https://orcid.org/0000-0001-6565-4011
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Abstract
Intraoperative neurophysiological information could increase accuracy of surgical deep brain stimulation (DBS) lead placement. Subsequently, DBS therapy could be optimized by specifically targeting pathological activity. In Parkinson’s disease, local field potentials (LFPs) excessively synchronized in the beta band (13–35 Hz) correlate with akinetic-rigid symptoms and their response to DBS therapy, particularly low beta band suppression (13–20 Hz) and high frequency gamma facilitation (35–250 Hz). In dystonia, LFPs abnormally synchronize in the theta/alpha (4–13 Hz), beta and gamma (60–90 Hz) bands. Phasic dystonic symptoms and their response to DBS correlate with changes in theta/alpha synchronization. In essential tremor, LFPs excessively synchronize in the theta/alpha and beta bands. Adaptive DBS systems will individualize pathological characteristics of neurophysiological signals to automatically deliver therapeutic DBS pulses of specific spatial and temporal parameters.
Acknowledgments
The authors would like to thank Laura Rotolo, Michael Williams and Cassandra June for their support in the care of patients treated with deep brain stimulation at the Motor Physiology and Neuromodulation Program at the University of Rochester Medical Center, Rochester, NY, USA.
Financial & competing interests disclosure
KJ Lizarraga and C Zimmerman have been reimbursed for travel to educational activities sponsored by Abbott, Boston Scientific and Medtronic. KJ Lizarraga has received an educational grant by Medtronic. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.