs thrombolysis | Full Text | References | PDF (1.1 MB)
  • 163 Views
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Article
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction
Ai-Ling Cui, Ying-Hua Zhang, Jian-Zhong Li, Tianbin Song, Xue-Min Liu, Hui Wang, Ce Zhang, Guo-Lin Ma, Hui Zhang & Kefeng Li
Pages: 1243-1253
Published online: 18 Apr 2017
AbstractforHumanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction | Full Text | References | PDF (1.2 MB)
  • 70 Views
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Review

Review Article
Detection approaches for multidrug resistance genes of leukemia
Ying Du & Baoan Chen
Pages: 1255-1261
Published online: 18 Apr 2017
AbstractforDetection approaches for multidrug resistance genes of leukemia | Full Text | References | PDF (518.7 KB)
  • 91 Views
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Letter

Letter
Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis
Disha Thakkar & Ranjeet Prasad Dash
Pages: 1263-1265
Published online: 20 Apr 2017
First Page PreviewforPharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis | Full Text | References | PDF (203.8 KB)
  • 71 Views
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Original Research

Article
Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets
Marilita M Moschos, Giannis A Moustafa, Vasiliki D Papakonstantinou, Michael Tsatsos, Konstantinos Laios & Smaragdi Antonopoulou
Pages: 1267-1272
Published online: 19 Apr 2017
AbstractforAnti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets | Full Text | References | PDF (325.8 KB)
  • 83 Views
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Article
Cerebrolysin for functional recovery in patients with acute ischemic stroke: a meta-analysis of randomized controlled trials
Zefeng Wang, Ligen Shi, Shenbin Xu & Jianmin Zhang
Pages: 1273-1282
Published online: 19 Apr 2017
AbstractforCerebrolysin for functional recovery in patients with acute ischemic stroke: a meta-analysis of randomized controlled trials | Full Text | References | PDF (778 KB)
  • 160 Views
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Article
Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro
Ping Fang, Xiang Zheng, Jiayang He, Honglei Ge, Pengfei Tang, Jianping Cai & Guoxin Hu
Pages: 1283-1290
Published online: 21 Apr 2017
AbstractforFunctional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro | Full Text | References | PDF (749.2 KB)
  • 78 Views
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Article
Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies
Yi Yang, Kaisha C George, Wei-Feng Shang, Rui Zeng, Shu-Wang Ge & Gang Xu
Pages: 1291-1299
Published online: 24 Apr 2017
AbstractforProton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies | Full Text | References | PDF (697 KB)
  • 240 Views
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Clinical Trial Report

Case Report
A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers
Jieon Lee, Bo-Hyung Kim, Kyung-Sang Yu, Hee Sun Kim, Ji Duck Kim, Joo-Youn Cho, SeungHwan Lee & Namyi Gu
Pages: 1301-1313
Published online: 24 Apr 2017
AbstractforA first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers | Full Text | References | PDF (1.2 MB)
  • 79 Views
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Original Research

Article
Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors
Tatiana A Slastnikova, Andrey A Rosenkranz, Yuri V Khramtsov, Tatiana S Karyagina, Sergey A Ovechko & Alexander S Sobolev
Pages: 1315-1334
Published online: 26 Apr 2017
AbstractforDevelopment and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors | Full Text | References | PDF (5.3 MB)
  • 79 Views
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Article
Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent
Linda Rickardson, Emma Kutvonen, Satu Orasniemi, Marita Högberg, Marko J Kallio & Stefan Rehnmark
Pages: 1335-1351
Published online: 28 Apr 2017
AbstractforEvaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent | Full Text | References | PDF (8.6 MB)
  • 127 Views
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Article
Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats
Hanita Omar, Noraziah Nordin, Pouya Hassandarvish, Maryam Hajrezaie, Ainnul Hamidah Syahadah Azizan, Mehran Fadaeinasab, Nazia Abdul Majid, Mahmood Ameen Abdulla, Najihah Mohd Hashim & Hapipah Mohd Ali
Pages: 1353-1365
Published online: 04 May 2017
AbstractforMethanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats | Full Text | References | PDF (2.8 MB)
  • 146 Views
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Erratum

Correction
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum]
Page: 1367
Published online: 28 Apr 2017
CitationforCombined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome [Erratum] | Full Text | PDF (139.9 KB)
  • 54 Views
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Original Research

Article
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
Yuren Wang, Jason Wallach, Stephanie Duane, Yuan Wang, Jianghong Wu, Jeffrey Wang, Adeboye Adejare & Haiching Ma
Pages: 1369-1382
Published online: 02 May 2017
AbstractforDeveloping selective histone deacetylases (HDACs) inhibitors through ebselen and analogs | Full Text | References | PDF (1.4 MB)
  • 105 Views
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Article
Atorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study
Naglaa El-Nabarawi, Mohamed El-Wakd & Mostafa Salem
Pages: 1383-1391
Published online: 02 May 2017
AbstractforAtorvastatin, a double weapon in osteoporosis treatment: an experimental and clinical study | Full Text | References | PDF (2.5 MB)
  • 143 Views
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Article
Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth
Mehmet Sinan Dogan, Mehmet Cihan Yavas, Yasemin Yavuz, Sait Erdogan, İsmail Yener, İbrahim Simsek, Zeki Akkus, Veysel Eratilla, Abdulsamet Tanik & Mehmet Zulkuf Akdag
Pages: 1393-1398
Published online: 04 May 2017
AbstractforEffect of electromagnetic fields and antioxidants on the trace element content of rat teeth | Full Text | References | PDF (272.9 KB)
  • 101 Views
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Retraction

Retraction
Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]
Page: 1399
Published online: 12 May 2017
CitationforInvolvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction] | Full Text | PDF (157.7 KB)
  • 53 Views
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Original Research

Article
Propranolol therapy for infantile hemangioma: our experience
Ling Zhang, Hai-Wei Wu, Weien Yuan & Jia-Wei Zheng
Pages: 1401-1408
Published online: 08 May 2017
AbstractforPropranolol therapy for infantile hemangioma: our experience | Full Text | References | PDF (1.7 MB)
  • 100 Views
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Article
Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers
Tae-Eun Kim, Na Ha, Yunjeong Kim, Hyunsook Kim, Jae Wook Lee, Ji-Young Jeon & Min-Gul Kim
Pages: 1409-1416
Published online: 09 May 2017
AbstractforEffect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers | Full Text | References | PDF (666.7 KB)
  • 95 Views
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Article
Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles
Xiaojing Xia, Haowei Liu, Huixia Lv, Jing Zhang, Jianping Zhou & Zhiying Zhao
Pages: 1417-1427
Published online: 09 May 2017
AbstractforPreparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles | Full Text | References | PDF (5.4 MB)
  • 179 Views
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Review

Review Article
New developments in managing opioid addiction: impact of a subdermal buprenorphine implant
MariaLisa Itzoe & Michael Guarnieri
Pages: 1429-1437
Published online: 10 May 2017
AbstractforNew developments in managing opioid addiction: impact of a subdermal buprenorphine implant | Full Text | References | PDF (361.9 KB)
  • 412 Views
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Original Research

Article
Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
Xuemeng Xie, Jinfu Tu, Heyi You & Bingren Hu
Pages: 1439-1451
Published online: 03 Oct 2022
AbstractforDesign, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer | Full Text | References | PDF (1.9 MB)
  • 113 Views
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Article
Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability
Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Shahzeb Khan, Hani S Faidah, Naseemullah, Muhammad Khurram, Muhammad Usman Amin & Abdul Haseeb
Pages: 1453-1464
Published online: 15 May 2017
AbstractforFabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability | Full Text | References | PDF (1.6 MB)
  • 294 Views
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Article
Higher dose of palonosetron versus lower dose of palonosetron plus droperidol to prevent postoperative nausea and vomiting after eye enucleation and orbital hydroxyapatite implant surgery: a randomized, double-blind trial
Xiao Hu, Fang Tan & Lan Gong
Pages: 1465-1472
Published online: 15 May 2017
AbstractforHigher dose of palonosetron versus lower dose of palonosetron plus droperidol to prevent postoperative nausea and vomiting after eye enucleation and orbital hydroxyapatite implant surgery: a randomized, double-blind trial | Full Text | References | PDF (357.4 KB)
  • 74 Views
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Review

Review Article
Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy
Angelo Massimiliano D’Erme, Marco Romanelli & Andrea Chiricozzi
Pages: 1473-1480
Published online: 15 May 2017
AbstractforSpotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy | Full Text | References | PDF (341.9 KB)
  • 111 Views
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Original Research

Article
Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes
Giuseppe Derosa, Angela D’Angelo, Davide Romano & Pamela Maffioli
Pages: 1481-1488
Published online: 16 May 2017
AbstractforEffects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes | Full Text | References | PDF (689.5 KB)
  • 302 Views
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Review

Review Article
Ten years’ clinical experience with biosimilar human growth hormone: a review of efficacy data
Juan Pedro López-Siguero, Roland Pfäffle, Philippe Chanson, Mieczyslaw Szalecki, Nadja Höbel & Markus Zabransky
Pages: 1489-1495
Published online: 16 May 2017
AbstractforTen years’ clinical experience with biosimilar human growth hormone: a review of efficacy data | Full Text | References | PDF (616.3 KB)
  • 101 Views
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Review Article
Ten years of clinical experience with biosimilar human growth hormone: a review of safety data
Maria Victoria Borrás Pérez, Berit Kriström, Tomasz Romer, Mieczyslaw Walczak, Nadja Höbel & Markus Zabransky
Pages: 1497-1503
Published online: 16 May 2017
AbstractforTen years of clinical experience with biosimilar human growth hormone: a review of safety data | Full Text | References | PDF (358.3 KB)
  • 82 Views
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Review Article
Ten years of biosimilar recombinant human growth hormone in Europe
Paul Saenger
Pages: 1505-1507
Published online: 16 May 2017
AbstractforTen years of biosimilar recombinant human growth hormone in Europe | Full Text | References | PDF (249 KB)
  • 93 Views
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Review Article
Ten years of biosimilars in Europe: development and evolution of the regulatory pathways
Martin Schiestl, Markus Zabransky & Fritz Sörgel
Pages: 1509-1515
Published online: 16 May 2017
AbstractforTen years of biosimilars in Europe: development and evolution of the regulatory pathways | Full Text | References | PDF (422.8 KB)
  • 454 Views
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Original Research

