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Abstract
The normal development of the mammalian CNS is entirely dependent on the coordinated behavior of its cellular components. Particular importance is attributed to the correct morphology, migration and communication of neurons. Recent years have seen the identification of many extracellular, cell surface and intracellular signaling molecules that are important for normal CNS development, consequently triggering huge progress in our understanding of the complex processes involved. A key molecule to emerge is Cdk5. To date, Cdk5 has been functionally linked with controlled neuronal morphology, migration, synaptic function, cognition, drug addiction, neuronal death and neurodegeneration. The complexity of its function has been confirmed by the ever increasing number of diverse upstream regulators, protein substrates and biological consequences of altered catalytic function. The aim of this review is to consolidate recent findings concerning the role of Cdk5 in the developing nervous system, particularly the cerebral cortex, where its importance is most clearly evidenced.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.