Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

References

• Sanger H, Klotz G, Riesner D, Gross H, Kleinschmidt A. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci. 1976;73(11):3852–3856. doi:10.1073/pnas.73.11.3852
   PubMed Web of Science ®Google Scholar
• Arnberg A, Van Ommen G, Grivell L, Van Bruggen E, Borst P. Some yeast mitochondrial RNAs are circular. Cell. 1980;19(2):313–319. doi:10.1016/0092-8674(80)90505-X
   PubMed Web of Science ®Google Scholar
• Kos A, Dijkema R, Arnberg A, van der Meide P, Schellekens H. The hepatitis delta (delta) virus possesses a circular RNA. Nature. 1986;323(6088):558–560. doi:10.1038/323558a0
   PubMed Web of Science ®Google Scholar
• Jeck W, Sorrentino J, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19(2):141–157. doi:10.1261/rna.035667.112
   PubMed Web of Science ®Google Scholar
• Qu S, Yang X, Li X, et al. Circular RNA: a new star of noncoding RNAs. Cancer Lett. 2015;365(2):141–148. doi:10.1016/j.canlet.2015.06.003
   PubMed Web of Science ®Google Scholar
• Schmidt C, Noto J, Filonov G, Matera A. A method for expressing and imaging abundant, stable, circular RNAs in vivo using tRNA splicing. Methods Enzymol. 2016;572:215–236.
   PubMed Web of Science ®Google Scholar
• Xia S, Feng J, Lei L, et al. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Brief Bioinform. 2017;18(6):984–992. doi:10.1093/bib/bbw081
   PubMed Web of Science ®Google Scholar
• Wang M, Xie F, Lin J, et al. Diagnostic and prognostic value of circulating CircRNAs in cancer. Front Med. 2021;8:649383. doi:10.3389/fmed.2021.649383
   Web of Science ®Google Scholar
• Panda A, De S, Grammatikakis I, et al. High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Nucleic Acids Res. 2017;45(12):e116. doi:10.1093/nar/gkx297
   PubMed Web of Science ®Google Scholar
• Saunders G, Baudis M, Becker R, et al. Leveraging European infrastructures to access 1 million human genomes by 2022. Nat Rev Genet. 2019;20(11):693–701. doi:10.1038/s41576-019-0156-9
   PubMed Web of Science ®Google Scholar
• Rybak-Wolf A, Stottmeister C, Glažar P, et al. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 2015;58(5):870–885. doi:10.1016/j.molcel.2015.03.027
   PubMed Web of Science ®Google Scholar
• Ashwal-Fluss R, Meyer M, Pamudurti N, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66. doi:10.1016/j.molcel.2014.08.019
   PubMed Web of Science ®Google Scholar
• Ng W, Mohd Mohidin T, Shukla K. Functional role of circular RNAs in cancer development and progression. RNA Biol. 2018;15(8):995–1005. doi:10.1080/15476286.2018.1486659
   PubMed Web of Science ®Google Scholar
• Wang Z, Lei X. Identifying the sequence specificities of circRNA-binding proteins based on a capsule network architecture. BMC Bioinform. 2021;22(1):19. doi:10.1186/s12859-020-03942-3
   PubMed Web of Science ®Google Scholar
• Du W, Yang W, Liu E, Yang Z, Dhaliwal P, Yang B. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 2016;44(6):2846–2858. doi:10.1093/nar/gkw027
   PubMed Web of Science ®Google Scholar
• Dong R, Zhang X, Zhang Y, Ma X, Chen L, Yang L. CircRNA-derived pseudogenes. Cell Res. 2016;26(6):747–750. doi:10.1038/cr.2016.42
   PubMed Web of Science ®Google Scholar
• Liu J, Liu T, Wang X, He A. Circles reshaping the RNA world: from waste to treasure. Mol Cancer. 2017;16(1):58. doi:10.1186/s12943-017-0630-y
   PubMed Web of Science ®Google Scholar
• Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–338. doi:10.1038/nature11928
   PubMed Web of Science ®Google Scholar
• Yan T, Wunder J, Gokgoz N, et al. COPS3 amplification and clinical outcome in osteosarcoma. Cancer. 2007;109(9):1870–1876. doi:10.1002/cncr.22595
   PubMed Web of Science ®Google Scholar
• Zhong Z, Lv M, Chen J. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 2016;6:30919. doi:10.1038/srep30919
   PubMed Web of Science ®Google Scholar
• Wang Y, Shi S, Zhang Q, Dong H, Zhang J. MicroRNA-206 upregulation relieves circTCF25-induced osteosarcoma cell proliferation and migration. J Cell Physiol. 2020;2020:114.