Article
Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells
Ji-Fan Lin, Yi-Chia Lin, Te-Fu Tsai, Hung-En Chen, Kuang-Yu Chou & Thomas I-Sheng Hwang
Pages: 1517-1533
Published online: 16 May 2017
AbstractforCisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells | Full Text | References | PDF (16.6 MB)
  • 137 Views
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Article
An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2
Tomer Meirson, Abraham O Samson & Hava Gil-Henn
Pages: 1535-1557
Published online: 18 May 2017
AbstractforAn in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2 | Full Text | References | PDF (6.4 MB)
  • 77 Views
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Article
Outcome of stroke patients receiving different doses of recombinant tissue plasminogen activator
Cheung-Ter Ong, Yi-Sin Wong, Chi-Shun Wu & Yu-Hsiang Su
Pages: 1559-1566
Published online: 18 May 2017
AbstractforOutcome of stroke patients receiving different doses of recombinant tissue plasminogen activator | Full Text | References | PDF (666.8 KB)
  • 82 Views
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Review

Review Article
Past and current perspective on new therapeutic targets for Type-II diabetes
Pradip D Patil, Umesh B Mahajan, Kalpesh R Patil, Sandip Chaudhari, Chandragouda R Patil, Yogeeta O Agrawal, Shreesh Ojha & Sameer N Goyal
Pages: 1567-1583
Published online: 22 May 2017
AbstractforPast and current perspective on new therapeutic targets for Type-II diabetes | Full Text | References | PDF (794.5 KB)
  • 208 Views
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Original Research

Article
Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study
Sergio D’Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli & Giuseppe Derosa
Pages: 1585-1592
Published online: 23 May 2017
AbstractforEffect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study | Full Text | References | PDF (389.7 KB)
  • 260 Views
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Review

Review Article
Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
Maria Gabriella Raimondo, Martina Biggioggero, Chiara Crotti, Andrea Becciolini & Ennio Giulio Favalli
Pages: 1593-1603
Published online: 24 May 2017
AbstractforProfile of sarilumab and its potential in the treatment of rheumatoid arthritis | Full Text | References | PDF (497.4 KB)
  • 424 Views
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Original Research

Article
Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach
Lucia Ruxandra Tefas, Bianca Sylvester, Ioan Tomuta, Alina Sesarman, Emilia Licarete, Manuela Banciu & Alina Porfire
Pages: 1605-1621
Published online: 25 May 2017
AbstractforDevelopment of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach | Full Text | References | PDF (1.9 MB)
  • 391 Views
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Article
p-TSA-promoted syntheses of 5H-benzo[h] thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma
Amit K Keshari, Ashok K Singh, Vinit Raj, Amit Rai, Prakruti Trivedi, Balaram Ghosh, Umesh Kumar, Atul Rawat, Dinesh Kumar & Sudipta Saha
Pages: 1623-1642
Published online: 03 Oct 2022
Abstractforp-TSA-promoted syntheses of 5H-benzo[h] thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma | Full Text | References | PDF (2.2 MB)
  • 206 Views
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Review

Review Article
Spotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy
Alessandro Giunta, Alessandra Ventura, Maria Sole Chimenti, Luca Bianchi & Maria Esposito
Pages: 1643-1651
Published online: 02 Jun 2017
AbstractforSpotlight on ixekizumab for the treatment of moderate-to-severe plaque psoriasis: design, development, and use in therapy | Full Text | References | PDF (640.3 KB)
  • 66 Views
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Review Article
CT-P13: design, development, and place in therapy
Tommaso Gabbani, Simona Deiana & Vito Annese
Pages: 1653-1661
Published online: 06 Jun 2017
AbstractforCT-P13: design, development, and place in therapy | Full Text | References | PDF (335.7 KB)
  • 78 Views
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Original Research

Article
Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
Hui Ge, Hao Tang, Yanbing Liang, Jingguo Wu, Qing Yang, Lijin Zeng & Zhongfu Ma
Pages: 1663-1671
Published online: 06 Jun 2017
AbstractforRhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro | Full Text | References | PDF (915.6 KB)
  • 151 Views
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Article
Renal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy
Matthias Helmschrott, Rasmus Rivinius, Thomas Bruckner, Hugo A Katus & Andreas O Doesch
Pages: 1673-1680
Published online: 07 Jun 2017
AbstractforRenal function in heart transplant patients after switch to combined mammalian target of rapamycin inhibitor and calcineurin inhibitor therapy | Full Text | References | PDF (488.2 KB)
  • 54 Views
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Article
Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins
Fatma M Mady & Usama Farghaly Aly
Pages: 1681-1692
Published online: 07 Jun 2017
AbstractforExperimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins | Full Text | References | PDF (2.4 MB)
  • 240 Views
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Article
Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents
Masakazu Fukushima, Kenzo Iizuka, Cheng Jin, Chun Zhang, Mei Hong & Kiyoshi Eshima
Pages: 1693-1705
Published online: 07 Jun 2017
AbstractforDevelopment of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents | Full Text | References | PDF (1.7 MB)
  • 92 Views
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Article
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
Jong-Suep Baek, Eng Wan Yeo, Yin Hao Lee, Nguan Soon Tan & Say Chye Joachim Loo
Pages: 1707-1717
Published online: 08 Jun 2017
AbstractforControlled-release nanoencapsulating microcapsules to combat inflammatory diseases | Full Text | References | PDF (2.5 MB)
  • 135 Views
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Article
Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials
Ronald L Van Heertum, Robert Scarimbolo, John G Wolodzko, Barbara Klencke, Richard Messmann, Feza Tunc, Levi Sokol, Rajan Agarwal, James A Strafaci & Michael O’Neal
Pages: 1719-1728
Published online: 03 Oct 2022
AbstractforLugano 2014 criteria for assessing FDG-PET/CT in lymphoma: an operational approach for clinical trials | Full Text | References | PDF (1.3 MB)
  • 354 Views
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Article
Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study
Felix Greimel, Christine Scheuerer, Andre Gessner, Michaela Simon, Thomas Kalteis, Joachim Grifka, Achim Benditz, Hans-Robert Springorum & Jens Schaumburger
Pages: 1729-1736
Published online: 14 Jun 2017
AbstractforEfficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study | Full Text | References | PDF (535.3 KB)
  • 255 Views
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Article
Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic
Shun Feng, Lijun Zhu, Zhisheng Huang, Haojia Wang, Hong Li, Hua Zhou, Linlin Lu, Ying Wang, Zhongqiu Liu & Liang Liu
Pages: 1737-1752
Published online: 15 Jun 2017
AbstractforControlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic | Full Text | References | PDF (9.1 MB)
  • 107 Views
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Article
Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells
Fayong Ke, Zheng Wang, Xiaoling Song, Qiang Ma, Yunping Hu, Lin Jiang, Yijian Zhang, Yingbin Liu, Yong Zhang & Wei Gong
Pages: 1753-1766
Published online: 15 Jun 2017
AbstractforCryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells | Full Text | References | PDF (5.1 MB)
  • 83 Views
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Review

Review Article
Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes
Fernando Notario-Pérez, Roberto Ruiz-Caro & María-Dolores Veiga-Ochoa
Pages: 1767-1787
Published online: 15 Jun 2017
AbstractforHistorical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes | Full Text | References | PDF (3.4 MB)
  • 123 Views
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Original Research

Article
Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
Ling Gao, Li Wang, Zhen Sun, Haiyan Li, Qiaoping Wang, Cheng Yi & Xiujie Wang
Pages: 1789-1802
Published online: 16 Jun 2017
AbstractforMorusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition | Full Text | References | PDF (6.1 MB)
  • 121 Views
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Article
Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance
Yitav Glantz-Gashai, Tomer Meirson, Eli Reuveni & Abraham O Samson
Pages: 1803-1813
Published online: 19 Jun 2017
AbstractforVirtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance | Full Text | References | PDF (2.7 MB)
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Article
Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics
Ahmed M Fatouh, Ahmed H Elshafeey & Ahmed Abdelbary
Pages: 1815-1825
Published online: 19 Jun 2017
AbstractforIntranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics | Full Text | References | PDF (1.9 MB)
  • 388 Views
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Article
Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Hugo A Katus & Andreas O Doesch
Pages: 1827-1837
Published online: 19 Jun 2017
AbstractforComparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation | Full Text | References | PDF (564.3 KB)
  • 48 Views
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Open Access
Article
Enzymatic synthesis and in vitro evaluation of folate-functionalized liposomes
Bohong Guo, Danqiao Xu, Xiaohong Liu & Jun Yi
Pages: 1839-1847
Published online: 20 Jun 2017
AbstractforEnzymatic synthesis and in vitro evaluation of folate-functionalized liposomes | Full Text | References | PDF (1.7 MB)
  • 69 Views
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Article
Differential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts
Tomasz Guszczyn, Arkadiusz Surażyński, Ilona Zaręba, Edyta Rysiak, Janusz Popko & Jerzy Pałka
Pages: 1849-1857
Published online: 22 Jun 2017
AbstractforDifferential effect of platelet-rich plasma fractions on β1-integrin signaling, collagen biosynthesis, and prolidase activity in human skin fibroblasts | Full Text | References | PDF (1.9 MB)
  • 85 Views
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Article
Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer
Dharmendra K Yadav, Surendra Kumar, Saloni, Harpreet Singh, Mi-hyun Kim, Praveen Sharma, Sanjeev Misra & Feroz Khan
Pages: 1859-1870
Published online: 22 Jun 2017
AbstractforMolecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer | Full Text | References | PDF (1,023.4 KB)
  • 705 Views
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Clinical Trial Report

