Journal of Inflammation Research, Volume 14, Issue (2021)

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Journal of Inflammation Research, Volume 14, Issue (2021)

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Original Research

Article
Potential Impact of Local Anesthetics Inducing Granulocyte Arrest and Altering Immune Functions on Perioperative Outcome
Gesche Kolle, Thomas Metterlein, Michael Gruber, Timo Seyfried, Walter Petermichl, Sophie-Marie Pfaehler, Diane Bitzinger, Sigrid Wittmann & Andre Bredthauer
Pages: 1-12
Published online: 06 Jan 2021
AbstractforPotential Impact of Local Anesthetics Inducing Granulocyte Arrest and Altering Immune Functions on Perioperative Outcome | Full Text | References | PDF (2.7 MB) | EPUB
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Open Access

Review

Review Article
Understanding COVID-19 Pandemic: Molecular Mechanisms and Potential Therapeutic Strategies. An Evidence-Based Review
Reem Hanna, Snehal Dalvi, Tudor Sălăgean, Ioana Delia Pop, Ioana Roxana Bordea & Stefano Benedicenti
Pages: 13-56
Published online: 07 Jan 2021
AbstractforUnderstanding COVID-19 Pandemic: Molecular Mechanisms and Potential Therapeutic Strategies. An Evidence-Based Review | Full Text | References | PDF (3.1 MB) | EPUB
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Open Access

Hypothesis

Discussion
Proinflammatory Cytokines: Possible Accomplices for the Systemic Effects of Clostridioides difficile Toxin B
Katia Fettucciari, Alessandro Fruganti, Andrea Marchegiani, Stefano Brancorsini, Pierfrancesco Marconi & Gabrio Bassotti
Pages: 57-62
Published online: 11 Jan 2021
AbstractforProinflammatory Cytokines: Possible Accomplices for the Systemic Effects of Clostridioides difficile Toxin B | Full Text | References | PDF (2.3 MB) | EPUB
  • 81 Views
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Open Access

Original Research

Article
Inhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival
Ao Ren, Zhongqiu Li, Xuzhi Zhang, Ronghai Deng & Yi Ma
Pages: 63-73
Published online: 12 Jan 2021
AbstractforInhibition of Dectin-1 on Dendritic Cells Prevents Maturation and Prolongs Murine Islet Allograft Survival | Full Text | References | PDF (8.2 MB) | EPUB
  • 75 Views
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Open Access

Review

Review Article
The Role of Regulatory B Cells in Health and Diseases: A Systemic Review
Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie, Teklie Mengie Ayele, Nega Dagnew Baye, Assefa Agegnehu Teshome & Zelalem Tilahun Muche
Pages: 75-84
Published online: 12 Jan 2021
AbstractforThe Role of Regulatory B Cells in Health and Diseases: A Systemic Review | Full Text | References | PDF (316.6 KB) | EPUB
  • 602 Views
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Open Access

Original Research

Article
Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation
Chengxin Shi, Fengli Yue, Feiyu Shi, Qian Qin, Lizhao Wang, Guanghui Wang, Lijun Mu, Dan Liu, Yaguang Li, Tianyu Yu & Junjun She
Pages: 85-95
Published online: 18 Jul 2023
AbstractforSelenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation | Full Text | References | PDF (4.7 MB) | EPUB
  • 103 Views
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Open Access
Article
Identification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer
Fangteng Liu & Hengyu Wu
Pages: 97-114
Published online: 14 Jan 2021
AbstractforIdentification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer | Full Text | References | PDF (13 MB) | EPUB
  • 72 Views
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Open Access
Article
The Role of Cancer-Elicited Inflammatory Biomarkers in Predicting Early Recurrence Within Stage II–III Colorectal Cancer Patients After Curable Resection
Hou-Qun Ying, Yu-Cui Liao, Fan Sun, Hong-Xin Peng & Xue-Xin Cheng
Pages: 115-129
Published online: 18 Jan 2021
AbstractforThe Role of Cancer-Elicited Inflammatory Biomarkers in Predicting Early Recurrence Within Stage II–III Colorectal Cancer Patients After Curable Resection | Full Text | References | PDF (5.3 MB) | EPUB
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Open Access

Review

Review Article
Studying Neutrophil Function in vitro: Cell Models and Environmental Factors
Marfa Blanter, Mieke Gouwy & Sofie Struyf
Pages: 141-162
Published online: 20 Jan 2021
AbstractforStudying Neutrophil Function in vitro: Cell Models and Environmental Factors | Full Text | References | PDF (1.5 MB) | EPUB
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Open Access

Original Research

Article
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease
Paulina Krawiec & Elżbieta Pac-Kożuchowska
Pages: 163-174
Published online: 22 Jan 2021
AbstractforCathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease | Full Text | References | PDF (2.4 MB) | EPUB
  • 84 Views
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Open Access

Review

Review Article
Cytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms
Mohsin Ali Khan, Zaw Ali Khan, Mark Charles, Pushpendra Pratap, Abdul Naeem, Zainab Siddiqui, Nigar Naqvi & Shikha Srivastava
Pages: 175-189
Published online: 22 Jan 2021
AbstractforCytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms | Full Text | References | PDF (9 MB) | EPUB
  • 108 Views
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Open Access

Short Report

Brief Report
In vitro Phenotype Induction of Circulating Monocytes: CD16 and CD163 Analysis
Claudio Karsulovic, Fabian Tempio, Mercedes Lopez, Julia Guerrero & Annelise Goecke
Pages: 191-198
Published online: 18 Jul 2023
AbstractforIn vitro Phenotype Induction of Circulating Monocytes: CD16 and CD163 Analysis | Full Text | References | PDF (2.3 MB) | EPUB
  • 74 Views
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Open Access

Review

Review Article
Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality
Bushra Mdkhana, Narjes Saheb Sharif-Askari, Rakhee K Ramakrishnan, Swati Goel, Qutayba Hamid & Rabih Halwani
Pages: 199-216
Published online: 18 Jul 2023
AbstractforNucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality | Full Text | References | PDF (1.7 MB) | EPUB
  • 121 Views
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Open Access

Original Research

Article
Inducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis
Qing Zhang, Hu-Xinyue Duan, Ruo-Lan Li, Jia-Yi Sun, Jia Liu, Wei Peng, Chun-Jie Wu & Yong-Xiang Gao
Pages: 217-236
Published online: 26 Jan 2021
AbstractforInducing Apoptosis and Suppressing Inflammatory Reactions in Synovial Fibroblasts are Two Important Ways for Guizhi-Shaoyao-Zhimu Decoction Against Rheumatoid Arthritis | Full Text | References | PDF (11.7 MB) | EPUB
  • 71 Views
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Open Access
Article
Clinical Implications of Intestinal Barrier Damage in Psoriasis
Mariusz Sikora, Albert Stec, Magdalena Chrabaszcz, Joanna Giebultowicz, Emilia Samborowska, Radoslaw Jazwiec, Michal Dadlez, Malgorzata Olszewska & Lidia Rudnicka
Pages: 237-243
Published online: 27 Jan 2021
AbstractforClinical Implications of Intestinal Barrier Damage in Psoriasis | Full Text | References | PDF (602 KB) | EPUB
  • 112 Views
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Open Access

Review

Review Article
Neopterin: A Promising Candidate Biomarker for Severe COVID-19
Wasihun Hailemichael, Mulugeta Kiros, Yibeltal Akelew, Sisay Getu & Henok Andualem
Pages: 245-251
Published online: 02 Feb 2021
AbstractforNeopterin: A Promising Candidate Biomarker for Severe COVID-19 | Full Text | References | PDF (1.1 MB) | EPUB
  • 99 Views
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Open Access
Review Article
Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?
Gopa Mahesh, Kotha Anil Kumar & Pallu Reddanna
Pages: 253-263
Published online: 03 Feb 2021
AbstractforOverview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2? | Full Text | References | PDF (2.4 MB) | EPUB
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Open Access

Corrigendum

Correction
Association of Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism and Susceptibility to SLE in Egyptian Children and Adolescents: A Multicenter Study [Corrigendum]
Page: 265
Published online: 04 Feb 2021
CitationforAssociation of Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G Polymorphism and Susceptibility to SLE in Egyptian Children and Adolescents: A Multicenter Study [Corrigendum] | Full Text | PDF (169.9 KB) | EPUB
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Open Access

Original Research

Article
CC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets
Fangteng Liu & Hengyu Wu
Pages: 267-285
Published online: 05 Feb 2021
AbstractforCC Chemokine Receptors in Lung Adenocarcinoma: The Inflammation-Related Prognostic Biomarkers and Immunotherapeutic Targets | Full Text | References | PDF (17.2 MB) | EPUB
  • 101 Views
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Open Access
Article
Analysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19
Xiao-Yu Zhang, Tao Li, Haibing Wu, Yun Ling, Zhi-Ping Qian & Liang Chen
Pages: 287-298
Published online: 05 Feb 2021
AbstractforAnalysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19 | Full Text | References | PDF (442.7 KB) | EPUB
  • 72 Views
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Open Access
Article
Aryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis
Kwei-Yan Liu, Li-Ting Wang, Hsueh-Chun Wang, Shen-Nien Wang, Li-Wen Tseng, Chee-Yin Chai, Shyh-Shin Chiou, Shau-Ku Huang & Shih-Hsien Hsu
Pages: 299-311
Published online: 05 Feb 2021
AbstractforAryl Hydrocarbon Receptor is Essential in the Control of Lung Club Cell Homeostasis | Full Text | References | PDF (8.4 MB) | EPUB
  • 68 Views
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Open Access
Article
Association of a High Neutrophil-to-Lymphocyte Ratio with Hyperdense Artery Sign and Unfavorable Short-Term Outcomes in Patients with Acute Ischemic Stroke
Shinn-Kuang Lin, Pei-Ya Chen, Guei-Chiuan Chen, Po-Jen Hsu, Cheng-Lun Hsiao, Fu-Yi Yang, Chih-Yang Liu & Adam Tsou
Pages: 313-324
Published online: 05 Feb 2021
AbstractforAssociation of a High Neutrophil-to-Lymphocyte Ratio with Hyperdense Artery Sign and Unfavorable Short-Term Outcomes in Patients with Acute Ischemic Stroke | Full Text | References | PDF (1.2 MB) | EPUB
  • 69 Views
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Open Access
Article
Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity
Yan Chen, Jiafei Cheng, Yiling Zhang, Jiande D Z Chen & Florin M Seralu
Pages: 325-339
Published online: 05 Feb 2021
AbstractforElectroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity | Full Text | References | PDF (12.4 MB) | EPUB
  • 78 Views
  • 9 CrossRef citations
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Open Access
Article
Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways
Zhen-Hua Ying, Hui-Min Li, Wen-Ying Yu & Chen-Huan Yu
Pages: 341-354
Published online: 18 Jul 2023
AbstractforIridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways | Full Text | References | PDF (3.3 MB) | EPUB
  • 95 Views
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Open Access
Article
Exposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring
Yo Shimizu, Tsuyoshi Tsukada, Hiromi Sakata-Haga, Daisuke Sakai, Hiroki Shoji, Yutaka Saikawa & Toshihisa Hatta
Pages: 355-365
Published online: 12 Feb 2021
AbstractforExposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring | Full Text | References | PDF (5.3 MB) | EPUB
  • 82 Views
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Open Access
Article
Adenosine A2A Receptor Agonist Polydeoxyribonucleotide Alleviates Interstitial Cystitis-Induced Voiding Dysfunction by Suppressing Inflammation and Apoptosis in Rats
Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Kyu Yeoun Won, Yong Gil Na, Khae Hawn Kim & Su Jin Kim
Pages: 367-378
Published online: 15 Feb 2021
AbstractforAdenosine A2A Receptor Agonist Polydeoxyribonucleotide Alleviates Interstitial Cystitis-Induced Voiding Dysfunction by Suppressing Inflammation and Apoptosis in Rats | Full Text | References | PDF (7.4 MB) | EPUB
  • 90 Views
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Open Access

Review

Review Article
Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics
Ling-Zhi Hong, Qi Xue & Hong Shao
Pages: 379-392
Published online: 16 Feb 2021
AbstractforInflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics | Full Text | References | PDF (1.2 MB) | EPUB
  • 79 Views
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Open Access

Erratum

Correction
Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity [Erratum]
Page: 393
Published online: 16 Feb 2021
CitationforElectroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity [Erratum] | Full Text | PDF (158.2 KB) | EPUB
  • 54 Views
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Open Access

Original Research

Article
Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR-γ Signaling
Jian Zuo, Meng-Qing Tao, Xin-Yue Wu, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Jiyang Dong, Jun Han & Cong-Lan Ji
Pages: 395-411
Published online: 16 Feb 2021
AbstractforSecuridaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR-γ Signaling | Full Text | References | PDF (12 MB) | EPUB
  • 82 Views
  • 11 CrossRef citations
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Open Access
Article
Comprehensive Analysis of LncRNA-mRNA Expression Profiles and the ceRNA Network Associated with Pyroptosis in LPS-Induced Acute Lung Injury
Deqiang Luo, Fen Liu, Jianguo Zhang, Qiang Shao, Wenqiang Tao, Rui Xiao, Wei Dai, Chengzhi Ding & Kejian Qian
Pages: 413-428
Published online: 18 Jul 2023
AbstractforComprehensive Analysis of LncRNA-mRNA Expression Profiles and the ceRNA Network Associated with Pyroptosis in LPS-Induced Acute Lung Injury | Full Text | References | PDF (15.4 MB) | EPUB
  • 62 Views
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Open Access
Article
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease
Elena Milanesi, Gina Manda, Maria Dobre, Elena Codrici, Ionela Victoria Neagoe, Bogdan Ovidiu Popescu, Ovidiu Alexandru Bajenaru, Luiza Spiru, Catalina Tudose, Gabriel-Ioan Prada, Eugenia Irene Davidescu, Gerard Piñol-Ripoll & Antonio Cuadrado
Pages: 429-442
Published online: 18 Feb 2021
AbstractforDistinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease | Full Text | References | PDF (8.2 MB) | EPUB
  • 68 Views
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Open Access
Article
Therapeutic Potentials of Colocasia affinis Leaf Extract for the Alleviation of Streptozotocin-Induced Diabetes and Diabetic Complications: In vivo and in silico-Based Studies
Manik Chandra Shill, Asim Kumar Bepari, Mahi Khan, Zarin Tasneem, Tania Ahmed, Md Asif Hasan, Md Jahir Alam, Murad Hossain, Md Ashrafur Rahman, Shazid Md Sharker, Masum Shahriar, Ghazi Muhammad Sayedur Rahman & Hasan Mahmud Reza
Pages: 443-459
Published online: 19 Feb 2021
AbstractforTherapeutic Potentials of Colocasia affinis Leaf Extract for the Alleviation of Streptozotocin-Induced Diabetes and Diabetic Complications: In vivo and in silico-Based Studies | Full Text | References | PDF (6.1 MB) | EPUB
  • 103 Views
  • 2 CrossRef citations
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Open Access
Article
Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ
Qiang Wang, Hao Wang, Qingxu Jing, Yang Yang, Dongbo Xue, Chenjun Hao & Weihui Zhang
Pages: 461-477
Published online: 24 Feb 2021
AbstractforRegulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ | Full Text | References | PDF (11.4 MB) | EPUB
  • 76 Views
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Open Access
Article
Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System
Yi-Fang Meng, Qi Pu, San-You Dai, Qian Ma, Xinyu Li & Wei Zhu
Pages: 479-493
Published online: 22 Feb 2021
AbstractforNicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System | Full Text | References | PDF (6.1 MB) | EPUB
  • 88 Views
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Open Access
Article
Potential Biomarkers for Diagnosing Major Depressive Disorder Patients with Suicidal Ideation
Shunjie Bai, Liang Fang, Jing Xie, Huili Bai, Wei Wang & Jian-jun Chen
Pages: 495-503
Published online: 22 Feb 2021
AbstractforPotential Biomarkers for Diagnosing Major Depressive Disorder Patients with Suicidal Ideation | Full Text | References | PDF (2.6 MB) | EPUB
  • 116 Views
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Open Access
Article
AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling
Wen-Ching Shen, Yu-Hsiang Chou, Li-Shian Shi, Zhi-wei Chen, Hai-Jian Tu, Xin-yi Lin & Guei-Jane Wang
Pages: 505-518
Published online: 24 Feb 2021
AbstractforAST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling | Full Text | References | PDF (8.4 MB) | EPUB
  • 87 Views
  • 7 CrossRef citations
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Open Access
Article
Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs
Shuyan Zhang, Tao Luo & Jinke Wang
Pages: 917-928
Published online: 18 Jul 2023
AbstractforStable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs | Full Text | References | PDF (14.5 MB) | EPUB
  • 69 Views
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Open Access

Hypothesis

Discussion
The Binary Classification of Protein Kinases
Zeev Elkoshi
Pages: 929-947
Published online: 18 Mar 2021
AbstractforThe Binary Classification of Protein Kinases | Full Text | References | PDF (1.6 MB) | EPUB
  • 74 Views
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Open Access

Original Research

Article
Poor Clearance of Free Hemoglobin Due to Lower Active Haptoglobin Availability is Associated with Osteoarthritis Inflammation
Ashish Sarkar, Monu, Vijay Kumar, Rajesh Malhotra, Hemant Pandit, Elena Jones, Frederique Ponchel & Sagarika Biswas
Pages: 949-964
Published online: 18 Jul 2023
AbstractforPoor Clearance of Free Hemoglobin Due to Lower Active Haptoglobin Availability is Associated with Osteoarthritis Inflammation | Full Text | References | PDF (4.3 MB) | EPUB
  • 107 Views
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Open Access

Clinical Trial Report

Case Report
Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial
Mariana A Vetrici, Soheila Mokmeli, Andrew R Bohm, Monica Monici & Scott A Sigman
Pages: 965-979
Published online: 19 Mar 2021
AbstractforEvaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial | Full Text | References | PDF (4 MB) | EPUB
  • 107 Views
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Open Access

Original Research

Article
Mechanisms of Adiponectin in Regulation of Proinflammatory Cytokine Production and Migration in Macrophages
Xiaogao Jin & Yanlin Wang
Pages: 981-993
Published online: 22 Mar 2021
AbstractforMechanisms of Adiponectin in Regulation of Proinflammatory Cytokine Production and Migration in Macrophages | Full Text | References | PDF (1.2 MB) | EPUB
  • 74 Views
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Open Access
Article
The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study
Michael C Tanner, Raban Arved Heller, Andreas Grimm, Stefan Zimmermann, Maximilian Pilz, Louisa Jurytko, Matthias Miska, Lars Helbig, Gerhard Schmidmaier & Patrick Haubruck
Pages: 995-1005
Published online: 22 Mar 2021
AbstractforThe Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study | Full Text | References | PDF (2.2 MB) | EPUB
  • 86 Views
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Open Access
Article
CTRP9 Enhances Efferocytosis in Macrophages via MAPK/Drp1-Mediated Mitochondrial Fission and AdipoR1-Induced Immunometabolism
Cheng-Xiang Song, Ji-Ying Chen, Na Li & Yuan Guo
Pages: 1007-1017
Published online: 23 Mar 2021
AbstractforCTRP9 Enhances Efferocytosis in Macrophages via MAPK/Drp1-Mediated Mitochondrial Fission and AdipoR1-Induced Immunometabolism | Full Text | References | PDF (5.8 MB) | EPUB
  • 65 Views
  • 9 CrossRef citations
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Open Access
Article
BT2 Suppresses Human Monocytic-Endothelial Cell Adhesion, Bone Erosion and Inflammation
Mei-Chun Yeh, Ben J Wu, Yue Li, Mina Elahy, Leonel Prado-Lourenco, Jim Sockler, Herman Lau, Ric O Day & Levon M Khachigian
Pages: 1019-1028
Published online: 23 Mar 2021
AbstractforBT2 Suppresses Human Monocytic-Endothelial Cell Adhesion, Bone Erosion and Inflammation | Full Text | References | PDF (583.6 KB) | EPUB
  • 78 Views
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Open Access
Article
The Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation
Yaying Sun, Jinrong Lin, Zhiwen Luo, Yuhan Zhang & Jiwu Chen
Pages: 1055-1068
Published online: 23 Mar 2021
AbstractforThe Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation | Full Text | References | PDF (9.6 MB) | EPUB
  • 74 Views
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Open Access
Article
FUT7 Promotes the Epithelial–Mesenchymal Transition and Immune Infiltration in Bladder Urothelial Carcinoma
Mulin Liu, Qin Zheng, Siyi Chen, Jiwei Liu & Shijun Li
Pages: 1069-1084
Published online: 18 Jul 2023
AbstractforFUT7 Promotes the Epithelial–Mesenchymal Transition and Immune Infiltration in Bladder Urothelial Carcinoma | Full Text | References | PDF (843.1 KB) | EPUB
  • 70 Views
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Open Access
Article
Restraint Stress in Hypertensive Rats Activates the Intestinal Macrophages and Reduces Intestinal Barrier Accompanied by Intestinal Flora Dysbiosis
Tiantian Wang, Lei Gao, Zejun Yang, Feifei Wang, Yuexin Guo, Boya Wang, Rongxuan Hua, Hongwei Shang & Jingdong Xu
Pages: 1085-1110
Published online: 25 Mar 2021
AbstractforRestraint Stress in Hypertensive Rats Activates the Intestinal Macrophages and Reduces Intestinal Barrier Accompanied by Intestinal Flora Dysbiosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 78 Views
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Open Access
Article
Longitudinal Chest CT Features in Severe/Critical COVID-19 Cases and the Predictive Value of the Initial CT for Mortality
Hailan Li, Shiyong Luo, Youming Zhang, Xiaoyi Xiao & Huaping Liu
Pages: 1111-1124
Published online: 25 Mar 2021
AbstractforLongitudinal Chest CT Features in Severe/Critical COVID-19 Cases and the Predictive Value of the Initial CT for Mortality | Full Text | References | PDF (8.3 MB) | EPUB
  • 69 Views
  • 4 CrossRef citations
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Open Access
Article
MicroRNA-138-5p Regulates Hippocampal Neuroinflammation and Cognitive Impairment by NLRP3/Caspase-1 Signaling Pathway in Rats
Xiaojin Feng, Jialing Hu, Fenfang Zhan, Deqiang Luo, Fuzhou Hua & Guohai Xu
Pages: 1125-1143
Published online: 26 Mar 2021
AbstractforMicroRNA-138-5p Regulates Hippocampal Neuroinflammation and Cognitive Impairment by NLRP3/Caspase-1 Signaling Pathway in Rats | Full Text | References | PDF (6.9 MB) | EPUB
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Article
Helping Roles of Artificial Intelligence (AI) in the Screening and Evaluation of COVID-19 Based on the CT Images
Hui Xie, Qing Li, Ping-Feng Hu, Sen-Hua Zhu, Jian-Fang Zhang, Hong-Da Zhou & Hai-Bo Zhou
Pages: 1165-1172
Published online: 18 Jul 2023
AbstractforHelping Roles of Artificial Intelligence (AI) in the Screening and Evaluation of COVID-19 Based on the CT Images | Full Text | References | PDF (1.5 MB) | EPUB
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Review

Review Article
Current Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers
Yayun Xu & Feihu Chen
Pages: 1185-1193
Published online: 30 Mar 2021
AbstractforCurrent Status of Functional Studies on Circular RNAs in Rheumatoid Arthritis and Their Potential Role as Diagnostic Biomarkers | Full Text | References | PDF (569.7 KB) | EPUB
  • 71 Views
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Original Research

Article
Anti-Inflammatory and Antiviral Osmotic Polymeric Film to Treat Covid-19 Early-Stage Infection
Ravi Shrivastava, Remi Shrivastava, Bianca Johansen & Thibault Allain
Pages: 1195-1206
Published online: 18 Jul 2023
AbstractforAnti-Inflammatory and Antiviral Osmotic Polymeric Film to Treat Covid-19 Early-Stage Infection | Full Text | References | PDF (1 MB) | EPUB
  • 93 Views
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Article
Association of Early Inflammation with Age and Asymptomatic Disease in COVID-19
Chunmei Xie, Qing Li, Linhai Li, Xiaohua Peng, Zhijian Ling, Bin Xiao, Jingjing Feng, Zhenhong Chen, De Chang, Lixin Xie, Charles S Dela Cruz & Lokesh Sharma
Pages: 1207-1216
Published online: 30 Mar 2021
AbstractforAssociation of Early Inflammation with Age and Asymptomatic Disease in COVID-19 | Full Text | References | PDF (488.7 KB) | EPUB
  • 103 Views
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Article
Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling
Yu-fan Yang, Hui Wang, Nan Song, Ya-hui Jiang, Jun Zhang, Xiao-wen Meng, Xiao-mei Feng, Hong Liu, Ke Peng & Fu-hai Ji
Pages: 1217-1233
Published online: 31 Mar 2021
AbstractforDexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling | Full Text | References | PDF (13 MB) | EPUB
  • 71 Views
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Article
White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
Jae-Min Park, Hye Sun Lee, Ju-Young Park, Dong-Hyuk Jung & Ji-Won Lee
Pages: 1235-1242
Published online: 01 Apr 2021
AbstractforWhite Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study | Full Text | References | PDF (823.9 KB) | EPUB
  • 84 Views
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Article
Tripterygium wilfordii Polyglycoside Ameliorated TNBS-Induced Colitis in Rats via Regulating Th17/Treg Balance in Intestinal Mucosa
Cui Zhang, Jingyi Ju, Xiaohan Wu, Jiaolan Yang, Qinglu Yang, Changqin Liu, Liang Chen & Xiaomin Sun
Pages: 1243-1255
Published online: 01 Apr 2021
AbstractforTripterygium wilfordii Polyglycoside Ameliorated TNBS-Induced Colitis in Rats via Regulating Th17/Treg Balance in Intestinal Mucosa | Full Text | References | PDF (6.6 MB) | EPUB
  • 91 Views
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Article
Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis
Scott A Read, Brian S Gloss, Christopher Liddle, Jacob George & Golo Ahlenstiel
Pages: 1257-1270
Published online: 01 Apr 2021
AbstractforInterferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis | Full Text | References | PDF (854.4 KB) | EPUB
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Article
Hypothermia Protects Mice Against Ischemic Stroke by Modulating Macrophage Polarization Through Upregulation of Interferon Regulatory Factor-4
Xinyuan Yu, Yanping Feng, Renzhong Liu & Qianxue Chen
Pages: 1271-1281
Published online: 07 Apr 2021
AbstractforHypothermia Protects Mice Against Ischemic Stroke by Modulating Macrophage Polarization Through Upregulation of Interferon Regulatory Factor-4 | Full Text | References | PDF (5 MB) | EPUB
  • 66 Views
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Article
RETRACTED ARTICLE: SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury
Dawei Wang, Hongyan Cao, Xu Wang, Jinchun Wang, Manli Wang, Jian Zhang & Lin Wang
Pages: 1283-1296
Published online: 07 Apr 2021
AbstractforRETRACTED ARTICLE: SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury | PDF (13.1 MB)
  • 19 Views
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Article
Lack of Macrophage Migration Inhibitory Factor Reduces Susceptibility to Ventricular Arrhythmias During the Acute Phase of Myocardial Infarction
Juanjuan Lyu, Jia Huang, Jin Wu, Tao Yu, Xinchuan Wei & Qian Lei
Pages: 1297-1311
Published online: 07 Apr 2021
AbstractforLack of Macrophage Migration Inhibitory Factor Reduces Susceptibility to Ventricular Arrhythmias During the Acute Phase of Myocardial Infarction | Full Text | References | PDF (843.5 KB) | EPUB
  • 58 Views
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Article
RETRACTED ARTICLE: Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway
Komal Naeem, Lina Tariq Al Kury, Faiza Nasar, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Arif-ullah Khan & Shupeng Li
Pages: 1313-1329
Published online: 18 Jul 2023
AbstractforRETRACTED ARTICLE: Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway | PDF (927.8 KB)
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Article
Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
Jingjing Xu, Zhiyu Liu, Haitao Liu, Yunpeng Luo, Kai Kang, Xueting Li, Wei Yang, Dongsheng Fei, Changsong Wang & Kaijiang Yu
Pages: 1331-1340
Published online: 09 Apr 2021
AbstractforDecreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study | Full Text | References | PDF (1.7 MB) | EPUB
  • 64 Views
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Article
Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model
Lu Jing, Liyan Hou, Dongdong Zhang, Sheng Li, Zhengzheng Ruan, Xiaomeng Zhang, Jau-Shyong Hong & Qingshan Wang
Pages: 1341-1356
Published online: 18 Jul 2023
AbstractforMicroglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model | Full Text | References | PDF (9.5 MB) | EPUB
  • 114 Views
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Article
The Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation
Guanhua Li, Jianfeng Zeng, Zhaoyuan Liu, Yu Zhang & Xiaoping Fan
Pages: 1357-1364
Published online: 12 Apr 2021
AbstractforThe Pulsatile Modification Improves Hemodynamics and Attenuates Inflammatory Responses in Extracorporeal Membrane Oxygenation | Full Text | References | PDF (980.4 KB) | EPUB
  • 70 Views
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Article
Changes in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study
Ahmed Salman, Hossam El-Din Shaaban, Mohamed Salman, Sayed M Seif El Nasr, Ahmed Soliman, Abdoh Salem, Mohamed Tag El-Din, Hani Maurice Sabri Mikhail, Heba El Domiaty, Nesrin Abd Allah, Ghada M K GabAllah & Ahmed Youssef
Pages: 1365-1373
Published online: 18 Jul 2023
AbstractforChanges in Plasma Growth Differentiation Factor-15 After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients: A Prospective Study | Full Text | References | PDF (320.8 KB) | EPUB
  • 69 Views
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Article
LXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice
Hong-Xia Mei, Yang Ye, Hao-Ran Xu, Shu-Yang Xiang, Qian Yang, Hong-Yu Ma, Sheng-Wei Jin & Qian Wang
Pages: 1375-1385
Published online: 12 Apr 2021
AbstractforLXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice | Full Text | References | PDF (6.7 MB) | EPUB
  • 74 Views
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Article
Hydrogen (H2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway
Hongwei Lu, Wei Wang, Xiaodiao Kang, Zeng Lin, Jun Pan, Shaowen Cheng & Jingdong Zhang
Pages: 1387-1402
Published online: 13 Apr 2021
AbstractforHydrogen (H2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway | Full Text | References | PDF (822 KB) | EPUB
  • 123 Views
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Article
Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study
Xiaofen Hu, Ruijie Li, Ming Sun, Ying Kong, Haifeng Zhu, Fujiang Wang & Quanqing Wan
Pages: 1403-1414
Published online: 13 Apr 2021
AbstractforIsovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study | Full Text | References | PDF (7.7 MB) | EPUB
  • 72 Views
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Article
Acute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection
Mary Tetteh, Otchere Addai-Mensah, Zakaria Siedu, Eric Kyei-Baafour, Helena Lamptey, Jovis Williams, Edward Kupeh, Godfred Egbi, Anna Boadi Kwayie, Gabriel Abbam, David Amoah Afrifah, Alexander Yaw Debrah & Michael Fokuo Ofori
Pages: 1415-1426
Published online: 18 Jul 2023
AbstractforAcute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection | Full Text | References | PDF (3.9 MB) | EPUB
  • 73 Views
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Article
Research on Correlation Between Psychological Factors, Mast Cells, and PAR-2 Signal Pathway in Irritable Bowel syndrome
Guanqun Chao, Zhaojun Wang & Shuo Zhang
Pages: 1427-1436
Published online: 14 Apr 2021
AbstractforResearch on Correlation Between Psychological Factors, Mast Cells, and PAR-2 Signal Pathway in Irritable Bowel syndrome | Full Text | References | PDF (738.6 KB) | EPUB
  • 92 Views
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Article
Diet-Related Inflammation is Associated with Major Depressive Disorder in Bahraini Adults: Results of a Case-Control Study Using the Dietary Inflammatory Index
Wen Chen, Mo’ez Al-Islam E Faris, Nicola Luigi Bragazzi, Haifa M S AlGahtani, Zahra Saif, Ahmed Jahrami, Nitin Shivappa, James R Hebert & Haitham Jahrami
Pages: 1437-1445
Published online: 15 Apr 2021
AbstractforDiet-Related Inflammation is Associated with Major Depressive Disorder in Bahraini Adults: Results of a Case-Control Study Using the Dietary Inflammatory Index | Full Text | References | PDF (318.6 KB) | EPUB
  • 205 Views
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Article
Study of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis
Lei Li, Ling Chen, Fang Lin, Jinsong Mu, Dan Wang, Wei Zhang, Lai Mi, Yuling Qin & Yuesu Zhou
Pages: 1447-1453
Published online: 18 Jul 2023
AbstractforStudy of the Expression of Inflammatory Factors IL-4, IL-6, IL-10, and IL-17 in Liver Failure Complicated by Coagulation Dysfunction and Sepsis | Full Text | References | PDF (1.8 MB) | EPUB
  • 95 Views
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Article
Integrated Systems Pharmacology and Surface Plasmon Resonance Approaches to Reveal the Synergistic Effect of Multiple Components of Gu-Ben-Ke-Chuan Decoction on Chronic Bronchitis
Zhiqiang Luo, Guohua Yu, Wubin Wang, Rui Sun, Binbin Zhang, Jing Wang, Jing Liu, Shan Gao, Peng Wang & Yuanyuan Shi
Pages: 1455-1471
Published online: 15 Apr 2021
AbstractforIntegrated Systems Pharmacology and Surface Plasmon Resonance Approaches to Reveal the Synergistic Effect of Multiple Components of Gu-Ben-Ke-Chuan Decoction on Chronic Bronchitis | Full Text | References | PDF (8.3 MB) | EPUB
  • 79 Views
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Article
Histone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure
Yao Wang, Xun Li, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang & Zuojiong Gong
Pages: 1473-1485
Published online: 18 Jul 2023
AbstractforHistone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure | Full Text | References | PDF (8.5 MB) | EPUB
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Review