   Google Scholar
• Wang R, Zhang S, Chen X, et al. EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Mol Cancer. 2018;17(1):166. doi:10.1186/s12943-018-0911-0
   PubMed Web of Science ®Google Scholar
• Pan G, Hu T, Chen X, Zhang C. Upregulation of circMMP9 promotes osteosarcoma progression via targeting miR-1265/CHI3L1 axis. Cancer Manag Res. 2019;11:9225–9231. doi:10.2147/CMAR.S226264
   PubMed Web of Science ®Google Scholar
• Edge S, Compton C. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–1474. doi:10.1245/s10434-010-0985-4
   PubMed Web of Science ®Google Scholar
• Ji X, Shan L, Shen P, He M. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell Death Dis. 2020;11(1):18. doi:10.1038/s41419-019-2204-y
   PubMed Web of Science ®Google Scholar
• Wang L, Wang P, Su X, Zhao B. Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p/YB-1 axis. Cell Biochem Funct. 2020;38(1):77–86. doi:10.1002/cbf.3452
   PubMed Web of Science ®Google Scholar
• Tan X, Tan D, Li H, Lin Y, Wen Z, Zeng C. circEPSTI1 acts as a ceRNA to regulate the progression of osteosarcoma. Curr Cancer Drug Targets. 2020;20(4):288–294. doi:10.2174/1568009619666191107140948
   PubMed Web of Science ®Google Scholar
• Du Y, Guo L, Pan H, Liang Y, Li X. Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. Hum Cell. 2020;33(1):252–260. doi:10.1007/s13577-019-00298-6
   PubMed Web of Science ®Google Scholar
• Hu Y, Gu J, Shen H, et al. Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma. J Clin Lab Anal. 2020;34(2):e23045. doi:10.1002/jcla.23045
   PubMed Web of Science ®Google Scholar
• Wu Z, Shi W, Jiang C. Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/β-catenin pathway by regulating miR-1205/APC2 axis. Biochem Biophys Res Commun. 2018;502(4):465–471. doi:10.1016/j.bbrc.2018.05.184
   PubMed Web of Science ®Google Scholar
• Liu Y, Qiu G, Luo Y, et al. Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis. Exp Mol Med. 2022;54(7):1024–1037. doi:10.1038/s12276-022-00806-z
   PubMed Web of Science ®Google Scholar
• Hei R, Chen J, Zhang X, et al. CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2. Am J Cancer Res. 2022;12(6):2833–2849.
   PubMed Web of Science ®Google Scholar
• Li F, Zhang L, Li W, et al. Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Oncotarget. 2015;6(8):6001–6013. doi:10.18632/oncotarget.3469
   PubMed Web of Science ®Google Scholar
• Huang G, Zhu H, Shi Y, Wu W, Cai H, Chen X. cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLoS One. 2015;10(6):e0131225. doi:10.1371/journal.pone.0131225
   PubMed Web of Science ®Google Scholar
• Wan L, Zhang L, Fan K, Cheng Z, Sun Q, Wang J. Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-catenin pathway. Biomed Res Int. 2016;2016:1579490. doi:10.1155/2016/1579490
   PubMed Web of Science ®Google Scholar
• Li H, Lan M, Liao X, Tang Z, Yang C. cir-ITCHCircular RNA promotes osteosarcoma migration and invasion through /miR-7/EGFR pathway. Technol Cancer Res Treat. 2020;19:1533033819898728.
   Web of Science ®Google Scholar
• Ren C, Liu J, Zheng B, Yan P, Sun Y, Yue B. The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22. Artif Cells. 2019;47(1):3359–3367. doi:10.1080/21691401.2019.1649273
   PubMed Web of Science ®Google Scholar
• Xu J, Xie L, Guo W. Neoadjuvant chemotherapy followed by delayed surgery: is it necessary for all patients with nonmetastatic high-grade pelvic osteosarcoma? Clin Orthop Relat Res. 2018;476(11):2177–2186. doi:10.1097/CORR.0000000000000387
   PubMed Web of Science ®Google Scholar
• Zhang C, He J, Qi L, et al. Diagnostic and prognostic significance of dysregulated expression of circular RNAs in osteosarcoma. Expert Rev Mol Diagn. 2021;21(2):235–244. doi:10.1080/14737159.2021.1874922
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274. doi:10.1016/j.ebiom.2018.07.036
   PubMed Web of Science ®Google Scholar
• Wang S, Zhang K, Tan S, et al. Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies. Mol Cancer. 2021;20(1):13. doi:10.1186/s12943-020-01298-z
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang G, Ding C, et al. Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression. Oncotarget. 2017;8(37):61687–61697. doi:10.18632/oncotarget.18671
   PubMedGoogle Scholar
• Xiao-Long M, Kun-Peng Z, Chun-Lin Z. Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma. J Cancer. 2018;9(10):1856–1862. doi:10.7150/jca.24619
   PubMed Web of Science ®Google Scholar