Case Report
Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial
Hiroshi Toshida, Toshinari Funaki, Koichi Ono, Nobuhito Tabuchi, Sota Watanabe, Tamotsu Seki, Hiroshi Otake, Takuji Kato, Nobuyuki Ebihara & Akira Murakami
Pages: 1871-1879
Published online: 23 Jun 2017
AbstractforEfficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial | Full Text | References | PDF (515.5 KB)
  • 138 Views
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Review

Review Article
Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice
Yili Zhang, Junjie Jiang, Hao Shen, Yan Chai, Xu Wei & Yanming Xie
Pages: 1881-1890
Published online: 23 Jun 2017
AbstractforTotal flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: implication in clinical practice | Full Text | References | PDF (1.7 MB)
  • 125 Views
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Original Research

Article
Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway
Jingrun Chen, Junjie Liu, Dongxiao Cui, Chaoqun Yan, Liqiang Meng, Liqian Sun, Shurong Ban, Rui Ge, Taigang Liang & Qingshan Li
Pages: 1891-1904
Published online: 23 Jun 2017
AbstractforSynthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway | Full Text | References | PDF (2.7 MB)
  • 61 Views
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Article
Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway
Kai-Hong Zhao, Can Zhang, Yue Bai, Yan Li, Xun Kang, Jian-Xin Chen, Kun Yao, Tao Jiang, Xiao-Song Zhong & Wen-Bin Li
Pages: 1905-1915
Published online: 26 Jun 2017
AbstractforAntiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway | Full Text | References | PDF (3.2 MB)
  • 94 Views
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Article
Effect of picroside II on hind limb ischemia reperfusion injury in rats
Yiğit Kılıç, Abdullah Özer, Tolga Tatar, Mustafa Hakan Zor, Mehmet Kirişçi, Hakan Kartal, Ali Doğan Dursun, Deniz Billur, Mustafa Arslan & Ayşegül Küçük
Pages: 1917-1925
Published online: 26 Jun 2017
AbstractforEffect of picroside II on hind limb ischemia reperfusion injury in rats | Full Text | References | PDF (5.2 MB)
  • 109 Views
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Article
Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats
Ya Feng, Wuchao Liu, Lizhen Pan, Cong Jiang, Chengxi Zhang, Yuxuan Lu, Zhiyu Nie & Lingjing Jin
Pages: 1927-1939
Published online: 28 Jun 2017
AbstractforComparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats | Full Text | References | PDF (4.8 MB)
  • 68 Views
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Article
A novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine
Chuanyu Chen & Peijun You
Pages: 1941-1949
Published online: 28 Jun 2017
AbstractforA novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine | Full Text | References | PDF (1.8 MB)
  • 71 Views
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Article
Determining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation
Wei Yu, Jinru Ji, Tingting Xiao, Chaoqun Ying, Jiaheng Fang, Ping Shen & Yonghong Xiao
Pages: 1951-1956
Published online: 28 Jun 2017
AbstractforDetermining optimal dosing regimen of oral administration of dicloxacillin using Monte Carlo simulation | Full Text | References | PDF (475.4 KB)
  • 137 Views
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Review

Review Article
Cell and small animal models for phenotypic drug discovery
Mihaly Szabo, Sara Svensson Akusjärvi, Ankur Saxena, Jianping Liu, Gayathri Chandrasekar & Satish S Kitambi
Pages: 1957-1967
Published online: 03 Oct 2022
AbstractforCell and small animal models for phenotypic drug discovery | Full Text | References | PDF (5.6 MB)
  • 185 Views
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Review Article
A review of the literature analyzing benefits and concerns of infliximab biosimilar CT-P13 for the treatment of rheumatologic diseases: focus on interchangeability
Andrea Becciolini, Maria Gabriella Raimondo, Chiara Crotti, Elena Agape, Martina Biggioggero & Ennio Giulio Favalli
Pages: 1969-1978
Published online: 28 Jun 2017
AbstractforA review of the literature analyzing benefits and concerns of infliximab biosimilar CT-P13 for the treatment of rheumatologic diseases: focus on interchangeability | Full Text | References | PDF (427.2 KB)
  • 55 Views
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Review Article
Targeted therapy in severe asthma today: focus on immunoglobulin E
Girolamo Pelaia, Giorgio Walter Canonica, Andrea Matucci, Rossella Paolini, Massimo Triggiani & Pierluigi Paggiaro
Pages: 1979-1987
Published online: 29 Jun 2017
AbstractforTargeted therapy in severe asthma today: focus on immunoglobulin E | Full Text | References | PDF (778.4 KB)
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Original Research

Article
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice
Jiao Feng, Qinghui Zhang, Wenhui Mo, Liwei Wu, Sainan Li, Jingjing Li, Tong Liu, Shizan Xu, Xiaoming Fan & Chuanyong Guo
Pages: 1989-2006
Published online: 03 Jul 2017
AbstractforSalidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice | Full Text | References | PDF (12.9 MB)
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Review

Review Article
Inhibitors of the PD-1/PD-L1 axis for the treatment of head and neck cancer: current status and future perspectives
Xiongwen Ran & Kai Yang
Pages: 2007-2014
Published online: 03 Oct 2022
AbstractforInhibitors of the PD-1/PD-L1 axis for the treatment of head and neck cancer: current status and future perspectives | Full Text | References | PDF (1.2 MB)
  • 136 Views
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Original Research

Article
Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3′,4′-dihydro-1′H-spiro[isoindoline-2,2′-isoquinoline] skeleton
Krzysztof Bielawski, Katarzyna Leszczyńska, Zbigniew Kałuża, Anna Bielawska, Olga Michalak, Tamara Daniluk, Olga Staszewska-Krajewska, Anna Czajkowska, Natalia Pawłowska & Agnieszka Gornowicz
Pages: 2015-2028
Published online: 05 Jul 2017
AbstractforSynthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3′,4′-dihydro-1′H-spiro[isoindoline-2,2′-isoquinoline] skeleton | Full Text | References | PDF (1.6 MB)
  • 97 Views
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Open Access
Article
Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies
Qamar Abbas, Zaman Ashraf, Mubashir Hassan, Humaira Nadeem, Muhammad Latif, Samina Afzal & Sung-Yum Seo
Pages: 2029-2046
Published online: 03 Oct 2022
AbstractforDevelopment of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies | Full Text | References | PDF (2.9 MB)
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Review

Review Article
Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy
Mariacarmela Santarpia, Maria Grazia Daffinà, Alessandro D’Aveni, Grazia Marabello, Alessia Liguori, Elisa Giovannetti, Niki Karachaliou, Maria Gonzalez Cao, Rafael Rosell & Giuseppe Altavilla
Pages: 2047-2063
Published online: 03 Oct 2022
AbstractforSpotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy | Full Text | References | PDF (490.6 KB)
  • 128 Views
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Review Article
Spotlight on brodalumab in the treatment of moderate-to-severe plaque psoriasis: design, development, and potential place in therapy
Michael Roman & Melvin W Chiu
Pages: 2065-2075
Published online: 07 Jul 2017
AbstractforSpotlight on brodalumab in the treatment of moderate-to-severe plaque psoriasis: design, development, and potential place in therapy | Full Text | References | PDF (597.7 KB)
  • 89 Views
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Original Research

Article
Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects
Zancong Shen, Michael Gillen, Jeffrey N Miner, Gail Bucci, David M Wilson & Jesse W Hall
Pages: 2077-2086
Published online: 07 Jul 2017
AbstractforPharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects | Full Text | References | PDF (1.7 MB)
  • 88 Views
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Article
Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids
Rachel Taylor, Bruce Sunderland, Giuseppe Luna & Petra Czarniak
Pages: 2087-2097
Published online: 10 Jul 2017
AbstractforEvaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids | Full Text | References | PDF (969.7 KB)
  • 291 Views
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Article
A 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis
Seunghoon Han, Gun Hyung Na & Dong-Goo Kim
Pages: 2099-2107
Published online: 11 Jul 2017
AbstractforA 6-month mixed-effect pharmacokinetic model for post-transplant intravenous anti-hepatitis B immunoglobulin prophylaxis | Full Text | References | PDF (592.7 KB)
  • 55 Views
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Open Access
Article
Bioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: a randomized, open-label, three-way, reference-replicated crossover study
Yifan Zhang, Xiaoyan Chen, Yunbiao Tang, Youming Lu, Lixia Guo & Dafang Zhong
Pages: 2109-2119
Published online: 11 Jul 2017
AbstractforBioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: a randomized, open-label, three-way, reference-replicated crossover study | Full Text | References | PDF (633.3 KB)
  • 226 Views
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Review

Review Article
Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up
Dave L Dixon, Leo F Buckley, Cory R Trankle, Dinesh Kadariya & Antonio Abbate
Pages: 2121-2129
Published online: 11 Jul 2017
AbstractforClinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up | Full Text | References | PDF (762.5 KB)
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Original Research

Article
Efficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort
Sebastian Bernuth, Daniel Grimm, Johanna Vollmar, Felix Darstein, Jens Mittler, Michael Heise, Maria Hoppe-Lotichius, Peter R Galle, Hauke Lang & Tim Zimmermann
Pages: 2131-2138
Published online: 12 Jul 2017
AbstractforEfficacy and safety of direct-acting antiviral therapy in previous hard-to-treat patients with recurrent hepatitis C virus infection after liver transplantation: a real-world cohort | Full Text | References | PDF (697.9 KB)
  • 62 Views
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Article
Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro
Yuh-Hwa Liu, Yeh-Lin Lu, Der-Zen Liu & Wen-Chi Hou
Pages: 2139-2147
Published online: 13 Jul 2017
AbstractforAntiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro | Full Text | References | PDF (950.9 KB)
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Review

Review Article
Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature
David G Parr & Beatriz Lara
Pages: 2149-2162
Published online: 14 Jul 2017
AbstractforClinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature | Full Text | References | PDF (621.2 KB)
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Original Research