Review Article
Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications
Adekunle Babajide Rowaiye, Okiemute Ajiroghene Okpalefe, Olukemi Onuh Adejoke, Joyce Oloaigbe Ogidigo, Oluwakemi Hannah Oladipo, Amoge Chidinma Ogu, Angus Nnamdi Oli, Samson Olofinase, Onyekachi Onyekwere, Abdullahi Rabiu Abubakar, Dilshad Jahan, Salequl Islam, Siddhartha Dutta & Mainul Haque
Pages: 1487-1510
Published online: 16 Apr 2021
AbstractforAttenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications | Full Text | References | PDF (3.9 MB) | EPUB
  • 272 Views
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Original Research

Article
Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
Faris A Alrumaihi, Masood A Khan, Khaled S Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Hina Younus, Sultan A Alsuhaibani, Mohammad Algahtani & Arif Khan
Pages: 1511-1535
Published online: 18 Jul 2023
AbstractforMethanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 135 Views
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Article
Rosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway
Hao-Ran Xu, Qian Yang, Shu-Yang Xiang, Pu-Hong Zhang, Yang Ye, Yan Chen, Ke-Wen Xu, Xi-Ya Ren, Hong-Xia Mei, Chen-Xi Shen, Hong-Yu Ma, Fang-Gao Smith, Sheng-Wei Jin & Qian Wang
Pages: 1537-1549
Published online: 18 Jul 2023
AbstractforRosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway | Full Text | References | PDF (873.1 KB) | EPUB
  • 77 Views
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Article
HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury
Min Zhou, Yadi Zhang, Rui Tang, Haiyan Liu, Min Du, Zhi Gao, Zongshu Ji & Haoshu Fang
Pages: 1551-1561
Published online: 18 Jul 2023
AbstractforHMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury | Full Text | References | PDF (5.4 MB) | EPUB
  • 89 Views
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Article
Silenced SNHG1 Inhibited Epithelial-Mesenchymal Transition and Inflammatory Response of ARPE-19 Cells Induced by High Glucose
Jing Yang, Kun Yang, Xuxia Meng, Penghui Liu, Yudong Fu & Yibo Wang
Pages: 1563-1573
Published online: 20 Apr 2021
AbstractforSilenced SNHG1 Inhibited Epithelial-Mesenchymal Transition and Inflammatory Response of ARPE-19 Cells Induced by High Glucose | Full Text | References | PDF (6.6 MB) | EPUB
  • 71 Views
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Review

Review Article
Inflammasome as an Effective Platform for Fibrosis Therapy
Ting-Ting Chen, Feng Xiao, Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei & Wu-Yi Sun
Pages: 1575-1590
Published online: 20 Apr 2021
AbstractforInflammasome as an Effective Platform for Fibrosis Therapy | Full Text | References | PDF (3.2 MB) | EPUB
  • 69 Views
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Original Research

Article
Models Based on Dynamic Clinicopathological Indices for Predicting Prognosis During the Perioperative Period for Patients with Colorectal Cancer
Yifei Ma, Ping Lu, Xinjun Liang & Shaozhong Wei
Pages: 1591-1601
Published online: 18 Jul 2023
AbstractforModels Based on Dynamic Clinicopathological Indices for Predicting Prognosis During the Perioperative Period for Patients with Colorectal Cancer | Full Text | References | PDF (526.8 KB) | EPUB
  • 64 Views
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Article
Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
Johann Lechner, Marlene Schmidt, Volker von Baehr & Fabian Schick
Pages: 1603-1612
Published online: 21 Apr 2021
AbstractforUndetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions? | Full Text | References | PDF (403 KB) | EPUB
  • 85 Views
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Article
Comprehensive Identification of Bridge Genes to Explain the Progression from Chronic Hepatitis B Virus Infection to Hepatocellular Carcinoma
Wenwei Nong, Liping Ma, Biyang Lan, Ning Liu, Hongzhi Yang, Xiaoxia Lao, Qiaomei Deng & Zhihu Huang
Pages: 1613-1624
Published online: 21 Apr 2021
AbstractforComprehensive Identification of Bridge Genes to Explain the Progression from Chronic Hepatitis B Virus Infection to Hepatocellular Carcinoma | Full Text | References | PDF (8.4 MB) | EPUB
  • 184 Views
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Article
Chemokine Receptor 2 (CXCR2) Gene Polymorphisms and Their Association with the Risk of Developing Peri-Implantitis in Chinese Han Population
Yuesun Qi, Cheng Li, Yimin Du, Jichao Lin, Nan Li & Youcheng Yu
Pages: 1625-1631
Published online: 23 Apr 2021
AbstractforChemokine Receptor 2 (CXCR2) Gene Polymorphisms and Their Association with the Risk of Developing Peri-Implantitis in Chinese Han Population | Full Text | References | PDF (283.3 KB) | EPUB
  • 69 Views
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Article
An Indole-2-Carboxamide Derivative, LG4, Alleviates Diabetic Kidney Disease Through Inhibiting MAPK-Mediated Inflammatory Responses
Jianchang Qian, Sihui Yin, Lin Ye, Zhe Wang, Sheng Shu, Zhenxin Mou, Mingjiang Xu, Nipon Chattipakorn, Zhiguo Liu & Guang Liang
Pages: 1633-1645
Published online: 27 Apr 2021
AbstractforAn Indole-2-Carboxamide Derivative, LG4, Alleviates Diabetic Kidney Disease Through Inhibiting MAPK-Mediated Inflammatory Responses | Full Text | References | PDF (819 KB) | EPUB
  • 64 Views
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Case Report

Case Report
Extremity Gangrene Caused by HBV-Related Cryoglobulinemia Vasculitis in a Patient with Diabetes – A Case Report
Yunyi Gao, Dawei Chen, Yan Li, Huijiao Chen & Xingwu Ran
Pages: 1661-1666
Published online: 28 Apr 2021
AbstractforExtremity Gangrene Caused by HBV-Related Cryoglobulinemia Vasculitis in a Patient with Diabetes – A Case Report | Full Text | References | PDF (338.6 KB) | EPUB
  • 72 Views
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Original Research

Article
Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis
Yang Zong, Haojie Shan, Fuli Yin, Xin Ma, Chaolai Jiang, Nan Wang, Lihui Zhou, Yiwei Lin, Zubin Zhou & Xiaowei Yu
Pages: 1667-1676
Published online: 28 Apr 2021
AbstractforDdb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis | Full Text | References | PDF (3.6 MB) | EPUB
  • 70 Views
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Article
Factors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC
Wuping Bao, Xue Zhang, Yubiao Jin, Huijuan Hao, Fu Yang, Dongning Yin, Xi Chen, Yishu Xue, Lei Han & Min Zhang
Pages: 1677-1687
Published online: 28 Apr 2021
AbstractforFactors Associated with the Expression of ACE2 in Human Lung Tissue: Pathological Evidence from Patients with Normal FEV1 and FEV1/FVC | Full Text | References | PDF (533 KB) | EPUB
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Article
Identification of Circulating Biomarkers and Construction of a Prognostic Signature for Survival Prediction in Locally Advanced Pancreatic Cancer After Irreversible Electroporation
Chaobin He, Shuxin Sun, Yu Zhang & Shengping Li
Pages: 1689-1699
Published online: 28 Apr 2021
AbstractforIdentification of Circulating Biomarkers and Construction of a Prognostic Signature for Survival Prediction in Locally Advanced Pancreatic Cancer After Irreversible Electroporation | Full Text | References | PDF (6.1 MB) | EPUB
  • 59 Views
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Review

Review Article
Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease
Liucan Wang, Min Yu & Hua Yang
Pages: 1701-1716
Published online: 18 Jul 2023
AbstractforRecent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease | Full Text | References | PDF (1.9 MB) | EPUB
  • 95 Views
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Original Research

Article
Activation of GSK3 Prevents Termination of TNF-Induced Signaling
Bastian Welz, Rolf Bikker, Leonie Hoffmeister, Mareike Diekmann, Martin Christmann, Korbinian Brand & René Huber
Pages: 1717-1730
Published online: 06 May 2021
AbstractforActivation of GSK3 Prevents Termination of TNF-Induced Signaling | Full Text | References | PDF (11.2 MB) | EPUB
  • 66 Views
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Article
Inhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p
Aixia Song, Yuying Yang, Hongmei He, Jian Sun, Qing Chang & Qian Xue
Pages: 1731-1742
Published online: 05 May 2021
AbstractforInhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p | Full Text | References | PDF (6.3 MB) | EPUB
  • 138 Views
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Article
The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study
Nasser M Rizk, Amina Fadel, Wasaif AlShammari, Noura Younes & Moataz Bashah
Pages: 1743-1757
Published online: 05 May 2021
AbstractforThe Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study | Full Text | References | PDF (2.9 MB) | EPUB
  • 73 Views
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Article
Lycopus lucidus Turcz Exerts Neuroprotective Effects Against H2O2-Induced Neuroinflammation by Inhibiting NLRP3 Inflammasome Activation in Cortical Neurons
Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Junseon Lee, Seung Ho Baek & In-Hyuk Ha
Pages: 1759-1773
Published online: 05 May 2021
AbstractforLycopus lucidus Turcz Exerts Neuroprotective Effects Against H2O2-Induced Neuroinflammation by Inhibiting NLRP3 Inflammasome Activation in Cortical Neurons | Full Text | References | PDF (11.8 MB) | EPUB
  • 82 Views
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Article
Investigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract of Achyranthes aspera L. (Amaranthaceae) in Rats
Teklie Mengie, Solomon Mequanente, Dereje Nigussie, Belete Legesse & Eyasu Makonnen
Pages: 1775-1787
Published online: 18 Jul 2023
AbstractforInvestigation of Wound Healing and Anti-Inflammatory Activities of Solvent Fractions of 80% Methanol Leaf Extract of Achyranthes aspera L. (Amaranthaceae) in Rats | Full Text | References | PDF (1.5 MB) | EPUB
  • 249 Views
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Article
Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy
Shihua Wang, Yimeng Cui, Minqi Xiong, Mei Li, Peiwei Wang, Jingang Cui, Xiaoye Du, Yu Chen & Teng Zhang
Pages: 1789-1806
Published online: 05 May 2021
AbstractforDual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy | Full Text | References | PDF (16.9 MB) | EPUB
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Article
Changes of Lipopolysaccharide-Induced Acute Kidney and Liver Injuries in Rats Based on Metabolomics Analysis
Huan Gao, Tao Yang, Xuan Chen & Yanqing Song
Pages: 1807-1825
Published online: 06 May 2021
AbstractforChanges of Lipopolysaccharide-Induced Acute Kidney and Liver Injuries in Rats Based on Metabolomics Analysis | Full Text | References | PDF (9.7 MB) | EPUB
  • 123 Views
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Review

Review Article
PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis
Weronika Wasyluk & Agnieszka Zwolak
Pages: 1827-1844
Published online: 06 May 2021
AbstractforPARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis | Full Text | References | PDF (4 MB) | EPUB
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Original Research

Article
microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3
Qi-Bin Yang, Ling-Qin Li, Quan-Bo Zhang, Yong-Long He, Qing-Sheng Mi & Jing-Guo Zhou
Pages: 1845-1858
Published online: 11 May 2021
AbstractformicroRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3 | Full Text | References | PDF (9.3 MB) | EPUB
  • 66 Views
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Article
An Inflammation-Index Signature Predicts Prognosis of Patients with Intrahepatic Cholangiocarcinoma After Curative Resection
Chaobin He, Chongyu Zhao, Yu Zhang, Cheng Chen & Xiaojun Lin
Pages: 1859-1872
Published online: 11 May 2021
AbstractforAn Inflammation-Index Signature Predicts Prognosis of Patients with Intrahepatic Cholangiocarcinoma After Curative Resection | Full Text | References | PDF (625.2 KB) | EPUB
  • 52 Views
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Article
MCTR1 Intervention Reverses Experimental Lung Fibrosis in Mice
Jingyi Pan, Xinyu Li, Xinyang Wang, Lili Yang, Houlin Chen, Nana Su, Chenghua Wu, Yu Hao, Shengwei Jin & Hui Li
Pages: 1873-1881
Published online: 11 May 2021
AbstractforMCTR1 Intervention Reverses Experimental Lung Fibrosis in Mice | Full Text | References | PDF (737.7 KB) | EPUB
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Article
The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease
Monika Katko, Erika Galgoczi, Annamaria Erdei, Annamaria Gazdag, Eszter Berta, Miklos Bodor, Ildiko Seres, Ildiko Hircsu, Arpad Badics, Bernadett Ujhelyi, Livia Sira, Harjit Pal Bhattoa & Endre V Nagy
Pages: 1883-1890
Published online: 18 Jul 2023
AbstractforThe 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease | Full Text | References | PDF (285.5 KB) | EPUB
  • 81 Views
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Article
Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum
Hsuan-Wei Chen, Jung-Chun Lin, Ying-Hsuen Wu & Yi-Lin Chiu
Pages: 1891-1899
Published online: 12 May 2021
AbstractforRisk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum | Full Text | References | PDF (462.5 KB) | EPUB
  • 367 Views
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Article
Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis
Mingcheng Huang, Keping Wu, Shan Zeng, Wenfen Liu, Tianjiao Cui, Zhiqing Chen, Lian Lin, Dongying Chen & Hui Ouyang
Pages: 1901-1913
Published online: 12 May 2021
AbstractforPunicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis | Full Text | References | PDF (657.7 KB) | EPUB
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Review

Review Article
Effect of Biologics on Cardiovascular Inflammation: Mechanistic Insights and Risk Reduction
George E Fragoulis, Stergios Soulaidopoulos, Petros P Sfikakis, Theodoros Dimitroulas & George D Kitas
Pages: 1915-1931
Published online: 18 Jul 2023
AbstractforEffect of Biologics on Cardiovascular Inflammation: Mechanistic Insights and Risk Reduction | Full Text | References | PDF (432.3 KB) | EPUB
  • 205 Views
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Original Research

Article
Application of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease
Qiongrong Huang, Xiuli Zhang & Zhiyuan Hu
Pages: 1933-1943
Published online: 14 May 2021
AbstractforApplication of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease | Full Text | References | PDF (531.8 KB) | EPUB
  • 107 Views
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Article
Lentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/β-Catenin Signaling Pathway
Meng-yuan Zhou, Li Cai, Xiao-wen Feng, Yu-rong Mu, Bo Meng, Fang-yuan Liu & Rong Li
Pages: 1945-1957
Published online: 14 May 2021
AbstractforLentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (900.6 KB) | EPUB
  • 100 Views
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Article
Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
Liu Li, Li Yang, Feng Yang, Xin-lan Zhao, Shengjiang Xue & Fang-hua Gong
Pages: 1959-1971
Published online: 18 Jul 2023
AbstractforGinkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice | Full Text | References | PDF (894 KB) | EPUB
  • 116 Views
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Article
Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages
Ruijie Wang, Wenliang Song, Chengyuan Xie, Wenhong Zhong, Hui Xu, Qiuping Zhou, Yiyu Deng, Yimei Hong, Xin Li & Ming Fang
Pages: 1973-1989
Published online: 17 May 2021
AbstractforUrinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages | Full Text | References | PDF (1,019.5 KB) | EPUB
  • 66 Views
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Article
Prognostic Significance of Tumor-Associated Macrophages in Chondroblastoma and Their Association with Response to Adjuvant Radiotherapy
Bo-Wen Zheng, Min-Liang Yang, Wei Huang, Bo-Yv Zheng, Tao-Lan Zhang, Jing Li, Guo-Hua Lv, Yi-Guo Yan & Ming-Xiang Zou
Pages: 1991-2005
Published online: 17 May 2021
AbstractforPrognostic Significance of Tumor-Associated Macrophages in Chondroblastoma and Their Association with Response to Adjuvant Radiotherapy | Full Text | References | PDF (668.3 KB) | EPUB
  • 73 Views
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Article
Orexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways
Wen Ye, Yan Yan, Yunliang Tang, Xiaoyang Dong, Gengfa Chen, Junwei Kang, Lianghua Huang, Qi Xiong & Zhen Feng
Pages: 2007-2017
Published online: 18 May 2021
AbstractforOrexin-A Attenuates Inflammatory Responses in Lipopolysaccharide-Induced Neural Stem Cells by Regulating NF-KB and Phosphorylation of MAPK/P38/Erk Pathways | Full Text | References | PDF (4.7 MB) | EPUB
  • 64 Views
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Article
Association Between Interleukin-12 and Sarcopenia
Yuan-Yuei Chen, Tung-Wei Kao, Yi-Lin Chiu, Tao-Chun Peng, Hui-Fang Yang & Wei-Liang Chen
Pages: 2019-2029
Published online: 18 May 2021
AbstractforAssociation Between Interleukin-12 and Sarcopenia | Full Text | References | PDF (3 MB) | EPUB
  • 70 Views
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Article
MiRNA-29c-3p Promotes Intestinal Inflammation via Targeting Leukemia Inhibitory Factor in Ulcerative Colitis
Jian Guo, Ruiya Zhang, Yiqing Zhao & Junping Wang
Pages: 2031-2043
Published online: 18 May 2021
AbstractforMiRNA-29c-3p Promotes Intestinal Inflammation via Targeting Leukemia Inhibitory Factor in Ulcerative Colitis | Full Text | References | PDF (723.6 KB) | EPUB
  • 79 Views
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Article
The ACE2-Ang-(1‑7)-Mas Axis Modulates M1/M2 Macrophage Polarization to Relieve CLP-Induced Inflammation via TLR4-Mediated NF-кb and MAPK Pathways
Hang Pan, Wenhan Huang, Zhongjie Wang, Feifeng Ren, Lei Luo, Jun Zhou, Mengxue Tian & Lin Tang
Pages: 2045-2060
Published online: 20 May 2021
AbstractforThe ACE2-Ang-(1‑7)-Mas Axis Modulates M1/M2 Macrophage Polarization to Relieve CLP-Induced Inflammation via TLR4-Mediated NF-кb and MAPK Pathways | Full Text | References | PDF (1.7 MB) | EPUB
  • 99 Views
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Article
Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion
Xing Lin, Jian Zhan, Jin Jiang & Yikun Ren
Pages: 2061-2078
Published online: 18 Jul 2023
AbstractforUpregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion | Full Text | References | PDF (1.1 MB) | EPUB
  • 65 Views
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Review

Review Article
Role of Ferroptosis in Lung Diseases
Wenting Xu, Huimin Deng, Song Hu, Yiguo Zhang, Li Zheng, Meiyun Liu, Yuanli Chen, Juan Wei, Hao Yang & Xin Lv
Pages: 2079-2090
Published online: 18 Jul 2023
AbstractforRole of Ferroptosis in Lung Diseases | Full Text | References | PDF (1.5 MB) | EPUB
  • 157 Views
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Review Article
Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review
Nandeeta Samad, Siddhartha Dutta, Temitayo Eniola Sodunke, Adiba Fairuz, Ashmita Sapkota, Zannatul Ferdous Miftah, Iffat Jahan, Paras Sharma, Abdullahi Rabiu Abubakar, Adekunle Babajide Rowaiye, Angus Nnamdi Oli, Jaykaran Charan, Salequl Islam & Mainul Haque
Pages: 2091-2110
Published online: 18 Jul 2023
AbstractforFat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review | Full Text | References | PDF (711.8 KB) | EPUB
  • 184 Views
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Hypothesis

Discussion
A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies
Martin Kulke, Felix Nagel, Lukas Schulig, Norman Geist, Marcel Gabor, Julia Mayerle, Markus M Lerch, Andreas Link & Mihaela Delcea
Pages: 2111-2119
Published online: 21 May 2021
AbstractforA Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies | Full Text | References | PDF (537.4 KB) | EPUB
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Original Research

Article
In vivo and in vitro Evaluation of Cytokine Expression Profiles During Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection
Ayman Mubarak, Bahauddeen Alrfaei, Abdullah Aljurayyan, Mahfoudh M Alqafil, Mohamed A Farrag, Maaweya E Hamed, Bandar Alosaimi, Fahad Almajhdi & Wael Alturaiki
Pages: 2121-2131
Published online: 21 May 2021
AbstractforIn vivo and in vitro Evaluation of Cytokine Expression Profiles During Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection | Full Text | References | PDF (618.1 KB) | EPUB
  • 76 Views
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Article
Preclinical Characterization of the Selective JAK1 Inhibitor LW402 for Treatment of Rheumatoid Arthritis
Ning Zhang, Changqing Zhang, Zhihong Zeng, Jiyong Zhang, Shengnan Du, Chunde Bao & Zhe Wang
Pages: 2133-2147
Published online: 18 Jul 2023
AbstractforPreclinical Characterization of the Selective JAK1 Inhibitor LW402 for Treatment of Rheumatoid Arthritis | Full Text | References | PDF (895.6 KB) | EPUB
  • 136 Views
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Article
A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction
Rana El Sabeh, Mélanie Bonnet, Katy Le Corf, Kevin Lang, Alain Kfoury, Bassam Badran, Nader Hussein, Francois Virard, Isabelle Treilleux, Muriel Le Romancer, Serge Lebecque, Serge Manie, Isabelle Coste & Toufic Renno
Pages: 2149-2156
Published online: 18 Jul 2023
AbstractforA Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction | Full Text | References | PDF (564 KB) | EPUB
  • 73 Views
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Article
Exogenous Plant gma-miR-159a, Identified by miRNA Library Functional Screening, Ameliorated Hepatic Stellate Cell Activation and Inflammation via Inhibiting GSK-3β-Mediated Pathways
Wen-Ying Yu, Wei Cai, Hua-Zhong Ying, Wen-You Zhang, Huan-Huan Zhang & Chen-Huan Yu
Pages: 2157-2172
Published online: 24 May 2021
AbstractforExogenous Plant gma-miR-159a, Identified by miRNA Library Functional Screening, Ameliorated Hepatic Stellate Cell Activation and Inflammation via Inhibiting GSK-3β-Mediated Pathways | Full Text | References | PDF (8.9 MB) | EPUB
  • 75 Views
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Article
Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma–COPD Overlap in vivo and in vitro
Shuyi Li, Yang Hui, Jiqiao Yuan, Ziqian Zhang, Xuyu Li, Nan Fang, Mingbao Lin & Qi Hou
Pages: 2173-2185
Published online: 24 May 2021
AbstractforSyk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma–COPD Overlap in vivo and in vitro | Full Text | References | PDF (8.6 MB) | EPUB
  • 74 Views
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Review

Review Article
Role of Pyroptosis in Diabetes and Its Therapeutic Implications
Abdullah Al Mamun, Yanqing Wu, Fatema Nasrin, Afroza Akter, Masuma Afrin Taniya, Fahad Munir, Chang Jia & Jian Xiao
Pages: 2187-2206
Published online: 24 May 2021
AbstractforRole of Pyroptosis in Diabetes and Its Therapeutic Implications | Full Text | References | PDF (2.7 MB) | EPUB
  • 178 Views
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Original Research

Article
Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Yuhan Chen, Yuanyuan Chen, Xueze Jiang, Mengkun Shi, Zhenwei Yang, Zhiyong Chen, Xuesheng Hua, Jie Chen & Yuepeng Wang
Pages: 2207-2223
Published online: 25 May 2021
AbstractforVascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo | Full Text | References | PDF (1.3 MB) | EPUB
  • 87 Views
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Article
Prognostic and Predictive Value of Circulating Inflammation Signature in Non-Metastatic Nasopharyngeal Carcinoma: Potential Role for Individualized Induction Chemotherapy
Shu-Hui Lv, Wang-Zhong Li, Hu Liang, Guo-Ying Liu, Wei-Xiong Xia & Yan-Qun Xiang
Pages: 2225-2237
Published online: 25 May 2021
AbstractforPrognostic and Predictive Value of Circulating Inflammation Signature in Non-Metastatic Nasopharyngeal Carcinoma: Potential Role for Individualized Induction Chemotherapy | Full Text | References | PDF (601.1 KB) | EPUB
  • 61 Views
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Article
Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway
Yue Zhou, Ai-Qing Nie, Shang Chen, Meng-Meng Wang, Rui Yin, Bo-Hao Tang, Yue-E Wu, Fan Yang, Bin Du, Hai-Yan Shi, Xin-Mei Yang, Guo-Xiang Hao, Xiu-Li Guo, Qiu-Ju Han, Yi Zheng & Wei Zhao
Pages: 2239-2252
Published online: 18 Jul 2023
AbstractforDownregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway | Full Text | References | PDF (756.4 KB) | EPUB
  • 55 Views
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Article
RETRACTED ARTICLE: Melatonin Inhibits Migration and Invasion in LPS-Stimulated and -Unstimulated Prostate Cancer Cells Through Blocking Multiple EMT-Relative Pathways
Qi-Xing Tian, Zhi-Hui Zhang, Qing-Lin Ye, Shen Xu, Qian Hong, Wei-Yang Xing, Lei Chen, De-Xin Yu, De-Xiang Xu & Dong-Dong Xie
Pages: 2253-2265
Published online: 25 May 2021
AbstractforRETRACTED ARTICLE: Melatonin Inhibits Migration and Invasion in LPS-Stimulated and -Unstimulated Prostate Cancer Cells Through Blocking Multiple EMT-Relative Pathways | PDF (777.1 KB)
  • 163 Views
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Review

Review Article
Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto & Eduardo Tibirica
Pages: 2267-2276
Published online: 27 May 2021
AbstractforObesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity | Full Text | References | PDF (362.1 KB) | EPUB
  • 84 Views
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Original Research

Article
Empagliflozin Alleviates Atherosclerosis Progression by Inhibiting Inflammation and Sympathetic Activity in a Normoglycemic Mouse Model
Yihai Liu, Mingyue Wu, Biao Xu & Lina Kang
Pages: 2277-2287
Published online: 31 May 2021
AbstractforEmpagliflozin Alleviates Atherosclerosis Progression by Inhibiting Inflammation and Sympathetic Activity in a Normoglycemic Mouse Model | Full Text | References | PDF (543.9 KB) | EPUB
  • 96 Views
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Article
Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation
Ning Li, Rui Xiong, Ruyuan He, Bohao Liu, Bo Wang & Qing Geng
Pages: 2289-2300
Published online: 18 Jul 2023
AbstractforMangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation | Full Text | References | PDF (799.7 KB) | EPUB
  • 88 Views
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Article
Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice
Chen-miao Huang, Jia-jing Cai, Shao-wu Jin, Qi-cheng Lin, Qian-juan Fang, Ke Nan, Yuan Han, Wen-wei Ge, Yu Liu, Yuan-xiang Tao, Hong Cao & Jun Li
Pages: 2301-2315
Published online: 18 Jul 2023
AbstractforClass IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice | Full Text | References | PDF (12.5 MB) | EPUB
  • 69 Views
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Article
Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a
Jiayu Yao, Xiaotong Liu, Yingxu Sun, Xin Dong, Li Liu & Hailun Gu
Pages: 2317-2331
Published online: 01 Jun 2021
AbstractforCurcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a | Full Text | References | PDF (830.8 KB) | EPUB
  • 70 Views
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Article
A Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus
Supichcha Saithong, Wilasinee Saisorn, Peerapat Visitchanakun, Kritsanawan Sae-khow, Direkrit Chiewchengchol & Asada Leelahavanichkul
Pages: 2333-2352
Published online: 18 Jul 2023
AbstractforA Synergy Between Endotoxin and (1→3)-Beta-D-Glucan Enhanced Neutrophil Extracellular Traps in Candida Administered Dextran Sulfate Solution Induced Colitis in FcGRIIB-/- Lupus Mice, an Impact of Intestinal Fungi in Lupus | Full Text | References | PDF (1.6 MB) | EPUB
  • 77 Views
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Article
Identification of an Alveolar Macrophage-Related Core Gene Set in Acute Respiratory Distress Syndrome
Chunling Zhao, Jingjia Mo, Xiaowen Zheng, Zimeng Wu, Qian Li, Jihua Feng, Jiefeng Luo, Junyu Lu & Jianfeng Zhang
Pages: 2353-2361
Published online: 18 Jul 2023
AbstractforIdentification of an Alveolar Macrophage-Related Core Gene Set in Acute Respiratory Distress Syndrome | Full Text | References | PDF (537.1 KB) | EPUB
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Article
A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia
Hao-Kuang Wang, Jui-Sheng Chen, Chien-Yu Hsu, Yu-Ting Su, Tzu-Ching Sung, Cheng-Loong Liang, Aij-Lie Kwan & Cheng-Chun Wu
Pages: 2363-2376
Published online: 01 Jun 2021
AbstractforA Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia | Full Text | References | PDF (1 MB) | EPUB
  • 63 Views
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Article
Multi-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis
Izabela Rumienczyk, Maria Kulecka, Jerzy Ostrowski, Daniel Mar, Karol Bomsztyk, Stephen W Standage & Michal Mikula
Pages: 2377-2388
Published online: 03 Jun 2021
AbstractforMulti-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis | Full Text | References | PDF (2.2 MB) | EPUB
  • 135 Views
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Article
Zc3h12d, a Novel of Hypomethylated and Immune-Related for Prognostic Marker of Lung Adenocarcinoma
Bo Yang, Lin-Lin Ji, Hong-Liang Xu, Xiao-Ping Li, Hong-Gang Zhou, Ting Xiao, Xiao-He Li, Zhou-Yong Gao, Jian-Zhong Li, Wei-Dong Zhang, Guang-Shun Wang & Ming-Jiang Li
Pages: 2389-2401
Published online: 18 Jul 2023
AbstractforZc3h12d, a Novel of Hypomethylated and Immune-Related for Prognostic Marker of Lung Adenocarcinoma | Full Text | References | PDF (8.9 MB) | EPUB
  • 67 Views
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Article
The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
Weijian E, Zhixin Wang, Mingquan Pang, Yongliang Lu & Haining Fan
Pages: 2403-2409
Published online: 18 Jul 2023
AbstractforThe Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis | Full Text | References | PDF (373.9 KB) | EPUB
  • 55 Views
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Article
Protective Role of microRNA-200a in Diabetic Retinopathy Through Downregulation of PDLIM1
Wencui Wan, Yang Long, Xuemin Jin, Qiuming Li, Weiwei Wan, Hongzhuo Liu & Yu Zhu
Pages: 2411-2424
Published online: 04 Jun 2021
AbstractforProtective Role of microRNA-200a in Diabetic Retinopathy Through Downregulation of PDLIM1 | Full Text | References | PDF (737.5 KB) | EPUB
  • 66 Views
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Article
Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance
Rahnuma Ahmad, Qazi Shamima Akhter & Mainul Haque
Pages: 2425-2444
Published online: 09 Jun 2021
AbstractforOccupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance | Full Text | References | PDF (6.9 MB) | EPUB
  • 163 Views
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Article
LncRNA NEAT1 Promote Inflammatory Responses in Coronary Slow Flow Through Regulating miR-148b-3p/ICAM-1 Axis
Qing Zhu, Cuiting Zhao, Yonghuai Wang, Xinxin Li, Yixue Xue & Chunyan Ma
Pages: 2445-2463
Published online: 09 Jun 2021
AbstractforLncRNA NEAT1 Promote Inflammatory Responses in Coronary Slow Flow Through Regulating miR-148b-3p/ICAM-1 Axis | Full Text | References | PDF (11.8 MB) | EPUB
  • 65 Views
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Article
Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease?
Ferdinand W Nangole, Kelsey Ouyang, Omu Anzala, Julius Ogengo & George W Agak
Pages: 2465-2470
Published online: 10 Jun 2021
AbstractforMultiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease? | Full Text | References | PDF (252 KB) | EPUB
  • 69 Views
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Article
High Inflammatory Tendency Induced by Malignant Stimulation Through Imbalance of CD28 and CTLA-4/PD-1 Contributes to Dopamine Neuron Injury
Li Dong, Yu-Min Zheng, Xiao-Guang Luo & Zhi-Yi He
Pages: 2471-2482
Published online: 18 Jul 2023
AbstractforHigh Inflammatory Tendency Induced by Malignant Stimulation Through Imbalance of CD28 and CTLA-4/PD-1 Contributes to Dopamine Neuron Injury | Full Text | References | PDF (10.2 MB) | EPUB
  • 65 Views
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Article
Prognostic Value of the Preoperative Lymphocyte-C-Reactive Protein Ratio in Hepatocellular Carcinoma Patients Treated with Curative Intent: A Large-Scale Multicentre Study
Yong-Fa Zhang, Liang-He Lu, Chong Zhong, Min-Shan Chen, Rong-Ping Guo & Lu Wang
Pages: 2483-2495
Published online: 10 Jun 2021
AbstractforPrognostic Value of the Preoperative Lymphocyte-C-Reactive Protein Ratio in Hepatocellular Carcinoma Patients Treated with Curative Intent: A Large-Scale Multicentre Study | Full Text | References | PDF (5.1 MB) | EPUB
  • 62 Views
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Article
Longitudinal Antibody Dynamics Against Structural Proteins of SARS-CoV-2 in Three COVID-19 Patients Shows Concurrent Development of IgA, IgM, and IgG
Mohd Raeed Jamiruddin, Md Ahsanul Haq, Kazuhito Tomizawa, Eiry Kobatake, Masayasu Mie, Sohel Ahmed, Shahad Saif Khandker, Tamanna Ali, Nowshin Jahan, Mumtarin Jannat Oishee, Mohib Ullah Khondoker, Bijon Kumar Sil, Mainul Haque & Nihad Adnan
Pages: 2497-2506
Published online: 14 Jun 2021
AbstractforLongitudinal Antibody Dynamics Against Structural Proteins of SARS-CoV-2 in Three COVID-19 Patients Shows Concurrent Development of IgA, IgM, and IgG | Full Text | References | PDF (4.1 MB) | EPUB
  • 77 Views
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Article
TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer
Xiaohang Li, Xu Li, Simei Chen, Yang Wu, Yuhan Liu, Tingting Hu, Jiayi Huang, Jianlin Yu, Zihuan Pei, Tingting Zeng & Liming Tan
Pages: 2507-2514
Published online: 14 Jun 2021
AbstractforTRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer | Full Text | References | PDF (3.2 MB) | EPUB
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Review

