Stimulatory Effect of Epidermal Growth Factor on Liver Regeneration after Partial Hepatectomy in Rats

T. N. Rasmussen Dept. of Surgery C and Dept. of Medicine A, Rigshospitalet, University of Copenhagen, Denmark; Dept. of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark

P. E. JøSrgensen Dept. of Surgery C and Dept. of Medicine A, Rigshospitalet, University of Copenhagen, Denmark; Dept. of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark

T. Almdal Dept. of Surgery C and Dept. of Medicine A, Rigshospitalet, University of Copenhagen, Denmark; Dept. of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark

P. Kirkegaard Dept. of Surgery C and Dept. of Medicine A, Rigshospitalet, University of Copenhagen, Denmark; Dept. of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark

P. Skov Olsen Dept. of Surgery C and Dept. of Medicine A, Rigshospitalet, University of Copenhagen, Denmark; Dept. of Medical Physiology C, The Panum Institute, University of Copenhagen, Denmark

Abstract

The effect of epidermal growth factor (EGF) on liver regeneration was investigated in rats subjected to partial hepatectomy. In a dose-response study EGF in doses of 6 and 24 nmol/kg X day increased liver regeneration after treatment for 48 h compared with controls, whereas a dose of 48 nmol/kg X day had no effect. In a subsequent study EGF, 6 nmol/kg X day, accelerated liver regeneration significantly after 36, 48, and 72 h of treatment. A possible influence of EGF on other hepatotrophic factors was investigated. No changes in the concentration of gastrin, insulin, or glucagon was found in portal venous blood. This study has shown that EGF in small doses can stimulate liver regeneration, whereas higher doses are ineffective. The study suggests that EGF should be regarded as a hepatotrophic factor.

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Stimulatory Effect of Epidermal Growth Factor on Liver Regeneration after Partial Hepatectomy in Rats

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Stimulatory Effect of Epidermal Growth Factor on Liver Regeneration after Partial Hepatectomy in Rats

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