P2RX7 Gene rs1718125 Polymorphism is Related with Postoperative Pain and Fentanyl Intake in Esophageal Cancer Patients

Abstract

Background

Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient’s genotype before surgery may help to control the fentanyl dose in the perioperative period.

Patients and Methods

This study enrolling 645 esophageal cancer (EC) patients was aimed to investigate the associations of P2RX7 gene rs1718125 polymorphism with fentanyl intake and postoperative pains in a Chinese Han population. Genotyping was accomplished by direct sequencing and polymerase chain reaction.

Results

The GA/AA genotype carriers showed lower visual analog scale scores at postoperative 0, 6 and 24 h, but not at 48 h, compared with the GG genotype. The fentanyl consumption of GG genotype was remarkably more relative to the GA/AA genotype at 6 and 24 h after treatment.

Conclusion

P2RX7 rs1718125 polymorphism is connected to the postoperative pains and fentanyl use for EC patients.

Keywords:

• esophageal cancer
• fentanyl
• P2RX7
• single nucleotide polymorphism
• postoperative pain

Abbreviations

EC, esophageal cancer; PCR, polymerase chain reaction; VAS, visual analog scale; P2RX7, purinergic receptor P2X7; SNP, single-nucleotide polymorphism.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

There is no funding to report.