• Kun-Peng Z, Xiao-Long M, Chun-Lin Z. Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1. Int J Biol Sci. 2018;14(3):321–330. doi:10.7150/ijbs.24360
   PubMed Web of Science ®Google Scholar
• Gu Y, Wang G, Ran B. Has_circ_0010220 regulates the miR-574-3p/IL-6 axis to increase doxorubicin resistance in osteosarcoma. Hum Exp Toxicol. 2022;41:9603271221131307. doi:10.1177/09603271221131307
   Web of Science ®Google Scholar
• Li H, Peng K, Yang K, et al. Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies. Theranostics. 2022;12(14):6422–6436. doi:10.7150/thno.77350
   PubMed Web of Science ®Google Scholar
• Zhao X, Zhong Y, Wang X, Shen J, An W. Advances in circular RNA and its applications. Int J Med Sci. 2022;19(6):975–985. doi:10.7150/ijms.71840
   PubMed Web of Science ®Google Scholar
• Ojea-Jiménez I, Comenge J, García-Fernández L, Megson Z, Casals E, Puntes V. Engineered inorganic nanoparticles for drug delivery applications. Curr Drug Metab. 2013;14(5):518–530. doi:10.2174/13892002113149990008
   PubMed Web of Science ®Google Scholar
• Du W, Fang L, Yang W, et al. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Cell Death Differ. 2017;24(2):357–370. doi:10.1038/cdd.2016.133
   PubMed Web of Science ®Google Scholar
• Al-Sudani B, Ragazzon-Smith A, Aziz A, et al. Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Adv. 2020;10(73):45008–45018. doi:10.1039/D0RA07857C
   PubMed Web of Science ®Google Scholar
• Umekage S, Kikuchi Y. In vitro and in vivo production and purification of circular RNA aptamer. J Biotechnol. 2009;139(4):265–272. doi:10.1016/j.jbiotec.2008.12.012
   PubMed Web of Science ®Google Scholar
• Litke J, Jaffrey S. Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts. Nat Biotechnol. 2019;37(6):667–675. doi:10.1038/s41587-019-0090-6
   PubMed Web of Science ®Google Scholar
• Chen Z, Li L, Li Z, et al. Identification of key serum biomarkers for the diagnosis and metastatic prediction of osteosarcoma by analysis of immune cell infiltration. Cancer Cell Int. 2022;22(1):78. doi:10.1186/s12935-022-02500-6
   PubMed Web of Science ®Google Scholar
• Shi X, Wang B, Feng X, Xu Y, Lu K, Sun M. circRNAs and exosomes: a mysterious frontier for human cancer. Mol Ther Nucleic Acids. 2020;19:384–392. doi:10.1016/j.omtn.2019.11.023
   PubMedGoogle Scholar
• Pan Y, Lin Y, Mi C. Cisplatin-resistant osteosarcoma cell-derived exosomes confer cisplatin resistance to recipient cells in an exosomal circ_103801-dependent manner. Cell Biol Int. 2021;45(4):858–868. doi:10.1002/cbin.11532
   PubMed Web of Science ®Google Scholar
• Huo S, Dou D. Circ_0056285 regulates proliferation, apoptosis and glycolysis of osteosarcoma cells via miR-1244/TRIM44 axis. Cancer Manag Res. 2021;13:1257–1270. doi:10.2147/CMAR.S290645
   PubMed Web of Science ®Google Scholar
• Han Z, Chen H, Guo Z, et al. Circular RNAs and their role in exosomes. Front Oncol. 2022;12:848341. doi:10.3389/fonc.2022.848341
   PubMed Web of Science ®Google Scholar
• Ye D, Gong M, Deng Y, et al. Roles and clinical application of exosomal circRNAs in the diagnosis and treatment of malignant tumors. J Transl Med. 2022;20(1):161. doi:10.1186/s12967-022-03367-x
   PubMed Web of Science ®Google Scholar
• Verdi J, Ketabchi N, Noorbakhsh N, et al. Development and clinical application of tumor-derived exosomes in patients with cancer. Curr Stem Cell Res Ther. 2022;17(1):91–102. doi:10.2174/1574888X16666210622123942
   PubMed Web of Science ®Google Scholar
• Farooqi A, Desai N, Qureshi M, et al. Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds. Biotechnol Adv. 2018;36(1):328–334. doi:10.1016/j.biotechadv.2017.12.010
   PubMed Web of Science ®Google Scholar
• Wen G, Zhou T, Gu W. The potential of using blood circular RNA as liquid biopsy biomarker for human diseases. Protein Cell. 2021;12(12):911–946.
   PubMed Web of Science ®Google Scholar
• Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: from the bench to the clinic. Pharmacol Ther. 2018;187:31–44. doi:10.1016/j.pharmthera.2018.01.010
   PubMed Web of Science ®Google Scholar
• Pamudurti N, Bartok O, Jens M, et al. Translation of CircRNAs. Mol Cell. 2017;66(1):9–21.e7. doi:10.1016/j.molcel.2017.02.021
   PubMed Web of Science ®Google Scholar
• Liu J, Yang L, Fu Q, Liu S. Emerging roles and potential biological value of CircRNA in osteosarcoma. Front Oncol. 2020;10:552236. doi:10.3389/fonc.2020.552236
   PubMed Web of Science ®Google Scholar