Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Abstract

Osteosarcoma is the most common primary malignant bone tumor in young adult, which is prone to early metastasis and poor prognosis. The current treatment methods need to be improved. Circular RNA is a covalently blocked circular, non-coding RNA that plays an essential role in the occurrence, development, clinical diagnosis, and treatment of various diseases. Recently, an increasing number of circRNAs have been identified in osteosarcoma. Understanding its role in osteosarcoma is conducive to the early detection, diagnosis, and treatment of osteosarcoma. In this paper, we reviewed the mechanism of action of circular RNA in the occurrence and development of osteosarcoma and its clinical application in recent years.

Keywords:

• osteosarcoma
• circular RNA
• biomarker
• exosome

Abbreviations

circRNA, circular RNA; ecircRNA, exonic circRNA; EIciRNA, exon-intron circRNA; ciRNA, circular intronic RNA; tricRNA, tRNA intronic circRNA; RBP, RNA binding protein; ORF, open reading frame; OS, osteosarcoma; CHI3L1, chitinase-3-like protein 1; ALP, alkaline phosphatase.

Acknowledgments

The authors would like to thank Innovative Research and Development Platform for Individualized Precise Clinical Diagnosis and Treatment of Innovation and Entrepreneurship Incubation Base of China Medical University, for its support. The authors would like to thank Zesi Liu, Yuze Hu, Yifan Xiao, Linbo Zhang, Mohammad Showkat Hossain from China Medical University for their help and contributions.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that they have no competing interests.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China(81272946); The College Students’ Innovation Project of China Medical University; Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma(2020Y2014).