Article
Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials
Yu Zhu, Yuting Yang, Chengmao Zhou & Zeqing Bao
Pages: 2163-2170
Published online: 18 Jul 2017
AbstractforUsing dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials | Full Text | References | PDF (745.6 KB)
  • 68 Views
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Review

Review Article
The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus
Débora Moitinho Abram, Luis Gustavo Romani Fernandes, Antônio Celso Saragossa Ramos Filho & Patrícia Ucelli Simioni
Pages: 2171-2178
Published online: 24 Jul 2017
AbstractforThe modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus | Full Text | References | PDF (455.2 KB)
  • 75 Views
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Original Research

Article
Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
Qingshan Chen, Hai Zhang, Yan Cao, Ying Li, Sen Sun, Junping Zhang & Guoqing Zhang
Pages: 2179-2191
Published online: 26 Jul 2017
AbstractforSchisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways | Full Text | References | PDF (2.5 MB)
  • 144 Views
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Review

Review Article
Comparison of efficacy and safety of oral agents for the treatment of relapsing–remitting multiple sclerosis
Cristina Guarnera, Placido Bramanti & Emanuela Mazzon
Pages: 2193-2207
Published online: 28 Jul 2017
AbstractforComparison of efficacy and safety of oral agents for the treatment of relapsing–remitting multiple sclerosis | Full Text | References | PDF (364.7 KB)
  • 94 Views
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Review Article
Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection
Maria Teresa Mascellino, Barbara Porowska, Massimiliano De Angelis & Alessandra Oliva
Pages: 2209-2220
Published online: 28 Jul 2017
AbstractforAntibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection | Full Text | References | PDF (600.8 KB)
  • 205 Views
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Original Research

Article
Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction
Kourosh Hasanzadeh Ghahramanloo, Behnam Kamalidehghan, Hamid Akbari Javar, Riyanto Teguh Widodo, Keivan Majidzadeh & Mohamed Ibrahim Noordin
Pages: 2221-2226
Published online: 28 Jul 2017
AbstractforComparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction | Full Text | References | PDF (534.3 KB)
  • 508 Views
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Article
Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index
Jie Bai, Rui-Hui Wang, Yan Qiao, Aidong Wang & Chen-Jie Fang
Pages: 2227-2237
Published online: 31 Jul 2017
AbstractforSchiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index | Full Text | References | PDF (3.5 MB)
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Open Access
Article
Combinatorial and sequential delivery of gemcitabine and oseltamivir phosphate from implantable poly(d,l-lactic-co-glycolic acid) cylinders disables human pancreatic cancer cell survival
Stephanie Allison Logan, Amanda J Brissenden, Myron R Szewczuk & Ronald J Neufeld
Pages: 2239-2250
Published online: 31 Jul 2017
AbstractforCombinatorial and sequential delivery of gemcitabine and oseltamivir phosphate from implantable poly(d,l-lactic-co-glycolic acid) cylinders disables human pancreatic cancer cell survival | Full Text | References | PDF (1.7 MB)
  • 65 Views
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Article
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds
Jorge E Toblli, Gabriel Cao, Jorge F Giani, Fernando P Dominici & Margarita Angerosa
Pages: 2251-2263
Published online: 01 Aug 2017
AbstractforMarkers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds | Full Text | References | PDF (4.4 MB)
  • 118 Views
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Review

Review Article
Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates
Muhammad Kalim, Jie Chen, Shenghao Wang, Caiyao Lin, Saif Ullah, Keying Liang, Qian Ding, Shuqing Chen & Jinbiao Zhan
Pages: 2265-2276
Published online: 02 Aug 2017
AbstractforIntracellular trafficking of new anticancer therapeutics: antibody–drug conjugates | Full Text | References | PDF (3.9 MB)
  • 402 Views
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Original Research

Article
Efficacy and tolerability of two different formulations of atorvastatin in Korean patients with hypercholesterolemia: a multicenter, prospective, randomized clinical trial
Ju-Hee Lee, Sang-Hyun Kim, Dong-Ju Choi, Seung-Jea Tahk, Jung-Han Yoon, Si Wan Choi, Taek-Jong Hong & Hyo-Soo Kim
Pages: 2277-2285
Published online: 02 Aug 2017
AbstractforEfficacy and tolerability of two different formulations of atorvastatin in Korean patients with hypercholesterolemia: a multicenter, prospective, randomized clinical trial | Full Text | References | PDF (617.2 KB)
  • 82 Views
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Article
Safety of switching from brand-name to generic levetiracetam in patients with epilepsy
Magdalena Bosak, Agnieszka Słowik & Wojciech Turaj
Pages: 2287-2291
Published online: 03 Aug 2017
AbstractforSafety of switching from brand-name to generic levetiracetam in patients with epilepsy | Full Text | References | PDF (222.4 KB)
  • 142 Views
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Clinical Trial Report

Case Report
Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients
Luigina Guasti, Giovanni Gaudio, Alessandro Lupi, Marinella D’Avino, Carla Sala, Amedeo Mugellini, Vito Vulpis, Salvatore Felis, Riccardo Sarzani, Massimo Vanasia, Pamela Maffioli & Giuseppe Derosa
Pages: 2293-2300
Published online: 04 Aug 2017
AbstractforAmbulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients | Full Text | References | PDF (437.9 KB)
  • 55 Views
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Original Research

Article
Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade
Marawan Ahmed, Horia Jalily Hasani, Aravindhan Ganesan, Michael Houghton & Khaled Barakat
Pages: 2301-2324
Published online: 04 Aug 2017
AbstractforModeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade | Full Text | References | PDF (6.2 MB)
  • 198 Views
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Review

Review Article
Anamorelin hydrochloride in the treatment of cancer anorexia–cachexia syndrome: design, development, and potential place in therapy
Solomon A Graf & Jose M Garcia
Pages: 2325-2331
Published online: 03 Oct 2022
AbstractforAnamorelin hydrochloride in the treatment of cancer anorexia–cachexia syndrome: design, development, and potential place in therapy | Full Text | References | PDF (222.8 KB)
  • 118 Views
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Original Research

Article
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
Hatem A Abdel-Aziz, Wagdy M Eldehna, Adam B Keeton, Gary A Piazza, Adnan A Kadi, Mohamed W Attwa, Ali S Abdelhameed & Mohamed I Attia
Pages: 2333-2346
Published online: 09 Aug 2017
AbstractforIsatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling | Full Text | References | PDF (929.3 KB)
  • 129 Views
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Article
Microbial challenge test of a novel epoprostenol sodium formulation
Dirk Bandilla, Marcel Goverde, Paolo Giudici & Olivier Lambert
Pages: 2347-2357
Published online: 10 Aug 2017
AbstractforMicrobial challenge test of a novel epoprostenol sodium formulation | Full Text | References | PDF (721.4 KB)
  • 60 Views
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Review

Review Article
Widening use of dexamethasone implant for the treatment of macular edema
Vincenza Bonfiglio, Michele Reibaldi, Matteo Fallico, Andrea Russo, Alessandra Pizzo, Stefano Fichera, Carlo Rapisarda, Iacopo Macchi, Teresio Avitabile & Antonio Longo
Pages: 2359-2372
Published online: 16 Aug 2017
AbstractforWidening use of dexamethasone implant for the treatment of macular edema | Full Text | References | PDF (377.2 KB)
  • 100 Views
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Case Report

Case Report
Onychomadesis associated with chemotherapy: case report and mini literature review
Ang Li, Yanqiong Li, Lingzhi Ge, Ping Li & Wenfei Li
Pages: 2373-2376
Published online: 14 Aug 2017
AbstractforOnychomadesis associated with chemotherapy: case report and mini literature review | Full Text | References | PDF (909.8 KB)
  • 63 Views
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Original Research

Article
α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion
Hsien-Hao Huang, Liang-Yu Chen, Ming-Luen Doong, Shi-Chuan Chang & Chih-Yen Chen
Pages: 2377-2386
Published online: 16 Aug 2017
Abstractforα-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion | Full Text | References | PDF (1,023.3 KB)
  • 55 Views
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Article
Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis
Jun-Jie Guo, Feng-Qiang Xu, Yong-Hong Li, Jian Li, Xin Liu, Xiao-Fan Wang, Long-Gang Hu & Yi An
Pages: 2387-2397
Published online: 18 Aug 2017
AbstractforAlginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis | Full Text | References | PDF (2.6 MB)
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Review

Review Article
Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy
Rafael Ríos-Tamayo, Agustín Martín-García, Carolina Alarcón-Payer, Dolores Sánchez-Rodríguez, Ana María del Valle Díaz de la Guardia, Carlos Gustavo García Collado, Alberto Jiménez Morales, Manuel Jurado Chacón & José Cabeza Barrera
Pages: 2399-2408
Published online: 22 Aug 2017
AbstractforPomalidomide in the treatment of multiple myeloma: design, development and place in therapy | Full Text | References | PDF (571.2 KB)
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Article
A comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients
Krzysztof Nosek, Wojciech Leppert, Hanna Nosek, Jerzy Wordliczek & Dariusz Onichimowski
Pages: 2409-2419
Published online: 22 Aug 2017
AbstractforA comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients | Full Text | References | PDF (512.3 KB)
  • 159 Views
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Review