Review Article
Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials
Magdalena Pawelczyk-Madalińska, Stefano Benedicenti, Tudor Sălăgean, Ioana Roxana Bordea & Reem Hanna
Pages: 2515-2545
Published online: 18 Jul 2023
AbstractforImpact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials | Full Text | References | PDF (5.6 MB) | EPUB
  • 256 Views
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Review Article
Rheumatoid Arthritis Relapse and Remission – Advancing Our Predictive Capability Using Modern Imaging
Lene Terslev & Mikkel Ostergaard
Pages: 2547-2555
Published online: 18 Jul 2023
AbstractforRheumatoid Arthritis Relapse and Remission – Advancing Our Predictive Capability Using Modern Imaging | Full Text | References | PDF (856.1 KB) | EPUB
  • 83 Views
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Clinical Trial Report

Case Report
Efficacy and Safety of First-Generation EGFR-TKIs Combined with Chemotherapy for Treatment-Naïve Advanced Non-Small-Cell Lung Cancer Patients Harboring Sensitive EGFR Mutations: A Single-Center, Open-Label, Single-Arm, Phase II Clinical Trial
Jinghui Lin, Meifang Li, Shijie Chen, Lihong Weng & Zhiyong He
Pages: 2557-2567
Published online: 18 Jul 2023
AbstractforEfficacy and Safety of First-Generation EGFR-TKIs Combined with Chemotherapy for Treatment-Naïve Advanced Non-Small-Cell Lung Cancer Patients Harboring Sensitive EGFR Mutations: A Single-Center, Open-Label, Single-Arm, Phase II Clinical Trial | Full Text | References | PDF (1.9 MB) | EPUB
  • 75 Views
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Original Research

Article
Sodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils
Susanne Schiffmann, Sandra Gunne, Marina Henke, Thomas Ulshöfer, Dieter Steinhilber, Annette Sethmann & Michael J Parnham
Pages: 2569-2582
Published online: 18 Jul 2023
AbstractforSodium Bituminosulfonate Used to Treat Rosacea Modulates Generation of Inflammatory Mediators by Primary Human Neutrophils | Full Text | References | PDF (2 MB) | EPUB
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Commentary

Article Commentary
LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease
Youcui Wang, Xiaoqin Zhang, Fenghua Chen, Leilei Chen, Jun Wang & Junxia Xie
Pages: 2583-2586
Published online: 18 Jul 2023
AbstractforLRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease | Full Text | References | PDF (569.9 KB) | EPUB
  • 86 Views
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Original Research

Article
Genistein Attenuates Isoflurane-Induced Neuroinflammation by Inhibiting TLR4-Mediated Microglial-Polarization in vivo and in vitro
Tao Jiang, Shoucai Xu, Yangyang Shen, Yong Xu & Yuwen Li
Pages: 2587-2600
Published online: 18 Jul 2023
AbstractforGenistein Attenuates Isoflurane-Induced Neuroinflammation by Inhibiting TLR4-Mediated Microglial-Polarization in vivo and in vitro | Full Text | References | PDF (9.6 MB) | EPUB
  • 75 Views
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Article
Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment
Mena Al-Ani, Noha Mousaad Elemam, Ibrahim Y Hachim, Tom K Raju, Jibran Sualeh Muhammad, Mahmood Y Hachim, Riyad Bendardaf & Azzam A Maghazachi
Pages: 2601-2617
Published online: 18 Jul 2023
AbstractforMolecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment | Full Text | References | PDF (9 MB) | EPUB
  • 96 Views
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Article
Gut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever
Yaya Zhou, Xing Shi, Wei Fu, Fei Xiang, Xinliang He, Bohan Yang, Xiaorong Wang & Wan-Li Ma
Pages: 2619-2631
Published online: 18 Jul 2023
AbstractforGut Microbiota Dysbiosis Correlates with Abnormal Immune Response in Moderate COVID-19 Patients with Fever | Full Text | References | PDF (6 MB) | EPUB
  • 104 Views
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Article
FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population
Kun Lin, Linyuan Zhang, Yishuai Wang, Jinqing Li, Yufen Xu, Di Che, Hanran Mai, Hongyan Yu, Lanyan Fu, Bing Wei, Zhiyong Jiang, Lei Pi & Xiaoqiong Gu
Pages: 2633-2640
Published online: 18 Jul 2023
AbstractforFNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population | Full Text | References | PDF (264.1 KB) | EPUB
  • 62 Views
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Article
Treatment Effect of Mammary Duct Exploration Combined with Focal Resection on Granulomatous Lobular Mastitis
Ximeng Zuo, Xiaoguang Shi, Xiang Gao, Rui Lai, Pengzhou Liu & Ze Zhao
Pages: 2641-2646
Published online: 18 Jul 2023
AbstractforTreatment Effect of Mammary Duct Exploration Combined with Focal Resection on Granulomatous Lobular Mastitis | Full Text | References | PDF (614.3 KB) | EPUB
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Review

Review Article
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Nan Ji, Zhongwen Qi, Yueyao Wang, Xiaoya Yang, Zhipeng Yan, Meng Li, Qihui Ge & Junping Zhang
Pages: 2647-2666
Published online: 18 Jul 2023
AbstractforPyroptosis: A New Regulating Mechanism in Cardiovascular Disease | Full Text | References | PDF (3 MB) | EPUB
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Original Research

Article
Transcriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neat1 in Experimental Ischemic Stroke
Fa Jin, Weiyang Ou, Boyang Wei, Haiyan Fan, Chengcong Wei, Dazhao Fang, Guangxu Li, Wenchao Liu, Jiahui Liu, Lei Jin, Xuying He & Chuanzhi Duan
Pages: 2667-2680
Published online: 18 Jul 2023
AbstractforTranscriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neat1 in Experimental Ischemic Stroke | Full Text | References | PDF (6.9 MB) | EPUB
  • 89 Views
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Article
PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function
Mingyan Jiang, Yong Xue, Jianchun Li, Kairui Rao, Shili Yan, Hongmei Li, Xuanqin Chen, Rongtao Li & Dan Liu
Pages: 2681-2696
Published online: 18 Jul 2023
AbstractforPKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function | Full Text | References | PDF (11.2 MB) | EPUB
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Article
Donor-Specific Antibodies Against Donor Human Leukocyte Antigen are Associated with Graft Inflammation but Not with Fibrosis Long-Term After Liver Transplantation: An Analysis of Protocol Biopsies
Safak Gül-Klein, Henriette Hegermann, Robert Röhle, Moritz Schmelzle, Frank Tacke, Wenzel Schöning, Robert Öllinger, Tomasz Dziodzio, Patrick Maier, Julius M Plewe, David Horst, Igor Maximilian Sauer, Johann Pratschke, Nils Lachmann & Dennis Eurich
Pages: 2697-2712
Published online: 18 Jul 2023
AbstractforDonor-Specific Antibodies Against Donor Human Leukocyte Antigen are Associated with Graft Inflammation but Not with Fibrosis Long-Term After Liver Transplantation: An Analysis of Protocol Biopsies | Full Text | References | PDF (440.3 KB) | EPUB
  • 74 Views
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Article
Spermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou & Fang Peng
Pages: 2713-2721
Published online: 18 Jul 2023
AbstractforSpermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis | Full Text | References | PDF (3.1 MB) | EPUB
  • 134 Views
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Article
The Association Among Serum Growth Differentiation Factor 15 Level and Suicidal Ideation is Dependent on Testosterone Deficiency in Depressive Patients
Rui Peng, Di Li, Si-Qing Mei & Yan Li
Pages: 2723-2730
Published online: 18 Jul 2023
AbstractforThe Association Among Serum Growth Differentiation Factor 15 Level and Suicidal Ideation is Dependent on Testosterone Deficiency in Depressive Patients | Full Text | References | PDF (817.7 KB) | EPUB
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Article
A Novel Radiomics Nomogram for the Prediction of Secondary Loss of Response to Infliximab in Crohn’s Disease
Yueying Chen, Hanyang Li, Jing Feng, Shiteng Suo, Qi Feng & Jun Shen
Pages: 2731-2740
Published online: 24 Jun 2021
AbstractforA Novel Radiomics Nomogram for the Prediction of Secondary Loss of Response to Infliximab in Crohn’s Disease | Full Text | References | PDF (5.7 MB) | EPUB
  • 91 Views
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Article
Solitary Pulmonary Inflammatory Nodule: CT Features and Pathological Findings
Yun-Dan Xiao, Fa-Jin Lv, Wang-Jia Li, Bin-Jie Fu, Rui-Yu Lin & Zhi-Gang Chu
Pages: 2741-2751
Published online: 18 Jul 2023
AbstractforSolitary Pulmonary Inflammatory Nodule: CT Features and Pathological Findings | Full Text | References | PDF (1.4 MB) | EPUB
  • 64 Views
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Article
Hydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway
Zixi Chen, Mengzhe Zhang, Yunzhi Zhao, Wenjuan Xu, Fenfen Xiang, Xiaoxiao Li, Tao Zhang, Rong Wu & Xiangdong Kang
Pages: 2753-2768
Published online: 25 Jun 2021
AbstractforHydrogen Sulfide Contributes to Uterine Quiescence Through Inhibition of NLRP3 Inflammasome Activation by Suppressing the TLR4/NF-κB Signalling Pathway | Full Text | References | PDF (11.3 MB) | EPUB
  • 74 Views
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Article
Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment
Haiyu Hong, Kai Sen Tan, Yan Yan, Fenghong Chen, Hsiao Hui Ong, Yukei Oo, Jing Liu, Yew Kwang Ong, Mark Thong, Richard Sugrue, Vincent T Chow & De Yun Wang
Pages: 2769-2780
Published online: 28 Jun 2021
AbstractforInduction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment | Full Text | References | PDF (6.1 MB) | EPUB
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Article
The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation
Jing Liu, Qiling Shen, Huiping Zhang, Xueying Xiao, Changming lv, Yueyue Chu, Yujun Shen, Dong Wang & Qiying Shen
Pages: 2781-2791
Published online: 18 Jul 2023
AbstractforThe Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation | Full Text | References | PDF (5.7 MB) | EPUB
  • 112 Views
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Article
Phenotypic Variations of Mild-to-Moderate Obstructive Pulmonary Diseases According to Airway Inflammation and Clinical Features
Małgorzata Proboszcz, Krzysztof Goryca, Patrycja Nejman-Gryz, Tadeusz Przybyłowski, Katarzyna Górska, Rafał Krenke & Magdalena Paplińska-Goryca
Pages: 2793-2806
Published online: 28 Jun 2021
AbstractforPhenotypic Variations of Mild-to-Moderate Obstructive Pulmonary Diseases According to Airway Inflammation and Clinical Features | Full Text | References | PDF (1 MB) | EPUB
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Article
Upregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts
Chuen-Mao Yang, Chien-Chung Yang, Li-Der Hsiao, Chia-Ying Yu, Hui-Ching Tseng, Chih-Kai Hsu & Jiro Hasegawa Situmorang
Pages: 2807-2824
Published online: 28 Jun 2021
AbstractforUpregulation of COX-2 and PGE2 Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts | Full Text | References | PDF (11.5 MB) | EPUB
  • 79 Views
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Article
The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders
Shangzhi Gao, Corbin Quick, Marta Guasch-Ferre, Zhu Zhuo, John M Hutchinson, Li Su, Frank Hu, Xihong Lin & David Christiani
Pages: 2825-2839
Published online: 29 Jun 2021
AbstractforThe Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders | Full Text | References | PDF (2 MB) | EPUB
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Article
Acute P38-Mediated Enhancement of P2X3 Receptor Currents by TNF-α in Rat Dorsal Root Ganglion Neurons
Ying Jin, Shuang Wei, Ting-Ting Liu, Chun-Yu Qiu & Wang-Ping Hu
Pages: 2841-2850
Published online: 18 Jul 2023
AbstractforAcute P38-Mediated Enhancement of P2X3 Receptor Currents by TNF-α in Rat Dorsal Root Ganglion Neurons | Full Text | References | PDF (3.7 MB) | EPUB
  • 67 Views
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Article
Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia
Fangfang Lu, Ronglin Wang, Li Xia, Tiejian Nie, Fei Gao, Shaosong Yang, Lu Huang, Kaifeng Shao, Jiankang Liu & Qian Yang
Pages: 2851-2863
Published online: 29 Jun 2021
AbstractforRegulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia | Full Text | References | PDF (9.6 MB) | EPUB
  • 78 Views
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Article
The lncRNA ANRIL Gene rs2151280 GG Genotype is Associated with Increased Susceptibility to Recurrent Miscarriage in a Southern Chinese Population
Di Che, Zhenzhen Fang, Hanran Mai, Yufen Xu, LanYan Fu, Huazhong Zhou, Linyuan Zhang, Lei Pi & Xiaoqiong Gu
Pages: 2865-2872
Published online: 18 Jul 2023
AbstractforThe lncRNA ANRIL Gene rs2151280 GG Genotype is Associated with Increased Susceptibility to Recurrent Miscarriage in a Southern Chinese Population | Full Text | References | PDF (256.1 KB) | EPUB
  • 67 Views
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Article
Study on the Clinical Significance of ACE2 and Its Age-Related Expression
Jie Gu, JiangWen Yin, MengJie Zhang, JinHui Li, YeMing Wu, Jun Chen & HongJun Miao
Pages: 2873-2882
Published online: 30 Jun 2021
AbstractforStudy on the Clinical Significance of ACE2 and Its Age-Related Expression | Full Text | References | PDF (4.8 MB) | EPUB
  • 61 Views
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Article
Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation
Eileen Moritz, Gabriele Jedlitschky, Josefine Negnal, Mladen V Tzvetkov, Günter Daum, Marcus Dörr, Stephan B Felix, Henry Völzke, Matthias Nauck, Edzard Schwedhelm, Peter Meisel, Thomas Kocher, Bernhard H Rauch & Birte Holtfreter
Pages: 2883-2896
Published online: 18 Jul 2023
AbstractforIncreased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation | Full Text | References | PDF (523.1 KB) | EPUB
  • 89 Views
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Article
Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation
Wei Cao, Shuai Song, Guojian Fang, Yingze Li, Yuepeng Wang & Qun-Shan Wang
Pages: 2897-2911
Published online: 02 Jul 2021
AbstractforCadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation | Full Text | References | PDF (14.4 MB) | EPUB
  • 68 Views
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Article
P2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain
Yucui Jiang, Fan Ye, Ying Du, Yingxin Zong & Zongxiang Tang
Pages: 2913-2931
Published online: 18 Jul 2023
AbstractforP2X7R in Mast Cells is a Potential Target for Salicylic Acid and Aspirin in Treatment of Inflammatory Pain | Full Text | References | PDF (16.9 MB) | EPUB
  • 95 Views
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Article
Features for Predicting Absorbable Pulmonary Solid Nodules as Depicted on Thin-Section Computed Tomography
Rui-Yu Lin, Fa-Jin Lv, Bin-Jie Fu, Wang-Jia Li, Zhang-Rui Liang & Zhi-Gang Chu
Pages: 2933-2939
Published online: 18 Jul 2023
AbstractforFeatures for Predicting Absorbable Pulmonary Solid Nodules as Depicted on Thin-Section Computed Tomography | Full Text | References | PDF (487.3 KB) | EPUB
  • 73 Views
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Article
Systematic Metabolic Profiling of Mice with Dextran Sulfate Sodium-Induced Colitis
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei & Pei Jiang
Pages: 2941-2953
Published online: 18 Jul 2023
AbstractforSystematic Metabolic Profiling of Mice with Dextran Sulfate Sodium-Induced Colitis | Full Text | References | PDF (8.2 MB) | EPUB
  • 115 Views
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Article
Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease
Jing Zhang, Yiqin Dai, Yujing Yang & Jianjiang Xu
Pages: 2955-2962
Published online: 05 Jul 2021
AbstractforCalcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease | Full Text | References | PDF (3.3 MB) | EPUB
  • 81 Views
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Article
Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis
Kangfeng Jiang, Jing Yang, Guanhong Xue, Ailing Dai & Haichong Wu
Pages: 2963-2978
Published online: 18 Jul 2023
AbstractforFisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis | Full Text | References | PDF (14.6 MB) | EPUB
  • 137 Views
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Article
Overexpression of Neutrophil MMP-9 and HIF-1α May Contribute to the Finger-Like Projections Formation and Histo-Pathogenesis in Nasal Inverted Papilloma
Tao Li, Kai Sen Tan, Yan Yi Tu, Li Zhao, Jing Liu, Hsiao Hui Ong, De Yun Wang & Li Shi
Pages: 2979-2991
Published online: 06 Jul 2021
AbstractforOverexpression of Neutrophil MMP-9 and HIF-1α May Contribute to the Finger-Like Projections Formation and Histo-Pathogenesis in Nasal Inverted Papilloma | Full Text | References | PDF (6.5 MB) | EPUB
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Perspectives

Discussion
N-Acetylcysteine as Adjuvant Therapy for COVID-19 – A Perspective on the Current State of the Evidence
Kon Ken Wong, Shaun Wen Huey Lee & Kok Pim Kua
Pages: 2993-3013
Published online: 18 Jul 2023
AbstractforN-Acetylcysteine as Adjuvant Therapy for COVID-19 – A Perspective on the Current State of the Evidence | Full Text | References | PDF (591.1 KB) | EPUB
  • 187 Views
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Original Research

Article
Inverse Association Between Helicobacter pylori Infection and Unexplained Isolated Terminal Ileitis: A Retrospective Study
Yu Lei, Xiaoyu Liu, Jingmei Liu, Min Zhang, Yan Zhou, Wei Yan, Dean Tian, Ping Zhang & Ping Han
Pages: 3015-3021
Published online: 07 Jul 2021
AbstractforInverse Association Between Helicobacter pylori Infection and Unexplained Isolated Terminal Ileitis: A Retrospective Study | Full Text | References | PDF (1.9 MB) | EPUB
  • 72 Views
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Article
Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
Chen-Hao Zhang, Xiao-Lan Su, Yi-Ying Liu, Long Lin, Yin-Chun Wang, Xiao-Dong Li, Jin-Ze Zhang & Wei Wei
Pages: 3023-3037
Published online: 18 Jul 2023
AbstractforStudy on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis | Full Text | References | PDF (5.8 MB) | EPUB
  • 67 Views
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Article
Association of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction
Li-Ping Zhu, Wei-Lan Yin, Lei Peng, Xiao-Hong Zhou, Peng Zhou, Shu-Xia Xuan, Ying Luo, Chen Chen, Bin Cheng, Jin-Duan Lin, Yan-Mei Liu, Feng-Jun Tan & Wei-Guo Yin
Pages: 3039-3047
Published online: 07 Jul 2021
AbstractforAssociation of Aldehyde Dehydrogenase 2 Gene Polymorphism with Myocardial Infarction | Full Text | References | PDF (327.3 KB) | EPUB
  • 71 Views
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Article
The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury
Fonny Josh, Tomie Hermawan Soekamto, Januar Rizky Adriani, Billy Jonatan, Hiroshi Mizuno & Muhammad Faruk
Pages: 3049-3061
Published online: 18 Jul 2023
AbstractforThe Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury | Full Text | References | PDF (3.6 MB) | EPUB
  • 87 Views
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Article
Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease
Ran Zheng, Yang Ruan, Yiqun Yan, Zhihao Lin, Naijia Xue, Yaping Yan, Jun Tian, Xinzhen Yin, Jiali Pu & Baorong Zhang
Pages: 3063-3075
Published online: 18 Jul 2023
AbstractforMelatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease | Full Text | References | PDF (9.4 MB) | EPUB
  • 125 Views
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Review

Review Article
Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects
Wenlu Zou, Jie Lu & Yan Hao
Pages: 3077-3088
Published online: 08 Jul 2021
AbstractforMyocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms and Therapeutic Prospects | Full Text | References | PDF (2.9 MB) | EPUB
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Original Research

Article
Oral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice
Akihiro Uchida, Taro Yasuma, Atsuro Takeshita, Masaaki Toda, Yuko Okano, Kota Nishihama, Corina N D’Alessandro-Gabazza, Valeria Fridman D’Alessandro, Chisa Inoue, Takehiro Takagi, Hiroyuki Mukaiyama, Norio Takagi, Katsumi Shimizu, Yutaka Yano & Esteban C Gabazza
Pages: 3089-3105
Published online: 09 Jul 2021
AbstractforOral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice | Full Text | References | PDF (6.6 MB) | EPUB
  • 90 Views
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Article
Methyl Diet Enhanced Sepsis-Induced Mortality Through Altering Gut Microbiota
Chang Yu, Xiaojun Zhu, Chao Zheng, Yichun Luo, Fang Wang, Yueqiu Gao, Hailong Wu, Xuehua Sun & Xiaoni Kong
Pages: 3107-3121
Published online: 18 Jul 2023
AbstractforMethyl Diet Enhanced Sepsis-Induced Mortality Through Altering Gut Microbiota | Full Text | References | PDF (11.3 MB) | EPUB
  • 73 Views
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Case Series

Case Report
Prevalence and Characteristics of Rheumatoid-Associated Autoantibodies in Patients with COVID-19
Chen Xu, Junli Fan, Yi Luo, Ziwu Zhao, Peng Tang, Gui Yang, Yunbao Pan, Shuang Guo, Yingjuan Liu, Yong Xiong, Wen Xie & Xinghua Long
Pages: 3123-3128
Published online: 12 Jul 2021
AbstractforPrevalence and Characteristics of Rheumatoid-Associated Autoantibodies in Patients with COVID-19 | Full Text | References | PDF (427.1 KB) | EPUB
  • 61 Views
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Original Research

Article
Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan & Jing Yu
Pages: 3129-3143
Published online: 12 Jul 2021
AbstractforGrape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway | Full Text | References | PDF (9.5 MB) | EPUB
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Review

Review Article
Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review
YaLan Luo, ZhaoXia Li, Peng Ge, HaoYa Guo, Lei Li, GuiXin Zhang, CaiMing Xu & HaiLong Chen
Pages: 3145-3169
Published online: 12 Jul 2021
AbstractforComprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review | Full Text | References | PDF (2.8 MB) | EPUB
  • 133 Views
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Review Article
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Songwei Yang & Min Yu
Pages: 3171-3183
Published online: 18 Jul 2023
AbstractforRole of Goblet Cells in Intestinal Barrier and Mucosal Immunity | Full Text | References | PDF (3.3 MB) | EPUB
  • 461 Views
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Original Research

Article
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis
Ding Wang, Xi Zhan, Rui Wu, Yan You, Weixian Chen & Liang Duan
Pages: 3185-3196
Published online: 13 Jul 2021
AbstractforAssessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis | Full Text | References | PDF (5.1 MB) | EPUB
  • 72 Views
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Article
Exploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats
Chao Qin, Yi Jiang, Mingdong Yu, Yingxue Bian & Yonghao Yu
Pages: 3197-3206
Published online: 18 Jul 2023
AbstractforExploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats | Full Text | References | PDF (4.3 MB) | EPUB
  • 54 Views
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Article
Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis
Tiewei Li, Xiaojuan Li, Yulei Wei, Geng Dong, Jianwei Yang, Junmei Yang, Panpan Fang & Minglu Qi
Pages: 3207-3215
Published online: 13 Jul 2021
AbstractforPredictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis | Full Text | References | PDF (2.1 MB) | EPUB
  • 143 Views
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Article
Mesenchymal Stem Cell-Derived Exosomes Induced by IL-1β Attenuate Urethral Stricture Through Let-7c/PAK1/NF-κB-Regulated Macrophage M2 Polarization
Ye-Hui Chen, Ru-Nan Dong, Jian Hou, Ting-Ting Lin, Shao-Hao Chen, Hang Chen, Jun-Ming Zhu, Jia-Yin Chen, Zhi-Bin Ke, Fei Lin, Xue-Yi Xue, Yong Wei & Ning Xu
Pages: 3217-3229
Published online: 13 Jul 2021
AbstractforMesenchymal Stem Cell-Derived Exosomes Induced by IL-1β Attenuate Urethral Stricture Through Let-7c/PAK1/NF-κB-Regulated Macrophage M2 Polarization | Full Text | References | PDF (7.3 MB) | EPUB
  • 90 Views
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Article
Combining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy
Meilong Wu, Shizhong Yang, Xiaobin Feng, Chengquan Li, Xiangchen Liu, Zhenyu Zhang, Ying Xiao, Chuchu Liu & Jiahong Dong
Pages: 3231-3245
Published online: 13 Jul 2021
AbstractforCombining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy | Full Text | References | PDF (13.6 MB) | EPUB
  • 67 Views
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Article
Efficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate
Yuki Yamanashi, Mika Ohmichi, Yusuke Ohmichi, Tatsunori Ikemoto, Young-Chang Arai, Yohei Maruyama, Shun Otsuka, Shuichi Hirai, Munekazu Naito & Masataka Deie
Pages: 3247-3259
Published online: 15 Jul 2021
AbstractforEfficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate | Full Text | References | PDF (7.8 MB) | EPUB
  • 114 Views
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Article
Duzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice
Lili Li, Shanshan Fan, Wenqi Zhang, Dongna Li, Zhen Yang, Pengwei Zhuang, Juan Han, Hong Guo & Yanjun Zhang
Pages: 3261-3276
Published online: 23 Jul 2021
AbstractforDuzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice | Full Text | References | PDF (10 MB) | EPUB
  • 70 Views
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Article
Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells
Alhaji Osman Smith, Wen Ju, Seyram Yao Adzraku, Lu wenyi, Chen Yuting, Jianlin Qiao, Kailin Xu & Lingyu Zeng
Pages: 3277-3288
Published online: 18 Jul 2023
AbstractforGamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells | Full Text | References | PDF (7.1 MB) | EPUB
  • 150 Views
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Review

Review Article
The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
Xinwei Xu, Jintu Huang, Dickson Kofi Wiredu Ocansey, Yuxuan Xia, Zihan Zhao, Zhiwei Xu, Yongmin Yan, Xu Zhang & Fei Mao
Pages: 3289-3306
Published online: 18 Jul 2023
AbstractforThe Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer | Full Text | References | PDF (4.2 MB) | EPUB
  • 100 Views
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Original Research

Article
A Cardiac Protection of Germinated Brown Rice During Cardiopulmonary Bypass Surgery and Simulated Myocardial Ischemia
Kanokwan Demeekul, Pratch Sukumolanan, Ratikorn Bootcha, Chattida Panprom & Soontaree Petchdee
Pages: 3307-3319
Published online: 18 Jul 2023
AbstractforA Cardiac Protection of Germinated Brown Rice During Cardiopulmonary Bypass Surgery and Simulated Myocardial Ischemia | Full Text | References | PDF (6.3 MB) | EPUB
  • 72 Views
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Article
Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis
Xiao Ran, Qin Zhang, Shaoping Li, Zhen Yu, Li Wan, Bin Wu, Rongxue Wu & Shusheng Li
Pages: 3321-3333
Published online: 18 Jul 2023
AbstractforTissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis | Full Text | References | PDF (6.1 MB) | EPUB
  • 69 Views
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Article
Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP
Haiyan Ge, Xuanqi Liu, Wenchao Gu, Xiumin Feng, Fengying Zhang, Fengfeng Han, Yechang Qian, Xiaoyan Jin, Beilan Gao, Li Yu, Hong Bao, Min Zhou, Shengqing Li, Zhijun Jie, Jian Wang, Zhihong Chen, Jingqing Hang, Jingxi Zhang & Huili Zhu
Pages: 3335-3348
Published online: 15 Jul 2021
AbstractforDistribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP | Full Text | References | PDF (7.3 MB) | EPUB
  • 90 Views
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Article
Genetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents
Mohamed M Zedan, Zeinab Rizk Attia, Rania A Abd El Azeem, Thuraya M Mutawi, Amora S El Shehawy & Ashraf Bakr
Pages: 3349-3358
Published online: 15 Jul 2021
AbstractforGenetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents | Full Text | References | PDF (1 MB) | EPUB
  • 82 Views
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Article
Effectiveness of Tocilizumab with and without Dexamethasone in Patients with Severe COVID-19: A Retrospective Study
Dorota Zarębska-Michaluk, Jerzy Jaroszewicz, Magdalena Rogalska, Diana Martonik, Paweł Pabjan, Aleksandra Berkan-Kawińska, Beata Bolewska, Barbara Oczko-Grzesik, Dorota Kozielewicz, Magdalena Tudrujek-Zdunek, Justyna Kowalska, Anna Moniuszko-Malinowska, Krzysztof Kłos, Marta Rorat, Piotr Leszczyński, Anna Piekarska, Joanna Polańska & Robert Flisiak
Pages: 3359-3366
Published online: 16 Jul 2021
AbstractforEffectiveness of Tocilizumab with and without Dexamethasone in Patients with Severe COVID-19: A Retrospective Study | Full Text | References | PDF (723.6 KB) | EPUB
  • 75 Views
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Review

