Manganese dioxide nanosheets: from preparation to biomedical applications

Abstract

Advancements in nanotechnology and molecular biology have promoted the development of a diverse range of models to intervene in various disorders (from diagnosis to treatment and even theranostics). Manganese dioxide nanosheets (MnO₂ NSs), a typical two-dimensional (2D) transition metal oxide of nanomaterial that possesses unique structure and distinct properties have been employed in multiple disciplines in recent decades, especially in the field of biomedicine, including biocatalysis, fluorescence sensing, magnetic resonance imaging and cargo-loading functionality. A brief overview of the different synthetic methodologies for MnO₂ NSs and their state-of-the-art biomedical applications is presented below, as well as the challenges and future perspectives of MnO₂ NSs.

Keywords:

• MnO₂ nanosheets
• synthetic methods
• biocatalysis
• fluorescence sensing
• controlled drug delivery
• stimuli-activated imaging

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81771904, 81502280), the Natural Science Foundation of Jiangsu Province for the Excellent Young Scholars (BK20170054), China Postdoctoral Science Foundation (2016M601890, 177607), Qing Lan Project, the Peak of Six Talents of Jiangsu Province (WSN-112), Jiangsu Provincial Medical Youth Talent (QNRC2016776), Six One Project of Jiangsu Province (LGY2018083) and Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX18_0708).

Disclosure

The authors report no conflicts of interest in this work.