Resting Functional Connectivity and Mild Cognitive Impairment in Parkinson’s Disease. An Electroencephalogram Study

Abstract

Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI.

Keywords::

• cognitive impairment
• electroencephalography
• executive functions
• functional connectivity
• Parkinson’s disease
• resting state

Financial & competing interests disclosure

This study was supported by the Research Development Committee (CODI) of the University of Antioquia, Colombia. Research project: “Procesamiento del lenguaje de acción en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicológica y neurofisiológica” (grant reference PRG-2014-768). The study sponsor had no role in the collection, analysis or interpretation of data, nor in the writing of the final manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical disclosure

The authors state that the present study protocol had the approval of the Ethical Research Committee of the University of Antioquia (No. 15-10-569). All participants gave their written informed consent after an explanation of the study characteristics, and before any clinical or experimental evaluation, according to the declaration of Helsinki.

Additional information

Funding

This study was supported by the Research Development Committee (CODI) of the University of Antioquia, Colombia. Research project: “Procesamiento del lenguaje de acción en pacientes con enfermedad ganglio-basal desde una perspectiva neuropsicológica y neurofisiológica” (grant reference PRG-2014-768). The study sponsor had no role in the collection, analysis or interpretation of data, nor in the writing of the final manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.