Review Article
Metformin: a review of its potential indications
Yi-Wei Wang, Si-Jia He, Xiao Feng, Jin Cheng, Yun-Tao Luo, Ling Tian & Qian Huang
Pages: 2421-2429
Published online: 22 Aug 2017
AbstractforMetformin: a review of its potential indications | Full Text | References | PDF (871.1 KB)
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Article
Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
Muhammad Saif Ur Rahman, Ling Zhang, Lingyan Wu, Yuqiong Xie, Chunchun Li & Jiang Cao
Pages: 2431-2441
Published online: 22 Aug 2017
AbstractforSensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death | Full Text | References | PDF (7.6 MB)
  • 74 Views
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Article
Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies
Haroon Rahim, Abdul Sadiq, Shahzeb Khan, Mir Azam Khan, Syed Muhammad Hassan Shah, Zahid Hussain, Riaz Ullah, Abdelaaty Abdelaziz Shahat & Khalid Ibrahim
Pages: 2443-2452
Published online: 03 Oct 2022
AbstractforAceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies | Full Text | References | PDF (1.8 MB)
  • 386 Views
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Article
Preliminary study of nanonized lamotrigine containing products for nasal powder formulation
Péter Gieszinger, Ildikó Csóka, Edina Pallagi, Gábor Katona, Orsolya Jójárt-Laczkovich, Piroska Szabó-Révész & Rita Ambrus
Pages: 2453-2466
Published online: 23 Aug 2017
AbstractforPreliminary study of nanonized lamotrigine containing products for nasal powder formulation | Full Text | References | PDF (2.4 MB)
  • 136 Views
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Review

Review Article
Development of idursulfase therapy for mucopolysaccharidosis type II (Hunter syndrome): the past, the present and the future
David AH Whiteman & Alan Kimura
Pages: 2467-2480
Published online: 23 Aug 2017
AbstractforDevelopment of idursulfase therapy for mucopolysaccharidosis type II (Hunter syndrome): the past, the present and the future | Full Text | References | PDF (1.7 MB)
  • 255 Views
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Original Research

Article
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression
Yuejun Li, Lili Gong, Ruili Qi, Qian Sun, Xinxin Xia, Haihui He, Jianshu Ren, Ouning Zhu & Debin Zhuo
Pages: 2481-2491
Published online: 23 Aug 2017
AbstractforPaeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression | Full Text | References | PDF (2.9 MB)
  • 112 Views
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Review

Review Article
Advances in the delivery of buprenorphine for opioid dependence
Richard N Rosenthal & Viral V Goradia
Pages: 2493-2505
Published online: 28 Aug 2017
AbstractforAdvances in the delivery of buprenorphine for opioid dependence | Full Text | References | PDF (300.1 KB)
  • 251 Views
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Article
Therapy with pamidronate in children with osteogenesis imperfecta
Otilia Marginean, Raluca Corina Tamasanu, Niculina Mang, Ioana Mozos & Giorgiana Flavia Brad
Pages: 2507-2515
Published online: 28 Aug 2017
AbstractforTherapy with pamidronate in children with osteogenesis imperfecta | Full Text | References | PDF (1,006.8 KB)
  • 175 Views
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Article
Secondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis
Ping Zhong, Danhong Wu, Xiaofei Ye, Ying Wu, Tuming Li, Shuwen Tong & Xueyuan Liu
Pages: 2517-2526
Published online: 30 Aug 2017
AbstractforSecondary prevention of major cerebrovascular events with seven different statins: a multi-treatment meta-analysis | Full Text | References | PDF (549.1 KB)
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Review

Review Article
New insight into the pathogenesis of nail psoriasis and overview of treatment strategies
Alessandra Ventura, Mauro Mazzeo, Roberta Gaziano, Marco Galluzzo, Luca Bianchi & Elena Campione
Pages: 2527-2535
Published online: 30 Aug 2017
AbstractforNew insight into the pathogenesis of nail psoriasis and overview of treatment strategies | Full Text | References | PDF (2.5 MB)
  • 267 Views
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Review Article
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy
Sulsal Haque, Mahender Yellu, Jaskirat Randhawa & Nooshin Hashemi-Sadraei
Pages: 2537-2549
Published online: 31 Aug 2017
AbstractforProfile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy | Full Text | References | PDF (325.2 KB)
  • 60 Views
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Review Article
Quantum mechanics implementation in drug-design workflows: does it really help?
Olayide A Arodola & Mahmoud ES Soliman
Pages: 2551-2564
Published online: 31 Aug 2017
AbstractforQuantum mechanics implementation in drug-design workflows: does it really help? | Full Text | References | PDF (586.4 KB)
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Original Research

Article
Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair
Yong Yang, Zhenhuan Ma, Guokai Yang, Jia Wan, Guojian Li, Lingjuan Du & Ping Lu
Pages: 2565-2579
Published online: 01 Sep 2017
AbstractforAlginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair | Full Text | References | PDF (1.5 MB)
  • 92 Views
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Article
Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol
Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang & Chang Yang
Pages: 2581-2593
Published online: 01 Sep 2017
AbstractforPuerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol | Full Text | References | PDF (2.7 MB)
  • 58 Views
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Article
Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy
Zhuanglei Gao, Zhaoxia Li, Jieke Yan & Peilin Wang
Pages: 2595-2604
Published online: 03 Oct 2022
AbstractforIrinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy | Full Text | References | PDF (3.2 MB)
  • 159 Views
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Article
RETRACTED ARTICLE: Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models
Entaz Bahar, Geum-Hwa Lee, Kashi Raj Bhattarai, Hwa-Young Lee, Hyun-Kyoung Kim, Mallikarjun Handigund, Min-Kyung Choi, Sun-Young Han, Han-Jung Chae & Hyonok Yoon
Pages: 2605-2619
Published online: 05 Sep 2017
AbstractforRETRACTED ARTICLE: Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models | PDF (7.8 MB)
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Review

Review Article
Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations
Bernardo Leon Rapoport, Matti Aapro, Martin R Chasen, Karin Jordan, Rudolph M Navari, Ian Schnadig & Lee Schwartzberg
Pages: 2621-2629
Published online: 05 Sep 2017
AbstractforRecent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations | Full Text | References | PDF (304.1 KB)
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Original Research

Article
Layer-by-layer nanoparticles co-loading gemcitabine and platinum (IV) prodrugs for synergistic combination therapy of lung cancer
Rongrong Zhang, Yun Ru, Yiping Gao, Jinyin Li & Shilong Mao
Pages: 2631-2642
Published online: 05 Sep 2017
AbstractforLayer-by-layer nanoparticles co-loading gemcitabine and platinum (IV) prodrugs for synergistic combination therapy of lung cancer | Full Text | References | PDF (1.9 MB)
  • 123 Views
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Review

Review Article
Radium 223 dichloride for prostate cancer treatment
Emmanuel Deshayes, Mathieu Roumiguie, Constance Thibault, Philippe Beuzeboc, Florent Cachin, Christophe Hennequin, Damien Huglo, François Rozet, Diana Kassab-Chahmi, Xavier Rebillard & Nadine Houédé
Pages: 2643-2651
Published online: 06 Sep 2017
AbstractforRadium 223 dichloride for prostate cancer treatment | Full Text | References | PDF (507.3 KB)
  • 479 Views
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Article
In vitro inhibitory activities of magnolol against Candida spp.
Peiru Zhou, Jingya Fu, Hong Hua & Xiaosong Liu
Pages: 2653-2661
Published online: 06 Sep 2017
AbstractforIn vitro inhibitory activities of magnolol against Candida spp. | Full Text | References | PDF (1.1 MB)
  • 67 Views
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Article
Palatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate
Vanessa Zann, John McDermott, Jeffrey W Jacobs, James P Davidson, Fangling Lin, Paul Korner, Robert C Blanks & David P Rosenbaum
Pages: 2663-2673
Published online: 06 Sep 2017
AbstractforPalatability and physical properties of potassium-binding resin RDX7675: comparison with sodium polystyrene sulfonate | Full Text | References | PDF (2.1 MB)
  • 93 Views
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Retraction

Retraction
The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery [Retraction]
Page: 2675
Published online: 06 Sep 2017
CitationforThe influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery [Retraction] | Full Text | PDF (151.4 KB)
  • 56 Views
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Article
Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia
Mohamed M Ibrahim, Tarek Fouad Tammam, Mohy El Deen Ebaed, Hatem A Sarhan, Gamal F Gad & Amal K Hussein
Pages: 2677-2682
Published online: 06 Sep 2017
AbstractforExtended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia | Full Text | References | PDF (689.9 KB)
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Corrigendum

Correction
Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum]
Page: 2683
Published online: 12 Sep 2017
CitationforCissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum] | Full Text | PDF (319.2 KB)
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Article
Metal organic frameworks as a drug delivery system for flurbiprofen
Muder AL Haydar, Hussein Rasool Abid, Bruce Sunderland & Shaobin Wang
Pages: 2685-2695
Published online: 11 Sep 2017
AbstractforMetal organic frameworks as a drug delivery system for flurbiprofen | Full Text | References | PDF (7.2 MB)
  • 700 Views
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Article
Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment
Chen Chen, Jie Wu, Pengfei Zhu, Congjian Xu & Liangqing Yao
Pages: 2697-2707
Published online: 11 Sep 2017
AbstractforInvestigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment | Full Text | References | PDF (4.7 MB)
  • 82 Views
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Review

Review Article
Localized neuropathic pain: an expert consensus on local treatments
Gisèle Pickering, Elodie Martin, Florence Tiberghien, Claire Delorme & Gérard Mick
Pages: 2709-2718
Published online: 13 Sep 2017
AbstractforLocalized neuropathic pain: an expert consensus on local treatments | Full Text | References | PDF (263.5 KB)
  • 202 Views
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Article
Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate
Hae Won Lee, Sook Jin Seong, Boram Ohk, Woo Youl Kang, Mi-Ri Gwon, Bo Kyung Kim, Hyun-Ju Kim & Young-Ran Yoon
Pages: 2719-2725
Published online: 13 Sep 2017
AbstractforPharmacokinetic and safety evaluation of MB12066, an NQO1 substrate | Full Text | References | PDF (393.4 KB)
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Article
Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism
Sook Joung Lee, Min Kyu Park, Dong-Seong Shin & Min Ho Chun
Pages: 2727-2736
Published online: 13 Sep 2017
AbstractforVariability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism | Full Text | References | PDF (662 KB)
  • 75 Views
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Review