Review Article
Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy
Tobias Engel, Jonathon Smith & Mariana Alves
Pages: 3367-3392
Published online: 18 Jul 2021
AbstractforTargeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy | Full Text | References | PDF (2.1 MB) | EPUB
  • 109 Views
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Original Research

Article
Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling
Wenjun Li, Yeyang Wang, Yaqin Tang, Hanyu Lu, Yong Qi, Guitao Li, Hebei He, Fanglian Lu, Yixin Yang & Hongtao Sun
Pages: 3393-3403
Published online: 18 Jul 2023
AbstractforQuercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling | Full Text | References | PDF (7.8 MB) | EPUB
  • 105 Views
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Article
Platelet-Derived Growth Factor Regulates the Biological Behavior of Oral Mucosal Fibroblasts by Inducing Cell Autophagy and Its Mechanism
Jie Wang, Lina Yang, Jialing You, Dada Wen, Bo Yang & Canhua Jiang
Pages: 3405-3417
Published online: 17 Jul 2021
AbstractforPlatelet-Derived Growth Factor Regulates the Biological Behavior of Oral Mucosal Fibroblasts by Inducing Cell Autophagy and Its Mechanism | Full Text | References | PDF (6.6 MB) | EPUB
  • 61 Views
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Review

Review Article
Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future
Decsa Medika Hertanto, Bayu Satria Wiratama, Henry Sutanto & Citrawati Dyah Kencono Wungu
Pages: 3419-3428
Published online: 20 Jul 2021
AbstractforImmunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future | Full Text | References | PDF (1.7 MB) | EPUB
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Review Article
Recent Insights into the Management of Behçet Syndrome
Yesim Ozguler, Ayse Ozdede & Gulen Hatemi
Pages: 3429-3441
Published online: 18 Jul 2023
AbstractforRecent Insights into the Management of Behçet Syndrome | Full Text | References | PDF (469.7 KB) | EPUB
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Original Research

Article
The Supportive Role of NSC328382, a P2X7R Antagonist, in Enhancing the Inhibitory Effect of CRID3 on NLRP3 Inflammasome Activation in Rats with Dextran Sodium Sulfate-Induced Colitis
Sameh Saber, Galal Yahya, Naglaa A Gobba, Hossam Sharaf, Reem Alshaman, Abdullah Alattar, Noha A Amin, Ruwyda El-Shedody, Farah H Aboutouk, Yumna Abd El-Galeel, Amr El-Hefnawy, Dina Shabaka, Arwa Khalifa, Renad Saleh, Donya Osama, Ghada El-Zoghby & Mahmoud E Youssef
Pages: 3443-3463
Published online: 21 Jul 2021
AbstractforThe Supportive Role of NSC328382, a P2X7R Antagonist, in Enhancing the Inhibitory Effect of CRID3 on NLRP3 Inflammasome Activation in Rats with Dextran Sodium Sulfate-Induced Colitis | Full Text | References | PDF (22.2 MB) | EPUB
  • 107 Views
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Article
GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice
Yifan Cai, Qiutang Zeng, Yuzhou Liu, Ruirui Zhu, Kunwu Yu, Wenbin Xu, Yue Wang, Yan Ding, Jian Yu, Chengliang Pan, Yudong Peng, Yi Mao, Peng Cheng, Lun Huang, Xiaobo Mao & Yucheng Zhong
Pages: 3465-3479
Published online: 22 Jul 2021
AbstractforGARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice | Full Text | References | PDF (10.8 MB) | EPUB
  • 62 Views
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Article
Examining the Association Between Serum Leptin and Sarcopenic Obesity
Zhe-Yu Yang & Wei-Liang Chen
Pages: 3481-3487
Published online: 22 Jul 2021
AbstractforExamining the Association Between Serum Leptin and Sarcopenic Obesity | Full Text | References | PDF (345 KB) | EPUB
  • 83 Views
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Article
PADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles
Bo Huang, Yating Zhao, Lin Zhou, Tingyu Gong, Jiawen Feng, Peilin Han & Jianhua Qian
Pages: 3489-3500
Published online: 18 Jul 2023
AbstractforPADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles | Full Text | References | PDF (10.6 MB) | EPUB
  • 65 Views
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Article
Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture
Yao Zou, Owais M Bhat, Xinxu Yuan, Guangbi Li, Dandan Huang, Yi Guo, Dan Zhou & Pin-Lan Li
Pages: 3501-3521
Published online: 18 Jul 2023
AbstractforRelease and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture | Full Text | References | PDF (14.8 MB) | EPUB
  • 108 Views
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Article
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes
Weimin Fan, Shixian Chen, Xianghui Wu, Junqing Zhu & Juan Li
Pages: 3523-3536
Published online: 24 Jul 2021
AbstractforResveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes | Full Text | References | PDF (9 MB) | EPUB
  • 106 Views
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Article
Identification of Key Candidate Genes Related to Inflammatory Osteolysis Associated with Vitamin E-Blended UHMWPE Debris of Orthopedic Implants by Integrated Bioinformatics Analysis and Experimental Confirmation
Fanxiao Liu, Jun Dong, Dongsheng Zhou & Qingyu Zhang
Pages: 3537-3554
Published online: 26 Jul 2021
AbstractforIdentification of Key Candidate Genes Related to Inflammatory Osteolysis Associated with Vitamin E-Blended UHMWPE Debris of Orthopedic Implants by Integrated Bioinformatics Analysis and Experimental Confirmation | Full Text | References | PDF (13 MB) | EPUB
  • 84 Views
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Article
IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis
Mohammad Amjad Hossain, Aravinthan Adithan, Md Jahangir Alam, Spandana Rajendra Kopalli, Bumseok Kim, Chang-Won Kang, Ki-Chul Hwang & Jong-Hoon Kim
Pages: 3555-3568
Published online: 24 Jul 2021
AbstractforIGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis | Full Text | References | PDF (10.8 MB) | EPUB
  • 129 Views
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Article
Effects of Photobiomodulation Therapy Combined with Static Magnetic Field in Severe COVID-19 Patients Requiring Intubation: A Pragmatic Randomized Placebo-Controlled Trial
Thiago De Marchi, Fabiano Frâncio, João Vitor Ferlito, Renata Weigert, Cristiane de Oliveira, Ana Paula Merlo, Délcio Luis Pandini, Bolivar Antônio Pasqual-Júnior, Daniela Giovanella, Shaiane Silva Tomazoni & Ernesto Cesar Leal-Junior
Pages: 3569-3585
Published online: 18 Jul 2023
AbstractforEffects of Photobiomodulation Therapy Combined with Static Magnetic Field in Severe COVID-19 Patients Requiring Intubation: A Pragmatic Randomized Placebo-Controlled Trial | Full Text | References | PDF (4.9 MB) | EPUB
  • 101 Views
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Article
Associations of Single Nucleotide Polymorphisms in IL-18 Gene with Plasmodium falciparum-Associated Malaria
Alaa U AlRuwaisan, Mashael R Al-Anazi, Mohammed I Shafeai, Fuad H Rudiny, Ali M Motaen, Saad M Bin Dajem, Hani Alothaid, Kareem Morsy, Saad Alkahtani & Ahmed A Al-Qahtani
Pages: 3587-3619
Published online: 18 Jul 2023
AbstractforAssociations of Single Nucleotide Polymorphisms in IL-18 Gene with Plasmodium falciparum-Associated Malaria | Full Text | References | PDF (2 MB) | EPUB
  • 99 Views
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Review

Review Article
Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
Shafiu A Umar Shinge, Daifang Zhang, Tobias Achu Muluh, Yongmei Nie & Fengxu Yu
Pages: 3621-3636
Published online: 27 Jul 2021
AbstractforMechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis | Full Text | References | PDF (3.6 MB) | EPUB
  • 226 Views
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Original Research

Article
Overexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling
Shan Lin, Qingui Chen, Lishan Zhang, Shanhui Ge, Yuling Luo, Wanmei He, Caixia Xu & Mian Zeng
Pages: 3637-3649
Published online: 18 Jul 2023
AbstractforOverexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling | Full Text | References | PDF (8.1 MB) | EPUB
  • 59 Views
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Review

Review Article
A Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review
Azzah Alharbi
Pages: 3651-3664
Published online: 30 Jul 2021
AbstractforA Potential Role of Vitamin D on Platelet Leukocyte Aggregation and Pathological Events in Sepsis: An Updated Review | Full Text | References | PDF (1.4 MB) | EPUB
  • 77 Views
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Original Research

Article
Integrating Bioinformatic Strategies with Real-World Data to Infer Distinctive Immunocyte Infiltration Landscape and Immunologically Relevant Transcriptome Fingerprints in Ossification of Ligamentum Flavum
Baoliang Zhang, Guanghui Chen, Xi Chen, Xiaoxi Yang, Tianqi Fan, Chuiguo Sun & Zhongqiang Chen
Pages: 3665-3685
Published online: 30 Jul 2021
AbstractforIntegrating Bioinformatic Strategies with Real-World Data to Infer Distinctive Immunocyte Infiltration Landscape and Immunologically Relevant Transcriptome Fingerprints in Ossification of Ligamentum Flavum | Full Text | References | PDF (19.2 MB) | EPUB
  • 74 Views
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Article
miR-486-5p Serves as a Diagnostic Biomarker for Sepsis and Its Predictive Value for Clinical Outcomes
Baobin Sun & Shubin Guo
Pages: 3687-3695
Published online: 30 Jul 2021
AbstractformiR-486-5p Serves as a Diagnostic Biomarker for Sepsis and Its Predictive Value for Clinical Outcomes | Full Text | References | PDF (2.1 MB) | EPUB
  • 82 Views
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Article
LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner
Yi Zheng, Pan-Pan Ye, Yue Zhou, Su-Ying Wu, Xi-Ting Liu, Bin Du, Bo-Hao Tang, Min Kan, Ai-Qing Nie, Rui Yin, Meng Wang, Guo-Xiang Hao, Lin-Lin Song, Xin-Mei Yang, Xin Huang, Le-Qun Su, Wen-Qi Wang, John van den Anker & Wei Zhao
Pages: 3697-3706
Published online: 03 Aug 2021
AbstractforLPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner | Full Text | References | PDF (3.6 MB) | EPUB
  • 64 Views
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Review

Review Article
The Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research
Yu-Long Lan, Yongjian Zhu, Gao Chen & Jianmin Zhang
Pages: 3707-3720
Published online: 18 Jul 2023
AbstractforThe Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research | Full Text | References | PDF (4.7 MB) | EPUB
  • 108 Views
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Original Research

Article
A Single-Center Retrospective Observational Study Evaluating the Favorable Predictive Factors for the Disease Control Time of Treatment with Tocilizumab in Patients of Rheumatoid Arthritis
Nobuyasu Ishii, Toshiki Shimizu, Yoshihisa Ishiura, Hideki Amuro, Tohru Nishizawa, Takeshi Tamaki & Shosaku Nomura
Pages: 3721-3728
Published online: 05 Aug 2021
AbstractforA Single-Center Retrospective Observational Study Evaluating the Favorable Predictive Factors for the Disease Control Time of Treatment with Tocilizumab in Patients of Rheumatoid Arthritis | Full Text | References | PDF (1 MB) | EPUB
  • 64 Views
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Article
Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells
Sanah Malomile Nkadimeng, Christiaan M L Steinmann & Jacobus N Eloff
Pages: 3729-3738
Published online: 18 Jul 2023
AbstractforAnti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells | Full Text | References | PDF (1.4 MB) | EPUB
  • 504 Views
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Article
Profiling the Expression of Circulating Acute-Phase Proteins, Cytokines, and Checkpoint Proteins in Patients with Severe Trauma: A Pilot Study
Shao-Chun Wu, Cheng-Shyuan Rau, Pao-Jen Kuo, Fu-Yuan Shih, Hui-Ping Lin, Yi-Chan Wu, Ting-Min Hsieh, Hang-Tsung Liu & Ching-Hua Hsieh
Pages: 3739-3753
Published online: 18 Jul 2023
AbstractforProfiling the Expression of Circulating Acute-Phase Proteins, Cytokines, and Checkpoint Proteins in Patients with Severe Trauma: A Pilot Study | Full Text | References | PDF (4.1 MB) | EPUB
  • 82 Views
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Article
Gut Microbiota-Derived Inflammation-Related Serum Metabolites as Potential Biomarkers for Major Depressive Disorder
Shunjie Bai, Jing Xie, Huili Bai, Tian Tian, Tao Zou & Jian-Jun Chen
Pages: 3755-3766
Published online: 06 Aug 2021
AbstractforGut Microbiota-Derived Inflammation-Related Serum Metabolites as Potential Biomarkers for Major Depressive Disorder | Full Text | References | PDF (8.2 MB) | EPUB
  • 140 Views
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Article
Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice
Yajie Zhu, Xiaoli Ge, Di Xie, Shangyuan Wang, Feng Chen & Shuming Pan
Pages: 3767-3780
Published online: 18 Jul 2023
AbstractforClinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice | Full Text | References | PDF (10.7 MB) | EPUB
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Article
Characterization of Virus Replication, Pathogenesis, and Cytokine Responses in Syrian Hamsters Inoculated with SARS-CoV-2
Shiu-Ju Yang, Ting-Chun Wei, Chih-Hao Hsu, Sin-Ni Ho, Chi-Yun Lai, Shiu-Feng Huang, Yih-Yuan Chen, Shih-Jen Liu, Guann-Yi Yu & Horng-Yunn Dou
Pages: 3781-3795
Published online: 18 Jul 2023
AbstractforCharacterization of Virus Replication, Pathogenesis, and Cytokine Responses in Syrian Hamsters Inoculated with SARS-CoV-2 | Full Text | References | PDF (10.5 MB) | EPUB
  • 99 Views
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Article
Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
Aleksandra Gąsecka, Piotr Szwed, Karolina Jasińska, Oliwia Fidali, Aleksandra Kłębukowska, Ceren Eyileten, Marek Postula, Łukasz Szarpak, Tomasz Mazurek, Grzegorz Opolski, Krzysztof J Filipiak & Marcin Ufnal
Pages: 3797-3808
Published online: 10 Aug 2021
AbstractforSymmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes | Full Text | References | PDF (3.7 MB) | EPUB
  • 68 Views
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Article
Identification and Validation of a Novel Inflammatory Response-Related Gene Signature for the Prognosis of Colon Cancer
Yichao Liang, Xin Wu, Qi Su, Yujie Liu & Hong Xiao
Pages: 3809-3821
Published online: 18 Jul 2023
AbstractforIdentification and Validation of a Novel Inflammatory Response-Related Gene Signature for the Prognosis of Colon Cancer | Full Text | References | PDF (11.8 MB) | EPUB
  • 103 Views
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Article
Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33
Angela J Okragly, Katie Brannon Corwin, Marikka Elia, Dongmei He, Oliver Schroeder, Qing Zhang, Tatiyana Shiyanova, Stuart Bright, Sarah B Dicker, Lukasz Chlewicki, Stephanie M E Truhlar, Julian Davies, Chetan N Patel & Robert J Benschop
Pages: 3823-3835
Published online: 18 Jul 2023
AbstractforGeneration and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33 | Full Text | References | PDF (2.1 MB) | EPUB
  • 130 Views
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Article
Early Elevation of Thioredoxin-1 Serum Levels Predicts 28-Day Mortality in Patients with Sepsis
Xing Li, Hua Shen, Tinghong Zhou, Xiaoyu Cao, Ying Chen, Yan Liang, Ting Lu, JiaFen He, ZhouLin Dou, ChuaiKai Liu, Yong Tang & Zeixang Zhu
Pages: 3837-3848
Published online: 18 Jul 2023
AbstractforEarly Elevation of Thioredoxin-1 Serum Levels Predicts 28-Day Mortality in Patients with Sepsis | Full Text | References | PDF (2.9 MB) | EPUB
  • 66 Views
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Article
Propofol Ameliorates Exaggerated Human Neutrophil Activation in a LPS Sepsis Model
Andre Bredthauer, Angela Geiger, Michael Gruber, Sophie-Marie Pfaehler, Walter Petermichl, Diane Bitzinger, Thomas Metterlein & Timo Seyfried
Pages: 3849-3862
Published online: 11 Aug 2021
AbstractforPropofol Ameliorates Exaggerated Human Neutrophil Activation in a LPS Sepsis Model | Full Text | References | PDF (3.4 MB) | EPUB
  • 72 Views
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Article
Neuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats
Ching-Yi Tsai, Chi Fang, Jacqueline C C Wu, Chiung-Ju Wu, Kuang-Yu Dai & Shu-Mi Chen
Pages: 3863-3877
Published online: 11 Aug 2021
AbstractforNeuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats | Full Text | References | PDF (5.3 MB) | EPUB
  • 80 Views
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Article
Comparison of the Prognostic Value of Inflammation-Based Scores in Patients with Hepatocellular Carcinoma After Anti-PD-1 Therapy
Jie Mei, Xu-Qi Sun, Wen-Ping Lin, Shao-Hua Li, Liang-He Lu, Jing-Wen Zou, Wei Wei & Rong-Ping Guo
Pages: 3879-3890
Published online: 18 Jul 2023
AbstractforComparison of the Prognostic Value of Inflammation-Based Scores in Patients with Hepatocellular Carcinoma After Anti-PD-1 Therapy | Full Text | References | PDF (1.1 MB) | EPUB
  • 79 Views
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Article
Progranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma
Meixuan Liu, Mengtian Shan, Yunxuan Zhang & Zhongliang Guo
Pages: 3891-3904
Published online: 18 Jul 2023
AbstractforProgranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma | Full Text | References | PDF (14.3 MB) | EPUB
  • 81 Views
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Article
Anti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats
John Oludele Olanlokun, Adeola Oluwakemi Olowofolahan, Olusola Bodede, Adekunle Theophilus Adegbuyi, Gerhard Prinsloo, Paul Steenkamp & Olufunso Olabode Olorunsogo
Pages: 3905-3920
Published online: 13 Aug 2021
AbstractforAnti-Inflammatory Potentials of the n-Hexane Fraction of Alstonia boonei Stem Bark in Lipopolysaccharide-Induced Inflammation in Wistar Rats | Full Text | References | PDF (2.4 MB) | EPUB
  • 147 Views
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Article
Relationship Between Prognostic Nutritional Index and Mortality in Overweight or Obese Patients with Cancer: A Multicenter Observational Study
Xi Zhang, Jing-Hua Li, Qi Zhang, Qin-Qin Li, Kang-Ping Zhang, Meng Tang, Yi-Zhong Ge, Wei Li, Hong-Xia Xu, Zeng-Qing Guo & Han-Ping Shi
Pages: 3921-3932
Published online: 14 Aug 2021
AbstractforRelationship Between Prognostic Nutritional Index and Mortality in Overweight or Obese Patients with Cancer: A Multicenter Observational Study | Full Text | References | PDF (4.6 MB) | EPUB
  • 72 Views
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Article
Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
Qianye Zhao, Teng Zhang, Beibei Zhu, Ying Bi, Shi-Wen Jiang, Yifan Zhu, Deyu Zhao & Feng Liu
Pages: 3933-3943
Published online: 14 Aug 2021
AbstractforIncreasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia | Full Text | References | PDF (5.2 MB) | EPUB
  • 69 Views
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Article
Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress
Jiang Zhu, Xia Zhang, Hong Xie, Yuye Wang, Xiaoxiao Zhang & Zhaoheng Lin
Pages: 3945-3958
Published online: 14 Aug 2021
AbstractforCardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress | Full Text | References | PDF (7.3 MB) | EPUB
  • 85 Views
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Article
The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells
Mansour Haddad
Pages: 3959-3967
Published online: 14 Aug 2021
AbstractforThe Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells | Full Text | References | PDF (2 MB) | EPUB
  • 98 Views
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Article
Necroptosis Underlies Neutrophilic Inflammation Associated with the Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Yadong Xie, Min Li, Kun Chen, Haoxiang Zhu, Mengyao Tang, Chun Zhou, Yaoming Zheng, Jing Wen, Miaomiao Han, Jia Zhang, Keqing Zhao, Hui Xiao & Huabin Li
Pages: 3969-3983
Published online: 16 Aug 2021
AbstractforNecroptosis Underlies Neutrophilic Inflammation Associated with the Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) | Full Text | References | PDF (10.8 MB) | EPUB
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Article
Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells
Ya Gao, Weiru Li, Xiaoyin Bu, Ying Xu, Shengchun Cai, Jinman Zhong, Meixue Du, Haitao Sun, Liping Huang, Yongjian He, Xiumei Hu, Qifa Liu, Hua Jin, Qian Wang & Baohong Ping
Pages: 3985-3999
Published online: 18 Jul 2023
AbstractforHuman Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells | Full Text | References | PDF (8.7 MB) | EPUB
  • 80 Views
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Article
The Role of Adenosine Receptor A2A in the Regulation of Macrophage Exosomes and Vascular Endothelial Cells During Bone Healing
Dong Wang, Jingyi Wang, Junlin Zhou & Xi Zheng
Pages: 4001-4017
Published online: 17 Aug 2021
AbstractforThe Role of Adenosine Receptor A2A in the Regulation of Macrophage Exosomes and Vascular Endothelial Cells During Bone Healing | Full Text | References | PDF (17.2 MB) | EPUB
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Article
Nomogram Based on Lactate Dehydrogenase-to-Albumin Ratio (LAR) and Platelet-to-Lymphocyte Ratio (PLR) for Predicting Survival in Nasopharyngeal Carcinoma
Ru-Rong Peng, Zhong-Guo Liang, Kai-Hua Chen, Ling Li, Song Qu & Xiao-Dong Zhu
Pages: 4019-4033
Published online: 18 Jul 2023
AbstractforNomogram Based on Lactate Dehydrogenase-to-Albumin Ratio (LAR) and Platelet-to-Lymphocyte Ratio (PLR) for Predicting Survival in Nasopharyngeal Carcinoma | Full Text | References | PDF (8.6 MB) | EPUB
  • 76 Views
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Article
Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk
Abigail C Burr, Jalene V Velazquez, Arzu Ulu, Rohan Kamath, Sang Yong Kim, Amanpreet K Bilg, Aileen Najera, Iman Sultan, Jon K Botthoff, Emma Aronson, Meera G Nair & Tara M Nordgren
Pages: 4035-4052
Published online: 18 Jul 2023
AbstractforLung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk | Full Text | References | PDF (10.7 MB) | EPUB
  • 71 Views
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Article
Localized and Systemic Inflammatory Mediators in a Murine Acute Mastitis Model
Miyuki Takashima, Christian Lalonde, Laura Ashley Olszanski & Feng-Qi Zhao
Pages: 4053-4067
Published online: 21 Aug 2021
AbstractforLocalized and Systemic Inflammatory Mediators in a Murine Acute Mastitis Model | Full Text | References | PDF (7.4 MB) | EPUB
  • 70 Views
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Article
The Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study
Xu Zhao, Jitao Zhang, Wenjuan Zhang, Ruping Dai, Junmei Xu, Zhijian Li & Lin Yang
Pages: 4069-4077
Published online: 21 Aug 2021
AbstractforThe Relationship Between Circulating Bone Morphogenetic Protein-4 and Inflammation Cytokines in Patients Undergoing Thoracic Surgery: A Prospective Randomized Study | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Nrf2 Regulates CHI3L1 to Suppress Inflammation and Improve Post-Traumatic Osteoarthritis
Yang Song, Dake Hao, Huan Jiang, Mingguang Huang, Qingjun Du, Yi Lin, Fei Liu & Bin Chen
Pages: 4079-4088
Published online: 18 Jul 2023
AbstractforNrf2 Regulates CHI3L1 to Suppress Inflammation and Improve Post-Traumatic Osteoarthritis | Full Text | References | PDF (6.2 MB) | EPUB
  • 102 Views
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Article
Predictive Models for HCC Prognosis, Recurrence Risk, and Immune Infiltration Based on Two Exosomal Genes: MYL6B and THOC2
Jinyu Zhu, Bufu Tang, Yang Gao, Suqin Xu, Jianfei Tu, Yajie Wang, Weibin Yang, Shiji Fang, Qiaoyou Weng, Zhongwei Zhao, Min Xu, Yang Yang, Minjiang Chen, Chenying Lu & Jiansong Ji
Pages: 4089-4109
Published online: 18 Jul 2023
AbstractforPredictive Models for HCC Prognosis, Recurrence Risk, and Immune Infiltration Based on Two Exosomal Genes: MYL6B and THOC2 | Full Text | References | PDF (17.5 MB) | EPUB
  • 87 Views
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Article
Transcriptome Analysis Reveals the Molecular Immunological Characteristics of Lesions in Patients with Halo Nevi When Compared to Stable Vitiligo, Normal Nevocytic Nevi and Cutaneous Melanoma
Chun Pan, Jingzhe Shang, Haiqin Jiang, Ying Shi, Wenyue Zhang, Jingshu Xiong, Youming Mei, Siyu Long, Gai Ge, Zhenzhen Wang, Ziwei Wu, Hongsheng Wang & Aiping Wu
Pages: 4111-4124
Published online: 24 Aug 2021
AbstractforTranscriptome Analysis Reveals the Molecular Immunological Characteristics of Lesions in Patients with Halo Nevi When Compared to Stable Vitiligo, Normal Nevocytic Nevi and Cutaneous Melanoma | Full Text | References | PDF (5.8 MB) | EPUB
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Article
Effect of Vitamin D Deficiency and Supplementation in Lactation and Early Life on Allergic Airway Inflammation and the Expression of Autophagy-Related Genes in an Ovalbumin Mouse Model
Yan Zhou, Yishu Xue, Aihua Bao, Lei Han, Wuping Bao, Chao Xia, Xue Tian & Min Zhang
Pages: 4125-4141
Published online: 24 Aug 2021
AbstractforEffect of Vitamin D Deficiency and Supplementation in Lactation and Early Life on Allergic Airway Inflammation and the Expression of Autophagy-Related Genes in an Ovalbumin Mouse Model | Full Text | References | PDF (10.3 MB) | EPUB
  • 73 Views
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Article
Bioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS
Liying Chen, Dingqi Lu, Kai Yu, Shiya He, Liu Liu, Xvfeng Zhang, Bo Feng & Xinchang Wang
Pages: 4143-4153
Published online: 18 Jul 2023
AbstractforBioinformatics Analysis for Identification of Key Genes in Salivary Gland and the Potential of a Combination of Biomarkers for the Diagnosis of SS | Full Text | References | PDF (8.8 MB) | EPUB
  • 69 Views
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Review

Review Article
New Insights into the Role of NLRP3 Inflammasome in Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease
Jie Zhang, Qiuyun Xu, Weichen Sun, Xiaorong Zhou, Da Fu & Liming Mao
Pages: 4155-4168
Published online: 26 Aug 2021
AbstractforNew Insights into the Role of NLRP3 Inflammasome in Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease | Full Text | References | PDF (3.6 MB) | EPUB
  • 112 Views
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Original Research

Article
Dysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars
ZongAn Chen, Zhen Gao, LingLing Xia, XiaoQing Wang, LiMing Lu & XiaoLi Wu
Pages: 4169-4180
Published online: 26 Aug 2021
AbstractforDysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars | Full Text | References | PDF (11.3 MB) | EPUB
  • 103 Views
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Article
Clinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p
Hong Zhang, Lihong Li, Leijie Xu & Yanyan Zheng
Pages: 4181-4188
Published online: 26 Aug 2021
AbstractforClinical Significance of the Serum lncRNA NORAD Expression in Patients with Neonatal Sepsis and Its Association with miR-410-3p | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Lipocalin-2 Alleviates LPS-Induced Inflammation Through Alteration of Macrophage Properties
Huahua Du, Li Liang, Jiahui Li, Qingqing Xiong, Xin Yu & Hong Yu
Pages: 4189-4203
Published online: 26 Aug 2021
AbstractforLipocalin-2 Alleviates LPS-Induced Inflammation Through Alteration of Macrophage Properties | Full Text | References | PDF (12.9 MB) | EPUB
  • 98 Views
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Article
Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors
Xin Zhang, Dingyi Yang, Yong Jiang, Luo Huang, Can Wang, Dan Tao, Xianfeng Liu, Yongyang Lei, Yongzhong Wu & Wei Zhou
Pages: 4205-4215
Published online: 28 Aug 2021
AbstractforComparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors | Full Text | References | PDF (1,020.9 KB) | EPUB
  • 60 Views
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Article
Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment
Min Luo, Yan Lin, Rong Liang, Yongqiang Li & Lianying Ge
Pages: 4217-4228
Published online: 28 Aug 2021
AbstractforClinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment | Full Text | References | PDF (4 MB) | EPUB
  • 97 Views
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Corrigendum

Correction
Overexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling [Corrigendum]
Pages: 4229-4231
Published online: 30 Aug 2021
First Page PreviewforOverexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling [Corrigendum] | Full Text | PDF (2.4 MB) | EPUB
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Original Research

Article
Dynamic Changes of Antibodies to SARS-CoV-2 in Close Contacts
JinJian Yao, Hangfei Wang, Weiling Yu, Yimin Li, Zhiqian Luo, Biao Wu, Wei Zhang, Xiaoran Liu & Chuanzhu Lv
Pages: 4233-4243
Published online: 18 Jul 2023
AbstractforDynamic Changes of Antibodies to SARS-CoV-2 in Close Contacts | Full Text | References | PDF (7.4 MB) | EPUB
  • 63 Views
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Article
Expression Pattern and Clinical Value of Key m6A RNA Modification Regulators in Abdominal Aortic Aneurysm
Tan Li, Tianlong Wang, Jingjing Jing & Liping Sun
Pages: 4245-4258
Published online: 29 Aug 2021
AbstractforExpression Pattern and Clinical Value of Key m6A RNA Modification Regulators in Abdominal Aortic Aneurysm | Full Text | References | PDF (6.2 MB) | EPUB
  • 66 Views
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Review

Review Article
Insights into the Implications of Coexisting Type 2 Inflammatory Diseases
Justin P McCormick & Jivianne T Lee
Pages: 4259-4266
Published online: 30 Aug 2021
AbstractforInsights into the Implications of Coexisting Type 2 Inflammatory Diseases | Full Text | References | PDF (348.6 KB) | EPUB
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Original Research

