Antidiabetic effect of glucosaminic acid-cobalt (II) chelate in streptozotocin-induced diabetes in mice

Abstract

Background

The purpose of this study was to assess the in vivo ability of glucosaminic acid-cobalt (II) chelate to reduce glycemia.

Methods

Different concentrations of chelate solution were administrated to mice with diabetes induced by streptozotocin.

Results

Daily oral administration of chelate solution 0.4 mL at various concentrations (0.32–0.4 g/mL) led to reduction in water intake by the diabetic mice after 5 days of treatment, with a subsequent reduction in glucose levels observed 2 weeks later. Daily food intake was related to both chelate concentration as well as glycemia reduction. The food intake of mice treated with glucosaminic acid-cobalt (II) chelate solution was 1.5-fold that of untreated mice.

Conclusion

Glucosaminic acid-cobalt chelate was effective as an antidiabetes agent; its efficacy was proportional to treatment period .The chelated form expressed much less toxicity compared to cobalt only, and stimulated subsequent food intake after daily administration.

Keywords:

• glucosaminic acid
• cobalt
• chelate
• streptozotocin
• glycemia reduction

Acknowledgments

The authors thank the Exploring Program of State Key Laboratory of Food Science and Technology, Jiangnan University, and the Nature Science Foundation of Jiangsu Province for their financial support.

Disclosure

The authors report no conflicts of interest in this work.