Review Article
The roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives
Sabrina Bimonte, Marco Cascella, Vincenzo Schiavone, Farrokh Mehrabi-Kermani & Arturo Cuomo
Pages: 2737-2742
Published online: 13 Sep 2017
AbstractforThe roles of epigallocatechin-3-gallate in the treatment of neuropathic pain: an update on preclinical in vivo studies and future perspectives | Full Text | References | PDF (536.3 KB)
  • 112 Views
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Article
Design and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers
Peijun You, Ran Yuan & Chuanyu Chen
Pages: 2743-2752
Published online: 18 Sep 2017
AbstractforDesign and evaluation of lidocaine- and prilocaine-coloaded nanoparticulate drug delivery systems for topical anesthetic analgesic therapy: a comparison between solid lipid nanoparticles and nanostructured lipid carriers | Full Text | References | PDF (2.6 MB)
  • 225 Views
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Article
Biodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections
Jochen Reinbold, Teresa Hierlemann, Lukas Urich, Ann-Kristin Uhde, Ingrid Müller, Tobias Weindl, Ulrich Vogel, Christian Schlensak, Hans Peter Wendel & Stefanie Krajewski
Pages: 2753-2762
Published online: 18 Sep 2017
AbstractforBiodegradable rifampicin-releasing coating of surgical meshes for the prevention of bacterial infections | Full Text | References | PDF (1.2 MB)
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Article
Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells
Su Ki Liew, Mohamad Nurul Azmi, Lionel LA In, Khalijah Awang & Noor Hasima Nagoor
Pages: 2763-2776
Published online: 18 Sep 2017
AbstractforAnti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells | Full Text | References | PDF (2.7 MB)
  • 137 Views
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Article
Assay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway
Laura Stanbery & Jyl S Matson
Pages: 2777-2785
Published online: 19 Sep 2017
AbstractforAssay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway | Full Text | References | PDF (951.6 KB)
  • 54 Views
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Article
Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
Yanhua Chen, Xu Zhang, Bingdong Zhang, Guodong He, Lifang Zhou & Yubo Xie
Pages: 2787-2799
Published online: 26 Sep 2017
AbstractforDexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway | Full Text | References | PDF (4 MB)
  • 71 Views
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Review

Review Article
Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy
Audrey Bellesoeur, Edith Carton, Jerome Alexandre, Francois Goldwasser & Olivier Huillard
Pages: 2801-2811
Published online: 21 Sep 2017
AbstractforAxitinib in the treatment of renal cell carcinoma: design, development, and place in therapy | Full Text | References | PDF (379.7 KB)
  • 194 Views
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Article
Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
Fengjuan Tang, Yarong Hao, Xue Zhang & Jian Qin
Pages: 2813-2826
Published online: 21 Sep 2017
AbstractforEffect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy | Full Text | References | PDF (8.6 MB)
  • 107 Views
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Review

Review Article
Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
Ayşe Elif Özdener & Anastasia Rivkin
Pages: 2827-2840
Published online: 26 Sep 2017
AbstractforEluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome | Full Text | References | PDF (329.5 KB)
  • 104 Views
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Article
Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells
Lei Yin, Zheng Fang, Ning-jia Shen, Ying-he Qiu, Ai-jun Li & Yong-jie Zhang
Pages: 2841-2850
Published online: 03 Oct 2022
AbstractforDownregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells | Full Text | References | PDF (2.5 MB)
  • 65 Views
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Article
Safety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials
Manni Wang, Xuelei Ma, Linghong Guo & Fan Xia
Pages: 2851-2860
Published online: 27 Sep 2017
AbstractforSafety and efficacy profile of pembrolizumab in solid cancer: pooled reanalysis based on randomized controlled trials | Full Text | References | PDF (1.5 MB)
  • 119 Views
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Article
New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients
Yu Kyong Kim, Anhye Kim, Shin Jung Park & Howard Lee
Pages: 2861-2869
Published online: 03 Oct 2022
AbstractforNew tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients | Full Text | References | PDF (458.6 KB)
  • 108 Views
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Review

Review Article
The new era of nanotechnology, an alternative to change cancer treatment
Ancuta Jurj, Cornelia Braicu, Laura-Ancuta Pop, Ciprian Tomuleasa, Claudia Diana Gherman & Ioana Berindan-Neagoe
Pages: 2871-2890
Published online: 27 Sep 2017
AbstractforThe new era of nanotechnology, an alternative to change cancer treatment | Full Text | References | PDF (2.1 MB)
  • 1783 Views
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Review Article
Current perspective on rituximab in rheumatic diseases
Tommaso Schioppo & Francesca Ingegnoli
Pages: 2891-2904
Published online: 03 Oct 2022
AbstractforCurrent perspective on rituximab in rheumatic diseases | Full Text | References | PDF (500.4 KB)
  • 165 Views
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Review Article
Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date
Francesca Cinti, Simona Moffa, Flavia Impronta, Chiara MA Cefalo, Vinsin A Sun, Gian Pio Sorice, Teresa Mezza & Andrea Giaccari
Pages: 2905-2919
Published online: 03 Oct 2017
AbstractforSpotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date | Full Text | References | PDF (718.8 KB)
  • 280 Views
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Review Article
Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy
Michele A Faulkner
Pages: 2921-2930
Published online: 04 Oct 2017
AbstractforSpotlight on perampanel in the management of seizures: design, development and an update on place in therapy | Full Text | References | PDF (319.7 KB)
  • 92 Views
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Original Research

Article
Functional and morphological effects of diazepam and midazolam on tumor vasculature in the 9L gliosarcoma brain tumor model using dynamic susceptibility contrast MRI: a comparative study
Nuo Yan, Yuzhen Zheng & Cheng Yang
Pages: 2931-2936
Published online: 04 Oct 2017
AbstractforFunctional and morphological effects of diazepam and midazolam on tumor vasculature in the 9L gliosarcoma brain tumor model using dynamic susceptibility contrast MRI: a comparative study | Full Text | References | PDF (1.2 MB)
  • 61 Views
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Article
Short vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries
Mariya Kronlage, Maximilian Wassmann, Britta Vogel, Oliver J Müller, Erwin Blessing, Hugo Katus & Christian Erbel
Pages: 2937-2945
Published online: 06 Oct 2017
AbstractforShort vs prolonged dual antiplatelet treatment upon endovascular stenting of peripheral arteries | Full Text | References | PDF (1.1 MB)
  • 60 Views
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Article
Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation
Weili Zhan, Yanhong Kang, Ning Chen, Chongshan Mao, Yi Kang & Jia Shang
Pages: 2947-2955
Published online: 10 Oct 2017
AbstractforHalofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation | Full Text | References | PDF (5.4 MB)
  • 64 Views
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Review

Review Article
Clinical and pharmacological hallmarks of rifapentine’s use in diabetes patients with active and latent tuberculosis: do we know enough?
Chunlan Zheng, Xiufen Hu, Li Zhao, Minhui Hu & Feng Gao
Pages: 2957-2968
Published online: 11 Oct 2017
AbstractforClinical and pharmacological hallmarks of rifapentine’s use in diabetes patients with active and latent tuberculosis: do we know enough? | Full Text | References | PDF (312.8 KB)
  • 83 Views
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Article
Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
Kiran Kumar Soni, Yu Seob Shin, Bo Ram Choi, Keshab Kumar Karna, Hye Kyung Kim, Sung Won Lee, Chul Young Kim & Jong Kwan Park
Pages: 2969-2979
Published online: 03 Oct 2022
AbstractforProtective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway | Full Text | References | PDF (3.4 MB)
  • 92 Views
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Article
5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction
Amit K Keshari, Ashok K Singh, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash & Sudipta Saha
Pages: 2981-2995
Published online: 13 Oct 2017
Abstractfor5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction | Full Text | References | PDF (3.8 MB)
  • 131 Views
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Article
Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides
Hongmei Jiang, Henggui Hu, Yali Zhang, Ping Yue, Lichang Ning, Yan Zhou, Ping Shi & Rui Yuan
Pages: 2997-3007
Published online: 13 Oct 2017
AbstractforAmelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides | Full Text | References | PDF (2.8 MB)
  • 52 Views
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Article
Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials
Jian xin Zhou, Li jin Feng & Xi Zhang
Pages: 3009-3017
Published online: 13 Oct 2017
AbstractforRisk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials | Full Text | References | PDF (866 KB)
  • 270 Views
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Article
Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor
Wei-Wei Zhang, Feng Bai, Jin Wang, Rong-Hua Zheng, Li-Wang Yang, Erskine A James & Zhi-Qing Zhao
Pages: 3019-3033
Published online: 16 Oct 2017
AbstractforEdaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor | Full Text | References | PDF (1.7 MB)
  • 85 Views
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Article
Failure mode and effects analysis drastically reduced potential risks in clinical trial conduct
Howard Lee, Heechan Lee, Jungmi Baik, Hyunjung Kim & Rachel Kim
Pages: 3035-3043
Published online: 19 Oct 2017
AbstractforFailure mode and effects analysis drastically reduced potential risks in clinical trial conduct | Full Text | References | PDF (419.9 KB)
  • 195 Views
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Article
10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes
Jianxin Zhang, Chen Ming, Wenzhi Zhang, Patrick Nwabueze Okechukwu, Beata Morak-Młodawska, Krystian Pluta, Małgorzata Jeleń, Abdah Md Akim, Kok-Pian Ang & Kah Kooi Ooi
Pages: 3045-3063
Published online: 24 Oct 2017
Abstractfor10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes | Full Text | References | PDF (8.1 MB)
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Article
Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice
Li Gao, Lunyang Xia, Ruhui Zhang, Dandan Duan, Xiuxiu Liu, Jianjian Xu & Lan Luo
Pages: 3065-3075
Published online: 20 Oct 2017
AbstractforEnhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice | Full Text | References | PDF (7.6 MB)
  • 91 Views
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Review

Review Article
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad
Graeme Jones, Elena Panova & Richard Day
Pages: 3077-3081
Published online: 24 Oct 2017
AbstractforGuideline development for the management of gout: role of combination therapy with a focus on lesinurad | Full Text | References | PDF (220.2 KB)
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Original Research

