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Abstract
Evaluation of: Rolstad S, Berg AI, Bjerke M, Johansson B, Zetterberg H, Wallin A. Cerebrospinal fluid biomarkers mirror rate of cognitive decline. J. Alzheimers Dis. 34(4), 949–956 (2013). This study investigates cerebrospinal fluid biomarkers 42-amino acid form of amyloid-β (Aβ42) and total tau (T-tau) as predictors of cognitive decline in 326 subjects followed for 2 years and ranging from cognitively healthy elders to demented patients. In healthy controls, no relationship was found between cerebrospinal fluid biomarkers and cognitive decline. In subjective cognitive impairment individuals and mild cognitive impairment patients, T-tau had an impact on executive functions. The impact of T-tau was even larger on semantic memory in demented patients. The influence of Aβ42 level was small on speed and executive functions in mild cognitive impairment patients and moderate on semantic and verbal working memory in dementia patients. These findings demonstrate that cerebrospinal fluid biomarkers are good predictors of cognitive decline across a continuum, from healthy elders to demented patients. Further research taking into account population studies with a follow-up of more than 2 years is needed to strengthen this notion.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.