Article
Antibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection
LianLi Duan, Jinyong Zhang, Zhifu Chen, Qiang Gou, Qingshan Xiong, Yue Yuan, Haiming Jing, Jiang Zhu, Li Ni, Yuling Zheng, Zhiyong Liu, Xiaokai Zhang, Hao Zeng, Quanming Zou & Zhuo Zhao
Pages: 4267-4282
Published online: 30 Aug 2021
AbstractforAntibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection | Full Text | References | PDF (10.3 MB) | EPUB
  • 77 Views
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Article
Increase in Blood–Brain Barrier Permeability is Modulated by Tissue Kallikrein via Activation of Bradykinin B1 and B2 Receptor-Mediated Signaling
Qin Zhang, Juan Tan, Li Wan, Chao Chen, Bin Wu, Xijian Ke, Rongxue Wu & Xiao Ran
Pages: 4283-4297
Published online: 18 Jul 2023
AbstractforIncrease in Blood–Brain Barrier Permeability is Modulated by Tissue Kallikrein via Activation of Bradykinin B1 and B2 Receptor-Mediated Signaling | Full Text | References | PDF (5.6 MB) | EPUB
  • 95 Views
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Article
Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes
Soyeon Jang, Soyoung Jang, Si-Yong Kim, Jiwon Ko, Eungyung Kim, Ji Yeong Park, Hyejin Hyung, Jin Hong Lee, Su-Geun Lim, Sijun Park, Junkoo Yi, Heon-Jin Lee, Myoung Ok Kim, Hyun-Shik Lee & Zae Young Ryoo
Pages: 4299-4312
Published online: 18 Jul 2023
AbstractforOverexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes | Full Text | References | PDF (8.1 MB) | EPUB
  • 76 Views
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Article
Alterations in the Plasma Proteome Induced by SARS-CoV-2 and MERS-CoV Reveal Biomarkers for Disease Outcomes for COVID-19 Patients
Ayodele Alaiya, Abeer Alshukairi, Zakia Shinwari, Mariam AL-Fares, Jawaher Alotaibi, Waleed AlOmaim, Ibtihaj Alsharif, Razan Bakheet, Layla Alharbi, Rabab Allam, Ayed Asiri, Ziad Memish, Khaldoun Alromaih & Maha Al-Mozaini
Pages: 4313-4328
Published online: 01 Sep 2021
AbstractforAlterations in the Plasma Proteome Induced by SARS-CoV-2 and MERS-CoV Reveal Biomarkers for Disease Outcomes for COVID-19 Patients | Full Text | References | PDF (6.4 MB) | EPUB
  • 124 Views
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Article
Inhibition of MALT1 Alleviates Spinal Ischemia/Reperfusion Injury-Induced Neuroinflammation by Modulating Glial Endoplasmic Reticulum Stress in Rats
Shutian Zhang, Yufeng Yan, Yongze Wang, Zhaodong Sun, Chengzhi Han, Xinyi Qian, Xiaorong Ren, Yi Feng, Jian Cai & Chunmei Xia
Pages: 4329-4345
Published online: 18 Jul 2023
AbstractforInhibition of MALT1 Alleviates Spinal Ischemia/Reperfusion Injury-Induced Neuroinflammation by Modulating Glial Endoplasmic Reticulum Stress in Rats | Full Text | References | PDF (15.6 MB) | EPUB
  • 89 Views
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Article
The Flavonoid Kurarinone Regulates Macrophage Functions via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Irritable Bowel Syndrome
Xiang Xu, Qiwei Dong, Qingling Zhong, Wenbo Xiu, Qinyuan Chen, Jinxia Wang & Zhou Zhou
Pages: 4347-4359
Published online: 18 Jul 2023
AbstractforThe Flavonoid Kurarinone Regulates Macrophage Functions via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Irritable Bowel Syndrome | Full Text | References | PDF (9.3 MB) | EPUB
  • 81 Views
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Article
The Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
Guomei Shi, Wenxiu Chen, Pengyu Gong, Meng Wang, Junshan Zhou, Xiaorong Wang, Minwang Guo, Jingye Lu, Yan Li, Hongxuan Feng, Xuetao Fu, Rujuan Zhou & Shouru Xue
Pages: 4361-4369
Published online: 02 Sep 2021
AbstractforThe Relationship Between Serum YKL-40 Levels on Admission and Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke | Full Text | References | PDF (561.8 KB) | EPUB
  • 65 Views
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Review

Review Article
Recent Insights into the Management of Inflammation in Asthma
Hitasha Rupani, Wei Chern Gavin Fong, Aref Kyyaly & Ramesh J Kurukulaaratchy
Pages: 4371-4397
Published online: 02 Sep 2021
AbstractforRecent Insights into the Management of Inflammation in Asthma | Full Text | References | PDF (2.7 MB) | EPUB
  • 163 Views
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Original Research

Article
Inflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy – The AISRNA Study
Qi-Wen Deng, Shi Huang, Shuo Li, Qian Zhai, Qing Zhang, Zhen-Jie Wang, Wen-Xia Chen, Huiling Sun, Min Lu & Junshan Zhou
Pages: 4399-4407
Published online: 18 Jul 2023
AbstractforInflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy – The AISRNA Study | Full Text | References | PDF (2.9 MB) | EPUB
  • 90 Views
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Article
Plasma Pentraxin-3 Combined with Plaque Characteristics Predict Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study
Ying Wang, Xiaoxiao Zhao, Peng Zhou, Chen Liu, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Runzhen Chen, Yi Chen, Li Song, Hanjun Zhao & Hongbing Yan
Pages: 4409-4419
Published online: 02 Sep 2021
AbstractforPlasma Pentraxin-3 Combined with Plaque Characteristics Predict Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study | Full Text | References | PDF (3.8 MB) | EPUB
  • 74 Views
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Article
Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model
Yida Li, Liqing Zou, Li Chu, Luxi Ye, Jianjiao Ni, Xiao Chu, Tiantian Guo, Xi Yang & Zhengfei Zhu
Pages: 4421-4431
Published online: 02 Sep 2021
AbstractforIdentification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model | Full Text | References | PDF (5.9 MB) | EPUB
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Article
The Prognostic Significance of Novel Pancreas Cancer Prognostic Index in Unresectable Locally Advanced Pancreas Cancers Treated with Definitive Concurrent Chemoradiotherapy
Erkan Topkan, Ugur Selek, Berrin Pehlivan, Ahmet Kucuk, Veysel Haksoyler, Nulifer Kilic Durankus, Duygu Sezen & Yasemin Bolukbasi
Pages: 4433-4444
Published online: 04 Sep 2021
AbstractforThe Prognostic Significance of Novel Pancreas Cancer Prognostic Index in Unresectable Locally Advanced Pancreas Cancers Treated with Definitive Concurrent Chemoradiotherapy | Full Text | References | PDF (2.6 MB) | EPUB
  • 89 Views
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Article
Erythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?
Soha R Youssef, Esraa H Hassan, Caroline S Morad, Adel A Elazab Elged & Rasha A El-Gamal
Pages: 4445-4455
Published online: 07 Sep 2021
AbstractforErythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity? | Full Text | References | PDF (753.4 KB) | EPUB
  • 137 Views
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Article
Elevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer
Jung Hyun Kim, Jae-Hoon Lee, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Eun-Suk Cho, Seung Hyuk Baik, Kang Young Lee & Jeonghyun Kang
Pages: 4457-4466
Published online: 18 Jul 2023
AbstractforElevated Neutrophil-to-Lymphocyte Ratio in Perioperative Periods is Suggestive of Poor Prognosis in Patients with Colorectal Cancer | Full Text | References | PDF (2.6 MB) | EPUB
  • 76 Views
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Review

Review Article
Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation
Yongli Pan, Qingzheng Jiao, Wei Wei, Tianyang Zheng, Xinyu Yang & Wenqiang Xin
Pages: 4467-4483
Published online: 07 Sep 2021
AbstractforEmerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation | Full Text | References | PDF (2.5 MB) | EPUB
  • 76 Views
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Original Research

Article
Plasma Metabolomic Profiles in Recovered COVID-19 Patients without Previous Underlying Diseases 3 Months After Discharge
Shujing Zhang, Ping Luo, Juanjuan Xu, Lian Yang, Pei Ma, Xueyun Tan, Qing Chen, Mei Zhou, Siwei Song, Hui Xia, Sufei Wang, Yanling Ma, Fan Yang, Yu Liu, Yumei Li, Guanzhou Ma, Zhihui Wang, Yanran Duan & Yang Jin
Pages: 4485-4501
Published online: 18 Jul 2023
AbstractforPlasma Metabolomic Profiles in Recovered COVID-19 Patients without Previous Underlying Diseases 3 Months After Discharge | Full Text | References | PDF (9.2 MB) | EPUB
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Research Letter

Letter
Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
Revathy Munuswamy, Jana De Brandt, Chris Burtin, Wim Derave, Joseph Aumann, Martijn A Spruit & Luc Michiels
Pages: 4503-4507
Published online: 18 Jul 2023
AbstractforMonomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons | Full Text | References | PDF (1.4 MB) | EPUB
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Original Research

Article
The Clinical Effects of Febuxostat Alone or Combined with Arthroscopic Surgery for Gout: A Single-Center Retrospective Study
Zhen Gong, Li Xia, Rune Xu, Min Luo, Hongxiang Deng, Zhiping Kang, Leping Liu, Yaqing Liu, Fangjie Zhang & Jian Shi
Pages: 4509-4517
Published online: 18 Jul 2023
AbstractforThe Clinical Effects of Febuxostat Alone or Combined with Arthroscopic Surgery for Gout: A Single-Center Retrospective Study | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Integrative Analysis of the Roles of lncRNAs and mRNAs in Itaconate-Mediated Protection Against Liver Ischemia-Reperfusion Injury in Mice
Yanan Xu, Zihao Li, Shounan Lu, Chaoqun Wang, Shanjia Ke, Xinglong Li, Bing Yin, Hongjun Yu, Menghua Zhou, Shangha Pan, Hongchi Jiang & Yong Ma
Pages: 4519-4536
Published online: 08 Sep 2021
AbstractforIntegrative Analysis of the Roles of lncRNAs and mRNAs in Itaconate-Mediated Protection Against Liver Ischemia-Reperfusion Injury in Mice | Full Text | References | PDF (11.9 MB) | EPUB
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Review

Review Article
Managing Exacerbations in Thunderstorm Asthma: Current Insights
Josh Chatelier, Samantha Chan, Ju Ann Tan, Alastair G Stewart & Jo Anne Douglass
Pages: 4537-4550
Published online: 08 Sep 2021
AbstractforManaging Exacerbations in Thunderstorm Asthma: Current Insights | Full Text | References | PDF (2 MB) | EPUB
  • 243 Views
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Original Research

Article
LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells
Ramcharan Singh Angom, Jian Zhu, Alexander T H Wu, Maryam Rachmawati Sumitra, Victoria Pham, Shamit Dutta, Enfeng Wang, Vijay Sagar Madamsetty, Gabriel D Perez-Cordero, Hsu-Shan Huang, Debabrata Mukhopadhyay & Ying Wang
Pages: 4551-4565
Published online: 18 Jul 2023
AbstractforLCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells | Full Text | References | PDF (7.4 MB) | EPUB
  • 71 Views
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Article
MiR-940 Serves as a Diagnostic Biomarker in Patients with Sepsis and Regulates Sepsis-Induced Inflammation and Myocardial Dysfunction
Shijuan Zhang, Yuhong Wei, Jinxia Liu & Yutian Zhuang
Pages: 4567-4574
Published online: 09 Sep 2021
AbstractforMiR-940 Serves as a Diagnostic Biomarker in Patients with Sepsis and Regulates Sepsis-Induced Inflammation and Myocardial Dysfunction | Full Text | References | PDF (2.7 MB) | EPUB
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Erratum

Correction
Exploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats [Erratum]
Pages: 4575-4576
Published online: 18 Jul 2023
CitationforExploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats [Erratum] | Full Text | PDF (138.1 KB) | EPUB
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Original Research

Article
Inflammation-Immunity-Nutrition Score: A Novel Prognostic Score for Patients with Resectable Colorectal Cancer
Xin-Ying Li, Shuang Yao, Yang-Ting He, Song-Qing Ke, Yi-Fei Ma, Ping Lu, Shao-Fa Nie, Shao-Zhong Wei, Xin-Jun Liang & Li Liu
Pages: 4577-4588
Published online: 18 Jul 2023
AbstractforInflammation-Immunity-Nutrition Score: A Novel Prognostic Score for Patients with Resectable Colorectal Cancer | Full Text | References | PDF (5.2 MB) | EPUB
  • 74 Views
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Article
Serum C1q Levels Have Prognostic Value for Sepsis and are Related to the Severity of Sepsis and Organ Damage
Huan Li, Juanjuan Chen, Yuanhui Hu, Xin Cai, Dongling Tang & Pingan Zhang
Pages: 4589-4600
Published online: 18 Jul 2023
AbstractforSerum C1q Levels Have Prognostic Value for Sepsis and are Related to the Severity of Sepsis and Organ Damage | Full Text | References | PDF (3.8 MB) | EPUB
  • 58 Views
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Corrigendum

Correction
Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment [Corrigendum]
Pages: 4601-4602
Published online: 14 Sep 2021
CitationforClinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment [Corrigendum] | Full Text | PDF (136.9 KB) | EPUB
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Letter

Letter
Recent Insights into the Management of Inflammation in Asthma [Letter]
Aleksandr Urakov & Natalya Urakova
Pages: 4603-4604
Published online: 18 Jul 2023
CitationforRecent Insights into the Management of Inflammation in Asthma [Letter] | Full Text | References | PDF (193 KB) | EPUB
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Original Research

Article
A Score of Low-Grade Inflammation for Predicting Stroke Recurrence in Patients with Ischemic Stroke
Min Wu, Xiaohao Zhang, Jingjing Chen, Mingming Zha, Kang Yuan, Kangmo Huang, Yi Xie, Jianzhong Xue & Xinfeng Liu
Pages: 4605-4614
Published online: 18 Jul 2023
AbstractforA Score of Low-Grade Inflammation for Predicting Stroke Recurrence in Patients with Ischemic Stroke | Full Text | References | PDF (2.6 MB) | EPUB
  • 96 Views
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Article
The Effect of Shaoyao Gancao Decoction on Sphincter of Oddi Dysfunction in Hypercholesterolemic Rabbits via Protecting the Enteric Nervous System–Interstitial Cells of Cajal–Smooth Muscle Cells Network
Gui-Ying Zhu, Dan-Dan Jia, Ying Yang, Ye Miao, Chao Wang & Chang-Miao Wang
Pages: 4615-4628
Published online: 15 Sep 2021
AbstractforThe Effect of Shaoyao Gancao Decoction on Sphincter of Oddi Dysfunction in Hypercholesterolemic Rabbits via Protecting the Enteric Nervous System–Interstitial Cells of Cajal–Smooth Muscle Cells Network | Full Text | References | PDF (6.3 MB) | EPUB
  • 76 Views
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Article
PLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma
Mulin Liu, Siyi Chen, Aihui Zhang, Qin Zheng & Juan Fu
Pages: 4629-4641
Published online: 15 Sep 2021
AbstractforPLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma | Full Text | References | PDF (6.2 MB) | EPUB
  • 71 Views
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Article
Inflammation and Insulin Resistance in a Group of Sub-Saharan African Women with Polycystic Ovary Syndrome
Christelle Chemaga Nkonpawa, Vicky Jocelyne Ama Moor, Aurel T Tankeu, Audrey Synthia Momo, Guy Sadeu Wafeu, Falmata Amazia, Jan Rene Nkeck, Tasha Manases, Julius Dohbit Sama & Simeon Pierre Choukem
Pages: 4643-4649
Published online: 15 Sep 2021
AbstractforInflammation and Insulin Resistance in a Group of Sub-Saharan African Women with Polycystic Ovary Syndrome | Full Text | References | PDF (320.1 KB) | EPUB
  • 106 Views
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Article
Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19
Christian Herr, Sebastian Mang, Bahareh Mozafari, Katharina Guenther, Thimoteus Speer, Martina Seibert, Sanjay Kumar Srikakulam, Christoph Beisswenger, Felix Ritzmann, Andreas Keller, Rolf Mueller, Sigrun Smola, Dominic Eisinger, Michael Zemlin, Guy Danziger, Thomas Volk, Sabrina Hoersch, Marcin Krawczyk, Frank Lammert, Thomas Adams, Gudrun Wagenpfeil, Michael Kindermann, Constantin Marcu, Zuhair Wolf Dietrich Ataya, Marc Mittag, Konrad Schwarzkopf, Florian Custodis, Daniel Grandt, Harald Schaefer, Kai Eltges, Philipp M Lepper, Robert Bals & On behalf of the CORSAAR Study Group
Pages: 4651-4667
Published online: 18 Jul 2023
AbstractforDistinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19 | Full Text | References | PDF (3.8 MB) | EPUB
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Article
The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice
Yifang Chen, Yang Li, Han Guo, Zhaoqi Zhang, Jiayu Zhang, Xue Dong, Yi Liu, Yuan Zhuang & Yong Zhao
Pages: 4669-4686
Published online: 16 Sep 2021
AbstractforThe Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice | Full Text | References | PDF (13.7 MB) | EPUB
  • 86 Views
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Article
Relationship Between the Eosinophil/Monocyte Ratio and Prognosis in Decompensated Heart Failure: A Retrospective Study
Xiehui Chen, Weichao Huang, Lingyue Zhao, Yichong Li, Lili Wang, Fanrui Mo & Wenqin Guo
Pages: 4687-4696
Published online: 16 Sep 2021
AbstractforRelationship Between the Eosinophil/Monocyte Ratio and Prognosis in Decompensated Heart Failure: A Retrospective Study | Full Text | References | PDF (3.1 MB) | EPUB
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Article
β-Hydroxybutyrate Mitigated Heart Failure with Preserved Ejection Fraction by Increasing Treg Cells via Nox2/GSK-3β
Shengen Liao, Yuan Tang, Xin Yue, Rongrong Gao, Wenming Yao, Yanli Zhou & Haifeng Zhang
Pages: 4697-4706
Published online: 16 Sep 2021
Abstractforβ-Hydroxybutyrate Mitigated Heart Failure with Preserved Ejection Fraction by Increasing Treg Cells via Nox2/GSK-3β | Full Text | References | PDF (7.7 MB) | EPUB
  • 70 Views
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Article
Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro
Caixia Pei, Fei Wang, Demei Huang, Shihua Shi, Xiaomin Wang, Yilan Wang, Shuiqin Li, Yongcan Wu & Zhenxing Wang
Pages: 4707-4721
Published online: 18 Jul 2023
AbstractforAstragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro | Full Text | References | PDF (10.7 MB) | EPUB
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Article
WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M
Petra Henning, Sofia Movérare-Skrtic, Anna Westerlund, Pedro Paulo Chaves de Souza, Thais Floriano-Marcelino, Karin H Nilsson, Maha El Shahawy, Claes Ohlsson & Ulf H Lerner
Pages: 4723-4741
Published online: 18 Jul 2023
AbstractforWNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M | Full Text | References | PDF (10.7 MB) | EPUB
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Article
Biotite-Calx Based Traditional Indian Medicine Sahastraputi-Abhrak-Bhasma Prophylactically Mitigates Allergic Airway Inflammation in a Mouse Model of Asthma by Amending Cytokine Responses
Acharya Balkrishna, Siva Kumar Solleti, Hoshiyar Singh, Rani Singh, Niti Sharma & Anurag Varshney
Pages: 4743-4760
Published online: 17 Sep 2021
AbstractforBiotite-Calx Based Traditional Indian Medicine Sahastraputi-Abhrak-Bhasma Prophylactically Mitigates Allergic Airway Inflammation in a Mouse Model of Asthma by Amending Cytokine Responses | Full Text | References | PDF (15 MB) | EPUB
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Review

Review Article
Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation
Chuan Qin, Yongning Li & Kewei Wang
Pages: 4761-4775
Published online: 17 Sep 2021
AbstractforFunctional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation | Full Text | References | PDF (4.6 MB) | EPUB
  • 146 Views
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Original Research

Article
A Prospective Clinical Study on MGMT Protein Expression and the Effect of Gene Promoter Methylation on Sensitivity to Chemotherapeutics in Spinal Glioma
Peng Sun, Duo-Jiao Fan, Tao Fan, Xin Li, Xue-Ling Qi, Xin-Gang Zhao & Qi-Fei Gai
Pages: 4777-4784
Published online: 18 Sep 2021
AbstractforA Prospective Clinical Study on MGMT Protein Expression and the Effect of Gene Promoter Methylation on Sensitivity to Chemotherapeutics in Spinal Glioma | Full Text | References | PDF (3.8 MB) | EPUB
  • 81 Views
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Article
Elevated Serum Levels of Progranulin and Soluble Vascular Cell Adhesion Molecule-1 in Patients with COVID-19
Shifei Yao, Nanning Luo, Jiaoyang Liu, He Zha, Yuanhang Ai, Juan Luo, Shi Shi & Kaifeng Wu
Pages: 4785-4794
Published online: 21 Sep 2021
AbstractforElevated Serum Levels of Progranulin and Soluble Vascular Cell Adhesion Molecule-1 in Patients with COVID-19 | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Irreversible Electroporation Plus Anti-PD-1 Antibody versus Irreversible Electroporation Alone for Patients with Locally Advanced Pancreatic Cancer
Chaobin He, Shuxin Sun, Yu Zhang & Shengping Li
Pages: 4795-4807
Published online: 21 Sep 2021
AbstractforIrreversible Electroporation Plus Anti-PD-1 Antibody versus Irreversible Electroporation Alone for Patients with Locally Advanced Pancreatic Cancer | Full Text | References | PDF (4.1 MB) | EPUB
  • 74 Views
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Article
Single-Nucleotide Polymorphism LncRNA AC008392.1/rs7248320 in CARD8 is Associated with Kawasaki Disease Susceptibility in the Han Chinese Population
Kai Guo, Lijuan Qiu, Yufen Xu, Xiaoqiong Gu, Linyuan Zhang, Kun Lin, Xiaohuan Wang, Shanshan Song, Yu Liu, Zijian Niu & Shuxuan Ma
Pages: 4809-4816
Published online: 18 Jul 2023
AbstractforSingle-Nucleotide Polymorphism LncRNA AC008392.1/rs7248320 in CARD8 is Associated with Kawasaki Disease Susceptibility in the Han Chinese Population | Full Text | References | PDF (371 KB) | EPUB
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Article
Potentially Functional microRNA-mRNA Regulatory Networks in Intestinal Ischemia-Reperfusion Injury: A Bioinformatics Analysis
Zhifeng Jiang, Song Chen, Lin Zhang, Jie Shen & Ming Zhong
Pages: 4817-4825
Published online: 18 Jul 2023
AbstractforPotentially Functional microRNA-mRNA Regulatory Networks in Intestinal Ischemia-Reperfusion Injury: A Bioinformatics Analysis | Full Text | References | PDF (4 MB) | EPUB
  • 57 Views
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Article
Alterations in Peripheral B Cell Subsets Correlate with the Disease Severity of Human Glaucoma
Ling Yu, Yang Chen, Xiang Xu, Qiwei Dong, Wenbo Xiu, Qinyuan Chen, Jinxia Wang, Chong He, Jian Ye & Fang Lu
Pages: 4827-4838
Published online: 21 Sep 2021
AbstractforAlterations in Peripheral B Cell Subsets Correlate with the Disease Severity of Human Glaucoma | Full Text | References | PDF (5.9 MB) | EPUB
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Article
Neutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS
Haitao Li, Yi Li, Chao Song, Yongbin Hu, Minhui Dai, Ben Liu & Pinhua Pan
Pages: 4839-4858
Published online: 18 Jul 2023
AbstractforNeutrophil Extracellular Traps Augmented Alveolar Macrophage Pyroptosis via AIM2 Inflammasome Activation in LPS-Induced ALI/ARDS | Full Text | References | PDF (14.7 MB) | EPUB
  • 131 Views
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Article
Implications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation
Ryan D Castle, Michelle A Williams, William C Bushell, J Adam Rindfleisch, Christine Tara Peterson, James Marzolf, Kimberly Brouwer & Paul J Mills
Pages: 4859-4876
Published online: 22 Sep 2021
AbstractforImplications for Systemic Approaches to COVID-19: Effect Sizes of Remdesivir, Tocilizumab, Melatonin, Vitamin D3, and Meditation | Full Text | References | PDF (7.1 MB) | EPUB
  • 102 Views
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Case Report

Case Report
Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
Phatcharawat Chirasuthat, Suthep Chirasuthat & Poonkiat Suchonwanit
Pages: 4877-4880
Published online: 21 Sep 2021
AbstractforAcute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings | Full Text | References | PDF (625.8 KB) | EPUB
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Original Research

Article
Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
Kumutnart Chanprapaph, Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Kanchana Leerunyakul & Poonkiat Suchonwanit
Pages: 4881-4891
Published online: 22 Sep 2021
AbstractforPrevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata | Full Text | References | PDF (425.3 KB) | EPUB
  • 159 Views
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Article
Angiogenesis Biomarkers in Ischemic Stroke Patients
Aziza Alrafiah, Ebtisam Alofi, Yasser Almohaya, Abdullah Hamami, Talal Qadah, Safa Almaghrabi, Nora Hakami, Moafaq S Alrawaili & Haythum O Tayeb
Pages: 4893-4900
Published online: 22 Sep 2021
AbstractforAngiogenesis Biomarkers in Ischemic Stroke Patients | Full Text | References | PDF (1.3 MB) | EPUB
  • 78 Views
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Article
In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer
Bashir Lawal, Yu-Cheng Kuo, Maryam Rachmawati Sumitra, Alexander T H Wu & Hsu-Shan Huang
Pages: 4901-4913
Published online: 22 Sep 2021
AbstractforIn vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer | Full Text | References | PDF (6.7 MB) | EPUB
  • 110 Views
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Article
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation
Shuo Zhang, Jingtao Gao, Shibo Liu, Lu Yu, Wen Zhang, Yinming Liang & Hui Wang
Pages: 4915-4926
Published online: 18 Jul 2023
AbstractforTranscription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation | Full Text | References | PDF (6.6 MB) | EPUB
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Article
TILRR (Toll-like Interleukin-1 Receptor Regulator), an Important Modulator of Inflammatory Responsive Genes, is Circulating in the Blood
Mohammad Abul Kashem, Xin-Yong Yuan, Lin Li, Joshua Kimani, Francis Plummer & Ma Luo
Pages: 4927-4943
Published online: 18 Jul 2023
AbstractforTILRR (Toll-like Interleukin-1 Receptor Regulator), an Important Modulator of Inflammatory Responsive Genes, is Circulating in the Blood | Full Text | References | PDF (5.7 MB) | EPUB
  • 75 Views
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Article
Association Between Micronutrient Concentrations and Human Epididymis Protein 4
Zhu Wei Lim & Wei Liang Chen
Pages: 4945-4954
Published online: 18 Jul 2023
AbstractforAssociation Between Micronutrient Concentrations and Human Epididymis Protein 4 | Full Text | References | PDF (2.5 MB) | EPUB
  • 73 Views
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Article
Circulating Inflammation Markers Partly Explain the Link Between the Dietary Inflammatory Index and Depressive Symptoms
Alessandro Gialluisi, Federica Santonastaso, Marialaura Bonaccio, Francesca Bracone, Nitin Shivappa, James R Hebert, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello & On behalf of the Moli-sani Investigators
Pages: 4955-4968
Published online: 18 Jul 2023
AbstractforCirculating Inflammation Markers Partly Explain the Link Between the Dietary Inflammatory Index and Depressive Symptoms | Full Text | References | PDF (2 MB) | EPUB
  • 414 Views
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Article
Development of an Interferon Gamma Response-Related Signature for Prediction of Survival in Clear Cell Renal Cell Carcinoma
Lixiao Liu, Xuedan Du, Jintao Fang, Jinduo Zhao, Yong Guo, Ye Zhao, Chengyang Zou, Xiaojian Yan & Wenfeng Li
Pages: 4969-4985
Published online: 18 Jul 2023
AbstractforDevelopment of an Interferon Gamma Response-Related Signature for Prediction of Survival in Clear Cell Renal Cell Carcinoma | Full Text | References | PDF (10.6 MB) | EPUB
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Article
Colocalization with MMP-7 in the Distal Colon is Crucial for Syndecan-2 Shedding in Dextran Sulfate Sodium-Induced Colitis Mice
Heejeong Hong, Hyun-Kuk Song, Bohee Jang, Eunhye Park, Dong Soo Han, Seong-Eun Kim & Eok-Soo Oh
Pages: 4987-5000
Published online: 29 Sep 2021
AbstractforColocalization with MMP-7 in the Distal Colon is Crucial for Syndecan-2 Shedding in Dextran Sulfate Sodium-Induced Colitis Mice | Full Text | References | PDF (8.7 MB) | EPUB
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Article
Effects of Berberine on the Chondrogenic Differentiation of Embryonic Limb Skeletal Progenitors
Cristina Duarte-Olivenza, Juan Antonio Montero & Carlos Ignacio Lorda-Diez
Pages: 5001-5011
Published online: 18 Jul 2023
AbstractforEffects of Berberine on the Chondrogenic Differentiation of Embryonic Limb Skeletal Progenitors | Full Text | References | PDF (4.8 MB) | EPUB
  • 76 Views
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Article
Clinical Values of miR-23a-3p in Oral Lichen Planus and Its Role in Keratinocyte Proliferation and Inflammatory Response
Jian Wang, Mingyan Hu & Leilei Li
Pages: 5013-5021
Published online: 29 Sep 2021
AbstractforClinical Values of miR-23a-3p in Oral Lichen Planus and Its Role in Keratinocyte Proliferation and Inflammatory Response | Full Text | References | PDF (3.1 MB) | EPUB
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Review

Review Article
Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu & Tie-Ning Zhang
Pages: 5023-5050
Published online: 18 Jul 2023
AbstractforNon-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases | Full Text | References | PDF (4.6 MB) | EPUB
  • 96 Views
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Original Research

Article
Expression and Correlation of IgG4 and IL-21 in Collagen-Induced Arthritis Rats
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu & Fang Peng
Pages: 5051-5058
Published online: 01 Oct 2021
AbstractforExpression and Correlation of IgG4 and IL-21 in Collagen-Induced Arthritis Rats | Full Text | References | PDF (5.2 MB) | EPUB
  • 56 Views
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Review

Review Article
Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
Junshuai Xue, Delin Ma, Jianjun Jiang & Yang Liu
Pages: 5059-5077
Published online: 02 Oct 2021
AbstractforDiagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice? | Full Text | References | PDF (1.7 MB) | EPUB
  • 89 Views
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Original Research

Article
The β3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury
Yao Tong, Chengrong Bao, Yi-Qiong Xu, Lei Tao, Yao Zhou, Lei Zhuang, Ying Meng, Hui Zhang, Jingjing Xue, Weijun Wang, Lele Zhang, Qingbo Pan, Zhenzhen Shao, Tianran Hu, Qian Guo, Qingsheng Xue, Han Lu & Yan Luo
Pages: 5079-5094
Published online: 05 Oct 2021
AbstractforThe β3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury | Full Text | References | PDF (12 MB) | EPUB
  • 73 Views
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Article
Maternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus
Pei Zhou, Hongbo Guan, Yanyan Guo, Liangliang Zhu & Xiaomei Liu
Pages: 5095-5110
Published online: 05 Oct 2021
AbstractforMaternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus | Full Text | References | PDF (14.4 MB) | EPUB
  • 71 Views
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Article
Preventive Effect of Flavonoid Extract from the Peel of Gonggan (Citrus reticulata Blanco Var. Gonggan) on CCl4-Induced Acute Liver Injury in Mice
Ya Wu, Yongpeng He, Rui Wang & Xin Zhao
Pages: 5111-5121
Published online: 18 Jul 2023
AbstractforPreventive Effect of Flavonoid Extract from the Peel of Gonggan (Citrus reticulata Blanco Var. Gonggan) on CCl4-Induced Acute Liver Injury in Mice | Full Text | References | PDF (5 MB) | EPUB
  • 100 Views
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Article
Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study
Xiaojuan Li, Tiewei Li, Jingjing Wang, Yichuan Feng, Chong Ren, Zhe Xu, Junmei Yang, Qian Zhang & Caiyan An
Pages: 5123-5129
Published online: 06 Oct 2021
AbstractforClinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study | Full Text | References | PDF (775.1 KB) | EPUB
  • 83 Views
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Article
Platelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients
Ebin Johny, Pathoori Bhaskar, Md Jahangir Alam, Indra Kuladhipati, Rupam Das & Ramu Adela
Pages: 5131-5147
Published online: 07 Oct 2021
AbstractforPlatelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients | Full Text | References | PDF (9.2 MB) | EPUB
  • 83 Views
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Article
Altered T-Cell Subsets are Associated with Dysregulated Cytokine Secretion of CD4+ T Cells During HIV Infection
Di Wang, Yu Jiang, Yangzi Song, Yongqin Zeng, Cuilin Li, Xinyue Wang, Ying Liu, Jiang Xiao, Yaxian Kong & Hongxin Zhao
Pages: 5149-5163
Published online: 07 Oct 2021
AbstractforAltered T-Cell Subsets are Associated with Dysregulated Cytokine Secretion of CD4+ T Cells During HIV Infection | Full Text | References | PDF (9.2 MB) | EPUB
  • 69 Views
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Article
β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice
Xianrong Zhou, Hang-Hang Du, Xingyao Long, Yanni Pan, Jian Hu, Jianjun Yu & Xin Zhao
Pages: 5165-5182
Published online: 07 Oct 2021
Abstractforβ-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice | Full Text | References | PDF (9.4 MB) | EPUB
  • 249 Views
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Response to Letter