Article
Development of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation
Rai Muhammad Sarfraz, Mahmood Ahmad, Asif Mahmood, Muhammad Rouf Akram & Asad Abrar
Pages: 3083-3096
Published online: 24 Oct 2017
AbstractforDevelopment of β-cyclodextrin-based hydrogel microparticles for solubility enhancement of rosuvastatin: an in vitro and in vivo evaluation | Full Text | References | PDF (3.2 MB)
  • 281 Views
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Article
High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis
Si Zeng, Hui Qiao, Xue-wen Lv, Dan Fan, Tong Liu & Dongli Xie
Pages: 3097-3104
Published online: 25 Oct 2017
AbstractforHigh-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis | Full Text | References | PDF (5.2 MB)
  • 99 Views
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Article
In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors
Yuan Ding, Wei Cui, Dan Sun, Gui-Ling Wang, Yu Hei, Shuai Meng, Jian-Hua Chen, Ying Xie & Zhi-Qiang Wang
Pages: 3105-3117
Published online: 26 Oct 2017
AbstractforIn vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors | Full Text | References | PDF (2.6 MB)
  • 176 Views
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Review

Review Article
Vitamin D levels in systemic sclerosis patients: a meta-analysis
Lin An, Ming-hui Sun, Feng Chen & Jin-ran Li
Pages: 3119-3125
Published online: 03 Oct 2022
AbstractforVitamin D levels in systemic sclerosis patients: a meta-analysis | Full Text | References | PDF (662.4 KB)
  • 103 Views
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Original Research

Article
Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers
Sumin Yoon, Su-jin Rhee, Sun Ju Heo, Tae Young Oh, Seo Hyun Yoon, Joo-Youn Cho, SeungHwan Lee & Kyung-Sang Yu
Pages: 3127-3135
Published online: 27 Oct 2017
AbstractforComparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers | Full Text | References | PDF (712.6 KB)
  • 137 Views
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Review

Review Article
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
Corrado Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Rosa Terracciano, Rocco Savino & Girolamo Pelaia
Pages: 3137-3144
Published online: 03 Oct 2022
AbstractforSevere eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab | Full Text | References | PDF (1.7 MB)
  • 184 Views
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Original Research

Article
Baracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety
Do Young Kim, Ju Hyun Kim, Won Young Tak, Jong Eun Yeon, Joon Hyeok Lee, Jung Hwan Yoon, Youn Jae Lee, Byung Seok Lee, Byung Hoon Han & Han Chu Lee
Pages: 3145-3152
Published online: 31 Oct 2017
AbstractforBaracle® vs Baraclude® for 48 weeks in patients with treatment-naïve chronic hepatitis B: a comparison of efficacy and safety | Full Text | References | PDF (594.2 KB)
  • 133 Views
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Review

Review Article
Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date
Alberto Gajofatto
Pages: 3153-3157
Published online: 02 Nov 2017
AbstractforSpotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date | Full Text | References | PDF (218.6 KB)
  • 99 Views
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Original Research

Article
Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa & Qosay Al-Balas
Pages: 3159-3170
Published online: 03 Nov 2017
AbstractforDevelopment of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria | Full Text | References | PDF (980.1 KB)
  • 344 Views
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Article
A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects
Yu Kyong Kim, Mun Ju Choi, Tae Young Oh, Kyung-Sang Yu & SeungHwan Lee
Pages: 3171-3177
Published online: 06 Nov 2017
AbstractforA comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects | Full Text | References | PDF (601.5 KB)
  • 62 Views
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Article
Impact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle
Haijuan Hu, Jidong Zhang, Yan Wang, Zejun Tian, Demin Liu, Guangming Zhang, Guoqiang Gu, Hongmei Zheng, Ruiqin Xie & Wei Cui
Pages: 3179-3186
Published online: 03 Oct 2022
AbstractforImpact of baseline blood pressure on the magnitude of blood pressure lowering by nifedipine gastrointestinal therapeutic system: refreshing the Wilder’s principle | Full Text | References | PDF (1.1 MB)
  • 55 Views
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Article
Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials
Seokuee Kim, SeungHwan Lee, Joo-Youn Cho, Seo Hyun Yoon, In-Jin Jang & Kyung-Sang Yu
Pages: 3187-3195
Published online: 03 Oct 2022
AbstractforPharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H: quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials | Full Text | References | PDF (894.9 KB)
  • 102 Views
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Review

Review Article
Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy
Eiichi Ogawa, Norihiro Furusyo & Mindie H Nguyen
Pages: 3197-3204
Published online: 06 Nov 2017
AbstractforTenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy | Full Text | References | PDF (348.2 KB)
  • 150 Views
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Corrigendum

Correction
Quantum mechanics implementation in drug-design workflows: does it really help? [Corrigendum]
Page: 3205
Published online: 08 Nov 2017
CitationforQuantum mechanics implementation in drug-design workflows: does it really help? [Corrigendum] | Full Text | PDF (244.8 KB)
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Original Research

Article
Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli
Sarra Setrerrahmane, Jian Yu, Jingchao Hao, Heng Zheng & Hanmei Xu
Pages: 3207-3220
Published online: 08 Nov 2017
AbstractforNovel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli | Full Text | References | PDF (4.2 MB)
  • 70 Views
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Article
Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway
Yun-xia Shao, Xing-xin Xu, Kun Wang, Xiang-ming Qi & Yong-gui Wu
Pages: 3221-3233
Published online: 09 Nov 2017
AbstractforPaeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway | Full Text | References | PDF (12.1 MB)
  • 85 Views
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Review

Review Article
Safety and efficacy of the addition of pertuzumab to T-DM1 ± taxane in patients with HER2-positive, locally advanced or metastatic breast cancer: a pooled analysis
Jing Zhang, Jinying Li, Chenjing Zhu, Yanlin Song, Fan Xia & Xuelei Ma
Pages: 3235-3244
Published online: 15 Nov 2017
AbstractforSafety and efficacy of the addition of pertuzumab to T-DM1 ± taxane in patients with HER2-positive, locally advanced or metastatic breast cancer: a pooled analysis | Full Text | References | PDF (1,018.4 KB)
  • 85 Views
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Original Research

Article
Adjuvant immunotherapy of dendritic cells and cytokine-induced killer cells is safe and enhances chemotherapy efficacy for multiple myeloma in China: a meta-analysis of clinical trials
Yan Wang, Benji Lv, Ke Li, Anqi Zhang & Hong Liu
Pages: 3245-3256
Published online: 15 Nov 2017
AbstractforAdjuvant immunotherapy of dendritic cells and cytokine-induced killer cells is safe and enhances chemotherapy efficacy for multiple myeloma in China: a meta-analysis of clinical trials | Full Text | References | PDF (998.2 KB)
  • 80 Views
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Review

Review Article
Role of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease
Pierachille Santus, Dejan Radovanovic, Andrea Cristiano, Vincenzo Valenti & Maurizio Rizzi
Pages: 3257-3271
Published online: 15 Nov 2017
AbstractforRole of nebulized glycopyrrolate in the treatment of chronic obstructive pulmonary disease | Full Text | References | PDF (553.7 KB)
  • 120 Views
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Original Research

Article
Differences of statin activity in 2D and 3D pancreatic cancer cell cultures
Miglė Paškevičiūtė & Vilma Petrikaitė
Pages: 3273-3280
Published online: 16 Nov 2017
AbstractforDifferences of statin activity in 2D and 3D pancreatic cancer cell cultures | Full Text | References | PDF (3.4 MB)
  • 208 Views
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Article
In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically
Jrhau Lung, Kuan-Liang Chen, Chien-Hui Hung, Chih-Cheng Chen, Ming-Szu Hung, Yu-Ching Lin, Ching-Yuan Wu, Kuan-Der Lee, Neng-Yao Shih & Ying Huang Tsai
Pages: 3281-3290
Published online: 16 Nov 2017
AbstractforIn silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically | Full Text | References | PDF (2.8 MB)
  • 103 Views
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Article
Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules
Abdel Naser Zaid, Nihal Zohud, Bushra E’layan, Tasneem Aburadi, Nidal Jaradat, Iyad Ali, Fatima Hussein, Mashhour Ghanem, Aiman Qaddomi & Yara Abu Zaaror
Pages: 3291-3298
Published online: 03 Oct 2022
AbstractforPharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules | Full Text | References | PDF (718.9 KB)
  • 207 Views
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Article
Efficacy and safety of quadruple therapy including tirofiban in the treatment of Chinese NSTE-ACS patients failing to receive timely percutaneous coronary intervention
Lan Li, Zhenrong Ge, Dengke Zhang, Jun Kuang, Xiang Ma & Shubin Jiang
Pages: 3299-3307
Published online: 21 Nov 2017
AbstractforEfficacy and safety of quadruple therapy including tirofiban in the treatment of Chinese NSTE-ACS patients failing to receive timely percutaneous coronary intervention | Full Text | References | PDF (524.3 KB)
  • 61 Views
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Article
Anticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line
Ashwaq Shakir AL-Abboodi, Abdullah Rasedee, Ahmad Bustamam Abdul, Yun Hin Taufiq-Yap, Wafaa Abd Alwahed Alkaby, Mostafa Saddam Ghaji, Peter M Waziri & Mothanna Sadiq Al-Qubaisi
Pages: 3309-3319
Published online: 23 Nov 2017
AbstractforAnticancer effect of dentatin and dentatin-hydroxypropyl-β-cyclodextrin complex on human colon cancer (HT-29) cell line | Full Text | References | PDF (1.8 MB)
  • 79 Views
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Case Report

Case Report
Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
Shaul Lev, David Snyder, Carmil Azran, Victor Zolotarsky & Arik Dahan
Pages: 3321-3324
Published online: 22 Nov 2017
AbstractforSevere hypertriglyceridemia and colchicine intoxication following suicide attempt | Full Text | References | PDF (405.3 KB)
  • 68 Views
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Original Research

