Insights into the Implications of Coexisting Type 2 Inflammatory Diseases

Abstract

The role of type 2 inflammation in the pathogenesis of certain human diseases is an area of active investigation. Certain asthma, atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis phenotypes are characterized by a Th2 predominant inflammatory pathway and are frequently associated with comorbid conditions in patients. The purpose of this article is to review the evidence behind concurrent Th2-mediated diseases and explore how the presence of these comorbid conditions affect patient and disease outcomes.

Keywords:

• type 2 inflammation
• Th2 inflammation
• asthma
• atopic dermatitis
• eosinophilic esophagitis
• chronic rhinosinusitis

Disclosure

Dr Jivianne Lee reports personal fees from Sanofi and Regeneron, outside the submitted work. The authors report no other potential conflicts of interest for this work.