Reply
A Role for Mucolytics and Expectorants in Aiding Inhaled Therapies in Asthma? [Response To Letter]
Ramesh J Kurukulaaratchy, Hitasha Rupani, Wei Chern Gavin Fong & Aref Kyyaly
Pages: 5183-5185
Published online: 08 Oct 2021
First Page PreviewforA Role for Mucolytics and Expectorants in Aiding Inhaled Therapies in Asthma? [Response To Letter] | Full Text | References | PDF (227 KB) | EPUB
  • 143 Views
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Review

Review Article
Interferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence
Howard Chung, Peter H R Green, Timothy C Wang & Xiao-Fei Kong
Pages: 5187-5200
Published online: 07 Oct 2021
AbstractforInterferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence | Full Text | References | PDF (3.1 MB) | EPUB
  • 102 Views
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Original Research

Article
Investigating Associations Between Depressive Symptoms and Anti-/Pro-Inflammatory Nutrients in an Elderly Population in Northern China: A Bayesian Kernel Machine Regression Approach
Ruiqiang Li, Wenqiang Zhan, Xin Huang, Limin Zhang, Yan Sun, Zechen Zhang, Wei Bao & Yuxia Ma
Pages: 5201-5213
Published online: 18 Jul 2023
AbstractforInvestigating Associations Between Depressive Symptoms and Anti-/Pro-Inflammatory Nutrients in an Elderly Population in Northern China: A Bayesian Kernel Machine Regression Approach | Full Text | References | PDF (5.3 MB) | EPUB
  • 193 Views
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Article
Gut Microbiota Contributes to Host Defense Against Klebsiella pneumoniae-Induced Liver Abscess
Yahong Zheng, Yuting Ding, Mengran Xu, Haoran Chen, Hui zhang, Yanyan Liu, Weihua Shen & Jiabin Li
Pages: 5215-5225
Published online: 09 Oct 2021
AbstractforGut Microbiota Contributes to Host Defense Against Klebsiella pneumoniae-Induced Liver Abscess | Full Text | References | PDF (5.4 MB) | EPUB
  • 231 Views
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Article
Distinct Polarization Dynamics of Microglia and Infiltrating Macrophages: A Novel Mechanism of Spinal Cord Ischemia/Reperfusion Injury
Hui Li, Pengfei Wang, Lin Tang, Jingjing Sun, Yanling Zhang, Wei Luo, Cong Luo, Zhaolan Hu & Lin Yang
Pages: 5227-5239
Published online: 13 Oct 2021
AbstractforDistinct Polarization Dynamics of Microglia and Infiltrating Macrophages: A Novel Mechanism of Spinal Cord Ischemia/Reperfusion Injury | Full Text | References | PDF (13.6 MB) | EPUB
  • 63 Views
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Article
Different Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages
Chun-Yi Lai, Po-Chun Tseng, Chia-Ling Chen, Rahmat Dani Satria, Yung-Ting Wang & Chiou-Feng Lin
Pages: 5241-5249
Published online: 13 Oct 2021
AbstractforDifferent Induction of PD-L1 (CD274) and PD-1 (CD279) Expression in THP-1-Differentiated Types 1 and 2 Macrophages | Full Text | References | PDF (5.2 MB) | EPUB
  • 94 Views
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Review

Review Article
New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis
Wujun Chen, Shuai Wang & Dongming Xing
Pages: 5251-5271
Published online: 18 Jul 2023
AbstractforNew Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis | Full Text | References | PDF (10 MB) | EPUB
  • 80 Views
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Review Article
The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
Junyu Deng, Ye Liu, Yiqiu Liu, Wei Li & Xuqiang Nie
Pages: 5273-5290
Published online: 18 Jul 2023
AbstractforThe Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy | Full Text | References | PDF (3.8 MB) | EPUB
  • 98 Views
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Original Research

Article
Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-κB and PI3K/AKT/mTOR Pathways
Hui Chen, Na Li, Xiang Zhan, Ting Zheng, Xinzhou Huang, Qianglin Chen, Zihao Song, Fei Yang, Hao Nie, Yanxiang Zhang, Bing Zheng & Quan Gong
Pages: 5291-5304
Published online: 14 Oct 2021
AbstractforCapsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-κB and PI3K/AKT/mTOR Pathways | Full Text | References | PDF (9.9 MB) | EPUB
  • 94 Views
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Article
SJMHE1 Peptide from Schistosoma japonicum Inhibits Asthma in Mice by Regulating Th17/Treg Cell Balance via miR-155
Li Li, Wenqi Shan, Haijin Zhu, Fei Xue, Yongbin Ma, Liyang Dong, Dingqi Feng, Jiahui Mao, Guoyue Yuan & Xuefeng Wang
Pages: 5305-5318
Published online: 18 Jul 2023
AbstractforSJMHE1 Peptide from Schistosoma japonicum Inhibits Asthma in Mice by Regulating Th17/Treg Cell Balance via miR-155 | Full Text | References | PDF (8.4 MB) | EPUB
  • 72 Views
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Clinical Trial Report

Case Report
Proprotein Convertase Subtilisin/Kexin Type 9 and Systemic Inflammatory Biomarker Pentraxin 3 for Risk Stratification Among STEMI Patients Undergoing Primary PCI
Xiaoxiao Zhao, Li Song, Ying Wang, Jiannan Li, Jinying Zhou, Runzhen Chen, Chen Liu, Peng Zhou, Zhaoxue Sheng, Yi Chen, Hanjun Zhao & Hongbing Yan
Pages: 5319-5335
Published online: 14 Oct 2021
AbstractforProprotein Convertase Subtilisin/Kexin Type 9 and Systemic Inflammatory Biomarker Pentraxin 3 for Risk Stratification Among STEMI Patients Undergoing Primary PCI | Full Text | References | PDF (7.1 MB) | EPUB
  • 70 Views
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Original Research

Article
A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis
Jie Deng, Lorne M Golub, Hsi-Ming Lee, Veena Raja, Francis Johnson, Allan Kucine, Wonsae Lee, Tian-Min Xu & Ying Gu
Pages: 5337-5347
Published online: 16 Oct 2021
AbstractforA Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis | Full Text | References | PDF (4.9 MB) | EPUB
  • 153 Views
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Review

Review Article
Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
Layla Kamareddine, Crystal M Ghantous, Soumaya Allouch, Sarah A Al-Ashmar, Gulsen Anlar, Surya Kannan, Laiche Djouhri, Hesham M Korashy, Abdelali Agouni & Asad Zeidan
Pages: 5349-5365
Published online: 16 Oct 2021
AbstractforBetween Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling | Full Text | References | PDF (3.4 MB) | EPUB
  • 97 Views
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Open Access

Original Research

Article
B-Cell Deficiency Exacerbates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice
Wenmin Zeng, Guojing Liu, Qingxian Luan, Chunyu Yang, Shiyi Li, Xiaoqian Yu & Li Su
Pages: 5367-5380
Published online: 18 Jul 2023
AbstractforB-Cell Deficiency Exacerbates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice | Full Text | References | PDF (7.9 MB) | EPUB
  • 121 Views
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Article
The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures
Ling Tang & Jie-Ru Chen
Pages: 5381-5392
Published online: 18 Oct 2021
AbstractforThe Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures | Full Text | References | PDF (2.5 MB) | EPUB
  • 93 Views
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Article
Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats
Danyun Jia, Jinyu Zheng, Yiyang Zhou, Jinqiu Jia, Xiaoxiao Ye, Bingbing Zhou, Xingxing Chen, Yunchang Mo & Junlu Wang
Pages: 5393-5401
Published online: 18 Oct 2021
AbstractforFerroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats | Full Text | References | PDF (3.5 MB) | EPUB
  • 79 Views
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Article
Clinical Impact of X-Ray Repair Cross-Complementary 1 (XRCC1) and the Immune Environment in Colorectal Adenoma–Carcinoma Pathway Progression
Yu Zhang, Xin Zhang, Zhuoyi Jin, Huiyan Chen, Chenjing Zhang, wangyue Wang, Jiyong Jing & Wensheng Pan
Pages: 5403-5417
Published online: 20 Oct 2021
AbstractforClinical Impact of X-Ray Repair Cross-Complementary 1 (XRCC1) and the Immune Environment in Colorectal Adenoma–Carcinoma Pathway Progression | Full Text | References | PDF (10 MB) | EPUB
  • 83 Views
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Article
Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease
Michał Konwerski, Agnieszka Gromadka, Adam Arendarczyk, Marta Koblowska, Roksana Iwanicka-Nowicka, Radosław Wilimski, Paweł Czub, Krzysztof Jerzy Filipiak, Piotr Hendzel, Piotr Zielenkiewicz, Grzegorz Opolski, Aleksandra Gąsecka & Tomasz Mazurek
Pages: 5419-5431
Published online: 20 Oct 2021
AbstractforAtherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease | Full Text | References | PDF (5.7 MB) | EPUB
  • 67 Views
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Article
Immune Dysfunction is Associated with Readmission in Survivors of Sepsis Following Infected Pancreatic Necrosis
Jiangtao Yin, Wenjian Mao, Xiaojia Xiao, Xianqiang Yu, Baiqiang Li, Faxi Chen, Jiajia Lin, Jing Zhou, Jing Zhou, Zhihui Tong, Lu Ke & Weiqin Li
Pages: 5433-5442
Published online: 20 Oct 2021
AbstractforImmune Dysfunction is Associated with Readmission in Survivors of Sepsis Following Infected Pancreatic Necrosis | Full Text | References | PDF (3.3 MB) | EPUB
  • 63 Views
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Article
A Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis
Yue-Rong Zhang, Hui Wang, Ning Zhou, Yao-Di Zhang, Yan Lin, Li-Yang Wu, Shi-Fang Wei, Yan-Yun Ma & Chun-Xia Wang
Pages: 5443-5450
Published online: 22 Oct 2021
AbstractforA Multidisciplinary Team Approach to the Treatment of Liver Cirrhosis | Full Text | References | PDF (2.3 MB) | EPUB
  • 89 Views
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Review

Review Article
The Adverse Impact of Incense Smoke on Human Health: From Mechanisms to Implications
Chiang-Wen Lee, Thi Thuy Tien Vo, Yinshen Wee, Yao-Chang Chiang, Miao-Ching Chi, Min-Li Chen, Lee-Fen Hsu, Mei-Ling Fang, Kuan-Han Lee, Su-Er Guo, Hsin-Chung Cheng & I-Ta Lee
Pages: 5451-5472
Published online: 22 Oct 2021
AbstractforThe Adverse Impact of Incense Smoke on Human Health: From Mechanisms to Implications | Full Text | References | PDF (3.1 MB) | EPUB
  • 422 Views
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Open Access

Corrigendum

Correction
Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes [Corrigendum]
Pages: 5473-5474
Published online: 22 Oct 2021
CitationforOverexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes [Corrigendum] | Full Text | PDF (135.4 KB) | EPUB
  • 58 Views
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Review

Review Article
Comparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections
Tong Liu, Meng Feng, Zexin Wen, Yijie He, Wei Lin & Min Zhang
Pages: 5475-5487
Published online: 23 Oct 2021
AbstractforComparison of the Characteristics of Cytokine Storm and Immune Response Induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections | Full Text | References | PDF (2.9 MB) | EPUB
  • 104 Views
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Original Research

Article
Exosomal lncRNA HOTTIP Mediates Antiviral Effect of Tenofovir Alafenamide (TAF) on HBV Infection
Qing-Min Liu, Yi-Yu He, Li-Li Liu & Li-Kun Wang
Pages: 5489-5500
Published online: 23 Oct 2021
AbstractforExosomal lncRNA HOTTIP Mediates Antiviral Effect of Tenofovir Alafenamide (TAF) on HBV Infection | Full Text | References | PDF (7 MB) | EPUB
  • 82 Views
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Article
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines
Yong Chen, Yanjuan Chen, Li Zhao, Hui He, Laiyou Wei, Wenjuan Lai, Jingxia Yuan, Xiaoping Hong, Lixiong Liu, Baojiang Wang, Kutty Selva Nandakumar & Dongzhou Liu
Pages: 5501-5511
Published online: 18 Jul 2023
AbstractforAlbumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines | Full Text | References | PDF (6.8 MB) | EPUB
  • 167 Views
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Article
The Value of Prognostic Nutritional Index (PNI) on Newly Diagnosed Diffuse Large B-Cell Lymphoma Patients: A Multicenter Retrospective Study of HHLWG Based on Propensity Score Matched Analysis
Ziyuan Shen, Fei Wang, Chenlu He, Dashan Li, Shanlin Nie, Zhenzhen Bian, Mingkang Yao, Yuhao Xue, Ying Wang, Weiying Gu, Taigang Zhu, Yuye Shi, Hao Zhang, Shuiping Huang, Yuqing Miao, Wei Sang & On behalf of the Huaihai Lymphoma Working Group
Pages: 5513-5522
Published online: 18 Jul 2023
AbstractforThe Value of Prognostic Nutritional Index (PNI) on Newly Diagnosed Diffuse Large B-Cell Lymphoma Patients: A Multicenter Retrospective Study of HHLWG Based on Propensity Score Matched Analysis | Full Text | References | PDF (4.4 MB) | EPUB
  • 105 Views
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Commentary

Article Commentary
IgE and TGF-β Signaling: From Immune to Cardiac Remodeling
Hua Cao, Chungang Xiao, Zhangxiu He, Hong Huang & Huifang Tang
Pages: 5523-5526
Published online: 27 Oct 2021
AbstractforIgE and TGF-β Signaling: From Immune to Cardiac Remodeling | Full Text | References | PDF (538.2 KB) | EPUB
  • 63 Views
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Original Research

Article
Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study
Guo-Tian Ruan, Ming Yang, Xiao-Wei Zhang, Meng-Meng Song, Chun-Lei Hu, Yi-Zhong Ge, Hai-Lun Xie, Tong Liu, Meng Tang, Qi Zhang, Xi Zhang, Kang-Ping Zhang, Xiang-Rui Li, Qin-Qin Li, Yong-Bing Chen, Kai-Ying Yu, Ming-Hua Cong, Kun-Hua Wang & Han-Ping Shi
Pages: 5527-5540
Published online: 27 Oct 2021
AbstractforAssociation of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study | Full Text | References | PDF (2.3 MB) | EPUB
  • 89 Views
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Article
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice
Boyan Liu, Yunbo Xie, Jun Chen, Junli Xue, Xiaoyi Zhang, Min Zhao, Xiubin Jia, Yiwei Wang & Shucun Qin
Pages: 5541-5550
Published online: 27 Oct 2021
AbstractforProtective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice | Full Text | References | PDF (6.9 MB) | EPUB
  • 103 Views
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Article
Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota
Yunyan Zhang, Xuelian Li & Xinghua Li
Pages: 5551-5566
Published online: 27 Oct 2021
AbstractforCurcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota | Full Text | References | PDF (8.9 MB) | EPUB
  • 83 Views
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Article
Investigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats
Haile Tazeze, Solomon Mequanente, Dereje Nigussie, Belete Legesse, Eyasu Makonnen & Teklie Mengie
Pages: 5567-5580
Published online: 28 Oct 2021
AbstractforInvestigation of Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats | Full Text | References | PDF (891.9 KB) | EPUB
  • 203 Views
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Article
Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis
Monu, Prachi Agnihotri, Mohd Saquib, Ashish Sarkar, Debolina Chakraborty, Uma Kumar & Sagarika Biswas
Pages: 5581-5596
Published online: 18 Jul 2023
AbstractforTransthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis | Full Text | References | PDF (10 MB) | EPUB
  • 143 Views
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Article
Crosstalk between Circulatory Microenvironment and Vascular Endothelial Cells in Acute Myocardial Infarction
Beiyou Lin, Weiwei Zheng & Xiaofei Jiang
Pages: 5597-5610
Published online: 29 Oct 2021
AbstractforCrosstalk between Circulatory Microenvironment and Vascular Endothelial Cells in Acute Myocardial Infarction | Full Text | References | PDF (12.3 MB) | EPUB
  • 59 Views
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Review

Review Article
Literature Overview of the IL-17 Inhibition from Psoriasis to COVID-19
Yulin Zou & Zudong Meng
Pages: 5611-5618
Published online: 01 Nov 2021
AbstractforLiterature Overview of the IL-17 Inhibition from Psoriasis to COVID-19 | Full Text | References | PDF (2.2 MB) | EPUB
  • 72 Views
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Original Research

Article
Alteration of the Immune Microenvironment in HBsAg and HBeAg Dual-Positive Pregnant Women Presenting a High HBV Viral Load
Fan Gao, Hongyan Wang, Xia Li, Fanfan Guo, Yufei Yuan, Xiaona Wang, Yidan Zhang & Guiqin Bai
Pages: 5619-5632
Published online: 18 Jul 2023
AbstractforAlteration of the Immune Microenvironment in HBsAg and HBeAg Dual-Positive Pregnant Women Presenting a High HBV Viral Load | Full Text | References | PDF (8.9 MB) | EPUB
  • 79 Views
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Article
Peripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study
Ci Dian Dan Zeng, Yi Xin Tong, Ai Tang Xiao, Chun Gao & Sheng Zhang
Pages: 5633-5646
Published online: 18 Jul 2023
AbstractforPeripheral Lymphocyte Subsets Absolute Counts as Feasible Clinical Markers for Predicting Surgical Outcome in Gastric Cancer Patients After Laparoscopic D2 Gastrectomy: A Prospective Cohort Study | Full Text | References | PDF (4.6 MB) | EPUB
  • 76 Views
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Article
Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
Yonghui Gui, Yuanhong Xu & Peng Yang
Pages: 5647-5652
Published online: 18 Jul 2023
AbstractforPredictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome | Full Text | References | PDF (839.1 KB) | EPUB
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Rapid Communication

Letter
Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
Mohammed Al-Hariri, Ahmed Alsunni, Mohammad Habeeb Shaikh, Tharwat Gamal Eldin, Kholoud Al Ghamdi, Abdulelah Fawzi Alharbi, Hussain Alhawaj & Shahanas Chathoth
Pages: 5653-5657
Published online: 18 Jul 2023
AbstractforCaffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model | Full Text | References | PDF (990.1 KB) | EPUB
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Original Research

Article
Investigation of 1, 3, 4 Oxadiazole Derivative in PTZ-Induced Neurodegeneration: A Simulation and Molecular Approach
Muhammad Faheem, Yusuf S Althobaiti, Abdul Waheed Khan, Aman Ullah, Syed Hussain Ali & Umair Ilyas
Pages: 5659-5679
Published online: 18 Jul 2023
AbstractforInvestigation of 1, 3, 4 Oxadiazole Derivative in PTZ-Induced Neurodegeneration: A Simulation and Molecular Approach | Full Text | References | PDF (15.5 MB) | EPUB
  • 72 Views
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Article
Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model
Hiroshi Saito, Yuya Nakamura, Masahiro Inagaki, Shiho Yamadera, Hideo Misawa, Naoki Sato, Tatsunori Oguchi, Takae Inagaki, Yuya Tsuji, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh & Yuji Kiuchi
Pages: 5681-5686
Published online: 02 Nov 2021
AbstractforLinagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model | Full Text | References | PDF (3.4 MB) | EPUB
  • 66 Views
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Article
Genetic Polymorphisms in NLRP3 Inflammasome-Associated Genes in Patients with B-Cell Non-Hodgkin’s Lymphoma
Zhi-He Liu, Lin Zhang, Fan-Jing Jing, Shu-Xin Xiao, Yan Gao, Hai-Yan Bian & Xia Zhao
Pages: 5687-5697
Published online: 18 Jul 2023
AbstractforGenetic Polymorphisms in NLRP3 Inflammasome-Associated Genes in Patients with B-Cell Non-Hodgkin’s Lymphoma | Full Text | References | PDF (1.6 MB) | EPUB
  • 66 Views
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Article
Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension
Lizhe Guo, Gang Qin, Yanan Cao, Yue Yang, Sisi Dai, Lu Wang & E Wang
Pages: 5699-5711
Published online: 18 Jul 2023
AbstractforRegulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension | Full Text | References | PDF (5.6 MB) | EPUB
  • 87 Views
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Review

Review Article
Neuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury
Xue Wu, Yaping Yan & Qian Zhang
Pages: 5713-5737
Published online: 18 Jul 2023
AbstractforNeuroinflammation and Modulation Role of Natural Products After Spinal Cord Injury | Full Text | References | PDF (4 MB) | EPUB
  • 132 Views
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Original Research

Article
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test
Marta Szandruk-Bender, Anna Merwid-Ląd, Benita Wiatrak, Maciej Danielewski, Stanisław Dzimira, Danuta Szkudlarek, Łukasz Szczukowski, Piotr Świątek & Adam Szeląg
Pages: 5739-5756
Published online: 18 Jul 2023
AbstractforNovel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test | Full Text | References | PDF (8.4 MB) | EPUB
  • 118 Views
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Short Report

Brief Report
Aged IRF3-KO Mice are Protected from Sepsis
Dinesh G Goswami & Wendy E Walker
Pages: 5757-5767
Published online: 03 Nov 2021
AbstractforAged IRF3-KO Mice are Protected from Sepsis | Full Text | References | PDF (1.8 MB) | EPUB
  • 69 Views
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Original Research

Article
The Efficacy of Different Inflammatory Markers for the Prognosis of Patients with Malignant Tumors
Kaiwen Zheng, Xiangliang Liu, Wei Ji, Jin Lu, Jiuwei Cui & Wei Li
Pages: 5769-5785
Published online: 03 Nov 2021
AbstractforThe Efficacy of Different Inflammatory Markers for the Prognosis of Patients with Malignant Tumors | Full Text | References | PDF (7.4 MB) | EPUB
  • 65 Views
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Review

Review Article
Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress
Yaodong He, Wei Wang, Pingping Jiang, Lin Yang, Qi Guo, Junwei Xiang, Yuling Gao, Yuanyin Wang & Ran Chen
Pages: 5787-5800
Published online: 18 Jul 2023
AbstractforLong Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress | Full Text | References | PDF (2.6 MB) | EPUB
  • 59 Views
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Original Research

Article
Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury
Dong Zhang, Jin-tao Zhang, Yun Pan, Xiao-fei Liu, Jia-wei Xu, Wen-jing Cui, Xin-rui Qiao & Liang Dong
Pages: 5801-5816
Published online: 04 Nov 2021
AbstractforSyndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury | Full Text | References | PDF (16.2 MB) | EPUB
  • 135 Views
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Article
Higher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults
Tung-Wei Kao, Tao-Chun Peng, Wei-Liang Chen, Yu-Chiao Chi, Chi-Ling Chen & Wei-Shiung Yang
Pages: 5817-5825
Published online: 03 Nov 2021
AbstractforHigher Serum Leptin Levels are Associated with a Reduced Risk of Sarcopenia but a Higher Risk of Dynapenia Among Older Adults | Full Text | References | PDF (1.7 MB) | EPUB
  • 66 Views
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Article
The Relationship Between Ambient Air Pollution and Hospitalizations for Gout in a Humid Subtropical Region of China
Yi-Sheng He, Gui-Hong Wang, Qian Wu, Zheng-Dong Wu, Yue Chen, Jin-Hui Tao, Xin-Yu Fang, Zhiwei Xu & Hai-Feng Pan
Pages: 5827-5835
Published online: 04 Nov 2021
AbstractforThe Relationship Between Ambient Air Pollution and Hospitalizations for Gout in a Humid Subtropical Region of China | Full Text | References | PDF (5.5 MB) | EPUB
  • 88 Views
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Article
Could Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?
Ayman M Mousa, Khaled S Allemailem, Fahad A Alhumaydhi, Faris Alrumaihi, Ahmad Almatroudi, Ameen S Alwashmi, Mohammad Aljasir, Osamah Al Rugaie, Abdullah S M Aljohani, Khaled E A Soliman, Mohamad Y Rezk, Ahmed M S Hegazy & Hanan S Seleem
Pages: 5837-5847
Published online: 08 Nov 2021
AbstractforCould Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits? | Full Text | References | PDF (9.1 MB) | EPUB
  • 87 Views
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Article
Bacterial Lipopolysaccharide Augmented Malignant Transformation and Promoted the Stemness in Prostate Cancer Epithelial Cells
Sijie Tang, Xueqi Lian, Huiying Cheng, Jiaqian Guo, Daguang Ni, Can Huang, Xiang Gu, Hong Meng, Jiajia Jiang & Xiaohua Li
Pages: 5849-5862
Published online: 18 Jul 2023
AbstractforBacterial Lipopolysaccharide Augmented Malignant Transformation and Promoted the Stemness in Prostate Cancer Epithelial Cells | Full Text | References | PDF (8.4 MB) | EPUB
  • 89 Views
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Article
The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine
Yue Yu, Qinyan Yang, Zhou Wang, Qian Ding, Meng Li, Yudong Fang, Qida He & Yi Zhun Zhu
Pages: 5863-5875
Published online: 18 Jul 2023
AbstractforThe Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine | Full Text | References | PDF (8.1 MB) | EPUB
  • 96 Views
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Article
circ_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a
Zhenjun Xu, Kai Zhong, Guanjun Guo, Can Xu, Zhizhao Song, Dongjin Wang & Jun Pan
Pages: 5877-5890
Published online: 18 Jul 2023
Abstractforcirc_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a | Full Text | References | PDF (9.9 MB) | EPUB
  • 67 Views
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Article
Predicting Neoadjuvant Chemoradiotherapy Response in Locally Advanced Rectal Cancer Using Tumor-Infiltrating Lymphocytes Density
Yao Xu, Xiaoying Lou, Yanting Liang, Shenyan Zhang, Shangqing Yang, Qicong Chen, Zeyan Xu, Minning Zhao, Zhenhui Li, Ke Zhao & Zaiyi Liu
Pages: 5891-5899
Published online: 18 Jul 2023
AbstractforPredicting Neoadjuvant Chemoradiotherapy Response in Locally Advanced Rectal Cancer Using Tumor-Infiltrating Lymphocytes Density | Full Text | References | PDF (2.6 MB) | EPUB
  • 70 Views
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Article
Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia
Zhijie Wang, Yinhua Huang, Feixue Chu, Shangli Ji, Kai Liao, Zekai Cui, Jiansu Chen & Shibo Tang
Pages: 5901-5918
Published online: 11 Nov 2021
AbstractforClock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia | Full Text | References | PDF (5.3 MB) | EPUB
  • 92 Views
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Article
Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats
Shuqi Jiang, Huifang Wang, Qiuping Zhou, Qian Li, Nan Liu, Zhenggong Li, Chunbo Chen & Yiyu Deng
Pages: 5919-5937
Published online: 12 Nov 2021
AbstractforMelatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats | Full Text | References | PDF (12.1 MB) | EPUB
  • 102 Views
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Review

Review Article
Mucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease
Yaqin Zhang, Lan Wang, Dickson Kofi Wiredu Ocansey, Bo Wang, Li Wang & Zhiwei Xu
Pages: 5939-5953
Published online: 18 Jul 2023
AbstractforMucin-Type O-Glycans: Barrier, Microbiota, and Immune Anchors in Inflammatory Bowel Disease | Full Text | References | PDF (4.7 MB) | EPUB
  • 110 Views
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Original Research

Article
Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway
Chun-Han Hou, Chih-Hsin Tang, Po-Chun Chen & Ju-Fang Liu
Pages: 5955-5967
Published online: 18 Jul 2023
AbstractforThrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway | Full Text | References | PDF (5.8 MB) | EPUB
  • 109 Views
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Article
A Genome-Wide Association Study Identifies Novel Risk Loci for Sarcopenia in a Taiwanese Population
Shou-En Wu & Wei Liang Chen
Pages: 5969-5980
Published online: 16 Nov 2021
AbstractforA Genome-Wide Association Study Identifies Novel Risk Loci for Sarcopenia in a Taiwanese Population | Full Text | References | PDF (506.8 KB) | EPUB
  • 74 Views
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Article
IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica
Yang Bai, Fei Guan, Feifan Zhu, Chunjie Jiang, XiaoXiao Xu, Fang Zheng, Wenqi Liu & Jiahui Lei
Pages: 5981-5998
Published online: 15 Nov 2021
AbstractforIL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica | Full Text | References | PDF (13.8 MB) | EPUB
  • 85 Views
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Article
Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain
Aitao Wang, Dongmei Guo, Hongyu Cheng, Hui Jiang, Xiaojuan Liu & Zhizhong Yun
Pages: 5999-6010
Published online: 16 Nov 2021
AbstractforTranscriptome Sequencing Explores the Mechanism of Baicalin on Bone Cancer Pain | Full Text | References | PDF (2.5 MB) | EPUB
  • 79 Views
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Article
Altered Pattern of Macrophage Polarization as a Biomarker for Severity of Childhood Asthma
Chang-Hung Kuo, Mei-Lan Tsai, Chung-Hsiang Li, Hui-Pin Hsiao, Mei-Chyn Chao, Ming-Sheng Lee, Yi-Ching Lin & Chih-Hsing Hung
Pages: 6011-6023
Published online: 18 Nov 2021
AbstractforAltered Pattern of Macrophage Polarization as a Biomarker for Severity of Childhood Asthma | Full Text | References | PDF (11.3 MB) | EPUB
  • 62 Views
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Review

Review Article
The Immunomodulatory Functions of Butyrate
Mohamed Tausif Siddiqui & Gail A M Cresci
Pages: 6025-6041
Published online: 18 Nov 2021
AbstractforThe Immunomodulatory Functions of Butyrate | Full Text | References | PDF (4.5 MB) | EPUB
  • 416 Views
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Original Research

