Magnetically Driven Treatments: Optimizing Performance by Mitigation of Eddy Currents

Abstract

Aim: In this work, we study the eddy current evolution naturally occurring in magnetically driven treatments, such as MRI and magnetic particle hyperthermia (MPH), and propose the mitigation of eddy currents by careful control of field parameters. Materials & methods: We start by simulation of typical MRI and MPH experimental setups to witness eddy currents and then we examine experimentally how field parameters (frequency, amplitude and pulse duration) mitigate eddy currents in a typical MPH treatment. Results and conclusion: By tuning the frequency, the amplitude and by applying pulsed field mode, we successfully attenuate undesirable heating, due to eddy currents’ evolution, on surrounding healthy tissues without sparing beneficial effect within the malignant region, thus treatment remains reliable yet with milder side effects.

Keywords::

• cancer therapy
• magnetic nanoparticles
• magnetic particle hyperthermia
• MRI
• pulsed AMF

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/nnm-2020-0383

Author contributions

A-R Tsiapla conducted the experimental part, K Angelou conducted the simulation part, M Angelakeris coordinated and supervised the whole effort. All authors have jointly worked in manuscript and carefully read the submitted manuscript version.

Financial & competing interests disclosure

This research is co-financed by Greece and the European Union (European Social Fund) through the Operational Programme ‘Human Resources Development, Education and Lifelong Learning 2014–2020’ in the context of the project “Thermal and mechanical activation of magnetic nanoparticles as anti-cancer strategy” (MIS: 5047898). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors confirm that all the research meets the ethical guidelines, including adherence to the legal requirements of the study country.

Additional information

Funding

This research is co-financed by Greece and the European Union (European Social Fund) through the Operational Programme ‘Human Resources Development, Education and Lifelong Learning 2014–2020’ in the context of the project “Thermal and mechanical activation of magnetic nanoparticles as anti-cancer strategy” (MIS: 5047898). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.