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Abstract
Recent breakthroughs in nanoparticle research have led to improved drug delivery and have overcome problems associated with normal drug delivery methods. Optimizing the design of nanoparticles in terms of controlled size, shape, and surface chemistry of nanoparticles can maximize the therapeutic efficacy. To maximize therapeutic effects, advanced formulation and fabrication methods have been developed. Biomedical applications of nanoparticles produced using the new fabrication techniques, including drug delivery and molecular imaging, have been widely explored. This review highlights the simple and versatile manufacturing techniques that can be used in the development of new types of nanoparticles that have strictly controlled physiochemical properties and their multifaceted advantages in drug delivery and molecular imaging.
Acknowledgment
This work was supported by grants from the National Research Foundation of Korea (NRF), No. 2018R1D1A1B07042339 and No. 2019K2A9A2A08000123.
Abbreviation list
CT, computed tomography; DCM, dichloromethane; DNA, deoxyribonucleic acid; DPN, discoidal polymeric nanoconstructs; EDS, Eudragit® S100; iNPG, injectable nanoparticle generator; MRI, magnetic resonance imaging; PET, positron emission tomography; PLGA, poly(lactic-co-glycolic acid); PRINT, particle replication in non-wetting templates; RBC, red blood cells; RNA, ribonucleic acid.
Disclosure
The authors report no conflicts of interest in this work.