Article
The Network of Pro-Inflammatory Factors CD147, DcR3, and IL33 in the Development of Kawasaki Disease
Yanqi Qi, Jiawen Xu, Zhe Lin, Yijing Tao, Fenglei Zheng, Yujia Wang, Yameng Sun, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang & Fangqi Gong
Pages: 6043-6053
Published online: 19 Nov 2021
AbstractforThe Network of Pro-Inflammatory Factors CD147, DcR3, and IL33 in the Development of Kawasaki Disease | Full Text | References | PDF (4.4 MB) | EPUB
  • 70 Views
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Article
Phenotypes, Lung Microbiota and Cytokine Responses in Pneumonia After Hematopoietic Stem Cell Transplantation
Yan Hu, Yanwen Jiang, Shuang Liu, Jiawei Shen & Youzhong An
Pages: 6055-6065
Published online: 19 Nov 2021
AbstractforPhenotypes, Lung Microbiota and Cytokine Responses in Pneumonia After Hematopoietic Stem Cell Transplantation | Full Text | References | PDF (3.9 MB) | EPUB
  • 59 Views
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Article
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3
Yu Jin, Zhenxia Li, Yanran Wu, Hairui Li, Zhen Liu, Lu Liu, Ningjuan Ouyang, Ting Zhou, Bing Fang & Lunguo Xia
Pages: 6067-6083
Published online: 19 Nov 2021
AbstractforAberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3 | Full Text | References | PDF (12.6 MB) | EPUB
  • 89 Views
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Article
Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer’s Disease
Elena Milanesi, Maria Dobre, Cătălina Anca Cucos, Ana I Rojo, José Jiménez-Villegas, Estibaliz Capetillo-Zarate, Carlos Matute, Gerard Piñol-Ripoll, Gina Manda & Antonio Cuadrado
Pages: 6085-6102
Published online: 20 Nov 2021
AbstractforWhole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer’s Disease | Full Text | References | PDF (7.4 MB) | EPUB
  • 83 Views
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Article
IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
Joanna Kamińska, Violetta Dymicka-Piekarska, Robert Chrzanowski, Karol Sawicki, Anna J Milewska, Justyna Zińczuk, Marzena Tylicka, Marek Jadeszko, Zenon Mariak, Ewa M Kratz, Joanna Matowicka-Karna, Johannes Kornhuber, Piotr Lewczuk & Olga M Koper-Lenkiewicz
Pages: 6103-6114
Published online: 23 Nov 2021
AbstractforIL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm | Full Text | References | PDF (3.6 MB) | EPUB
  • 76 Views
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Article
Association Between Pre-Treatment and Post-Treatment 3-Month Red Cell Distribution Width with Three-Year Prognosis of Prostate Cancer
Jie Cheng, Siyang Wang, Jingying Jia, Qian Chen, Yunxiao Song & Junsheng Li
Pages: 6115-6127
Published online: 23 Nov 2021
AbstractforAssociation Between Pre-Treatment and Post-Treatment 3-Month Red Cell Distribution Width with Three-Year Prognosis of Prostate Cancer | Full Text | References | PDF (3.5 MB) | EPUB
  • 140 Views
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Article
Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
Dong Guo, Jiafeng Liu, Yanping Li, Chao Li, Quan Liu, Shengjun Ji & Shuchai Zhu
Pages: 6129-6141
Published online: 18 Jul 2023
AbstractforEvaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer | Full Text | References | PDF (6.5 MB) | EPUB
  • 68 Views
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Article
Identification of Unique Transcriptomic Signatures and Hub Genes Through RNA Sequencing and Integrated WGCNA and PPI Network Analysis in Nonerosive Reflux Disease
Ye Zhao, Teng Ma & Duowu Zou
Pages: 6143-6156
Published online: 18 Jul 2023
AbstractforIdentification of Unique Transcriptomic Signatures and Hub Genes Through RNA Sequencing and Integrated WGCNA and PPI Network Analysis in Nonerosive Reflux Disease | Full Text | References | PDF (13.6 MB) | EPUB
  • 158 Views
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Article
Mesenchymal Stem Cell–Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis
Lihua Chang & Liang Kan
Pages: 6157-6171
Published online: 24 Nov 2021
AbstractforMesenchymal Stem Cell–Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis | Full Text | References | PDF (14.5 MB) | EPUB
  • 89 Views
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Corrigendum

Correction
Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice [Corrigendum]
Pages: 6173-6174
Published online: 18 Jul 2023
CitationforClass IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice [Corrigendum] | Full Text | PDF (132.7 KB) | EPUB
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Original Research

Article
Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice
Hui-Ling Chen, Yi-Bin Zeng, Zheng-Yan Zhang, Chao-Yue Kong, Shi-Long Zhang, Zhan-Ming Li, Jia-Ting Huang, Ya-Yun Xu, Yu-Qin Mao, Pei-Ran Cai, Bing Han, Wu-Qing Wang & Li-Shun Wang
Pages: 6175-6190
Published online: 18 Jul 2023
AbstractforGut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice | Full Text | References | PDF (13.1 MB) | EPUB
  • 157 Views
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Review

Review Article
SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases
Avaniyapuram Kannan Murugan & Ali S Alzahrani
Pages: 6191-6221
Published online: 24 Nov 2021
AbstractforSARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases | Full Text | References | PDF (8.5 MB) | EPUB
  • 178 Views
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Original Research

Article
Gasdermin D in Different Subcellular Locations Predicts Diverse Progression, Immune Microenvironment and Prognosis in Colorectal Cancer
Jiahui Wang, Yixin Kang, Yuxuan Li, Liang Sun, Jun Zhang, Senmi Qian, Ke Luo, Yi Jiang, Lichao Sun & Fangying Xu
Pages: 6223-6235
Published online: 18 Jul 2023
AbstractforGasdermin D in Different Subcellular Locations Predicts Diverse Progression, Immune Microenvironment and Prognosis in Colorectal Cancer | Full Text | References | PDF (4 MB) | EPUB
  • 87 Views
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Article
Direct CCL4 Inhibition Modulates Gut Microbiota, Reduces Circulating Trimethylamine N-Oxide, and Improves Glucose and Lipid Metabolism in High-Fat-Diet-Induced Diabetes Mellitus
Ting-Ting Chang & Jaw-Wen Chen
Pages: 6237-6250
Published online: 27 Nov 2021
AbstractforDirect CCL4 Inhibition Modulates Gut Microbiota, Reduces Circulating Trimethylamine N-Oxide, and Improves Glucose and Lipid Metabolism in High-Fat-Diet-Induced Diabetes Mellitus | Full Text | References | PDF (11.8 MB) | EPUB
  • 86 Views
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Review

Review Article
Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration
Muhammad Ikram, Hyun Young Park, Tahir Ali & Myeong Ok Kim
Pages: 6251-6264
Published online: 27 Nov 2021
AbstractforMelatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration | Full Text | References | PDF (4 MB) | EPUB
  • 149 Views
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Original Research

Article
A Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis
Qiaolin Wang, Chengzhi Lv, Xi Han, Minxue Shen & Yehong Kuang
Pages: 6265-6273
Published online: 18 Jul 2023
AbstractforA Web-Based Survey on Factors for Unvaccination and Adverse Reactions of SARS-CoV-2 Vaccines in Chinese Patients with Psoriasis | Full Text | References | PDF (893.6 KB) | EPUB
  • 71 Views
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Article
LncRNAs Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal Cancer
Yiyi Zhang, Bingjie Guan, Yong WU, Fan Du, Jinfu Zhuang, Yuanfeng Yang, Guoxian Guan & Xing Liu
Pages: 6275-6292
Published online: 27 Nov 2021
AbstractforLncRNAs Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal Cancer | Full Text | References | PDF (12.7 MB) | EPUB
  • 99 Views
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Article
Toll-Like Receptor 4 Polymorphisms (896A/G and 1196C/T) as an Indicator of COVID-19 Severity in a Convenience Sample of Egyptian Patients
Sara I Taha, Aalaa K Shata, Shereen A Baioumy, Shaimaa H Fouad, Sherif G Anis, Isis M Mossad, Nouran M Moustafa, Dina M Abdou & Mariam K Youssef
Pages: 6293-6303
Published online: 27 Nov 2021
AbstractforToll-Like Receptor 4 Polymorphisms (896A/G and 1196C/T) as an Indicator of COVID-19 Severity in a Convenience Sample of Egyptian Patients | Full Text | References | PDF (1.9 MB) | EPUB
  • 140 Views
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Article
Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects
Ayman M Mousa, Khaled E A Soliman, Fahad Alhumaydhi, Ahmad Almatroudi, Osamah Al Rugaie, Khaled S Allemailem, Faris Alrumaihi, Arif Khan, Mohamad Y Rezk, Mohammad Aljasir, Ameen S S Alwashmi, Faris F Aba Alkhayl, Aqel S Albutti & Hanan S Seleem
Pages: 6305-6316
Published online: 18 Jul 2023
AbstractforGarlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects | Full Text | References | PDF (7.9 MB) | EPUB
  • 168 Views
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Article
Cross-Talk Between Nitrosative Stress, Inflammation and Hypoxia-Inducible Factor in Patients with Adrenal Masses
Barbara Choromańska, Piotr Myśliwiec, Tomasz Kozłowski, Magdalena Łuba, Piotr Wojskowicz, Jacek Dadan, Hanna Myśliwiec, Katarzyna Choromańska, Katarzyna Makarewicz, Anna Zalewska & Mateusz Maciejczyk
Pages: 6317-6330
Published online: 30 Nov 2021
AbstractforCross-Talk Between Nitrosative Stress, Inflammation and Hypoxia-Inducible Factor in Patients with Adrenal Masses | Full Text | References | PDF (3.2 MB) | EPUB
  • 69 Views
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Article
PLIN2 Mediates Neuroinflammation and Oxidative/Nitrosative Stress via Downregulating Phosphatidylethanolamine in the Rostral Ventrolateral Medulla of Stressed Hypertensive Rats
Shutian Zhang, Li Hu, Chengzhi Han, Renhui Huang, Kokwin Ooi, Xinyi Qian, Xiaorong Ren, Dechang Chu, Haili Zhang, Dongshu Du & Chunmei Xia
Pages: 6331-6348
Published online: 30 Nov 2021
AbstractforPLIN2 Mediates Neuroinflammation and Oxidative/Nitrosative Stress via Downregulating Phosphatidylethanolamine in the Rostral Ventrolateral Medulla of Stressed Hypertensive Rats | Full Text | References | PDF (13.3 MB) | EPUB
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Review

Review Article
Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
Valery Danilenko, Andrey Devyatkin, Mariya Marsova, Madina Shibilova, Rustem Ilyasov & Vladimir Shmyrev
Pages: 6349-6381
Published online: 30 Nov 2021
AbstractforCommon Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention | Full Text | References | PDF (3 MB) | EPUB
  • 163 Views
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Review Article
Indeterminate Colitis – Update on Treatment Options
Niranjani Venkateswaran, Scott Weismiller & Kofi Clarke
Pages: 6383-6395
Published online: 18 Jul 2023
AbstractforIndeterminate Colitis – Update on Treatment Options | Full Text | References | PDF (426 KB) | EPUB
  • 144 Views
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Original Research

Article
Circular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction
Guang Sun, Jian-Fen Shen, Xiu-Fang Wei & Guo-Xian Qi
Pages: 6397-6407
Published online: 18 Jul 2023
AbstractforCircular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction | Full Text | References | PDF (8.4 MB) | EPUB
  • 77 Views
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Article
Combined Use of Fecal Biomarkers in Inflammatory Bowel Diseases: Oncostatin M and Calprotectin
Ying Cao, Yibei Dai, Lingyu Zhang, Danhua Wang, Wen Hu, Qiao Yu, Xuchu Wang, Pan Yu, Weiwei Liu, Ying Ping, Tao Sun, Yiwen Sang, Zhenping Liu, Yan Chen & Zhihua Tao
Pages: 6409-6419
Published online: 01 Dec 2021
AbstractforCombined Use of Fecal Biomarkers in Inflammatory Bowel Diseases: Oncostatin M and Calprotectin | Full Text | References | PDF (1.1 MB) | EPUB
  • 98 Views
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Article
Upregulation of TMEM45A Promoted the Progression of Clear Cell Renal Cell Carcinoma in vitro
Huiming Jiang, Haibin Chen, Pei Wan, Meng Liang & Nanhui Chen
Pages: 6421-6430
Published online: 01 Dec 2021
AbstractforUpregulation of TMEM45A Promoted the Progression of Clear Cell Renal Cell Carcinoma in vitro | Full Text | References | PDF (8.1 MB) | EPUB
  • 68 Views
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Article
The Differential Expression of the Inflammasomes in Adipose Tissue and Colon Influences the Development of Colon Cancer in a Context of Obesity by Regulating Intestinal Inflammation
Gema Frühbeck, Amaia Mentxaka, Patricia Ahechu, Javier Gómez-Ambrosi, Beatriz Ramírez, Sara Becerril, Amaia Rodríguez, Xabier Unamuno, Javier A Cienfuegos, Marcos Casado, María A Burrell, Marina Martín, Jorge Baixauli, Victor Valentí, Rafael Moncada, Gabriel Reina, Camilo Silva & Victoria Catalán
Pages: 6431-6446
Published online: 01 Dec 2021
AbstractforThe Differential Expression of the Inflammasomes in Adipose Tissue and Colon Influences the Development of Colon Cancer in a Context of Obesity by Regulating Intestinal Inflammation | Full Text | References | PDF (8 MB) | EPUB
  • 100 Views
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Article
Construction of ceRNA Network to Reveal Potential Biomarkers in Crohn’s Disease and Validation in a TNBS Induced Mice Model
Chenglin Ye, Sizhe Zhu & Jingping Yuan
Pages: 6447-6459
Published online: 02 Dec 2021
AbstractforConstruction of ceRNA Network to Reveal Potential Biomarkers in Crohn’s Disease and Validation in a TNBS Induced Mice Model | Full Text | References | PDF (9.9 MB) | EPUB
  • 64 Views
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Article
Investigation of Association of Complement 5 Genetic Polymorphisms with Sepsis and Sepsis-Induced Inflammatory Responses
Kaidian Chen, Yao Lin, Yuchun Liu, Shuanglin Liao, Ruoxuan Yang, Jiefeng Huang, Mingwei Xu & Junbing He
Pages: 6461-6475
Published online: 02 Dec 2021
AbstractforInvestigation of Association of Complement 5 Genetic Polymorphisms with Sepsis and Sepsis-Induced Inflammatory Responses | Full Text | References | PDF (5.5 MB) | EPUB
  • 72 Views
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Article
Methylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin
Matheus L Medeiros, Akila L Oliveira, Mariana G de Oliveira, Fabíola Z Mónica & Edson Antunes
Pages: 6477-6489
Published online: 02 Dec 2021
AbstractforMethylglyoxal Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via RAGE-Induced ROS Generation: Protective Effects of Metformin | Full Text | References | PDF (10.5 MB) | EPUB
  • 77 Views
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Article
Interleukin -1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway
Qi Tan, Limin Duan, Qi Huang, Wenjuan Chen, Zimo Yang, Jiangbin Chen & Yang Jin
Pages: 6491-6509
Published online: 18 Jul 2023
AbstractforInterleukin -1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway | Full Text | References | PDF (11.1 MB) | EPUB
  • 86 Views
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Article
A Novel Clinical Radiomics Nomogram to Identify Crohn’s Disease from Intestinal Tuberculosis
Chao Zhu, Yongmei Yu, Shihui Wang, Xia Wang, Yankun Gao, Cuiping Li, Jianying Li, Yaqiong Ge & Xingwang Wu
Pages: 6511-6521
Published online: 03 Dec 2021
AbstractforA Novel Clinical Radiomics Nomogram to Identify Crohn’s Disease from Intestinal Tuberculosis | Full Text | References | PDF (6.2 MB) | EPUB
  • 93 Views
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Article
RETRACTED ARTICLE: 1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages
Ao Duan, Zemeng Ma, Wanshun Liu, Kai Shen, Hao Zhou, Shunbing Wang, Renyi Kong, Yuqi Shao, Yunzi Chen, Wei Guo & Feng Liu
Pages: 6523-6542
Published online: 03 Dec 2021
AbstractforRETRACTED ARTICLE: 1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages | PDF (17.8 MB)
  • 18 Views
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Review

Review Article
Progranulin as a Potential Therapeutic Target in Immune-Mediated Diseases
Yue-Jiao Lan, Napoleon Bellua Sam, Ming-Han Cheng, Hai-Feng Pan & Jian Gao
Pages: 6543-6556
Published online: 04 Dec 2021
AbstractforProgranulin as a Potential Therapeutic Target in Immune-Mediated Diseases | Full Text | References | PDF (3.4 MB) | EPUB
  • 125 Views
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Original Research

Article
ARL14 as a Prognostic Biomarker in Non-Small Cell Lung Cancer
Binbin Zhang, Aiqun Xu, Dong Wu, Wanli Xia, Pulin Li, Enze Wang, Rui Han, Peng Sun, Sijing Zhou & Ran Wang
Pages: 6557-6574
Published online: 18 Jul 2023
AbstractforARL14 as a Prognostic Biomarker in Non-Small Cell Lung Cancer | Full Text | References | PDF (11.5 MB) | EPUB
  • 69 Views
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Article
A Mixture of Lactobacillus fermentum HFY06 and Arabinoxylan Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice
Fang Li, Hui Huang, Fulejia Zhu, Xianrong Zhou, Zhennai Yang & Xin Zhao
Pages: 6575-6585
Published online: 06 Dec 2021
AbstractforA Mixture of Lactobacillus fermentum HFY06 and Arabinoxylan Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice | Full Text | References | PDF (5.1 MB) | EPUB
  • 80 Views
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Article
Th1/Th2 Balance in Young Subjects: Relationship with Cytokine Levels and Metabolic Profile
Ines Matia-Garcia, Eduardo Vadillo, Rosana Pelayo, José F Muñoz-Valle, Mariel García-Chagollán, Jaqueline Loaeza-Loaeza, Amalia Vences-Velázquez, Lorenzo Salgado-Goytia, Samuel García-Arellano & Isela Parra-Rojas
Pages: 6587-6600
Published online: 06 Dec 2021
AbstractforTh1/Th2 Balance in Young Subjects: Relationship with Cytokine Levels and Metabolic Profile | Full Text | References | PDF (3.3 MB) | EPUB
  • 134 Views
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Article
Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
Yiye Zhu, Guoshun Huang, Yang Yang, Chen Yong, Xiang Yu, Gang Wang, Lan Yi, Kun Gao, Fang Tian, Shushu Qian, Enchao Zhou & Yanqin Zou
Pages: 6601-6618
Published online: 18 Jul 2023
AbstractforChinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury | Full Text | References | PDF (14.4 MB) | EPUB
  • 80 Views
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Article
RETRACTED ARTICLE: Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling
Yueyi Yao, Changyan Li, Fusheng Qian, Yu Zhao, Xiaoyi Shi, Dan Hong, Qinglong Ai & Lianmei Zhong
Pages: 6619-6632
Published online: 07 Dec 2021
AbstractforRETRACTED ARTICLE: Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling | PDF (7.5 MB)
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Article
The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice
Jun Zhang, Chun-Lin Mai, Ying Xiong, Zhen-Jia Lin, Ying-Tao Jie, Jie-Zhen Mai, Chong Liu, Man-Xiu Xie, Xin Zhou & Xian-Guo Liu
Pages: 6633-6656
Published online: 07 Dec 2021
AbstractforThe Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice | Full Text | References | PDF (24.1 MB) | EPUB
  • 182 Views
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Article
Dynamic Nomogram for Predicting Thrombocytopenia in Adults with Acute Pancreatitis
Hongbin Deng, Xianqiang Yu, Kun Gao, Yang Liu, Zhihui Tong, Yuxiu Liu & Weiqin Li
Pages: 6657-6667
Published online: 08 Dec 2021
AbstractforDynamic Nomogram for Predicting Thrombocytopenia in Adults with Acute Pancreatitis | Full Text | References | PDF (4.1 MB) | EPUB
  • 70 Views
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Corrigendum

Correction
Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review [Corrigendum]
Pages: 6669-6670
Published online: 08 Dec 2021
CitationforComprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review [Corrigendum] | Full Text | PDF (136.3 KB) | EPUB
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Original Research

Article
The Inverted-U Relationship Between Dietary Inflammatory Potential and Hearing Loss Among Adults Aged 20 Years and Over in the United States: A Cross-Sectional Study
Yanpeng Fu, Wenyu Chen, Liqing Guo & Yuehui Liu
Pages: 6671-6683
Published online: 18 Jul 2023
AbstractforThe Inverted-U Relationship Between Dietary Inflammatory Potential and Hearing Loss Among Adults Aged 20 Years and Over in the United States: A Cross-Sectional Study | Full Text | References | PDF (8.2 MB) | EPUB
  • 73 Views
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Article
Jintiange Capsule Alleviates Rheumatoid Arthritis and Reverses Changes of Serum Metabolic Profile in Collagen-Induced Arthritic Rats
Xiaoyan Wang, Yi Shen, Xinying Zhuang, Na Wang, Qi Zhang, Lulin Zhu, Yuling Liu, Xinyu Lu, Luping Qin & Qiaoyan Zhang
Pages: 6685-6706
Published online: 18 Jul 2023
AbstractforJintiange Capsule Alleviates Rheumatoid Arthritis and Reverses Changes of Serum Metabolic Profile in Collagen-Induced Arthritic Rats | Full Text | References | PDF (18.9 MB) | EPUB
  • 111 Views
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Article
A Nomogram Based on Circulating CD4+ T Lymphocytes and Lactate Dehydrogenase to Predict Distant Metastasis in Patients with Nasopharyngeal Carcinoma
De-song Shen, Chang Yan, Kai-hua Chen, Ling Li, Song Qu & Xiao-dong Zhu
Pages: 6707-6718
Published online: 18 Jul 2023
AbstractforA Nomogram Based on Circulating CD4+ T Lymphocytes and Lactate Dehydrogenase to Predict Distant Metastasis in Patients with Nasopharyngeal Carcinoma | Full Text | References | PDF (3.6 MB) | EPUB
  • 63 Views
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Article
Exploration and Validation of a Novel Inflammatory Response-Associated Gene Signature to Predict Osteosarcoma Prognosis and Immune Infiltration
Yucheng Fu, Guoyu He, Zhuochao Liu, Jun Wang, Zhusheng Zhang, Qiyuan Bao, Junxiang Wen, Zhijian Jin & Weibin Zhang
Pages: 6719-6734
Published online: 09 Dec 2021
AbstractforExploration and Validation of a Novel Inflammatory Response-Associated Gene Signature to Predict Osteosarcoma Prognosis and Immune Infiltration | Full Text | References | PDF (6.5 MB) | EPUB
  • 92 Views
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Article
Antioxidant and Anti-inflammatory Properties Mediate the Neuroprotective Effects of Hydro-ethanolic Extract of Tiliacora triandra Against Cisplatin-induced Neurotoxicity
Yanping Huang, Chunhong Liu, Xianbing Song, Mei An, Meimei Liu, Lei Yao, Ademola C Famurewa & Opeyemi Joshua Olatunji
Pages: 6735-6748
Published online: 18 Jul 2023
AbstractforAntioxidant and Anti-inflammatory Properties Mediate the Neuroprotective Effects of Hydro-ethanolic Extract of Tiliacora triandra Against Cisplatin-induced Neurotoxicity | Full Text | References | PDF (8.8 MB) | EPUB
  • 114 Views
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Article
Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha & Alexander T H Wu
Pages: 6749-6764
Published online: 09 Dec 2021
AbstractforSterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment | Full Text | References | PDF (8.3 MB) | EPUB
  • 99 Views
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Article
Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming
Han She, Yi Hu, Yuanqun Zhou, Lei Tan, Yu Zhu, Chunhua Ma, Yue Wu, Wei Chen, Li Wang, Zisen Zhang, Li Wang, Liangming Liu & Tao Li
Pages: 6765-6782
Published online: 18 Jul 2023
AbstractforProtective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming | Full Text | References | PDF (17.7 MB) | EPUB
  • 169 Views
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Article
A Next-Generation Sequencing of Plasma Exosome-Derived microRNAs and Target Gene Analysis with a Microarray Database of Thermally Injured Skins: Identification of Blood-to-Tissue Interactions at Early Burn Stage
Shi-Ji Li, Zhi-Wen Cai, Hong-Fu Yang, Xu-Dong Tang, Xiao Fang, Le Qiu, Fei Wang & Xu-Lin Chen
Pages: 6783-6798
Published online: 18 Jul 2023
AbstractforA Next-Generation Sequencing of Plasma Exosome-Derived microRNAs and Target Gene Analysis with a Microarray Database of Thermally Injured Skins: Identification of Blood-to-Tissue Interactions at Early Burn Stage | Full Text | References | PDF (9 MB) | EPUB
  • 123 Views
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Article
Melatonin Alleviates Age-Associated Endothelial Injury of Atherosclerosis via Regulating Telomere Function
Yinghua Xie, Danfei Lou & Daimin Zhang
Pages: 6799-6812
Published online: 11 Dec 2021
AbstractforMelatonin Alleviates Age-Associated Endothelial Injury of Atherosclerosis via Regulating Telomere Function | Full Text | References | PDF (9.8 MB) | EPUB
  • 78 Views
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Article
Microglia Impede Oligodendrocyte Generation in Aged Brain
Weimin Luan, Xiqian Qi, Feng Liang, Xiaotao Zhang, Ziyang Jin, Ligen Shi, Benyan Luo & Xuejiao Dai
Pages: 6813-6831
Published online: 11 Dec 2021
AbstractforMicroglia Impede Oligodendrocyte Generation in Aged Brain | Full Text | References | PDF (9.3 MB) | EPUB
  • 135 Views
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Article
Polymorphism rs10105606 of LPL as a Novel Risk Factor for Microalbuminuria
Zhu Wei Lim & Wei Liang Chen
Pages: 6833-6844
Published online: 14 Dec 2021
AbstractforPolymorphism rs10105606 of LPL as a Novel Risk Factor for Microalbuminuria | Full Text | References | PDF (1.6 MB) | EPUB
  • 74 Views
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Review

Review Article
Impact of Anti-Type 2 Inflammation Biologic Therapy on COVID-19 Clinical Course and Outcome
Dimitri Poddighe & Elena Kovzel
Pages: 6845-6853
Published online: 18 Jul 2023
AbstractforImpact of Anti-Type 2 Inflammation Biologic Therapy on COVID-19 Clinical Course and Outcome | Full Text | References | PDF (342.7 KB) | EPUB
  • 69 Views
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Retraction

Retraction
Increased Leptin/Leptin Receptor Pathway Affects Systemic and Airway Inflammation in COPD Former Smokers [Retraction]
Pages: 6855-6856
Published online: 14 Dec 2021
CitationforIncreased Leptin/Leptin Receptor Pathway Affects Systemic and Airway Inflammation in COPD Former Smokers [Retraction] | Full Text | PDF (138.8 KB) | EPUB
  • 51 Views
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Original Research

Article
Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury
Qianxue Mou, Ke Yao, Meng Ye, Bowen Zhao, Yuanyuan Hu, Xiaotong Lou, Huixia Li, Hong Zhang & Yin Zhao
Pages: 6857-6869
Published online: 18 Jul 2023
AbstractforModulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury | Full Text | References | PDF (9.2 MB) | EPUB
  • 105 Views
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Article
Identifying Potential Diagnostic Genes for Diabetic Nephropathy Based on Hypoxia and Immune Status
Changyan Li, Feng Su, Le Zhang, Fang Liu, Wenxing Fan, Zhen Li & JingYuan Ma
Pages: 6871-6891
Published online: 18 Jul 2023
AbstractforIdentifying Potential Diagnostic Genes for Diabetic Nephropathy Based on Hypoxia and Immune Status | Full Text | References | PDF (21.2 MB) | EPUB
  • 81 Views
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Review

Review Article
Monitoring and Managing Cardiovascular Risk in Immune Mediated Inflammatory Diseases
Panagiota Anyfanti, Athanasia Dara, Elena Angeloudi, Eleni Bekiari, Theodoros Dimitroulas & George D Kitas
Pages: 6893-6906
Published online: 14 Dec 2021
AbstractforMonitoring and Managing Cardiovascular Risk in Immune Mediated Inflammatory Diseases | Full Text | References | PDF (1.5 MB) | EPUB
  • 94 Views
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Original Research

Article
The Impact of the Duration of Cardiac Troponin I Elevation on the Clinical Prognosis as Well as Incidence of New-Onset Atrial Fibrillation Respectively in Elderly Non-ST-Elevation Acute Myocardial Infarction Patients without PCI
Yu Wang, Xue-Dong Wang, Ji-Wen Yao, Bei-Bei Shi, Qing-Xiang Gu, Jing Zhang, Xiao-Ting Cui & Yan Wang
Pages: 6907-6916
Published online: 18 Jul 2023
AbstractforThe Impact of the Duration of Cardiac Troponin I Elevation on the Clinical Prognosis as Well as Incidence of New-Onset Atrial Fibrillation Respectively in Elderly Non-ST-Elevation Acute Myocardial Infarction Patients without PCI | Full Text | References | PDF (1.9 MB) | EPUB
  • 66 Views
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Article
An Analysis of the Correlation Between Clinical Indexes and Pathological Classifications in 202 Patients with Lupus Nephritis
Bang-Pin Pan, Zhi-Jian Feng, Xiao-Lan Li, Li-Ping He, Dong Jiang, Rui-Xian Zhang, Wen-Ting Cao, Mei Cai, Yun-Feng Bi, Wen-Fang Wang & Chun-Yan Luan
Pages: 6917-6927
Published online: 18 Jul 2023
AbstractforAn Analysis of the Correlation Between Clinical Indexes and Pathological Classifications in 202 Patients with Lupus Nephritis | Full Text | References | PDF (10.2 MB) | EPUB
  • 81 Views
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Review

Review Article
Recent Insights into the Role of Gut Microbiota in Diabetic Retinopathy
Jinghua Jiao, Honghua Yu, Litong Yao, Lihua Li, Xiaohong Yang & Lei Liu
Pages: 6929-6938
Published online: 16 Dec 2021
AbstractforRecent Insights into the Role of Gut Microbiota in Diabetic Retinopathy | Full Text | References | PDF (1.1 MB) | EPUB
  • 116 Views
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Original Research

Article
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis
Wei Zhou, Yugen Sha, Jingxia Zeng, Xiaoyue Zhang, Aihua Zhang & Xuhua Ge
Pages: 6939-6958
Published online: 16 Dec 2021
AbstractforComputational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis | Full Text | References | PDF (17.9 MB) | EPUB
  • 78 Views
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Review

Review Article
Association of Dietary Inflammatory Index (DII) and Depressive Disorders
Ruiqiang Li, Wenqiang Zhan, Xin Huang, Zhan Liu, Shuaishuai Lv, Jiaqi Wang, Luyao Liang & Yuxia Ma
Pages: 6959-6973
Published online: 18 Jul 2023
AbstractforAssociation of Dietary Inflammatory Index (DII) and Depressive Disorders | Full Text | References | PDF (2.8 MB) | EPUB
  • 94 Views
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Review Article
Ixekizumab for Psoriatic Arthritis: Safety, Efficacy, and Patient Selection
John Miller, Abin P Puravath & Ana-Maria Orbai
Pages: 6975-6991
Published online: 18 Jul 2023
AbstractforIxekizumab for Psoriatic Arthritis: Safety, Efficacy, and Patient Selection | Full Text | References | PDF (579.5 KB) | EPUB
  • 152 Views
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Original Research

Article
iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis
Jian Chen, Shu Li, Yan Ge, Jin Kang, Jia-fen Liao, Jin-feng Du, Jing Tian, Xi Xie & Fen Li
Pages: 6993-7006
Published online: 18 Jul 2023
AbstractforiTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis | Full Text | References | PDF (5.9 MB) | EPUB
  • 89 Views
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Article
Angiotensin-(1–7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer's Disease
Rui Duan, Si-Yu Wang, Bin Wei, Yang Deng, Xin-Xin Fu, Peng-Yu Gong, Yan E, Xiao-Jin Sun, Hai-Ming Cao, Jian-Quan Shi, Teng Jiang & Ying-Dong Zhang
Pages: 7007-7019
Published online: 18 Jul 2023
AbstractforAngiotensin-(1–7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer's Disease | Full Text | References | PDF (7.3 MB) | EPUB
  • 134 Views
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Article
Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone
Maiko Kadowaki, Koichi Sato, Hisashi Kamio, Makoto Kumagai, Rikishi Sato, Takafumi Nyui, Yukihiro Umeda, Yuko Waseda, Masaki Anzai, Haruka Aoki-Saito, Yasuhiko Koga, Takeshi Hisada, Hideaki Tomura, Fumikazu Okajima & Tamotsu Ishizuka
Pages: 7021-7034
Published online: 18 Dec 2021
AbstractforMetal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone | Full Text | References | PDF (5.1 MB) | EPUB
  • 67 Views
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Article
OLFM4 Regulates Lung Epithelial Cell Function in Sepsis-Associated ARDS/ALI via LDHA-Mediated NF-κB Signaling
Fangchen Gong, Ranran Li, Xiangtao Zheng, Weiwei Chen, Yanjun Zheng, Zhitao Yang, Ying Chen, Hongping Qu, Enqiang Mao & Erzhen Chen
Pages: 7035-7051
Published online: 18 Jul 2023
AbstractforOLFM4 Regulates Lung Epithelial Cell Function in Sepsis-Associated ARDS/ALI via LDHA-Mediated NF-κB Signaling | Full Text | References | PDF (12.1 MB) | EPUB
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Article
Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway
Zhimin Zha, Yujia Cheng, Lu Cao, Yanxia Qian, Xinjian Liu, Yan Guo & Junhong Wang
Pages: 7053-7064
Published online: 18 Jul 2023
AbstractforMonomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway | Full Text | References | PDF (7.9 MB) | EPUB
  • 70 Views
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Review