Article
Fentanyl-induced respiratory depression is attenuated in pregnant patients
Xiaofei Cao, Shijiang Liu, Jie Sun, Min Yu, Yin Fang & Zhengnian Ding
Pages: 3325-3332
Published online: 22 Nov 2017
AbstractforFentanyl-induced respiratory depression is attenuated in pregnant patients | Full Text | References | PDF (1.9 MB)
  • 72 Views
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Article
Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
Meng Su, Baoli Qin, Fang Liu, Yuze Chen & Rui Zhang
Pages: 3333-3341
Published online: 23 Nov 2017
AbstractforAndrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway | Full Text | References | PDF (1.4 MB)
  • 117 Views
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Article
Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state
Chunlan Fan, Yuan Qiao & Minke Tang
Pages: 3343-3354
Published online: 23 Nov 2017
AbstractforNotoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state | Full Text | References | PDF (6.8 MB)
  • 71 Views
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Article
Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation
Burak Çelik
Pages: 3355-3365
Published online: 03 Oct 2022
AbstractforRisperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation | Full Text | References | PDF (1.5 MB)
  • 840 Views
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Review

Review Article
The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer
Wenjie Guo, Sihan Liu, Xiaoli Zhang, Yating Chen, Ruolan Qian, Ziyuan Zou, Xin Chen & Peng Luo
Pages: 3367-3376
Published online: 28 Nov 2017
AbstractforThe coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer | Full Text | References | PDF (722.9 KB)
  • 69 Views
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Original Research

Article
A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization
Shahira F El-Menshawe, Adel Ahmed Ali, Abdelkhalk Ali Halawa & Ahmed SG Srag El-Din
Pages: 3377-3388
Published online: 28 Nov 2017
AbstractforA novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization | Full Text | References | PDF (3.4 MB)
  • 199 Views
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Article
Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones
Galal Elgemeie, Farag Altalbawy, Mohammed Alfaidi, Rania Azab & Atef Hassan
Pages: 3389-3399
Published online: 28 Nov 2017
AbstractforSynthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones | Full Text | References | PDF (1,007.4 KB)
  • 78 Views
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Article
Cardiovascular, liver, and renal toxicity associated with an intravenous ferric carboxymaltose similar versus the originator compound
Jorge E Toblli, Gabriel Cao, Luis Rico & Margarita Angerosa
Pages: 3401-3412
Published online: 30 Nov 2017
AbstractforCardiovascular, liver, and renal toxicity associated with an intravenous ferric carboxymaltose similar versus the originator compound | Full Text | References | PDF (2.6 MB)
  • 133 Views
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Review

Review Article
Comparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials
ShuJun Sun, JiaMei Wang, NaRen Bao, Ying Chen & Jun Wang
Pages: 3413-3424
Published online: 01 Dec 2017
AbstractforComparison of dexmedetomidine and fentanyl as local anesthetic adjuvants in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials | Full Text | References | PDF (1.2 MB)
  • 428 Views
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Original Research

Article
High-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction
Mara Gavazzoni, Elio Gorga, Giuseppe Derosa, Pamela Maffioli, Marco Metra & Riccardo Raddino
Pages: 3425-3434
Published online: 03 Oct 2022
AbstractforHigh-dose atorvastatin versus moderate dose on early vascular protection after ST-elevation myocardial infarction | Full Text | References | PDF (1.2 MB)
  • 95 Views
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Article
The role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials
Liangzhe Zhang, Shugeng Gao & Jie He
Pages: 3435-3440
Published online: 01 Dec 2017
AbstractforThe role of maintenance therapy in the treatment of elderly non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials | Full Text | References | PDF (466 KB)
  • 57 Views
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Article
Bioequivalence study of two formulations of flupirtine maleate capsules in healthy male Chinese volunteers under fasting and fed conditions
Yanfang Liu, Hua Huo, Zhibo Zhao, Wenli Hu, Yujia Sun & Yunbiao Tang
Pages: 3441-3448
Published online: 01 Dec 2017
AbstractforBioequivalence study of two formulations of flupirtine maleate capsules in healthy male Chinese volunteers under fasting and fed conditions | Full Text | References | PDF (564.4 KB)
  • 59 Views
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Article
Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes
Wenxi He, Yanjiao Xu, Chengliang Zhang, Jingli Lu, Juan Li, Dong Xiang, Jinyu Yang, Mujun Chang & Dong Liu
Pages: 3449-3460
Published online: 05 Dec 2017
AbstractforHepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes | Full Text | References | PDF (3.7 MB)
  • 75 Views
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Article
Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
Chang Hee Kim, Hyungmi An, Sung Hye Kim & Dongseong Shin
Pages: 3461-3469
Published online: 05 Dec 2017
AbstractforPharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects | Full Text | References | PDF (1.2 MB)
  • 217 Views
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Article
Variability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists
Céline Audibert, Anna Perlaky, Mark Stuntz & Daniel Glass
Pages: 3471-3479
Published online: 06 Dec 2017
AbstractforVariability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists | Full Text | References | PDF (1.3 MB)
  • 68 Views
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Article
Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome
Ren Zhu & Ye Tian
Pages: 3481-3489
Published online: 06 Dec 2017
AbstractforPreparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome | Full Text | References | PDF (5.1 MB)
  • 70 Views
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Article
Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study
Qing-Tao Meng, Guang Yang, Ren-Bo Li, Jing-Xin Nie, Wei Zhou, Hong-De Yu, Bo Chen, Li Jiang & Jing-Bo Shang
Pages: 3491-3495
Published online: 06 Dec 2017
AbstractforInvolvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study | Full Text | References | PDF (242.4 KB)
  • 62 Views
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Review

Review Article
Anacetrapib as a potential cardioprotective strategy
Belinda A Di Bartolo & Stephen J Nicholls
Pages: 3497-3502
Published online: 03 Oct 2022
AbstractforAnacetrapib as a potential cardioprotective strategy | Full Text | References | PDF (213.8 KB)
  • 62 Views
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Original Research

Article
Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro
Ping Fang, Peng-fei Tang, Ren-ai Xu, Xiang Zheng, Jian Wen, Su-su Bao, Jian-ping Cai & Guo-xin Hu
Pages: 3503-3510
Published online: 07 Dec 2017
AbstractforFunctional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro | Full Text | References | PDF (779.3 KB)
  • 115 Views
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Review

Review Article
Regulation profile of the intestinal peptide transporter 1 (PepT1)
Chun-Yang Wang, Shu Liu, Xiao-Nv Xie & Zhi-Rong Tan
Pages: 3511-3517
Published online: 08 Dec 2017
AbstractforRegulation profile of the intestinal peptide transporter 1 (PepT1) | Full Text | References | PDF (245.3 KB)
  • 157 Views
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Original Research

Article
Redox-responsive and pH-sensitive nanoparticles enhanced stability and anticancer ability of erlotinib to treat lung cancer in vivo
Sheng Tan & Guoxiang Wang
Pages: 3519-3529
Published online: 03 Oct 2022
AbstractforRedox-responsive and pH-sensitive nanoparticles enhanced stability and anticancer ability of erlotinib to treat lung cancer in vivo | Full Text | References | PDF (1.5 MB)
  • 187 Views
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Perspectives

Article
Gut microbiota–derived short-chain fatty acids and kidney diseases
Lingzhi Li, Liang Ma & Ping Fu
Pages: 3531-3542
Published online: 11 Dec 2017
AbstractforGut microbiota–derived short-chain fatty acids and kidney diseases | Full Text | References | PDF (2.1 MB)
  • 300 Views
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Original Research

Article
Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers
Minkyung Oh, Sung-Eun Park, Jong-Lyul Ghim, Young-Kyung Choi, Eon-Jeong Shim, Jae-Gook Shin & Eun-Young Kim
Pages: 3543-3550
Published online: 11 Dec 2017
AbstractforComparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers | Full Text | References | PDF (1.4 MB)
  • 178 Views
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Clinical Trial Report

Case Report
EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis
Marco Romanelli, Alberto Piaggesi, Giovanni Scapagnini, Valentina Dini, Agata Janowska, Elisabetta Iacopi, Carlotta Scarpa, Stéphane Fauverghe & Franco Bassetto
Pages: 3551-3558
Published online: 11 Dec 2017
AbstractforEUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis | Full Text | References | PDF (473.2 KB)
  • 97 Views
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Review

Review Article
Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy
Bryan J Donald, Salim Surani, Harmeet S Deol, Uche J Mbadugha & George Udeani
Pages: 3559-3566
Published online: 13 Dec 2017
AbstractforSpotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy | Full Text | References | PDF (488.3 KB)
  • 96 Views
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Original Research

Article
Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury
Yuan Qiao, Chun-Lan Fan & Min-Ke Tang
Pages: 3567-3577
Published online: 13 Dec 2017
AbstractforAstragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury | Full Text | References | PDF (2.1 MB)
  • 75 Views
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Review

Review Article
Spotlight on olaratumab in the treatment of soft-tissue sarcoma: design, development, and place in therapy
Elizabeth J Davis & Rashmi Chugh
Pages: 3579-3587
Published online: 13 Dec 2017
AbstractforSpotlight on olaratumab in the treatment of soft-tissue sarcoma: design, development, and place in therapy | Full Text | References | PDF (332.3 KB)
  • 53 Views
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Corrigendum

Correction
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad [Corrigendum]
Pages: 3589-3590
Published online: 15 Dec 2017
CitationforGuideline development for the management of gout: role of combination therapy with a focus on lesinurad [Corrigendum] | Full Text | PDF (162.8 KB)
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Review

Review Article
Resveratrol as a potential therapeutic drug for respiratory system diseases
Xiao-dan Zhu, Xiao-ping Lei & Wen-bin Dong
Pages: 3591-3598
Published online: 15 Dec 2017
AbstractforResveratrol as a potential therapeutic drug for respiratory system diseases | Full Text | References | PDF (406.3 KB)
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