Pregnancy and Pharmacogenomics in the Context of Drug Metabolism and Response

Abstract

It is well-known that profound physiological and biochemical changes occur throughout the course of pregnancy. At the same time, the role of pharmacogenomics in modulating the metabolism and response profile to numerous medications has been elucidated. Yet, the clinical impact of pharmacogenomics during pregnancy is less well understood. We present an overview of factors modulating the pharmacokinetics and pharmacodynamics of medications throughout the time span of pregnancy while providing insights on how pharmacogenomics may contribute to interindividual variability in drug metabolism and response amongst pregnant women.

KEYWORDS::

• CYPs
• metabolism
• pharmacogenomics
• pregnancy
• response
• transporters

Acknowledgements

The authors would like to thank N Melamed for critically reviewing this manuscript and providing consultation in maternal–fetal medicine.

Financial & competing interests disclosure

A Helldén is supported by a research grant from The Foundation for Clinical Pharmacology and Pharmacotherapy, Stockholm, Sweden. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

A Helldén is supported by a research grant from The Foundation for Clinical Pharmacology and Pharmacotherapy, Stockholm, Sweden. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.