Review Article
The Potential of Drug Delivery Nanosystems for Sepsis Treatment
Yi Shi, Meng-Lu Zhu, Qian Wu, Yi Huang, Xiao-Ling Xu & Wei Chen
Pages: 7065-7077
Published online: 19 Dec 2021
AbstractforThe Potential of Drug Delivery Nanosystems for Sepsis Treatment | Full Text | References | PDF (859.4 KB) | EPUB
  • 105 Views
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Review Article
Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy
Kang Chen, Song Zhang, Jinghua Jiao & Shan Zhao
Pages: 7079-7090
Published online: 20 Dec 2021
AbstractforFerroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 97 Views
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Original Research

Article
Transcriptional Interactomic Inhibition of RORα Suppresses Th17-Related Inflammation
Chun-Chang Ho, Giha Kim, Chin Hee Mun, Ju-Won Kim, Jieun Han, Ji Yoon Park, Yong-Beom Park & Sang-Kyou Lee
Pages: 7091-7105
Published online: 21 Dec 2021
AbstractforTranscriptional Interactomic Inhibition of RORα Suppresses Th17-Related Inflammation | Full Text | References | PDF (7.3 MB) | EPUB
  • 68 Views
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Article
Isosteviol Sodium Exerts Anti-Colitic Effects on BALB/c Mice with Dextran Sodium Sulfate-Induced Colitis Through Metabolic Reprogramming and Immune Response Modulation
Shanping Wang, Jiandong Huang, Fei Liu, Keai Sinn Tan, Liangjun Deng, Yue Lin & Wen Tan
Pages: 7107-7130
Published online: 20 Dec 2021
AbstractforIsosteviol Sodium Exerts Anti-Colitic Effects on BALB/c Mice with Dextran Sodium Sulfate-Induced Colitis Through Metabolic Reprogramming and Immune Response Modulation | Full Text | References | PDF (21.1 MB) | EPUB
  • 73 Views
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Article
Systemic Immune-Inflammatory Index as a Predictor of Lymph Node Metastasis in Endometrial Cancer
HuiFang Lei, ShuXia Xu, XiaoDan Mao, XiaoYing Chen, YaoJia Chen, XiaoQi Sun & PengMing Sun
Pages: 7131-7142
Published online: 21 Dec 2021
AbstractforSystemic Immune-Inflammatory Index as a Predictor of Lymph Node Metastasis in Endometrial Cancer | Full Text | References | PDF (6.2 MB) | EPUB
  • 100 Views
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Review

Review Article
Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis
Chunteng Jiang, Santuan Xie, Guang Yang & Ningning Wang
Pages: 7143-7172
Published online: 21 Dec 2021
AbstractforSpotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis | Full Text | References | PDF (7.1 MB) | EPUB
  • 99 Views
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Original Research

Article
Composite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery
Jiakun Song & Yurong Lu
Pages: 7173-7179
Published online: 18 Jul 2023
AbstractforComposite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery | Full Text | References | PDF (3.9 MB) | EPUB
  • 61 Views
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Article
Clinical Value of Prognostic Nutritional Index in Prediction of the Presence and Severity of Neonatal Sepsis
Tiewei Li, Minglu Qi, Geng Dong, Xiaojuan Li, Zhe Xu, Yulei Wei, Yichuang Feng, Chong Ren, Yaguo Wang & Junmei Yang
Pages: 7181-7190
Published online: 21 Dec 2021
AbstractforClinical Value of Prognostic Nutritional Index in Prediction of the Presence and Severity of Neonatal Sepsis | Full Text | References | PDF (879.7 KB) | EPUB
  • 103 Views
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Review

Review Article
The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation
Ningcen Li, Yi Guo, Yinan Gong, Yue Zhang, Wen Fan, Kaifang Yao, Zhihan Chen, Baomin Dou, Xiaowei Lin, Bo Chen, Zelin Chen, Zhifang Xu & Zhongxi Lyu
Pages: 7191-7224
Published online: 18 Jul 2023
AbstractforThe Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation | Full Text | References | PDF (3.5 MB) | EPUB
  • 512 Views
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Review Article
Acute Respiratory Distress Syndrome and COVID-19: A Literature Review
Musaddique Hussain, Shahzada Khurram Syed, Mobeen Fatima, Saira Shaukat, Malik Saadullah, Ali M Alqahtani, Taha Alqahtani, Talha Bin Emran, Ali H Alamri, Muhammad Qasim Barkat & Ximei Wu
Pages: 7225-7242
Published online: 18 Jul 2023
AbstractforAcute Respiratory Distress Syndrome and COVID-19: A Literature Review | Full Text | References | PDF (600 KB) | EPUB
  • 427 Views
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Original Research

Article
A Comparison Between 1 Day versus 7 Days of Sepsis in Mice with the Experiments on LPS-Activated Macrophages Support the Use of Intravenous Immunoglobulin for Sepsis Attenuation
Jiradej Makjaroen, Arthid Thim-Uam, Cong Phi Dang, Trairak Pisitkun, Poorichaya Somparn & Asada Leelahavanichkul
Pages: 7243-7263
Published online: 22 Dec 2021
AbstractforA Comparison Between 1 Day versus 7 Days of Sepsis in Mice with the Experiments on LPS-Activated Macrophages Support the Use of Intravenous Immunoglobulin for Sepsis Attenuation | Full Text | References | PDF (18.3 MB) | EPUB
  • 122 Views
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Article
Acute Exposure to the Food-Borne Pathogen Listeria monocytogenes Does Not Induce α-Synuclein Pathology in the Colonic ENS of Nonhuman Primates
Anthony M Mancinelli, Jonathan M Vichich, Alexandra D Zinnen, Anna Marie Hugon, Viktoriya Bondarenko, Jeanette M Metzger, Heather A Simmons, Thaddeus G Golos & Marina E Emborg
Pages: 7265-7279
Published online: 18 Jul 2023
AbstractforAcute Exposure to the Food-Borne Pathogen Listeria monocytogenes Does Not Induce α-Synuclein Pathology in the Colonic ENS of Nonhuman Primates | Full Text | References | PDF (7.7 MB) | EPUB
  • 58 Views
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Article
Lactobacillus fermentum ZS09 Mediates Epithelial–Mesenchymal Transition (EMT) by Regulating the Transcriptional Activity of the Wnt/β-Catenin Signalling Pathway to Inhibit Colon Cancer Activity
Jia Liu, Xiufeng Chen, Xianrong Zhou, Ruokun Yi, Zhennai Yang & Xin Zhao
Pages: 7281-7293
Published online: 18 Jul 2023
AbstractforLactobacillus fermentum ZS09 Mediates Epithelial–Mesenchymal Transition (EMT) by Regulating the Transcriptional Activity of the Wnt/β-Catenin Signalling Pathway to Inhibit Colon Cancer Activity | Full Text | References | PDF (8.4 MB) | EPUB
  • 75 Views
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Article
HMGB1-Induced Hepatocyte Pyroptosis Expanding Inflammatory Responses Contributes to the Pathogenesis of Acute-on-Chronic Liver Failure (ACLF)
Weixin Hou, Xiaoyi Wei, Jiajun Liang, Peng Fang, Chongyang Ma, Qiuyun Zhang & Yanbin Gao
Pages: 7295-7313
Published online: 23 Dec 2021
AbstractforHMGB1-Induced Hepatocyte Pyroptosis Expanding Inflammatory Responses Contributes to the Pathogenesis of Acute-on-Chronic Liver Failure (ACLF) | Full Text | References | PDF (12.4 MB) | EPUB
  • 91 Views
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Article
CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment
Xiudong Guan, Yangyang Wang, Yueqian Sun, Chuanbao Zhang, Shunchang Ma, Dainan Zhang, Deling Li & Wang Jia
Pages: 7315-7329
Published online: 23 Dec 2021
AbstractforCTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment | Full Text | References | PDF (6.1 MB) | EPUB
  • 106 Views
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Article
Serum Level of Complement C1q is Associated with Contrast-Associated Acute Kidney Injury in Patients Undergoing Emergency Percutaneous Coronary Intervention
Jun Tao, Chenglin Ye, Wen Dai, Di Li, Man Zhou & Yan Li
Pages: 7331-7339
Published online: 24 Dec 2021
AbstractforSerum Level of Complement C1q is Associated with Contrast-Associated Acute Kidney Injury in Patients Undergoing Emergency Percutaneous Coronary Intervention | Full Text | References | PDF (2.6 MB) | EPUB
  • 85 Views
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Article
Genomic, Immunological, and Clinical Characterization of Pyroptosis in Ovarian Cancer
Min Zhou, Bingshu Li, Jianfeng Liu & Li Hong
Pages: 7341-7358
Published online: 18 Jul 2023
AbstractforGenomic, Immunological, and Clinical Characterization of Pyroptosis in Ovarian Cancer | Full Text | References | PDF (15.9 MB) | EPUB
  • 57 Views
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Article
Single-Cell RNA Sequencing Reveals CXCLs Enriched Fibroblasts Within Odontogenic Keratocysts
Qi-Wen Man, Rui-Fang Li, Su-Ran Li, Jing Wang, Lin-Lin Bu, Yi Zhao & Bing Liu
Pages: 7359-7369
Published online: 24 Dec 2021
AbstractforSingle-Cell RNA Sequencing Reveals CXCLs Enriched Fibroblasts Within Odontogenic Keratocysts | Full Text | References | PDF (6.2 MB) | EPUB
  • 161 Views
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Article
Prealbumin and Retinol-Binding Protein 4: The Promising Inflammatory Biomarkers for Identifying Endoscopic Remission in Crohn’s Disease
Rirong Chen, Li Li, Chao Li, Yuhan Su, Yingfan Zhang, Xiaobai Pang, Jieqi Zheng, Zhirong Zeng, Min-Hu Chen & Shenghong Zhang
Pages: 7371-7379
Published online: 18 Jul 2023
AbstractforPrealbumin and Retinol-Binding Protein 4: The Promising Inflammatory Biomarkers for Identifying Endoscopic Remission in Crohn’s Disease | Full Text | References | PDF (1.6 MB) | EPUB
  • 74 Views
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Article
Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis
Chaochao Tan, Yan Xiao, Xiangping Huang, Ling Wu & Ying Huang
Pages: 7381-7392
Published online: 18 Jul 2023
AbstractforAlterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis | Full Text | References | PDF (7.1 MB) | EPUB
  • 53 Views
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Article
RETRACTED ARTICLE: 1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway
Arooj Mohsin Alvi, Fawad Ali Shah, Asmaa Jan Muhammad, Jinxing Feng & Shupeng Li
Pages: 7393-7409
Published online: 29 Dec 2021
AbstractforRETRACTED ARTICLE: 1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway | PDF (13.3 MB)
  • 88 Views
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Article
Antimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in Rats Supported by Metabolomics Profiling
Badriyah Alotaibi, Fatma Alzahraa Mokhtar, Thanaa A El-Masry, Engy Elekhnawy, Sally A Mostafa, Dalia H Abdelkader, Mohamed E Elharty, Asmaa Saleh & Walaa A Negm
Pages: 7411-7430
Published online: 18 Jul 2023
AbstractforAntimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in Rats Supported by Metabolomics Profiling | Full Text | References | PDF (10.4 MB) | EPUB
  • 186 Views
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Article
Potential Biomarkers Associated with Differential Manifestations of Ulcerative Colitis (UC) in Uyghur and Han Population in China
Jia Jie Lu, Munila Maimaiti, Huan Liu, Wei Dong Liu, Wen Jia Hui, Xiao Ling Huang & Feng Gao
Pages: 7431-7441
Published online: 18 Jul 2023
AbstractforPotential Biomarkers Associated with Differential Manifestations of Ulcerative Colitis (UC) in Uyghur and Han Population in China | Full Text | References | PDF (6.7 MB) | EPUB
  • 70 Views
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Perspectives

Discussion
Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
Gabrio Bassotti, Alessandro Fruganti, Giovanni Maconi, Pierfrancesco Marconi & Katia Fettucciari
Pages: 7443-7453
Published online: 30 Dec 2021
AbstractforClostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network | Full Text | References | PDF (1.9 MB) | EPUB
  • 87 Views
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Original Research

Article
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau
Alessia Filippone, Tiffany Smith & Domenico Pratico
Pages: 7455-7465
Published online: 29 Dec 2021
AbstractforDysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau | Full Text | References | PDF (5.8 MB) | EPUB
  • 79 Views
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Article
Qing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes
Dan-Dan Wang, Xin-Yue Wu, Ji-Yang Dong, Xiu-Ping Cheng, Shao-Fei Gu, Opeyemi Joshua Olatunji, Yan Li & Jian Zuo
Pages: 7467-7486
Published online: 30 Dec 2021
AbstractforQing-Luo-Yin Alleviated Experimental Arthritis in Rats by Disrupting Immune Feedback Between Inflammatory T Cells and Monocytes: Key Evidences from Its Effects on Immune Cell Phenotypes | Full Text | References | PDF (13.4 MB) | EPUB
  • 79 Views
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Review

Review Article
Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression
Damian Jacenik, Jakub Fichna, Ewa Małecka-Wojciesko & Anna Mokrowiecka
Pages: 7487-7497
Published online: 18 Jul 2023
AbstractforProtease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression | Full Text | References | PDF (435.9 KB) | EPUB
  • 72 Views
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Corrigendum

Correction
Early Elevation of Thioredoxin-1 Serum Levels Predicts 28-Day Mortality in Patients with Sepsis [Corrigendum]
Pages: 7499-7500
Published online: 31 Dec 2021
CitationforEarly Elevation of Thioredoxin-1 Serum Levels Predicts 28-Day Mortality in Patients with Sepsis [Corrigendum] | Full Text | PDF (171.6 KB) | EPUB
  • 63 Views
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Original Research

Article
Glial Fibrillary Acidic Protein (GFAP): Neuroinflammation Biomarker in Acute Ischemic Stroke
Lisda Amalia
Pages: 7501-7506
Published online: 30 Dec 2021
AbstractforGlial Fibrillary Acidic Protein (GFAP): Neuroinflammation Biomarker in Acute Ischemic Stroke | Full Text | References | PDF (264.1 KB) | EPUB
  • 208 Views
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Review

Review Article
Recent Advances in the Clinical Value and Potential of Dexmedetomidine
Xiaotian Liu, Yueqin Li, Li Kang & Qian Wang
Pages: 7507-7527
Published online: 30 Dec 2021
AbstractforRecent Advances in the Clinical Value and Potential of Dexmedetomidine | Full Text | References | PDF (3.8 MB) | EPUB
  • 408 Views
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Original Research

Article
Establishment and Clinical Application of a Method for Detecting T Lymphocyte Subsets by Cellular Immunochip Technology
Chen Chen, Yan-Mei Liu, Shu-Xia Xuan, Mei-Fang Zhou, Peng Zhou, Bin Cheng, Jin-Duan Lin, Wei-Guo Yin & Lin-Hai Li
Pages: 7529-7537
Published online: 31 Dec 2021
AbstractforEstablishment and Clinical Application of a Method for Detecting T Lymphocyte Subsets by Cellular Immunochip Technology | Full Text | References | PDF (7.9 MB) | EPUB
  • 67 Views
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Article
The Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals
Ziqi Jin, Qiong Wu, Shuohua Chen, Jingli Gao, Xiaolan Li, Xuhui Zhang, Yaohan Zhou, Di He, Zongxue Cheng, Yimin Zhu & Shouling Wu
Pages: 131-140
Published online: 18 Jan 2021
AbstractforThe Associations of Two Novel Inflammation Indexes, SII and SIRI with the Risks for Cardiovascular Diseases and All-Cause Mortality: A Ten-Year Follow-Up Study in 85,154 Individuals | Full Text | References | PDF (2 MB) | EPUB
  • 147 Views
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Article
Plasma Neutrophil-to-Lymphocyte Ratio on the Third Day Postburn is Associated with 90-Day Mortality Among Patients with Burns Over 30% of Total Body Surface Area in Two Chinese Burns Centers
Le Qiu, Xu Jin, Jun-Jie Wang, Xu-Dong Tang, Xiao Fang, Shi-Ji Li, Fei Wang & Xu-Lin Chen
Pages: 519-526
Published online: 24 Feb 2021
AbstractforPlasma Neutrophil-to-Lymphocyte Ratio on the Third Day Postburn is Associated with 90-Day Mortality Among Patients with Burns Over 30% of Total Body Surface Area in Two Chinese Burns Centers | Full Text | References | PDF (1 MB) | EPUB
  • 76 Views
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Review

Review Article
The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
Nandeeta Samad, Temitayo Eniola Sodunke, Abdullahi Rabiu Abubakar, Iffat Jahan, Paras Sharma, Salequl Islam, Siddhartha Dutta & Mainul Haque
Pages: 527-550
Published online: 26 Feb 2021
AbstractforThe Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic | Full Text | References | PDF (6.1 MB) | EPUB
  • 156 Views
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Original Research

Article
Crm1-Dependent Nuclear Export of Bach1 is Involved in the Protective Effect of Hyperoside on Oxidative Damage in Hepatocytes and CCl4-induced Acute Liver Injury
Yongqing Cai, Bin Li, Dan Peng, Xianfeng Wang, Pan Li, Mingchun Huang, Haiyan Xing & Jianhong Chen
Pages: 551-565
Published online: 25 Feb 2021
AbstractforCrm1-Dependent Nuclear Export of Bach1 is Involved in the Protective Effect of Hyperoside on Oxidative Damage in Hepatocytes and CCl4-induced Acute Liver Injury | Full Text | References | PDF (9 MB) | EPUB
  • 71 Views
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Article
Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort
Eytan Cohen, Ili Margalit, Tzippy Shochat, Elad Goldberg & Ilan Krause
Pages: 567-573
Published online: 25 Feb 2021
AbstractforMarkers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort | Full Text | References | PDF (292.4 KB)
  • 176 Views
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Article
Transcriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A
Hui Jiang, Kefeng Cao, Chang Fan, Xiaoya Cui, Yanzhen Ma & Jian Liu
Pages: 575-586
Published online: 18 Jul 2023
AbstractforTranscriptome-Wide High-Throughput m6A Sequencing of Differential m6A Methylation Patterns in the Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line MH7A | Full Text | References | PDF (7.7 MB) | EPUB
  • 110 Views
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Article
Dysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages
Tian-Yong Hu, Hua Zhang, Yan-Yan Chen, Wei-Hua Jiao, Jun-Ting Fan, Zhi-Qiang Liu, Hou-Wen Lin & Bao-Hui Cheng
Pages: 587-597
Published online: 18 Jul 2023
AbstractforDysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages | Full Text | References | PDF (4.7 MB) | EPUB
  • 71 Views
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Article
High Concentrations of Etanercept Reduce Human Islet Function and Integrity
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Anju Abraham & Paul RV Johnson
Pages: 599-610
Published online: 26 Feb 2021
AbstractforHigh Concentrations of Etanercept Reduce Human Islet Function and Integrity | Full Text | References | PDF (3.3 MB) | EPUB
  • 76 Views
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Hypothesis

The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways
Xinwei Cao, Yajun Li, Jianrong Shi & Huifang Tang
Pages: 611-619
Published online: 26 Feb 2021
AbstractforThe Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways | Full Text | References | PDF (3.2 MB) | EPUB
  • 68 Views
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Original Research

Article
Identification of Potential Early Diagnostic Biomarkers of Sepsis
Zhenhua Li, Bin Huang, Wenfeng Yi, Fei Wang, Shizhuang Wei, Huaixing Yan, Pan Qin, Donghua Zou, Rongguo Wei & Nian Chen
Pages: 621-631
Published online: 03 Mar 2021
AbstractforIdentification of Potential Early Diagnostic Biomarkers of Sepsis | Full Text | References | PDF (23.9 MB) | EPUB
  • 159 Views
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Article
C-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study
Luting Nie, Dandan Wei, Pengling Liu, Li Zhang, Keliang Fan, Yu Song, Mian Wang, Lulu Wang, Qingqing Xu, Juan Wang, Xiaotian Liu, Linlin Li, Zhenxing Mao, Hui Huang, Chongjian Wang & Wenqian Huo
Pages: 633-644
Published online: 18 Jul 2023
AbstractforC-Reactive Protein Mediates the Effect of Serum Progesterone on Obesity for Men and Postmenopausal Women in Henan Rural Cohort Study | Full Text | References | PDF (2.1 MB) | EPUB
  • 65 Views
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Article
Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
Can Tu, Ming Niu, Ai-Wu Wei, Jin-Fa Tang, Le Zhang, Jing Jing, Xiao-He Xiao & Jia-Bo Wang
Pages: 645-655
Published online: 04 Mar 2021
AbstractforSusceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans | Full Text | References | PDF (2.9 MB) | EPUB
  • 78 Views
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Review

Review Article
Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases
Chien-Chung Yang & Chuen-Mao Yang
Pages: 657-687
Published online: 18 Jul 2023
AbstractforChinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases | Full Text | References | PDF (4.6 MB) | EPUB
  • 126 Views
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Original Research

Article
Exposure to High-Fat Style Diet Induced Renal and Liver Structural Changes, Lipid Accumulation and Inflammation in Intact and Ovariectomized Female Rats
Yamuna Sucedaram, Edward James Johns, Ruby Husain, Munavvar Abdul Sattar, Mohammed H Abdulla, Giribabu Nelli, Nur Syahrina Rahim, Manizheh Khalilpourfarshbafi & Nor Azizan Abdullah
Pages: 689-710
Published online: 18 Jul 2023
AbstractforExposure to High-Fat Style Diet Induced Renal and Liver Structural Changes, Lipid Accumulation and Inflammation in Intact and Ovariectomized Female Rats | Full Text | References | PDF (23.4 MB) | EPUB
  • 125 Views
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Article
Punicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway
Ruiting Shen, Peng Yin, Hua Yao, Lu Chen, Xinyu Chang, Huanrong Li & Xiaolin Hou
Pages: 711-718
Published online: 18 Jul 2023
AbstractforPunicalin Ameliorates Cell Pyroptosis Induced by LPS/ATP Through Suppression of ROS/NLRP3 Pathway | Full Text | References | PDF (4.2 MB) | EPUB
  • 112 Views
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Article
KCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease
Fenglei Zheng, Yijing Tao, Jingjing Liu, Zhimin Geng, Ying Wang, Yujia Wang, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang & Fangqi Gong
Pages: 719-735
Published online: 18 Jul 2023
AbstractforKCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease | Full Text | References | PDF (12.2 MB) | EPUB
  • 63 Views
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Article
Possible Role of Regulatory B Cells in Different Behçet’s Disease Phenotypes and Therapies: First Report from Egypt
Helal F Hetta, Alaa AA Mohamed, Asmaa M Zahran, Safaa A Mahran, Marwa MY Sayed, Mohamed GA Saleh, Khaled Abdelazeem, Gaber El-Saber Batiha, Salim Al-Rejaie, Yasir Waheed, Khalid Muhammad & Manal M Hassanien
Pages: 737-744
Published online: 18 Jul 2023
AbstractforPossible Role of Regulatory B Cells in Different Behçet’s Disease Phenotypes and Therapies: First Report from Egypt | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo
Hao Wang, Zengxin Jiang, Zhiying Pang, Guobin Qi, Bingxuan Hua, Zuoqin Yan & Hengfeng Yuan
Pages: 745-760
Published online: 09 Mar 2021
AbstractforEngeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo | Full Text | References | PDF (10.5 MB) | EPUB
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Article
Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury
Haibo Xie, Hui Wang, Qifeng Wu, Jiale Peng, Hua Huang, Yican Wang, Meng Huang, Wei Jiang, Yi Yang, Xuesong Zhang, Jiaxiang Zhang & Qixing Zhu
Pages: 761-776
Published online: 09 Mar 2021
AbstractforEndothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury | Full Text | References | PDF (12.1 MB) | EPUB
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Article
Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia
Yahong Zheng, Chengcheng Yue, Hui Zhang, Haoran Chen, Yanyan Liu & Jiabin Li
Pages: 777-789
Published online: 18 Jul 2023
AbstractforDeoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia | Full Text | References | PDF (8.1 MB) | EPUB
  • 86 Views
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Article
Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
Chaobin He, Xin Hua, Shuxin Sun, Shaolong Li, Jun Wang & Xin Huang
Pages: 791-802
Published online: 18 Jul 2023
AbstractforIntegrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers | Full Text | References | PDF (11.8 MB) | EPUB
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Article
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice
Dan Chen, Zhi-qi Gao, Ying-ying Wang, Bin-bin Wan, Gang Liu, Jun-liang Chen, Ya-xian Wu, Qin Zhou, Shan-yu Jiang, Ren-qiang Yu & Qing-feng Pang
Pages: 803-816
Published online: 10 Mar 2021
AbstractforSodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice | Full Text | References | PDF (7.7 MB) | EPUB
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Article
A Scoring System Based on Nutritional and Inflammatory Parameters to Predict the Efficacy of First-Line Chemotherapy and Survival Outcomes for De Novo Metastatic Nasopharyngeal Carcinoma
Wang-Zhong Li, Xin Hua, Shu-Hui Lv, Hu Liang, Guo-Ying Liu, Nian Lu, Wei-Xin Bei, Wei-Xiong Xia & Yan-Qun Xiang
Pages: 817-828
Published online: 10 Mar 2021
AbstractforA Scoring System Based on Nutritional and Inflammatory Parameters to Predict the Efficacy of First-Line Chemotherapy and Survival Outcomes for De Novo Metastatic Nasopharyngeal Carcinoma | Full Text | References | PDF (516.1 KB) | EPUB
  • 72 Views
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Article
Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis
Xiaoliang Zeng, Jihua Feng, Yanli Yang, Ruzhi Zhao, Qiao Yu, Han Qin, Lile Wei, Pan Ji, Hongyuan Li, Zimeng Wu & Jianfeng Zhang
Pages: 829-841
Published online: 11 Mar 2021
AbstractforScreening of Key Genes of Sepsis and Septic Shock Using Bioinformatics Analysis | Full Text | References | PDF (11.7 MB) | EPUB
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Article
Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis
Xiaoyu Hang, Zhenyu Zhang, Ruowen Niu, Chen Wang, Jing Yao, Yayun Xu, Jingjing Tao, Lanlan Li & Feihu Chen
Pages: 843-858
Published online: 12 Mar 2021
AbstractforEstrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis | Full Text | References | PDF (12.4 MB) | EPUB
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Article
Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema
Kuluvar Gouthamchandra, Heggar Venkataramana Sudeep, Siddappa Chandrappa, Amrith Raj, Puttaswamy Naveen & Kodimule Shyamaprasad
Pages: 859-868
Published online: 12 Mar 2021
AbstractforEfficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema | Full Text | References | PDF (1.7 MB) | EPUB
  • 120 Views
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Article
Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction
Acharya Balkrishna, Swati Haldar, Hoshiyar Singh, Partha Roy & Anurag Varshney
Pages: 869-884
Published online: 16 Mar 2021
AbstractforCoronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction | Full Text | References | PDF (7.9 MB) | EPUB
  • 122 Views
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Article
Altered Monocyte Subsets in Kawasaki Disease Revealed by Single-cell RNA-Sequencing
Zhimin Geng, Yijing Tao, Fenglei Zheng, Linlin Wu, Ying Wang, Yujia Wang, Yameng Sun, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang & Fangqi Gong
Pages: 885-896
Published online: 16 Mar 2021
AbstractforAltered Monocyte Subsets in Kawasaki Disease Revealed by Single-cell RNA-Sequencing | Full Text | References | PDF (6.1 MB) | EPUB
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Article
Associations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study
Rui Peng & Yan Li
Pages: 897-905
Published online: 16 Mar 2021
AbstractforAssociations Between Tenascin-C and Testosterone Deficiency in Men with Major Depressive Disorder: A Cross-Sectional Retrospective Study | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Adiponectin, but Not TGF-β1, CTGF, IL-6 or TNF-α, May Be a Potential Anti-Inflammation and Anti-Fibrosis Factor in Keloid
Limin Luo, Jun Li, Yuran Wu, Jianjun Qiao & Hong Fang
Pages: 907-916
Published online: 18 Jul 2023
AbstractforAdiponectin, but Not TGF-β1, CTGF, IL-6 or TNF-α, May Be a Potential Anti-Inflammation and Anti-Fibrosis Factor in Keloid | Full Text | References | PDF (3.3 MB) | EPUB
  • 87 Views
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Review

Review Article
Metalloproteinases in Inflammatory Bowel Diseases
Martin Marônek, Irene Marafini, Roman Gardlík, René Link, Edoardo Troncone & Giovanni Monteleone
Pages: 1029-1041
Published online: 18 Jul 2023
AbstractforMetalloproteinases in Inflammatory Bowel Diseases | Full Text | References | PDF (431.7 KB) | EPUB
  • 100 Views
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Original Research

Article
Complement Profiles in Patients with Amyotrophic Lateral Sclerosis: A Prospective Observational Cohort Study
Anne-Lene Kjældgaard, Katrine Pilely, Karsten Skovgaard Olsen, Anne Øberg Lauritsen, Stephen Wørlich Pedersen, Kirsten Svenstrup, Merete Karlsborg, Helle Thagesen, Morten Blaabjerg, Ásta Theódórsdóttir, Elisabeth Gundtoft Elmo, Anette Torvin Møller, Niels Anker Pedersen, Niels Kirkegaard, Kirsten Møller & Peter Garred
Pages: 1043-1053
Published online: 23 Mar 2021
AbstractforComplement Profiles in Patients with Amyotrophic Lateral Sclerosis: A Prospective Observational Cohort Study | Full Text | References | PDF (509.4 KB) | EPUB
  • 95 Views
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Review

Review Article
Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
SK Mohiuddin Choudhury, XuSheng Ma, Sahibzada Waheed Abdullah & HaiXue Zheng
Pages: 1145-1163
Published online: 26 Mar 2021
AbstractforActivation and Inhibition of the NLRP3 Inflammasome by RNA Viruses | Full Text | References | PDF (572.3 KB) | EPUB
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Original Research

Article
Anti-TWEAK Antibody Alleviates Renal Interstitial Fibrosis by Increasing PGC-1α Expression in Lupus Nephritis
Leixi Xue, Yi Zhang, Jiajun Xu, Wentian Lu, Qing Wang, Jinxiang Fu & Zhichun Liu
Pages: 1173-1184
Published online: 26 Mar 2021
AbstractforAnti-TWEAK Antibody Alleviates Renal Interstitial Fibrosis by Increasing PGC-1α Expression in Lupus Nephritis | Full Text | References | PDF (668.4 KB) | EPUB
  • 60 Views
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Article
Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways
Fuyu Jin, Fei Geng, Dingjie Xu, Yaqian Li, Tian Li, Xinyu Yang, Shupeng Liu, Hui Zhang, Zhongqiu Wei, Shifeng Li, Xuemin Gao, Wenchen Cai, Na Mao, Xue Yi, Heliang Liu, Ying Sun, Fang Yang & Hong Xu
Pages: 1647-1660
Published online: 18 Jul 2023
AbstractforAc-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways | Full Text | References | PDF (1.3 MB) | EPUB
  • 73 Views
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