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Abstract
Human cytomegalovirus (HCMV) generates a significant clinical burden worldwide, particularly among the immune compromised. In approximately 30% of untreated HIV/AIDS patients without access or sufficient response to antiretroviral therapies, for example, HCMV causes a sight-threatening retinitis. To study the mechanisms of AIDS-related HCMV retinitis, our lab has for many years used a mouse model in which a mixture of mouse retroviruses induces murine AIDS after approximately 10 weeks, rendering otherwise resistant mice susceptible to opportunistic pathogens. This immunodeficiency combined with subretinal inoculation of murine cytomegalovirus yields a reproducible model of the human disease, facilitating the discovery of many clinically relevant virologic and immunologic mechanisms of retinal destruction which we summarize in this review.
Acknowledgments
We thank all those whose work over the years has contributed to our knowledge of the topics discussed herein and sincerely apologize to those whose work may be relevant to this review but could not be included due to space restrictions. We thank Dr H Chien for illustrating the diagram used to make . was fashioned using the Motifolio Biology Toolkit (motifolio.com).
Financial & competing interests disclosure
This work was supported in part by NIH/NEI (grant number: EY024630), NIH/NEI Core (grant number: P30EY006360), Emory Eye Center Vision Training (grant number: NIH/NEI T32-EY007092) and Fight for Sight, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.